Insights into the antibacterial and immunomodulatory functions of the antimicrobial peptide, epinecidin-1, against Vibrio vulnificus infection in zebrafish

Fish and Shellfish Immunology

Volumn 31, Issue 6, 2011, Pages 1019-1025

  Pan, Chieh Yu ^a   Wu, Jen Leih ^b   Hui, Cho Fat ^b   Lin, Cheng Hui ^a   Chen, Jyh Yih ^b  

^a NATIONAL TAIWAN OCEAN UNIVERSITY   (Taiwan)

^b INSTITUTE OF CELLULAR AND ORGANISMIC BIOLOGY   (Taiwan)

Author keywords

Antimicrobial peptide; Danio rerio; Epinecidin 1; Immunomodulatory; Vibrio vulnificus

Indexed keywords

BACTERIA (MICROORGANISMS); DANIO RERIO; VIBRIO VULNIFICUS;

EID: 81255142200     PISSN: 10504648     EISSN: 10959947     Source Type: Journal    
DOI: 10.1016/j.fsi.2011.09.001     Document Type: Article

References (41)

1. Jones M.K., Oliver J.D. Vibrio vulnificus: disease and pathogenesis. Infect Immun 2009, 77(5):1723-1733.
2. Amaro C., Biosca E.G., Fouz B., Alcaide E., Esteve C. Evidence that water transmits Vibrio vulnificus biotype 2 infections to eels. Appl Environ Microbiol 1995, 61(3):1133-1137.
3. Feldhusen F. The role of seafood in bacterial foodborne diseases. Microbes Infect 2000, 2(13):1651-1660.
4. Hlady W.G., Klontz K.C. The epidemiology of Vibrio infections in Florida, 1981-1993. J Infect Dis 1996, 173(5):1176-1183.
5. Pedersen K., Skall H.F., Lassen-Nielsen A.M., Nielsen T.F., Henriksen N.H., Olesen N.J. Surveillance of health status on eight marine rainbow trout, Oncorhynchus mykiss (Walbaum), farms in Denmark in 2006. J Fish Dis 2008, 31(9):659-667.
6. Alday-Sanz V., Roque A., Turnbull J.F. Clearing mechanisms of Vibrio vulnificus biotype I in the black tiger shrimp Penaeus monodon. Dis Aquat Organ 2002, 48(2):91-99.
7. Hor L.I., Chang Y.K., Chang C.C., Lei H.Y., Ou J.T. Mechanism of high susceptibility of iron-overloaded mouse to Vibrio vulnificus infection. Microbiol Immunol 2000, 44(11):871-878.
8. Powell J.L., Wright A.C., Wasserman S.S., Hone D.M., Morris J.G. Release of tumor necrosis factor alpha in response to Vibrio vulnificus capsular polysaccharide in vivo and in vitro models. Infect Immun 1997 Sep, 65(9):3713-3718.
9. Shin S.H., Shin D.H., Ryu P.Y., Chung S.S., Rhee J.H. Proinflammatory cytokine profile in Vibrio vulnificus septicemic patients' sera. FEMS Immunol Med Microbiol 2002 Jun 3, 33(2):133-138.
10. Chiang S.R., Tang H.J., Chang P.C., Cheng K.C., Ko W.C., Chen C.H., et al. Synergistic antimicrobial effect of cefotaxime and minocycline on proinflammatory cytokine levels in a murine model of Vibrio vulnificus infection. J Microbiol Immunol Infect 2007, 40(2):123-133.
11. Lin S.B., Fan T.W., Wu J.L., Hui C.F., Chen J.Y. Immune response and inhibition of bacterial growth by electrotransfer of plasmid DNA containing the antimicrobial peptide, epinecidin-1, into zebrafish muscle. Fish Shellfish Immunol 2009, 26(3):451-458.
12. Pan C.Y., Chen J.Y., Lin T.L., Lin C.H. In vitro activities of three synthetic peptides derived from epinecidin-1 and an anti-lipopolysaccharide factor against Propionibacterium acnes, Candida albicans, and Trichomonas vaginalis. Peptides 2009, 30(6):1058-1068.
13. Wang Y.D., Kung C.W., Chen J.Y. Antiviral activity by fish antimicrobial peptides of epinecidin-1 and hepcidin 1-5 against nervous necrosis virus in medaka. Peptides 2010, 31(6):1026-1033.
14. Wang Y.D., Kung C.W., Chi S.C., Chen J.Y. Inactivation of nervous necrosis virus infecting grouper (Epinephelus coioides) by epinecidin-1 and hepcidin 1-5 antimicrobial peptides, and downregulation of Mx2 and Mx3 gene expressions. Fish Shellfish Immunol 2010, 28(1):113-120.
15. Camaschella C. Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders. Blood 2005, 106(12):3710-3717.
16. Rajanbabu V., Pan C.Y., Lee S.C., Lin W.J., Lin C.C., Li C.L., et al. Tilapia hepcidin 2-3 peptide modulates lipopolysaccharide-induced cytokines and inhibits tumor necrosis factor-alpha through cyclooxygenase-2 and phosphodiesterase 4D. J Biol Chem 2010, 285(40):30577-30586.
17. Linkous D.A., Oliver J.D. Pathogenesis of Vibrio vulnificus. FEMS Microbiol Lett 1999, 174(2):207-214.
18. Strom M.S., Paranjpye R.N. Epidemiology and pathogenesis of Vibrio vulnificus. Microbes Infect 2000, 2(2):177-188.
19. Baker-Austin C., McArthur J.V., Lindell A.H., Wright M.S., Tuckfield R.C., Gooch J., et al. Multi-site analysis reveals widespread antibiotic resistance in the marine pathogen Vibrio vulnificus. Microb Ecol 2009, 57(1):151-159.
