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Volumn 13, Issue 6, 2011, Pages 442-451

Beyond genome-wide association studies: New strategies for identifying genetic determinants of hypertension

Author keywords

Association analysis; Blood pressure; Epigenetics; Genome wide association study; GWAS; Histone modification; Hypertension; Linkage analysis; Methylation; microRNAs; Next generation sequencing; Post GWAS analysis

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; EPITHELIAL SODIUM CHANNEL; GENOMIC DNA; HISTONE H1; HISTONE H2B; HISTONE H3; HISTONE H4; MICRORNA; PROTEIN KINASE WNK4;

EID: 81255134093     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-011-0230-y     Document Type: Article
Times cited : (27)

References (99)
  • 1
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • N Risch K Merikangas 1996 The future of genetic studies of complex human diseases Science 273 5281 1516 1517 8801636 10.1126/science.273.5281.1516 1:CAS:528:DyaK28Xls1Wqs7o%3D (Pubitemid 26301653)
    • (1996) Science , vol.273 , Issue.5281 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 2
    • 78751694194 scopus 로고    scopus 로고
    • Candidate gene and genome-wide association studies in behavioral medicine
    • A. Steptoe (eds). Springer New York. 10.1007/978-0-387-09488-5-29
    • Nolte IM, McCaffery JM, Snieder H. Candidate gene and genome-wide association studies in behavioral medicine. In: Steptoe A, editor. Handbook of behavioral medicine: Methods and applications. New York: Springer; 2010. p. 423-41.
    • (2010) Handbook of Behavioral Medicine: Methods and Applications , pp. 423-441
    • Nolte, I.M.1    McCaffery, J.M.2    Snieder, H.3
  • 3
    • 79959378465 scopus 로고    scopus 로고
    • Family-based designs for genome-wide association studies
    • 21629274 10.1038/nrg2989 1:CAS:528:DC%2BC3MXnslShu7Y%3D
    • J Ott Y Kamatani M Lathrop 2011 Family-based designs for genome-wide association studies Nat Rev Genet 12 7 465 474 21629274 10.1038/nrg2989 1:CAS:528:DC%2BC3MXnslShu7Y%3D
    • (2011) Nat Rev Genet , vol.12 , Issue.7 , pp. 465-474
    • Ott, J.1    Kamatani, Y.2    Lathrop, M.3
  • 6
    • 72849144434 scopus 로고    scopus 로고
    • Sequencing technologies-the next generation
    • 19997069 10.1038/nrg2626 1:CAS:528:DC%2BD1MXhsFOht7fO
    • ML Metzker 2010 Sequencing technologies-the next generation Nat Rev Genet 11 1 31 46 19997069 10.1038/nrg2626 1:CAS:528:DC%2BD1MXhsFOht7fO
    • (2010) Nat Rev Genet , vol.11 , Issue.1 , pp. 31-46
    • Metzker, M.L.1
  • 7
    • 77249141481 scopus 로고    scopus 로고
    • Genome-wide association studies: Contribution of genomics to understanding blood pressure and essential hypertension
    • 20425154 10.1007/s11906-009-0086-6
    • GB Ehret 2010 Genome-wide association studies: contribution of genomics to understanding blood pressure and essential hypertension Curr Hypertens Rep 12 1 17 25 20425154 10.1007/s11906-009-0086-6
    • (2010) Curr Hypertens Rep , vol.12 , Issue.1 , pp. 17-25
    • Ehret, G.B.1
  • 8
    • 77952553812 scopus 로고    scopus 로고
    • Genome-wide case/control studies in hypertension: Only the 'tip of the iceberg'
    • 20216088 1:CAS:528:DC%2BC3cXmtVSmsrk%3D
    • K Zhang AB Weder E Eskin DT O'Connor 2010 Genome-wide case/control studies in hypertension: only the 'tip of the iceberg' J Hypertens 28 6 1115 1123 20216088 1:CAS:528:DC%2BC3cXmtVSmsrk%3D
    • (2010) J Hypertens , vol.28 , Issue.6 , pp. 1115-1123
    • Zhang, K.1    Weder, A.B.2    Eskin, E.3    O'Connor, D.T.4
  • 9
    • 78650420360 scopus 로고    scopus 로고
    • Genome-wide association studies and beyond: What's next in blood pressure genetics?
    • 21060002 10.1161/HYPERTENSIONAHA.110.157214 1:CAS:528:DC%2BC3cXhsVCrsLzE
    • X Wang H Snieder 2010 Genome-wide association studies and beyond: what's next in blood pressure genetics? Hypertension 56 6 1035 1037 21060002 10.1161/HYPERTENSIONAHA.110.157214 1:CAS:528:DC%2BC3cXhsVCrsLzE
    • (2010) Hypertension , vol.56 , Issue.6 , pp. 1035-1037
    • Wang, X.1    Snieder, H.2
  • 10
    • 33750202275 scopus 로고    scopus 로고
    • The genetic dissection of essential hypertension
    • DOI 10.1038/nrg1967, PII NRG1967
    • AW Cowley Jr 2006 The genetic dissection of essential hypertension Nat Rev Genet 7 11 829 840 17033627 10.1038/nrg1967 1:CAS:528:DC%2BD28XhtVyktLnI (Pubitemid 44607099)
    • (2006) Nature Reviews Genetics , vol.7 , Issue.11 , pp. 829-840
    • Cowley, A.W.1
  • 11
    • 2542427516 scopus 로고    scopus 로고
    • Geneticism of essential hypertension
    • DOI 10.1161/01.HYP.0000128242.41442.71
    • FC Luft 2004 Geneticism of essential hypertension Hypertension 43 6 1155 1159 15117914 10.1161/01.HYP.0000128242.41442.71 1:CAS:528:DC%2BD2cXktFSlu70%3D (Pubitemid 38691729)
    • (2004) Hypertension , vol.43 , Issue.6 , pp. 1155-1159
    • Luft, F.C.1
  • 12
    • 61349089775 scopus 로고    scopus 로고
    • Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure
    • This large-scale candidate gene study showed that SNPs in the genes that code for atrial and B-type natriuretic peptides also show association with systolic and diastolic BP.
    • • Newton-Cheh C, Larson MG, Vasan RS, et al.: Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. Nat Genet 2009, 41(3):348-353. This large-scale candidate gene study showed that SNPs in the genes that code for atrial and B-type natriuretic peptides also show association with systolic and diastolic BP.
