메뉴 건너뛰기




Volumn 60, Issue 12, 2011, Pages 1775-1780

Overexpression of hepatic 5α-reductase and 11β-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue is associated with hyperinsulinemia in morbidly obese patients

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; GLUCOSE; HYDROCORTISONE; INSULIN; RNA 18S; STEROID 5ALPHA REDUCTASE; STEROID 5BETA REDUCTASE;

EID: 81155133819     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2011.05.001     Document Type: Article
Times cited : (34)

References (32)
  • 1
    • 35548964739 scopus 로고    scopus 로고
    • Cardiovascular Morbidity and Mortality of the Metabolic Syndrome
    • DOI 10.1016/j.mcna.2007.06.003, PII S0025712507000764, Metabolic Syndrome
    • K. Obunai, S. Jani, and G.D. Dangas Cardiovascular morbidity and mortality of the metabolic syndrome Med Clin North Am 91 2007 1169 1184 (Pubitemid 350010914)
    • (2007) Medical Clinics of North America , vol.91 , Issue.6 , pp. 1169-1184
    • Obunai, K.1    Jani, S.2    Dangas, G.D.3
  • 4
    • 0030936556 scopus 로고    scopus 로고
    • Does central obesity reflect 'Cushing's disease of the omentum '?
    • I.J. Bujalska, S. Kumar, and P.M. Stewart Does central obesity reflect "Cushing's disease of the omentum"? Lancet 26 1997 1210 1213 (Pubitemid 27190044)
    • (1997) Lancet , vol.349 , Issue.9060 , pp. 1210-1213
    • Bujalska, I.J.1    Kumar, S.2    M Stewart, P.3
  • 5
    • 33845644003 scopus 로고    scopus 로고
    • Tissue production of cortisol by 11β-hydroxysteroid dehydrogenase type 1 and metabolic disease
    • DOI 10.1196/annals.1367.012, Stress, Obesity, and Metabolic Syndrome
    • B.R. Walker, and R. Andrew Tissue production of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 and metabolic disease Ann N Y Acad Sci 1083 2006 165 184 (Pubitemid 44955472)
    • (2006) Annals of the New York Academy of Sciences , vol.1083 , pp. 165-184
    • Walker, B.R.1    Andrew, R.2
  • 6
    • 73949158787 scopus 로고    scopus 로고
    • Overexpression of 11beta-hydroxysteroid dehydrogenase 1 in hepatic and visceral adipose tissue is associated with metabolic disorders in morbidly obese patients
    • R. Baudrand, C.A. Carvajal, and A. Riquelme Overexpression of 11beta-hydroxysteroid dehydrogenase 1 in hepatic and visceral adipose tissue is associated with metabolic disorders in morbidly obese patients Obes Surg 20 2010 77 83
    • (2010) Obes Surg , vol.20 , pp. 77-83
    • Baudrand, R.1    Carvajal, C.A.2    Riquelme, A.3
  • 8
    • 36448973807 scopus 로고    scopus 로고
    • Type 2 diabetes and metabolic syndrome are associated with increased expression of 11β-hydroxysteroid dehydrogenase 1 in obese subjects
    • DOI 10.1038/sj.ijo.0803677, PII 0803677
    • L. Alberti, A. Girola, and L. Gilardini Type 2 diabetes and metabolic syndrome are associated with increased expression of 11beta-hydroxysteroid dehydrogenase 1 in obese subjects Int J Obes (Lond) 31 2007 1826 1831 (Pubitemid 350174630)
    • (2007) International Journal of Obesity , vol.31 , Issue.12 , pp. 1826-1831
    • Alberti, L.1    Girola, A.2    Gilardini, L.3    Conti, A.4    Cattaldo, S.5    Micheletto, G.6    Invitti, C.7
  • 9
    • 73249141243 scopus 로고    scopus 로고
    • 11beta-Hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation
    • M.S. Cooper, and P.M. Stewart 11beta-Hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation J Clin Endocrinol Metab 94 2009 4645 4654
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 4645-4654
    • Cooper, M.S.1    Stewart, P.M.2
  • 11
    • 75949084447 scopus 로고    scopus 로고
    • 11beta-Hydroxysteroid dehydrogenase type-2 and type-1 (11beta-HSD2 and 11beta-HSD1) and 5beta-reductase activities in the pathogenesis of essential hypertension
