Changes in gene expression in macrophages infected with Mycobacterium tuberculosis: A combined transcriptomic and proteomic approach

Immunology

Volumn 104, Issue 1, 2001, Pages 99-108

  Ragno, Silvia ^a,d   Romano, Maria ^a,b   Howell, Steven ^a   Pappin, Darryl J C ^c   Jenner, Peter J ^a   Colston, Michael J ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b INSTITUTO NACIONAL DE TECNOLOGÍA AGROPECUARIA INTA   (Argentina)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^d Celldex Therapeutics Inc   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CCR3; CYTOKINE; EOTAXIN; GELATINASE B; HEAT SHOCK PROTEIN 27; INTEGRIN; INTEGRIN A3; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MANGANESE SUPEROXIDE DISMUTASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; MYELOID PROGENITOR INHIBITORY FACTOR 1; OSTEOPONTIN; PROTEIN; PROTEOME; PULMONARY AND ACTIVATION REGULATED CHEMOKINE; RANTES; TRANSCRIPTOME; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ARTICLE; CELL FUNCTION; CELL MIGRATION; CELL PH; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOREGULATION; MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REGULATORY MECHANISM; TH2 CELL;

CHEMOKINES; CYTOKINES; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GENE EXPRESSION REGULATION; HUMANS; MACROPHAGE ACTIVATION; MACROPHAGES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHAGOCYTOSIS; TUBERCULOSIS; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0034792227     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2001.01274.x     Document Type: Article

References (56)

1. The global tuberculosis situation and the new control strategy of the World Health Organization
2. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
3. Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis
4. Complement receptor-mediated uptake and tumor necrosis factor-alpha-mediated growth inhibition of Mycobacterium tuberculosis by human alveolar macrophages
5. Macrophage phagocytosis of virulent but not attenuated strains of Mycobacterium tuberculosis is mediated by mannose receptors in addition to complement receptors
6. Mycobacteria macrophage interactions: Macrophage phenotype determines the nonopsonic binding of Mycobacterium tuberculosis to murine macrophages
7. Selective receptor blockade during phagocytosis does not alter the survival and growth of Mycobacterium tuberculosis in human macrophages
8. A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43
9. Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. Reversal of the usual nonfusion pattern and observations on bacterial survival
10. Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase
11. Mycobacterium-containing phagosomes are accessible to early endosomes and reflect a transitional state in normal phagosome biogenesis
12. Essential role for cholesterol in entry of mycobacteria into macrophages
13. A coat protein on phagosomes involved in the intracellular survival of mycobacteria
14. Sequestration from immune CD4 T cells of mycobacteria growing in human macrophages
15. Defective antigen presentation by Mycobacterium tuberculosis-infected monocytes
16. Improved and simplified in-gel sample application using reswelling of dry immobilized pH gradients
17. Improvement and simplification of low-background silver staining of proteins by using sodium dithionite
18. Mass spectrometric sequencing of proteins from silver-stained polyacrylamide gels
19. Langerhans' cells produce type IV collagenase (MMP-9) following epicutaneous stimulation with haptens
20. Possible involvement of matrix metalloproteinase-9 in Langerhans' cell migration and maturation
21. +-ATPase
22. The proton-ATPase of bacteria and mitochondria
23. Chemokine production by a human alveolar epithelial cell line in response to Mycobacterium tuberculosis
24. Pulmonary epithelial cells are a source of IL-8 in the response to Mycobacterium tuberculosis: Essential role of IL-1 from infected monocytes in a NF-kappa B-dependent network
25. Interleukin-8 induces lymphocyte chemotaxis into the pleural space. Role of pleural macrophages
26. Chemokine secretion by human polymorphonuclear granulocytes after stimulation with Mycobacterium tuberculosis and lipoarabinomannan
27. Differential cytokine gene expression and secretion after phagocytosis by a human monocytic cell line of Toxoplasma gondii compared with Mycobacterium tuberculosis
28. A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis
29. Chemokines induced by infection of mononuclear phagocytes with mycobacteria and present in lung alveoli during active pulmonary tuberculosis
30. Phagocytosis of Mycobacterium tuberculosis or particulate stimuli by human monocytic cells induces equivalent monocyte chemotactic protein-1 gene expression
31. Expression of chemokines and induction of rapid cell death in human blood neutrophils by Mycobacterium tuberculosis
32. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
33. Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils
34. High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines
35. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils
36. Differential expression and cross-regulatory function of RANTES during mycobacterial (type 1) and schistosomal (type 2) antigen-elicited granulomatous inflammation
37. Characterization of eosinophils and detection of eotaxin in skin chamber fluid after challenge with relevant allergen in patients with mild asthma
38. Increases in eotaxin-positive cells in induced sputum from atopic asthmatic subjects after inhalational allergen challenge
39. Enhanced expression of eotaxin and CCR3 in atopic dermatitis
40. Eotaxin: From an eosinophilic chemokine to a major regulator of allergic reactions
41. CC chemokine receptor (CCR) 3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo
42. Influence of polymorphism in the genes for the interleukin (IL)-1 receptor antagonist and IL-1beta on tuberculosis
43. TNF-alpha and IL-10 modulate the induction of apoptosis by virulent Mycobacterium tuberculosis in murine macrophages
44. Mycobacterium tuberculosis CDC1551 induces a more vigorous host response in vivo and in vitro, but is not more virulent than other clinical isolates
45. Macrophage oxygen-dependent antimicrobial activity I V. Role of endogenous scavengers of oxygen intermediates
46. Rapid priming of human monocytes by human hematopoietic growth factors: Granulocyte-macrophage colony-stimulating factor (CSF), macrophage-CSF, and interleukin-3 selectively enhance superoxide release triggered by receptor-mediated agonists
47. Macrophage oxygen-dependent antimicrobiol activity III. Enhanced oxidative metabolism as an expression of macrophage
48. Induction of manganese superoxide dismutase by tumor necrosis factor: Possible protective mechanism
49. HIV type 1 infection of human macrophages induces an upregulation of manganese superoxide dismutase gene that may protect cells from death
50. hsp27 negatively regulates cell death by interacting with cytochrome c
51. Streptococcal cytoplasmic pH is regulated by changes in amount and activity of a proton-translocating ATPase
52. 0-ATPase, which functions as a regulator of cytoplasmic pH
53. 0-ATPase from Helicobacter pylori
54. Acid tolerance, proton permeabilities, and membrane ATPases of oral streptococci
55. Monitoring cellular responses to Listeria monocytogenes with oligonucleotide arrays
56. Salmonella typhimurium infection and lipopolysaccharide stimulation induce similar changes in macrophage gene expression