    • (2009) Nat Genet , vol.41 , Issue.3 , pp. 348-353
    • Newton-Cheh, C.1    Larson, M.G.2    Vasan, R.S.3
  • 13
    • 67650665283 scopus 로고    scopus 로고
    • Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array
    • 19562039 10.1371/journal.pone.0006034
    • S Sõber E Org K Kepp, et al. 2009 Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array PLoS One 4 6 e6034 19562039 10.1371/journal.pone.0006034
    • (2009) PLoS One , vol.4 , Issue.6 , pp. 6034
    • Sõber, S.1    Org, E.2    Kepp, K.3
  • 14
    • 78650415464 scopus 로고    scopus 로고
    • Genetic architecture of ambulatory blood pressure in the general population: Insights from cardiovascular gene-centric array
    • 21060006 10.1161/HYPERTENSIONAHA.110.155721 1:CAS:528:DC%2BC3cXhsVCrsL3K
    • M Tomaszewski R Debiec PS Braund, et al. 2010 Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array Hypertension 56 6 1069 1076 21060006 10.1161/HYPERTENSIONAHA.110.155721 1:CAS:528:DC%2BC3cXhsVCrsL3K
    • (2010) Hypertension , vol.56 , Issue.6 , pp. 1069-1076
    • Tomaszewski, M.1    Debiec, R.2    Braund, P.S.3
  • 15
    • 67349208839 scopus 로고    scopus 로고
    • Genome-wide association study of blood pressure and hypertension
    • This paper and the one by Newton-Cheh et al. [16••] were the first successful GWAS meta-analyses for blood pressure, identifying 13 independent BP loci
    • •• Levy D, Ehret GB, Rice K, et al.: Genome-wide association study of blood pressure and hypertension. Nat Genet 2009, 41(6):677-687. This paper and the one by Newton-Cheh et al. [16••] were the first successful GWAS meta-analyses for blood pressure, identifying 13 independent BP loci.
    • (2009) Nat Genet , vol.41 , Issue.6 , pp. 677-687
    • Levy, D.1    Ehret, G.B.2    Rice, K.3
  • 16
    • 67349085063 scopus 로고    scopus 로고
    • Genome-wide association study identifies eight loci associated with blood pressure
    • This paper and the one by Levy et al. [15••] were the first successful GWAS meta-analyses for blood pressure, identifying 13 independent BP loci
    • •• Newton-Cheh C, Johnson T, Gateva V, et al.: Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 2009, 41(6):666-676. This paper and the one by Levy et al. [15••] were the first successful GWAS meta-analyses for blood pressure, identifying 13 independent BP loci.
    • (2009) Nat Genet , vol.41 , Issue.6 , pp. 666-676
    • Newton-Cheh, C.1    Johnson, T.2    Gateva, V.3
  • 17
    • 79955471391 scopus 로고    scopus 로고
    • Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals
    • This study shows that candidate gene studies for BP and hypertension may be successful if using meta-GWAS-type sample sizes
    • • Johnson AD, Newton-Cheh C, Chasman DI, et al.: Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals. Hypertension 2011, 57(5):903-910. This study shows that candidate gene studies for BP and hypertension may be successful if using meta-GWAS-type sample sizes.
    • (2011) Hypertension , vol.57 , Issue.5 , pp. 903-910
    • Johnson, A.D.1    Newton-Cheh, C.2    Chasman, D.I.3
  • 19
    • 42649084334 scopus 로고    scopus 로고
    • Rare independent mutations in renal salt handling genes contribute to blood pressure variation
    • DOI 10.1038/ng.118, PII NG118
    • • Ji W, Foo JN, O'Roak BJ, et al.: Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nat Genet 2008, 40(5):592-599. This landmark study proved that rare variants may have a considerable effect on BP in the general population. (Pubitemid 351601207)
    • (2008) Nature Genetics , vol.40 , Issue.5 , pp. 592-599
    • Ji, W.1    Foo, J.N.2    O'Roak, B.J.3    Zhao, H.4    Larson, M.G.5    Simon, D.B.6    Newton-Cheh, C.7    State, M.W.8    Levy, D.9    Lifton, R.P.10
  • 20
    • 0035936780 scopus 로고    scopus 로고
    • Molecular mechanisms of human hypertension
    • DOI 10.1016/S0092-8674(01)00241-0
    • RP Lifton AG Gharavi DS Geller 2001 Molecular mechanisms of human hypertension Cell 104 4 545 556 11239411 10.1016/S0092-8674(01)00241-0 1:CAS:528:DC%2BD3MXis1Kks7w%3D (Pubitemid 32201949)
    • (2001) Cell , vol.104 , Issue.4 , pp. 545-556
    • Lifton, R.P.1    Gharavi, A.G.2    Geller, D.S.3
  • 21
    • 70149121527 scopus 로고    scopus 로고
    • Heritable forms of hypertension
    • 17647025 10.1007/s00467-007-0537-8
    • VM Vehaskari 2009 Heritable forms of hypertension Pediatr Nephrol 24 10 1929 1937 17647025 10.1007/s00467-007-0537-8
    • (2009) Pediatr Nephrol , vol.24 , Issue.10 , pp. 1929-1937
    • Vehaskari, V.M.1
  • 22
    • 80052031185 scopus 로고    scopus 로고
    • Further study of chromosome 7p22 to identify the molecular basis of familial hyperaldosteronism type II
    • 10.1038/jhh.2010.93
    • KJ Carrs M Stowasser RD Gordon KM O'Shaughnessy 2011 Further study of chromosome 7p22 to identify the molecular basis of familial hyperaldosteronism type II J Hum Hypertens 25 9 560 4 10.1038/jhh.2010.93
    • (2011) J Hum Hypertens , vol.25 , Issue.9 , pp. 560-4
    • Carrs, K.J.1    Stowasser, M.2    Gordon, R.D.3    O'Shaughnessy, K.M.4
  • 23
    • 77953230966 scopus 로고    scopus 로고
    • Blood pressure and hypertension are associated with 7 loci in the Japanese population
    • 20479155 10.1161/CIRCULATIONAHA.109.904664
    • F Takeuchi M Isono T Katsuya, et al. 2010 Blood pressure and hypertension are associated with 7 loci in the Japanese population Circulation 121 21 2302 2309 20479155 10.1161/CIRCULATIONAHA.109.904664
    • (2010) Circulation , vol.121 , Issue.21 , pp. 2302-2309
    • Takeuchi, F.1    Isono, M.2    Katsuya, T.3
  • 24
    • 78650802616 scopus 로고    scopus 로고
    • Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study
    • 10.1097/HJH.0b013e3283406927
    • JE Ho D Levy L Rose, et al. 2010 Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study J Hypertens 29 1 62 69 10.1097/HJH.0b013e3283406927
    • (2010) J Hypertens , vol.29 , Issue.1 , pp. 62-69
    • Ho, J.E.1    Levy, D.2    Rose, L.3
  • 25
    • 78449233580 scopus 로고    scopus 로고
    • Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension
    • This first successful GWAS for hypertension used an extreme case-control design and identified a locus near the Uromodulin gene.
    • • Padmanabhan S, Melander O, Johnson T, et al.: Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genet 2010, 6(10):e1001177. This first successful GWAS for hypertension used an extreme case-control design and identified a locus near the Uromodulin gene.