    • C. Campino, C.A. Carvajal, and J. Cornejo 11beta-Hydroxysteroid dehydrogenase type-2 and type-1 (11beta-HSD2 and 11beta-HSD1) and 5beta-reductase activities in the pathogenesis of essential hypertension Endocrine 37 2010 106 114
    • (2010) Endocrine , vol.37 , pp. 106-114
    • Campino, C.1    Carvajal, C.A.2    Cornejo, J.3
  • 12
    • 0028173882 scopus 로고
    • Steroid 5 alpha-reductase: Two genes/two enzymes
    • D.W. Russell, and J.D. Wilson Steroid 5 alpha-reductase: two genes/two enzymes Annu Rev Biochem 63 1994 25 61
    • (1994) Annu Rev Biochem , vol.63 , pp. 25-61
    • Russell, D.W.1    Wilson, J.D.2
  • 13
    • 33644666769 scopus 로고    scopus 로고
    • Increased A-ring reduction of glucocorticoids in obese Zucker rats: Effects of insulin sensitization
    • D.E. Livingstone, K.J. McInnes, and B.R. Walker Increased A-ring reduction of glucocorticoids in obese Zucker rats: effects of insulin sensitization Obes Res 13 2005 1523 1526
    • (2005) Obes Res , vol.13 , pp. 1523-1526
    • Livingstone, D.E.1    McInnes, K.J.2    Walker, B.R.3
  • 14
    • 0036877848 scopus 로고    scopus 로고
    • Determination of the insulin resistance index by the homeostasis model assessment in a population of metropolitan region in Chile
    • A.M. Acosta, M. Escalona, and A. Maiz Determination of the insulin resistance index by the homeostasis model assessment in a population of metropolitan region in Chile Rev Med Chil 130 2002 1227 1231
    • (2002) Rev Med Chil , vol.130 , pp. 1227-1231
    • Acosta, A.M.1    Escalona, M.2    Maiz, A.3
  • 15
    • 63249128191 scopus 로고    scopus 로고
    • Liver is the site of splanchnic cortisol production in obese nondiabetic humans
    • R. Basu, A. Basu, and M. Grudzien Liver is the site of splanchnic cortisol production in obese nondiabetic humans Diabetes 58 2009 39 45
    • (2009) Diabetes , vol.58 , pp. 39-45
    • Basu, R.1    Basu, A.2    Grudzien, M.3
  • 16
    • 3242800476 scopus 로고    scopus 로고
    • Splanchnic cortisol production occurs in humans: Evidence for conversion of cortisone to cortisol via the 11-β hydroxysteroid dehydrogenase (11β-HSD) type 1 pathway
    • DOI 10.2337/diabetes.53.8.2051
    • R. Basu, R.J. Singh, and A. Basu Splanchnic cortisol production occurs in humans: evidence for conversion of cortisone to cortisol via the 11-beta hydroxysteroid dehydrogenase (11beta-hsd) type 1 pathway Diabetes 53 2004 2051 2059 (Pubitemid 38970754)
    • (2004) Diabetes , vol.53 , Issue.8 , pp. 2051-2059
    • Basu, R.1    Singh, R.J.2    Basu, A.3    Chittilapilly, E.G.4    Johnson, C.M.5    Toffolo, G.6    Cobelli, C.7    Rizza, R.A.8
  • 17
    • 58149330675 scopus 로고    scopus 로고
    • Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity
    • J.W. Tomlinson, J. Finney, and C. Gay Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity Diabetes 57 2008 2652 2660
    • (2008) Diabetes , vol.57 , pp. 2652-2660
    • Tomlinson, J.W.1    Finney, J.2    Gay, C.3
  • 18
    • 69749124376 scopus 로고    scopus 로고
    • Stress-related development of obesity and cortisol in women
    • V. Vicennati, F. Pasqui, and C. Cavazza Stress-related development of obesity and cortisol in women Obesity (Silver Spring) 17 2009 1678 1683
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 1678-1683
    • Vicennati, V.1    Pasqui, F.2    Cavazza, C.3
  • 19
    • 85003195436 scopus 로고
    • Cortisol-induced insulin resistance in man: Impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor defect of insulin action
    • R.A. Rizza, L.J. Mandarino, and J.E. Gerich Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action J Clin Endocrinol Metab 54 1982 131 138 (Pubitemid 13242146)
    • (1982) Journal of Clinical Endocrinology and Metabolism , vol.54 , Issue.1 , pp. 131-138
    • Rizza, R.A.1    Mandarino, L.J.2    Gerich, J.E.3
