Role of TLR4 in the host response to Vibrio vulnificus, an emerging pathogen

FEMS Immunology and Medical Microbiology

Volumn 58, Issue 3, 2010, Pages 336-343

  Stamm, Lola V ^a  

^a University of North Carolina at Chapel Hill   (United States)

Author keywords

MyD88; TLR4; TNF ; Vibrio vulnificus

Indexed keywords

MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL CELL; BACTERIAL STRAIN; BLOOD; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EX VIVO STUDY; HUMAN; IMMUNE RESPONSE; MALE; MEDIATOR; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SPLEEN CELL; VIBRIO VULNIFICUS; VIBRIO VULNIFICUS INFECTION;

ANIMALS; HOST-PATHOGEN INTERACTIONS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; SPLEEN; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA; VIBRIO INFECTIONS; VIBRIO VULNIFICUS;

EID: 77949385468     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2009.00643.x     Document Type: Article

References (38)

1. Adachi O, Kawai T, Takeda K, Matsumoto M, Tsutsui H, Sakagami M, Nakanishi K & Akira S (1998) Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9: 143-150.
2. Babu MM & Sankaran K (2005) DOLOP - a database of bacterial lipoproteins, 101 predicted lipoproteins out of 4955 predicted ORFs for Vibrio vulnificus YJ016. Available at http://www.mrc-lmb.cam.ac.uk/ genomes/dolop/predicted/vb.shtml
3. Bradley JR (2008) TNF-mediated inflammatory disease. J Pathol 214: 149-160.
4. Centers for Disease Control and Prevention (2005) Vibrio illnesses after Hurricane Katrina-multiple states, August-September 2005. MMWR 54: 928-931.
5. Chung PH, Chuang SK, Tsang T, Wai-man L, Yung R, Lo J & the Collaborative Study Group on Vibrio vulnificus Infections in Hong Kong (2006) Cutaneous injury and Vibrio vulnificus infection. Emerg Infect Dis 12: 1302-1303.
6. Dechet AM, Yu PA, Koram N & Painter J (2008) Nonfoodborne Vibrio infections: an important cause of morbidity and mortality in the United States, 1997-2006. Clin Infect Dis 46: 970-976.
7. Espat NJ, Auffenberg T, Abouhamze A, Baumhofer J, Moldawer LL & Howard RJ (1996) A role for tumor necrosis factor-alpha in the increased mortality associated with Vibrio vulnificus infection in the presence of hepatic dysfunction. Ann Surg 223: 428-433.
8. Gao H, Evans TW & Finney SJ (2008) Sepsis, severe sepsis and septic shock- does the nature of the infecting organism matter? Crit Care 12: 213-218.
9. Gerold G, Zychlinsky A & de Diego JL (2007) What is the role of Toll-like receptors in bacterial infection? Semin Immunol 19: 41-47.
10. Goo SY, Han YS, Kim WH, Lee KH & Park SJ (2007) Vibrio vulnificus IlpA-induced cytokine production is mediated by Toll-like receptor 2. J Biol Chem 282: 27647-27658.
11. Gulig P, Bourdage KL & Starks AM (2005) Molecular pathogenesis of Vibrio vulnificus. J Microbiol 43: 118-131.
12. Hoshino K, Takeuchi O, Kawai T, Sandjo H, Ogawa T, Takeda Y, Takeda K & Akira S (1999) Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162: 3749-3752.
13. Jackson JK, Murphree RL &Tamplin ML (1997) Evidence that mortality from Vibrio vulnificus infection results from single strains among heterogeneous populations in shellfish. J Clin Microbiol 35: 2098-2191.
14. Jones MK & Oliver JD (2009) Vibrio vulnificus: disease and pathogenesis. Infect Immun 77: 1723-1733.
15. Kashimoto T, Ueno S, Hayashi H, Hanajima H, Yoshioka K, Yoshida K, Mutoh K & Susa N (2005) Depletion of lymphocytes, but not neutrophils, via apoptosis in a murine model of Vibrio vulnificus infection. J Med Microbiol 54: 15-22.
16. Khan AQ, Chen Q, Wu ZQ, Paton JC & Snapper CM (2005) Both innate immunity and type 1 humoral immunity to Streptococcus pneumoniae are mediated byMyD88 but differ in their relative levels of dependence on Toll-like receptor 2. Infect Immun 73: 298-307.
17. Langezaal I, Coecke S & Hartung T (2001)Whole blood cytokine response as a measure of immunotoxicity. Toxicol in Vitro 15: 313-318.