    • (2010) PLoS Genet , vol.6 , Issue.10
    • Padmanabhan, S.1    Melander, O.2    Johnson, T.3
  • 26
    • 68249107559 scopus 로고    scopus 로고
    • A genome-wide association study of hypertension and blood pressure in African Americans
    • 19609347 10.1371/journal.pgen.1000564
    • A Adeyemo N Gerry G Chen, et al. 2009 A genome-wide association study of hypertension and blood pressure in African Americans PLoS Genet 5 7 e1000564 19609347 10.1371/journal.pgen.1000564
    • (2009) PLoS Genet , vol.5 , Issue.7 , pp. 1000564
    • Adeyemo, A.1    Gerry, N.2    Chen, G.3
  • 27
    • 79956051525 scopus 로고    scopus 로고
    • Association of genetic variation with systolic and diastolic blood pressure among African Americans: The Candidate Gene Association Resource study
    • 21378095 10.1093/hmg/ddr092 1:CAS:528:DC%2BC3MXmtVyqur0%3D
    • ER Fox JH Young Y Li, et al. 2011 Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study Hum Mol Genet 20 11 2273 2284 21378095 10.1093/hmg/ddr092 1:CAS:528:DC%2BC3MXmtVyqur0%3D
    • (2011) Hum Mol Genet , vol.20 , Issue.11 , pp. 2273-2284
    • Fox, E.R.1    Young, J.H.2    Li, Y.3
  • 28
    • 79955989635 scopus 로고    scopus 로고
    • Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: Contributions from the CARe consortium
    • This paper shows that admixture mapping combined with large-scale follow-up association analysis may be a more powerful alternative than GWAS in admixed populations such as African Americans
    • • Zhu X, Young JH, Fox E, et al.: Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium. Hum Mol Genet 2011, 20(11):2285-2295. This paper shows that admixture mapping combined with large-scale follow-up association analysis may be a more powerful alternative than GWAS in admixed populations such as African Americans.
    • (2011) Hum Mol Genet , vol.20 , Issue.11 , pp. 2285-2295
    • Zhu, X.1    Young, J.H.2    Fox, E.3
  • 29
    • 79957585975 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians
    • This study shows that the meta-GWAS formula can be successfully transferred to other ethnic groups. In large sample sizes of east Asians, seven European BP loci were confirmed and six novel loci identified
    • •• Kato N, Takeuchi F, Tabara Y, et al.: Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet 2011, 43(6):531-538. This study shows that the meta-GWAS formula can be successfully transferred to other ethnic groups. In large sample sizes of east Asians, seven European BP loci were confirmed and six novel loci identified.
    • (2011) Nat Genet , vol.43 , Issue.6 , pp. 531-538
    • Kato, N.1    Takeuchi, F.2    Tabara, Y.3
  • 30
    • 79957604678 scopus 로고    scopus 로고
    • Principles for the post-GWAS functional characterization of cancer risk loci
    • This is the first study to highlight the importance of post-GWAS analysis and comprehensively describe its principles
    • •• Freedman ML, Monteiro AN, Gayther SA, et al.: Principles for the post-GWAS functional characterization of cancer risk loci. Nat Genet 2011, 43(6):513-518. This is the first study to highlight the importance of post-GWAS analysis and comprehensively describe its principles.
    • (2011) Nat Genet , vol.43 , Issue.6 , pp. 513-518
    • Freedman, M.L.1    Monteiro, A.N.2    Gayther, S.A.3
  • 31
    • 0034977045 scopus 로고    scopus 로고
    • Linkage disequilibrium in humans: Models and data
    • DOI 10.1086/321275
    • JK Pritchard M Przeworski 2001 Linkage disequilibrium in humans: models and data Am J Hum Genet 69 1 1 14 11410837 10.1086/321275 1:CAS:528: DC%2BD3MXls1emtro%3D (Pubitemid 32614013)
    • (2001) American Journal of Human Genetics , vol.69 , Issue.1 , pp. 1-14
    • Pritchard, J.K.1    Przeworski, M.2
  • 32
    • 84975742565 scopus 로고    scopus 로고
    • A map of human genome variation from population-scale sequencing
    • The 1000 Genomes Project Consortium This paper describes the aims of the 1000 Genomes Project and provides the results of its pilot phase
    • • The 1000 Genomes Project Consortium. A map of human genome variation from population-scale sequencing. Nature 2010, 467(7319):1061-1073. This paper describes the aims of the 1000 Genomes Project and provides the results of its pilot phase.
    • (2010) Nature , vol.467 , Issue.7319 , pp. 1061-1073
  • 33
    • 70449704529 scopus 로고    scopus 로고
    • Computational methods for discovering structural variation with next-generation sequencing
    • 19844226 10.1038/nmeth.1374 1:CAS:528:DC%2BD1MXht1ylu7jP
    • P Medvedev M Stanciu M Brudno 2009 Computational methods for discovering structural variation with next-generation sequencing Nat Methods 6 11 Suppl S13 20 19844226 10.1038/nmeth.1374 1:CAS:528:DC%2BD1MXht1ylu7jP
    • (2009) Nat Methods , vol.6 , Issue.11 SUPPL. , pp. 13-20
    • Medvedev, P.1    Stanciu, M.2    Brudno, M.3
  • 35
    • 41649083448 scopus 로고    scopus 로고
    • WGA Viewer: Software for genomic annotation of whole genome association studies
    • DOI 10.1101/gr.071571.107
    • D Ge K Zhang AC Need, et al. 2008 WGAViewer: software for genomic annotation of whole genome association studies Genome Res 18 4 640 643 18256235 10.1101/gr.071571.107 1:CAS:528:DC%2BD1cXks1alsb4%3D (Pubitemid 351482788)
    • (2008) Genome Research , vol.18 , Issue.4 , pp. 640-643
    • Ge, D.1    Zhang, K.2    Need, A.C.3    Martin, O.4    Fellay, J.5    Urban, T.J.6    Telenti, A.7    Goldstein, D.B.8
  • 36
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • 19474294 10.1073/pnas.0903103106 1:CAS:528:DC%2BD1MXot1Cgur4%3D
    • LA Hindorff P Sethupathy HA Junkins, et al. 2009 Potential etiologic and functional implications of genome-wide association loci for human diseases and traits Proc Natl Acad Sci U S A 106 23 9362 9367 19474294 10.1073/pnas. 0903103106 1:CAS:528:DC%2BD1MXot1Cgur4%3D
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.23 , pp. 9362-9367
    • Hindorff, L.A.1    Sethupathy, P.2    Junkins, H.A.3
  • 37
    • 77951640946 scopus 로고    scopus 로고
    • A method and server for predicting damaging missense mutations
    • 20354512 10.1038/nmeth0410-248 1:CAS:528:DC%2BC3cXjvFKqu78%3D
    • IA Adzhubei S Schmidt L Peshkin, et al. 2010 A method and server for predicting damaging missense mutations Nat Methods 7 4 248 249 20354512 10.1038/nmeth0410-248 1:CAS:528:DC%2BC3cXjvFKqu78%3D
    • (2010) Nat Methods , vol.7 , Issue.4 , pp. 248-249
    • Adzhubei, I.A.1    Schmidt, S.2    Peshkin, L.3
  • 38
    • 0043122919 scopus 로고    scopus 로고
    • SIFT: Predicting amino acid changes that affect protein function
    • DOI 10.1093/nar/gkg509
    • PC Ng S Henikoff 2003 SIFT: predicting amino acid changes that affect protein function Nucleic Acids Res 31 13 3812 3814 12824425 10.1093/nar/gkg509 1:CAS:528:DC%2BD3sXltVWjs7s%3D (Pubitemid 37442253)
    • (2003) Nucleic Acids Research , vol.31 , Issue.13 , pp. 3812-3814
    • Ng, P.C.1    Henikoff, S.2
  • 40
    • 69349092918 scopus 로고    scopus 로고
    • Natural antisense transcript of natriuretic peptide precursor A (NPPA): Structural organization and modulation of NPPA expression
    • 19671135 10.1186/1471-2199-10-81
    • T Annilo K Kepp M Laan 2009 Natural antisense transcript of natriuretic peptide precursor A (NPPA): structural organization and modulation of NPPA expression BMC Mol Biol 10 81 19671135 10.1186/1471-2199-10-81
    • (2009) BMC Mol Biol , vol.10 , pp. 81
    • Annilo, T.1    Kepp, K.2    Laan, M.3
  • 41
    • 68949216248 scopus 로고    scopus 로고
    • Systems genetics analysis of cancer susceptibility: From mouse models to humans
    • 19636343 10.1038/nrg2617 1:CAS:528:DC%2BD1MXhtVWhsLzL
    • D Quigley A Balmain 2009 Systems genetics analysis of cancer susceptibility: from mouse models to humans Nat Rev Genet 10 9 651 657 19636343 10.1038/nrg2617 1:CAS:528:DC%2BD1MXhtVWhsLzL
    • (2009) Nat Rev Genet , vol.10 , Issue.9 , pp. 651-657
    • Quigley, D.1    Balmain, A.2
  • 42
    • 78651324347 scopus 로고    scopus 로고
    • The STRING database in 2011: Functional interaction networks of proteins, globally integrated and scored
    • (Database issue)
    • Szklarczyk D, Franceschini A, Kuhn M, et al.: The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res 2011, 39(Database issue):D561-568.