20. Pini A., Falciani C., Mantengoli E., Bindi S., Brunetti J., Iozzi S., et al. A novel tetrabranched antimicrobial peptide that neutralizes bacterial lipopolysaccharide and prevents septic shock in vivo. FASEB J 2010, 24(4):1015-1022.
21. Huang H.N., Pan C.Y., Rajanbabu V., Chan Y.L., Wu C.J., Chen J.Y. Modulation of immune responses by the antimicrobial peptide, epinecidin (Epi)-1, and establishment of an Epi-1-based inactivated vaccine. Biomaterials 2011, 32(14):3627-3636.
22. Hancock R.E., Sahl H.G. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Nat Biotechnol 2006, 24(12):1551-1557.
23. Rajanbabu V., Chen J.Y. Applications of antimicrobial peptides from fish and perspectives for the future. Peptides 2011, 32(2):415-420.
24. Pan C.Y., Chow T.Y., Yu C.Y., Yu C.Y., Chen J.C., Chen J.Y. Antimicrobial peptides of an anti-lipopolysaccharide factor, epinecidin-1, and hepcidin reduce the lethality of Riemerella anatipestifer sepsis in ducks. Peptides 2010, 31(5):806-815.
25. Falco A., Brocal I., Pérez L., Coll J.M., Estepa A., Tafalla C. In vivo modulation of the rainbow trout (Oncorhynchus mykiss) immune response by the human alpha defensin 1, HNP1. Fish Shellfish Immunol 2008, 24(1):102-112.
26. Rajanbabu V., Chen J.Y. The antimicrobial peptide, tilapia hepcidin 2-3, and PMA differentially regulate the protein kinase C isoforms, TNF-α and COX-2, in mouse RAW264.7 macrophages. Peptides 2011, 32(2):333-341.
27. Rajanbabu V., Chen J.Y. Antiviral function of tilapia hepcidin 1-5 and its modulation of immune-related gene expressions against infectious pancreatic necrosis virus (IPNV) in Chinook salmon embryo (CHSE)-214 cells. Fish Shellfish Immunol 2011, 30(1):39-44.
28. Meijer A.H., Verbeek F.J., Salas-Vidal E., Corredor-Adámez M., Bussman J., van der Sar A.M., et al. Transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection. Mol Immunol 2005, 42(10):1185-1203.
29. Ragno S., Romano M., Howell S., Pappin D.J., Jenner P.J., Colston M.J. Changes in gene expression in macrophages infected with Mycobacterium tuberculosis: a combined transcriptomic and proteomic approach. Immunology 2001, 104(1):99-108.
30. Shin N.R., Lee D.Y., Yoo H.S. Analysis of gene expression in mouse alveolar macrophages stimulated with quorum-sensing mutants of Vibrio vulnificus. Jpn J Infect Dis 2008, 61(5):402-406.
31. Han Y., Zhou D., Pang X., Zhang L., Song Y., Tong Z., et al. Comparative transcriptome analysis of Yersinia pestis in response to hyperosmotic and high-salinity stress. Res Microbiol 2005, 156(3):403-415.
32. Liew K.J., Chow V.T. Microarray and real-time RT-PCR analyses of a novel set of differentially expressed human genes in ECV304 endothelial-like cells infected with dengue virus type 2. J Virol Methods 2006, 131(1):47-57.
33. Takeda K., Kaisho T., Akira S. Toll-like receptors. Annu Rev Immunol 2003, 21:335-376.
34. Jault C., Pichon L., Chluba J. Toll-like receptor gene family and TIR-domain adapters in Danio rerio. Mol Immunol 2004, 40(11):759-771.
35. Stamm L.V. Role of TLR4 in the host response to Vibrio vulnificus, an emerging pathogen. FEMS Immunol Med Microbiol 2010, 58(3):336-343.
36. Sepulcre M.P., Alcaraz-Pérez F., López-Muñoz A., Roca F.J., Meseguer J., Cayuela M.L., et al. Evolution of lipopolysaccharide (LPS) recognition and signaling: fish TLR4 does not recognize LPS and negatively regulates NF-kappaB activation. J Immunol 2009, 182(4):1836-1845.
37. Sullivan C., Charette J., Catchen J., Lage C.R., Giasson G., Postlethwait J.H., et al. The gene history of zebrafish tlr4a and tlr4b is predictive of their divergent functions. J Immunol 2009, 183(9):5896-5908.
38. Palti Y. Toll-like receptors in bony fish: from genomics to function. Dev Comp Immunol 2011, [Epub ahead of print].
39. Meijer A.H., Gabby Krens S.F., Medina Rodriguez I.A., He S., Bitter W., Ewa Snaar-Jagalska B., et al. Expression analysis of the toll-like receptor and TIR domain adaptor families of zebrafish. Mol Immunol 2004, 40(11):773-783.
40. Bucki R., Leszczyńska K., Namiot A., Sokołowski W. Cathelicidin LL-37: a multitask antimicrobial peptide. Arch Immunol Ther Exp (Warsz) 2010, 58(1):15-25.
41. Bandholtz L., Ekman G.J., Vilhelmsson M., Buentke E., Agerberth B., Scheynius A., et al. Antimicrobial peptide LL-37 internalized by immature human dendritic cells alters their phenotype. Scand J Immunol 2006, 63(6):410-419.