18. Leaver SK, Finney SJ, Burke-Gaffney A & Evans TW (2007) Sepsis since the discovery of toll-like receptors: disease concepts and therapeutic opportunities. Crit Care Med 35: 1404-1410.
19. Lee SE, Kim SY, Jeong BC et al. (2006) A bacterial flagellin, Vibrio vulnificus FlaB, has a strong mucosal adjuvant activity to induce protective immunity. Infect Immun 74: 694-702.
20. Lu ZQ, Li MF, Qiu QM, Liang H, Zhou TL, Hong GL &Wu B (2009) Effect of antimicrobial agents on the toll-like receptors and inflammatory cytokines in liver tissue of the alcohol-induced liver disease in rats with Vibrio vulnificus sepsis. Chinese Med J 122: 1910-1916.
21. Nau GJ, Schlesinger A, Richmond JFL & Young RA (2003) Cumulative toll-like receptor activation in human macrophages treated with whole bacteria. J Immunol 170: 5203-5209.
22. Ojeda MO, Silva CV, Rosainz MdJA & Fernandez-Ortega C (2002) TNFa production in whole blood cultures from healthy individuals. Biochem Bioph Res Co 292: 538-541.
23. Oliver JD (2005) Wound infections caused by Vibrio vulnificus and other marine bacteria. Epidemiol Infect 133: 383-391.
24. Paz S, Bisharat N, Paz E, Kidar O & Cohen D (2007) Climate change and the emergence of Vibrio vulnificus disease in Israel. Environ Res 103: 390-396.
25. Powell JL, Wright AC, Wasserman SS, Hone D & Morris JG Jr (1997) Release of tumor necrosis factor alpha in response to Vibrio vulnificus capsular polysaccharide in vivo and in vitro models. Infect Immun 65: 3713-3718.
26. Powell JL, Strauss KA, Wiley C, Zhan M & Morris JG Jr (2003) Inflammatory cytokine response to Vibrio vulnificus elicited by peripheral blood mononuclear cells from chronic alcohol users is associated with biomarkers of cellular oxidative stress. Infect Immun 71: 4212-4216.
27. Power MR, Peng Y, Maydanski E, Marshall JS & Lin TJ (2004) The development of early host response to Pseudomonas aeruginosa lung infection is critically dependent on myeloid differentiation factor 88 in mice. J Biol Chem 279: 49315-49322.
28. Roger T, Froidevaux C, Le Roy D, Reymond MK, Chanson AL, Mauri D, Burns K, Riederer BM, Akira S & Calandra T (2009) Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4. P Natl Acad Sci USA 106: 2348-2352.
29. Schluter D & Deckert M (2000) The divergent role of tumor necrosis factor receptors in infectious diseases. Microbes Infect 2: 1285-1292.
30. Shao CP & Hor LI (2000) Metalloprotease is not essential for Vibrio vulnificus virulence in mice. Infect Immun 68: 3569-3573.
31. Shin NR, Lee DY, Shin SJ, Kim KS & Yoo HS (2004) Regulation of proinflammatory mediator production in RAW264.7 macrophage by Vibrio vulnificus luxS and smcR. FEMS Immunol Med Mic 41: 169-176.
32. Shin SH, Shin DH, Ryu PY, Chung SS & Rhee JH (2002) Proinflammatory cytokine profile in Vibrio vulnificus septicemic patients' sera. FEMS Immunol Med Mic 33: 133-138.
33. Spiller S, Elson G, Ferstl R, Dreher S, Mueller T, Freudenberg M, Daubeuf B, Wagner H & Kirschning CJ (2008) TLR4-induced IFN-γ production increases TLR2 sensitivity and drives Gramnegative sepsis in mice. J Exp Med 205: 1747-1754.
34. Starks AM, Schoeb TR, Tamplin ML, Parveen S, Doyle T, Bomeisl PE, Escudero G & Gulig PA (2000) Pathogenesis of infection by clinical and environmental strains of Vibrio vulnificus in iron-dextran treated mice. Infect Immun 68: 5785-5793.
35. Takeda K & Akira S (2005) Toll-like receptors in innate immunity. Int Immunol 17: 1-14.
36. Vinh DC,Mubareka S, Fatoye B, Plourde P & Orr P (2006) Vibrio vulnificus septicemia after handling Tilapia species fish: a Canadian case report and review. Can J Infect Dis Med Microbiol 17: 129-132.
37. Weighardt H, Kaiser-Moore S, Vabulas RM, Kirschning CJ, Wagner H & Holzman B (2002) Myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection. J Immunol 169: 2823-2827.
38. Weiss DM, Takeda K, Akira S, Zychlinsky A & Moreno E (2005) MyD88, but not Toll-like receptors 4 and 2, is required for efficient clearance of Brucella abortus. Infect Immun 73: 5137-5143.