    • (2011) Nucleic Acids Res , vol.39
    • Szklarczyk, D.1    Franceschini, A.2    Kuhn, M.3
  • 43
    • 75549090213 scopus 로고    scopus 로고
    • KEGG for representation and analysis of molecular networks involving diseases and drugs
    • (Database issue)
    • Kanehisa M, Goto S, Furumichi M, et al.: KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res 2010, 38(Database issue):D355-360.
    • (2010) Nucleic Acids Res , vol.38
    • Kanehisa, M.1    Goto, S.2    Furumichi, M.3
  • 44
    • 0038458878 scopus 로고    scopus 로고
    • Heritability of blood pressure and hemodynamics in African- and European-American youth
    • DOI 10.1161/01.HYP.0000072269.19820.0D
    • H Snieder GA Harshfield JC Dekkers FA Treiber 2003 Heritability of resting hemodynamics in African and European American youth Hypertension 41 1196 1201 12719445 10.1161/01.HYP.0000072269.19820.0D 1:CAS:528:DC%2BD3sXktVyntbc%3D (Pubitemid 36706065)
    • (2003) Hypertension , vol.41 , Issue.6 , pp. 1196-1201
    • Snieder, H.1    Harshfield, G.A.2    Treiber, F.A.3
  • 45
    • 78650418586 scopus 로고    scopus 로고
    • Familial aggregation of blood pressure
    • J.T. Flynn J.R. Ingelfinger R.J. Portman (eds). 2 Humana Press Inc Totowa
    • Wang X, Snieder H. Familial aggregation of blood pressure. In: Flynn JT, Ingelfinger JR, Portman RJ, editors. Clinical hypertension and vascular diseases: pediatric hypertension. 2nd ed. Totowa: Humana Press Inc; 2011. p. 241-58.
    • (2010) Clinical Hypertension and Vascular Diseases: Pediatric Hypertension , pp. 241-258
    • Wang, X.1    Snieder, H.2
  • 46
    • 77956059154 scopus 로고    scopus 로고
    • Genome-wide searching of rare genetic variants in WTCCC data
    • 20549515 10.1007/s00439-010-0849-9
    • T Feng X Zhu 2010 Genome-wide searching of rare genetic variants in WTCCC data Hum Genet 128 3 269 280 20549515 10.1007/s00439-010-0849-9
    • (2010) Hum Genet , vol.128 , Issue.3 , pp. 269-280
    • Feng, T.1    Zhu, X.2
  • 47
    • 77950405093 scopus 로고    scopus 로고
    • Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
    • 20360734 10.1038/nature08979 1:CAS:528:DC%2BC3cXktVygsb4%3D
    • N Craddock ME Hurles N Cardin, et al. 2010 Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls Nature 464 7289 713 720 20360734 10.1038/nature08979 1:CAS:528: DC%2BC3cXktVygsb4%3D
    • (2010) Nature , vol.464 , Issue.7289 , pp. 713-720
    • Craddock, N.1    Hurles, M.E.2    Cardin, N.3
  • 48
    • 0025165779 scopus 로고
    • An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels
    • B Rigat C Hubert F Alhenc-Gelas, et al. 1990 An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels J Clin Invest 86 4 1343 1346 1976655 10.1172/JCI114844 1:CAS:528:DyaK3cXmt1Gmt7s%3D (Pubitemid 20370444)
    • (1990) Journal of Clinical Investigation , vol.86 , Issue.4 , pp. 1343-1346
    • Rigat, B.1    Hubert, C.2    Alhenc-Gelas, F.3    Cambien, F.4    Corvol, P.5    Soubrier, F.6
  • 49
    • 79959729030 scopus 로고    scopus 로고
    • Novel polymorphic AluYb8 insertion in the WNK1 gene is associated with blood pressure variation in Europeans
    • 21520334 10.1002/humu.21508 1:CAS:528:DC%2BC3MXotVehur4%3D
    • M Putku K Kepp E Org, et al. 2011 Novel polymorphic AluYb8 insertion in the WNK1 gene is associated with blood pressure variation in Europeans Hum Mutat 32 7 806 814 21520334 10.1002/humu.21508 1:CAS:528:DC%2BC3MXotVehur4%3D
    • (2011) Hum Mutat , vol.32 , Issue.7 , pp. 806-814
    • Putku, M.1    Kepp, K.2    Org, E.3
  • 50
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • 19167326 10.1016/j.cell.2009.01.002 1:CAS:528:DC%2BD1MXhs1Kiuro%3D
    • DP Bartel 2009 MicroRNAs: target recognition and regulatory functions Cell 136 2 215 233 19167326 10.1016/j.cell.2009.01.002 1:CAS:528: DC%2BD1MXhs1Kiuro%3D
    • (2009) Cell , vol.136 , Issue.2 , pp. 215-233
    • Bartel, D.P.1
  • 51
    • 77955644289 scopus 로고    scopus 로고
    • Mammalian microRNAs predominantly act to decrease target mRNA levels
    • 20703300 10.1038/nature09267 1:CAS:528:DC%2BC3cXhtVais7nN
    • H Guo NT Ingolia JS Weissman DP Bartel 2010 Mammalian microRNAs predominantly act to decrease target mRNA levels Nature 466 7308 835 840 20703300 10.1038/nature09267 1:CAS:528:DC%2BC3cXhtVais7nN
    • (2010) Nature , vol.466 , Issue.7308 , pp. 835-840
    • Guo, H.1    Ingolia, N.T.2    Weissman, J.S.3    Bartel, D.P.4
  • 52
    • 78651293534 scopus 로고    scopus 로고
    • MiRBase: Integrating microRNA annotation and deep-sequencing data
    • (Database issue)
    • Kozomara A, Griffiths-Jones S: miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res 2011, 39(Database issue):D152-157.