  • 20
    • 0346787539 scopus 로고    scopus 로고
    • Impaired basal glucose effectiveness but unaltered fasting glucose release and gluconeogenesis during short-term hypercortisolemia in healthy subjects
    • M.F. Nielsen, A. Caumo, and V. Chandramouli Impaired basal glucose effectiveness but unaltered fasting glucose release and gluconeogenesis during short-term hypercortisolemia in healthy subjects Am J Physiol Endocrinol Metab 286 2004 E102 E110
    • (2004) Am J Physiol Endocrinol Metab , vol.286
    • Nielsen, M.F.1    Caumo, A.2    Chandramouli, V.3
  • 21
    • 34547885436 scopus 로고    scopus 로고
    • Glucocorticoids, metabolism and metabolic diseases
    • DOI 10.1016/j.mce.2007.05.015, PII S0303720707002109
    • A. Vegiopoulos, and S. Herzig Glucocorticoids, metabolism and metabolic diseases Mol Cell Endocrinol 15 2007 43 61 (Pubitemid 47259280)
    • (2007) Molecular and Cellular Endocrinology , vol.275 , Issue.1-2 , pp. 43-61
    • Vegiopoulos, A.1    Herzig, S.2
  • 22
    • 58649095526 scopus 로고    scopus 로고
    • Novel insights into glucocorticoid-mediated diabetogenic effects: Towards expansion of therapeutic options?
    • D.H. Van Raalte, D.M. Ouwens, and M. Diamant Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options? Eur J Clin Invest 39 2009 81 93
    • (2009) Eur J Clin Invest , vol.39 , pp. 81-93
    • Van Raalte, D.H.1    Ouwens, D.M.2    Diamant, M.3
  • 24
    • 61449225726 scopus 로고    scopus 로고
    • Hepatic 11beta-HSD1 mRNA expression in fatty liver and nonalcoholic steatohepatitis
    • S. Konopelska, T. Kienitz, and B. Hughes Hepatic 11beta-HSD1 mRNA expression in fatty liver and nonalcoholic steatohepatitis Clin Endocrinol (Oxf) 70 2009 554 560
    • (2009) Clin Endocrinol (Oxf) , vol.70 , pp. 554-560
    • Konopelska, S.1    Kienitz, T.2    Hughes, B.3
  • 28
    • 79955046317 scopus 로고    scopus 로고
    • Effects of an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, MK-0916, in patients with type 2 diabetes mellitus and metabolic syndrome
    • P.U. Feig, S. Shah, and A. Hermanowski Vosatka Effects of an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, MK-0916, in patients with type 2 diabetes mellitus and metabolic syndrome Diabetes Obes Metab 13 6 2011 498 504
    • (2011) Diabetes Obes Metab , vol.13 , Issue.6 , pp. 498-504
    • Feig, P.U.1    Shah, S.2    Hermanowski Vosatka, A.3
  • 29
    • 72049107460 scopus 로고    scopus 로고
    • Preliminary report: Pharmacologic 11beta-hydroxysteroid dehydrogenase type 1 inhibition increases hepatic fat oxidation in vivo and expression of related genes in rats fed an obesogenic diet
    • M. Berthiaume, M. Laplante, and W.T. Festuccia Preliminary report: pharmacologic 11beta-hydroxysteroid dehydrogenase type 1 inhibition increases hepatic fat oxidation in vivo and expression of related genes in rats fed an obesogenic diet Metabolism 59 2010 114 117
    • (2010) Metabolism , vol.59 , pp. 114-117
    • Berthiaume, M.1    Laplante, M.2    Festuccia, W.T.3
  • 31
    • 33751215200 scopus 로고    scopus 로고
    • Cortisol-cause and cure for metabolic syndrome?
    • B.R. Walker Cortisol-cause and cure for metabolic syndrome? Diabet Med 23 2006 1281 1288
    • (2006) Diabet Med , vol.23 , pp. 1281-1288
    • Walker, B.R.1
  • 32
    • 77952936214 scopus 로고    scopus 로고
    • The cortisol awakening response and the metabolic syndrome in a population-based sample of middle-aged men and women
    • I. Bengtsson, L. Lissner, and T. Liung The cortisol awakening response and the metabolic syndrome in a population-based sample of middle-aged men and women Metabolism 59 2010 1012 1019
    • (2010) Metabolism , vol.59 , pp. 1012-1019
    • Bengtsson, I.1    Lissner, L.2    Liung, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.