    • (2011) Nucleic Acids Res , vol.39
    • Kozomara, A.1    Griffiths-Jones, S.2
  • 53
    • 77951841445 scopus 로고    scopus 로고
    • Reprogramming of miRNA networks in cancer and leukemia
    • 20439436 10.1101/gr.098046.109 1:CAS:528:DC%2BC3cXlslyis70%3D
    • S Volinia M Galasso S Costinean, et al. 2010 Reprogramming of miRNA networks in cancer and leukemia Genome Res 20 5 589 599 20439436 10.1101/gr.098046.109 1:CAS:528:DC%2BC3cXlslyis70%3D
    • (2010) Genome Res , vol.20 , Issue.5 , pp. 589-599
    • Volinia, S.1    Galasso, M.2    Costinean, S.3
  • 54
    • 79151481024 scopus 로고    scopus 로고
    • Control of cardiovascular differentiation by microRNAs
    • 21184089 10.1007/s00395-010-0139-7 1:CAS:528:DC%2BC3cXhs1ejtLbN
    • K Ohtani S Dimmeler 2011 Control of cardiovascular differentiation by microRNAs Basic Res Cardiol 106 1 5 11 21184089 10.1007/s00395-010-0139-7 1:CAS:528:DC%2BC3cXhs1ejtLbN
    • (2011) Basic Res Cardiol , vol.106 , Issue.1 , pp. 5-11
    • Ohtani, K.1    Dimmeler, S.2
  • 55
    • 77955628346 scopus 로고    scopus 로고
    • MicroRNAs in vascular biology and vascular disease
    • 20560045 10.1007/s12265-010-9164-z 1:CAS:528:DC%2BC3cXktVaisLw%3D
    • C Zhang 2010 MicroRNAs in vascular biology and vascular disease J Cardiovasc Transl Res 3 3 235 240 20560045 10.1007/s12265-010-9164-z 1:CAS:528:DC%2BC3cXktVaisLw%3D
    • (2010) J Cardiovasc Transl Res , vol.3 , Issue.3 , pp. 235-240
    • Zhang, C.1
  • 56
    • 78751660177 scopus 로고    scopus 로고
    • Pervasive roles of microRNAs in cardiovascular biology
    • 21248840 10.1038/nature09783 1:CAS:528:DC%2BC3MXnvVKhuw%3D%3D
    • EM Small EN Olson 2011 Pervasive roles of microRNAs in cardiovascular biology Nature 469 7330 336 342 21248840 10.1038/nature09783 1:CAS:528:DC%2BC3MXnvVKhuw%3D%3D
    • (2011) Nature , vol.469 , Issue.7330 , pp. 336-342
    • Small, E.M.1    Olson, E.N.2
  • 57
    • 33644850338 scopus 로고    scopus 로고
    • Assessment of the MicroRNA system in salt-sensitive hypertension
    • H Naraba N Iwai 2005 Assessment of the microRNA system in salt-sensitive hypertension Hypertens Res 28 10 819 826 16471176 10.1291/hypres.28.819 1:CAS:528:DC%2BD28XntlSjsg%3D%3D (Pubitemid 47400252)
    • (2005) Hypertension Research , vol.28 , Issue.10 , pp. 819-826
    • Naraba, H.1    Iwai, N.2
  • 58
    • 77950500403 scopus 로고    scopus 로고
    • Renal medullary microRNAs in Dahl salt-sensitive rats: MiR-29b regulates several collagens and related genes
    • 20194304 10.1161/HYPERTENSIONAHA.109.144428 1:CAS:528: DC%2BC3cXktFOrs7s%3D
    • Y Liu NE Taylor L Lu, et al. 2010 Renal medullary microRNAs in Dahl salt-sensitive rats: miR-29b regulates several collagens and related genes Hypertension 55 4 974 982 20194304 10.1161/HYPERTENSIONAHA.109.144428 1:CAS:528:DC%2BC3cXktFOrs7s%3D
    • (2010) Hypertension , vol.55 , Issue.4 , pp. 974-982
    • Liu, Y.1    Taylor, N.E.2    Lu, L.3
  • 59
    • 79955547741 scopus 로고    scopus 로고
    • Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function
    • This study demonstrates that in addition to embryonic development, miRNAs are also important in maintaining vascular smooth muscle cells and BP homeostasis in adult organisms.
    • • Albinsson S, Skoura A, Yu J, et al.: Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function. PLoS One 2011, 6(4):e18869. This study demonstrates that in addition to embryonic development, miRNAs are also important in maintaining vascular smooth muscle cells and BP homeostasis in adult organisms.
    • (2011) PLoS One , vol.6 , Issue.4
    • Albinsson, S.1    Skoura, A.2    Yu, J.3
  • 60
    • 77949905292 scopus 로고    scopus 로고
    • The microRNA-processing enzyme dicer maintains juxtaglomerular cells
    • 20056748 10.1681/ASN.2009090964 1:CAS:528:DC%2BC3cXjvFClurk%3D
    • ML Sequeira-Lopez ET Weatherford GR Borges, et al. 2010 The microRNA-processing enzyme dicer maintains juxtaglomerular cells J Am Soc Nephrol 21 3 460 467 20056748 10.1681/ASN.2009090964 1:CAS:528: DC%2BC3cXjvFClurk%3D
    • (2010) J Am Soc Nephrol , vol.21 , Issue.3 , pp. 460-467
    • Sequeira-Lopez, M.L.1    Weatherford, E.T.2    Borges, G.R.3
  • 61
    • 55749103053 scopus 로고    scopus 로고
    • Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease
    • 18776121 10.1681/ASN.2008020233 1:CAS:528:DC%2BD1cXhsVaitrvI
    • SJ Harvey G Jarad J Cunningham, et al. 2008 Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease J Am Soc Nephrol 19 11 2150 2158 18776121 10.1681/ASN.2008020233 1:CAS:528: DC%2BD1cXhsVaitrvI
    • (2008) J Am Soc Nephrol , vol.19 , Issue.11 , pp. 2150-2158
    • Harvey, S.J.1    Jarad, G.2    Cunningham, J.3
  • 62
    • 55749104549 scopus 로고    scopus 로고
    • Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury
    • 18832437 10.1681/ASN.2008020162 1:CAS:528:DC%2BD1cXhsVaitrrL
    • J Ho KH Ng S Rosen, et al. 2008 Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury J Am Soc Nephrol 19 11 2069 2075 18832437 10.1681/ASN.2008020162 1:CAS:528:DC%2BD1cXhsVaitrrL
    • (2008) J Am Soc Nephrol , vol.19 , Issue.11 , pp. 2069-2075
    • Ho, J.1    Ng, K.H.2    Rosen, S.3
  • 63
    • 55749112141 scopus 로고    scopus 로고
    • Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis
    • 18776119 10.1681/ASN.2008030312 1:CAS:528:DC%2BD1cXhsVaitrvJ
    • S Shi L Yu C Chiu, et al. 2008 Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis J Am Soc Nephrol 19 11 2159 2169 18776119 10.1681/ASN.2008030312 1:CAS:528:DC%2BD1cXhsVaitrvJ
    • (2008) J Am Soc Nephrol , vol.19 , Issue.11 , pp. 2159-2169
    • Shi, S.1    Yu, L.2    Chiu, C.3
  • 64
    • 70349125875 scopus 로고    scopus 로고
    • MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury
    • 19720868 10.1101/gad.1842409 1:CAS:528:DC%2BD1MXht1ersbvM
    • M Xin EM Small LB Sutherland, et al. 2009 MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury Genes Dev 23 18 2166 2178 19720868 10.1101/gad.1842409 1:CAS:528:DC%2BD1MXht1ersbvM
    • (2009) Genes Dev , vol.23 , Issue.18 , pp. 2166-2178
    • Xin, M.1    Small, E.M.2    Sutherland, L.B.3
  • 65
    • 72949121898 scopus 로고    scopus 로고
    • MicroRNAs miR-124 and miR-135a are potential regulators of the mineralocorticoid receptor gene (NR3C2) expression
    • 19944075 10.1016/j.bbrc.2009.11.128 1:CAS:528:DC%2BC3cXpsVOk
    • S Sober M Laan T Annilo 2010 MicroRNAs miR-124 and miR-135a are potential regulators of the mineralocorticoid receptor gene (NR3C2) expression Biochem Biophys Res Commun 391 1 727 732 19944075 10.1016/j.bbrc.2009.11.128 1:CAS:528:DC%2BC3cXpsVOk
    • (2010) Biochem Biophys Res Commun , vol.391 , Issue.1 , pp. 727-732
    • Sober, S.1    Laan, M.2    Annilo, T.3
  • 66
    • 78751618598 scopus 로고    scopus 로고
    • Interplay between miR-155, AT1R A1166C polymorphism, and AT1R expression in young untreated hypertensives
    • 20966899 10.1038/ajh.2010.211 1:CAS:528:DC%2BC3MXot1GktA%3D%3D
    • G Ceolotto I Papparella A Bortoluzzi, et al. 2011 Interplay between miR-155, AT1R A1166C polymorphism, and AT1R expression in young untreated hypertensives Am J Hypertens 24 2 241 246 20966899 10.1038/ajh.2010.211 1:CAS:528:DC%2BC3MXot1GktA%3D%3D
    • (2011) Am J Hypertens , vol.24 , Issue.2 , pp. 241-246
    • Ceolotto, G.1    Papparella, I.2    Bortoluzzi, A.3
  • 67
    • 34547727263 scopus 로고    scopus 로고
    • Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3′ untranslated region: A mechanism for functional single-nucleotide polymorphisms related to phenotypes
    • DOI 10.1086/519979
    • •• Sethupathy P, Borel C, Gagnebin M, et al.: Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes. Am J Hum Genet 2007, 81(2):405-413. This is the first report of a polymorphism in an miRNA binding site that affects blood pressure. (Pubitemid 47236088)
    • (2007) American Journal of Human Genetics , vol.81 , Issue.2 , pp. 405-413
    • Sethupathy, P.1    Borel, C.2    Gagnebin, M.3    Grant, G.R.4    Deutsch, S.5    Elton, T.S.6    Hatzigeorgiou, A.G.7    Antonarakis, S.E.8
  • 68
    • 80053298030 scopus 로고    scopus 로고
    • Cardiovascular Disease, Single Nucleotide Polymorphisms; And the Renin Angiotensin System: Is There a MicroRNA Connection?
    • published online 2010 Aug 4 doi: 10.4061/2010/281692
    • Elton TS, Sansom SE, Martin MM: Cardiovascular Disease, Single Nucleotide Polymorphisms; and the Renin Angiotensin System: Is There a MicroRNA Connection? Int J Hypertens 2010, published online 2010 Aug 4. doi: 10.4061/2010/281692.
    • (2010) Int J Hypertens
    • Elton, T.S.1    Sansom, S.E.2    Martin, M.M.3
  • 69
    • 68949191193 scopus 로고    scopus 로고
    • Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo
    • 19712806 10.1016/j.jacc.2009.05.035 1:CAS:528:DC%2BD1MXht1SrtrrE
    • L Wang F Rao K Zhang, et al. 2009 Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo J Am Coll Cardiol 54 10 944 954 19712806 10.1016/j.jacc.2009.05.035 1:CAS:528:DC%2BD1MXht1SrtrrE
    • (2009) J Am Coll Cardiol , vol.54 , Issue.10 , pp. 944-954
    • Wang, L.1    Rao, F.2    Zhang, K.3
  • 70
    • 59449087016 scopus 로고    scopus 로고
    • Histone modifying enzymes: Structures, mechanisms, and specificities
    • 18722564 1:CAS:528:DC%2BD1cXhsVOis7bJ
    • R Marmorstein RC Trievel 2009 Histone modifying enzymes: structures, mechanisms, and specificities Biochim Biophys Acta 1789 1 58 68 18722564 1:CAS:528:DC%2BD1cXhsVOis7bJ
    • (2009) Biochim Biophys Acta , vol.1789 , Issue.1 , pp. 58-68
    • Marmorstein, R.1    Trievel, R.C.2
  • 71
    • 34249299791 scopus 로고    scopus 로고
    • The complex language of chromatin regulation during transcription
    • DOI 10.1038/nature05915, PII NATURE05915
    • SL Berger 2007 The complex language of chromatin regulation during transcription Nature 447 7143 407 412 17522673 10.1038/nature05915 1:CAS:528:DC%2BD2sXlsFOgsrc%3D (Pubitemid 46816746)
    • (2007) Nature , vol.447 , Issue.7143 , pp. 407-412
    • Berger, S.L.1
  • 72
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • DOI 10.1126/science.1063127
    • T Jenuwein CD Allis 2001 Translating the histone code Science 293 5532 1074 1080 11498575 10.1126/science.1063127 1:CAS:528:DC%2BD3MXmtVWltro%3D (Pubitemid 32758077)
    • (2001) Science , vol.293 , Issue.5532 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 74
    • 0036955984 scopus 로고    scopus 로고
    • + channel causes type 1 pseudohypoaldosteronism
    • DOI 10.1007/s00467-002-0945-8
    • O Bonny N Knoers L Monnens BC Rossier 2002 A novel mutation of the epithelial Na∈+∈channel causes type 1 pseudohypoaldosteronism Pediatr Nephrol 17 10 804 808 12376807 10.1007/s00467-002-0945-8 (Pubitemid 36097368)
    • (2002) Pediatric Nephrology , vol.17 , Issue.10 , pp. 804-808
    • Bonny, O.1    Knoers, N.2    Monnens, L.3    Rossier, B.C.4
  • 75
    • 58349113159 scopus 로고    scopus 로고
    • Epigenetics and the control of epithelial sodium channel expression in collecting duct
    • 18818687 10.1038/ki.2008.475 1:CAS:528:DC%2BD1MXlvFCmtA%3D%3D
    • D Zhang ZY Yu P Cruz, et al. 2009 Epigenetics and the control of epithelial sodium channel expression in collecting duct Kidney Int 75 3 260 267 18818687 10.1038/ki.2008.475 1:CAS:528:DC%2BD1MXlvFCmtA%3D%3D
    • (2009) Kidney Int , vol.75 , Issue.3 , pp. 260-267
    • Zhang, D.1    Yu, Z.Y.2    Cruz, P.3
  • 77
    • 85027925594 scopus 로고    scopus 로고
    • Epigenetic modulation of the renal beta-adrenergic-WNK4 pathway in salt-sensitive hypertension
    • This study implicates the epigenetic modulation of WNK4 transcription in the development of salt-sensitive hypertension
    • • Mu S, Shimosawa T, Ogura S, et al.: Epigenetic modulation of the renal beta-adrenergic-WNK4 pathway in salt-sensitive hypertension. Nat Med 2011, 17(5):573-580. This study implicates the epigenetic modulation of WNK4 transcription in the development of salt-sensitive hypertension.
    • (2011) Nat Med , vol.17 , Issue.5 , pp. 573-580
    • Mu, S.1    Shimosawa, T.2    Ogura, S.3
  • 78
    • 0016439429 scopus 로고
    • DNA modification mechanisms and gene activity during development
    • 1111098 10.1126/science.1111098 1:CAS:528:DyaE2MXht1Sitrw%3D
    • R Holliday JE Pugh 1975 DNA modification mechanisms and gene activity during development Science 187 4173 226 232 1111098 10.1126/science.1111098 1:CAS:528:DyaE2MXht1Sitrw%3D
    • (1975) Science , vol.187 , Issue.4173 , pp. 226-232
    • Holliday, R.1    Pugh, J.E.2
  • 79
    • 0016692220 scopus 로고
    • X inactivation, differentiation, and DNA methylation
    • 1093816 10.1159/000130315 1:CAS:528:DyaE2MXksVSrsbk%3D
    • AD Riggs 1975 X inactivation, differentiation, and DNA methylation Cytogenet Cell Genet 14 1 9 25 1093816 10.1159/000130315 1:CAS:528: DyaE2MXksVSrsbk%3D
    • (1975) Cytogenet Cell Genet , vol.14 , Issue.1 , pp. 9-25
    • Riggs, A.D.1
  • 80
    • 33847065486 scopus 로고    scopus 로고
    • The Epigenomics of Cancer
    • DOI 10.1016/j.cell.2007.01.029, PII S0092867407001274
    • PA Jones SB Baylin 2007 The epigenomics of cancer Cell 128 4 683 692 17320506 10.1016/j.cell.2007.01.029 1:CAS:528:DC%2BD2sXis12ju7k%3D (Pubitemid 46273572)
    • (2007) Cell , vol.128 , Issue.4 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 81
    • 18944407842 scopus 로고    scopus 로고
    • Methylation of CpG islands: Potential relevance for hypertension and kidney diseases
    • DOI 10.1093/ndt/gfh746
    • FJ Frey 2005 Methylation of CpG islands: potential relevance for hypertension and kidney diseases Nephrol Dial Transplant 20 5 868 869 15728268 10.1093/ndt/gfh746 1:CAS:528:DC%2BD2MXltlCqs7g%3D (Pubitemid 40704020)
    • (2005) Nephrology Dialysis Transplantation , vol.20 , Issue.5 , pp. 868-869
    • Frey, F.J.1
  • 82
    • 65349144503 scopus 로고    scopus 로고
    • Epigenetic and microRNA-mediated regulation in diabetes
    • 19145005 10.1093/ndt/gfn728 1:CAS:528:DC%2BD1MXjsFeksb0%3D
    • P Muhonen H Holthofer 2009 Epigenetic and microRNA-mediated regulation in diabetes Nephrol Dial Transplant 24 4 1088 1096 19145005 10.1093/ndt/gfn728 1:CAS:528:DC%2BD1MXjsFeksb0%3D
    • (2009) Nephrol Dial Transplant , vol.24 , Issue.4 , pp. 1088-1096
    • Muhonen, P.1    Holthofer, H.2
  • 83
    • 49449115492 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression in the inflammatory response and relevance to common diseases
    • 18673005 10.1902/jop.2008.080172 1:CAS:528:DC%2BD1cXhtVClu7vK
    • AG Wilson 2008 Epigenetic regulation of gene expression in the inflammatory response and relevance to common diseases J Periodontol 79 8 Suppl 1514 1519 18673005 10.1902/jop.2008.080172 1:CAS:528:DC%2BD1cXhtVClu7vK
    • (2008) J Periodontol , vol.79 , Issue.8 SUPPL. , pp. 1514-1519
    • Wilson, A.G.1
  • 84
    • 78650291801 scopus 로고    scopus 로고
    • Obesity related methylation changes in DNA of peripheral blood leukocytes
    • 21176133 10.1186/1741-7015-8-87
    • X Wang H Zhu H Snieder, et al. 2010 Obesity related methylation changes in DNA of peripheral blood leukocytes BMC Med 8 87 21176133 10.1186/1741-7015-8- 87
    • (2010) BMC Med , vol.8 , pp. 87
    • Wang, X.1    Zhu, H.2    Snieder, H.3
  • 87
    • 81255168903 scopus 로고    scopus 로고
    • Combined epigenomic and genomic approach to hypertension
    • (Meeting Abstract Suppl)
    • Michalkiewicz M, Michalkiewicz T, MacGillis K: Combined epigenomic and genomic approach to hypertension. The FASEB Journal 2008, 22 (Meeting Abstract Suppl):968.
    • (2008) The FASEB Journal , vol.22 , pp. 968
    • Michalkiewicz, M.1    Michalkiewicz, T.2    MacGillis, K.3
  • 88
    • 0029843771 scopus 로고    scopus 로고
    • Is blood pressure inversely related to birth weight? The strength of evidence from a systematic review of the literature
    • CM Law AW Shiell 1996 Is blood pressure inversely related to birth weight? The strength of evidence from a systematic review of the literature J Hypertens 14 8 935 941 8884547 10.1097/00004872-199608000-00002 1:STN:280:DyaK2s%2FjvV2ltA%3D%3D (Pubitemid 26306057)
    • (1996) Journal of Hypertension , vol.14 , Issue.8 , pp. 935-941
    • Law, C.M.1    Shiell, A.W.2
  • 89
    • 0033589781 scopus 로고    scopus 로고
    • Association between birth weight and adult blood pressure in twins: Historical cohort study
    • NR Poulter CL Chang AJ MacGregor, et al. 1999 Association between birth weight and adult blood pressure in twins: historical cohort study BMJ 319 7221 1330 1333 10567135 10.1136/bmj.319.7221.1330 1:STN:280:DC%2BD3c%2FjsFamsg%3D%3D (Pubitemid 29537502)
    • (1999) British Medical Journal , vol.319 , Issue.7221 , pp. 1330-1333
    • Poulter, N.R.1    Chang, C.L.2    MacGregor, A.J.3    Snieder, H.4    Spector, T.D.5
  • 90
    • 7244238114 scopus 로고    scopus 로고
    • The role of genetic and environmental factors in the association between birthweight and blood pressure: Evidence from meta-analysis of twin studies
    • DOI 10.1093/ije/dyh260
    • G McNeill C Tuya WC Smith 2004 The role of genetic and environmental factors in the association between birthweight and blood pressure: evidence from meta-analysis of twin studies Int J Epidemiol 33 5 995 1001 15375085 10.1093/ije/dyh260 1:STN:280:DC%2BD2cvps1emtw%3D%3D (Pubitemid 39429992)
    • (2004) International Journal of Epidemiology , vol.33 , Issue.5 , pp. 995-1001
    • McNeill, G.1    Tuya, C.2    Smith, W.C.S.3
  • 91
    • 34250303799 scopus 로고    scopus 로고
    • Genetic and shared environmental factors do not confound the association between birth weight and hypertension: A study among Swedish twins
    • DOI 10.1161/CIRCULATIONAHA.106.674812
    • N Bergvall A Iliadou S Johansson, et al. 2007 Genetic and shared environmental factors do not confound the association between birth weight and hypertension: a study among Swedish twins Circulation 115 23 2931 2938 17515462 10.1161/CIRCULATIONAHA.106.674812 (Pubitemid 46912096)
    • (2007) Circulation , vol.115 , Issue.23 , pp. 2931-2938
    • Bergvall, N.1    Iliadou, A.2    Johansson, S.3    De Faire, U.4    Kramer, M.S.5    Pawitan, Y.6    Pedersen, N.L.7    Lichtenstein, P.8    Cnattingius, S.9
  • 92
    • 21344442830 scopus 로고    scopus 로고
    • Nutritional epigenomics of metabolic syndrome new perspective against the epidemic
    • DOI 10.2337/diabetes.54.7.1899
    • C Gallou-Kabani C Junien 2005 Nutritional epigenomics of metabolic syndrome: new perspective against the epidemic Diabetes 54 7 1899 1906 15983188 10.2337/diabetes.54.7.1899 1:CAS:528:DC%2BD2MXmtVels7g%3D (Pubitemid 40911250)
    • (2005) Diabetes , vol.54 , Issue.7 , pp. 1899-1906
    • Gallou-Kabani, C.1    Junien, C.2
  • 93
    • 33947517327 scopus 로고    scopus 로고
    • Epigenetic modification of the renin-angiotensin system in the fetal programming of hypertension
    • DOI 10.1161/01.RES.0000258855.60637.58, PII 0000301220070302000011
    • I Bogdarina S Welham PJ King, et al. 2007 Epigenetic modification of the renin-angiotensin system in the fetal programming of hypertension Circ Res 100 4 520 526 17255528 10.1161/01.RES.0000258855.60637.58 1:CAS:528: DC%2BD2sXitFylsbg%3D (Pubitemid 46673261)
    • (2007) Circulation Research , vol.100 , Issue.4 , pp. 520-526
    • Bogdarina, I.1    Welham, S.2    King, P.J.3    Burns, S.P.4    Clark, A.J.L.5
  • 95
    • 85047694610 scopus 로고    scopus 로고
    • Epigentic regulation of 11β-hydroxysteroid dehydrogenase type 2 expression
    • DOI 10.1172/JCI200421647
    • R Alikhani-Koopaei F Fouladkou FJ Frey BM Frey 2004 Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression J Clin Invest 114 8 1146 1157 15489962 1:CAS:528:DC%2BD2cXovVens7w%3D (Pubitemid 39578704)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.8 , pp. 1146-1157
    • Alikhani-Koopaei, R.1    Fouladkou, F.2    Frey, F.J.3    Frey, B.M.4
  • 96
    • 77954417384 scopus 로고    scopus 로고
    • Fetal growth restriction alters transcription factor binding and epigenetic mechanisms of renal 11beta-hydroxysteroid dehydrogenase type 2 in a sex-specific manner
    • 20427719 10.1152/ajpregu.00122.2010 1:CAS:528:DC%2BC3cXpsVOrtLg%3D
    • M Baserga R Kaur MA Hale, et al. 2010 Fetal growth restriction alters transcription factor binding and epigenetic mechanisms of renal 11beta-hydroxysteroid dehydrogenase type 2 in a sex-specific manner Am J Physiol Regul Integr Comp Physiol 299 1 R334 342 20427719 10.1152/ajpregu.00122.2010 1:CAS:528:DC%2BC3cXpsVOrtLg%3D
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.299 , Issue.1 , pp. 334-342
    • Baserga, M.1    Kaur, R.2    Hale, M.A.3
  • 97
    • 47649085663 scopus 로고    scopus 로고
    • Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension
    • 18178212 10.1016/j.atherosclerosis.2007.11.029 1:CAS:528: DC%2BD1cXptVWkt7g%3D
    • S Friso F Pizzolo SW Choi, et al. 2008 Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension Atherosclerosis 199 2 323 327 18178212 10.1016/j.atherosclerosis. 2007.11.029 1:CAS:528:DC%2BD1cXptVWkt7g%3D
    • (2008) Atherosclerosis , vol.199 , Issue.2 , pp. 323-327
    • Friso, S.1    Pizzolo, F.2    Choi, S.W.3
  • 98
    • 77649260034 scopus 로고    scopus 로고
    • Global DNA methylation changes in blood of patients with essential hypertension
    • Smolarek I, Wyszko E, Barciszewska AM, et al.: Global DNA methylation changes in blood of patients with essential hypertension. Med Sci Monit 2010, 16(3):CR149-155.
    • (2010) Med Sci Monit , vol.16 , Issue.3
    • Smolarek, I.1    Wyszko, E.2    Barciszewska, A.M.3
  • 99
    • 77955980639 scopus 로고    scopus 로고
    • DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia
    • 20442742 10.1038/ejhg.2010.63 1:CAS:528:DC%2BC3cXhtVCnurnF
    • RK Yuen MS Penaherrera P von Dadelszen, et al. 2010 DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia Eur J Hum Genet 18 9 1006 1012 20442742 10.1038/ejhg.2010.63 1:CAS:528:DC%2BC3cXhtVCnurnF
    • (2010) Eur J Hum Genet , vol.18 , Issue.9 , pp. 1006-1012
    • Yuen, R.K.1    Penaherrera, M.S.2    Von Dadelszen, P.3


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