A gene signature of primary tumor identifies metastasized seminoma

Urologic Oncology: Seminars and Original Investigations

Volumn 29, Issue 6, 2011, Pages 764-773

  Port, Matthias ^a   Wang, Yu ^b   Schmelz, Hans Ulrich ^c   Pottek, Tobias ^d   Meineke, Viktor ^e   Ruf, Christian ^e   Abend, Michael ^e  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c BUNDESWEHRZENTRALKRANKENHAUS KOBLENZ   (Germany)

^d Wedel Hospital   (Germany)

^e Bundeswehr Institute of Radiobiology   (Germany)

Author keywords

Gene classifier; Gene expression; Metastasized seminoma; Testis tumor

Indexed keywords

RNA;

ADULT; ARTICLE; CANCER STAGING; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DOWN REGULATION; GENE EXPRESSION; GENOME; HUMAN; HUMAN TISSUE; MALE; METASTASIZED SEMINOMA; MICROARRAY ANALYSIS; PREDICTION; PRIMARY TUMOR; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA ANALYSIS; SEMINOMA; TESTIS BIOPSY; TISSUE TYPES; VALIDATION PROCESS;

ADULT; GENE EXPRESSION PROFILING; HUMANS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM STAGING; REAL-TIME POLYMERASE CHAIN REACTION; SEMINOMA; SENSITIVITY AND SPECIFICITY; TESTICULAR NEOPLASMS;

EID: 81055144665     PISSN: 10781439     EISSN: 18732496     Source Type: Journal    
DOI: 10.1016/j.urolonc.2009.08.008     Document Type: Article

References (46)

1. Albers P., Albrecht W., Algaba F., et al. Guidelines on testicular cancer. Eur Urol 2005, 48:885-894.
2. Krege S., Souchon R., Schmoll H.J. Interdisciplinary consensus on diagnosis and treatment of testicular germ cell tumors: Result of an update conference on evidence-based medicine (EBM). Eur Urol 2001, 40:372-391.
3. Warde P., Specht L., Horwich A., et al. Prognostic factors for relapse in stage I seminoma managed by surveillance: A pooled analysis. J Clin Oncol 2002, 20:4448-4452.
4. Christofori G. New signals from the invasive front. Nature 2006, 441:444-450.
5. Nicolson G.L. Gene expression, cellular diversification, and tumor progression to the metastatic phenotype. Bioessays 1991, 13:337-342.
6. Mishina M., Ogawa O., Kinoshita H., et al. Equivalent parental distribution of frequently lost alleles and bi-allelic expression of the H19 gene in human testicular germ cell tumors. Jpn J Cancer Res 1996, 87:816-823.
7. Cavallaro U., Christofori G. Cell adhesion and signaling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer 2004, 4:118-132.
8. Johnson J.P. Cell adhesion molecules of the immunoglobulin supergene family and their role in malignant transformation and progression to metastatic disease. Cancer Metastasis Rev 1991, 10:11-22.
9. Dieckmann K.P., Skakkebaek N.E. Carcinoma in situ of the testis: Review of biological and clinical features. Int J Cancer 1999, 83:815-822.
10. Wang Y., Tetko I.V., Hall M.A., et al. Gene selection from microarray data for cancer classification-a machine learning approach. Comput Biol Chem 2005, 29:37-46.
11. Shi L., Jones W.D., Jensen R.V., et al. The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies. BMC Bioinformatics 2008, 9(Suppl 9):S10.
12. Shi L., Perkins R.G., Fang H., et al. Reproducible and reliable microarray results through quality control: Good laboratory proficiency and appropriate data analysis practices are essential. Curr Opin Biotechnol 2008, 19:10-18.
13. Port M., Schmelz H.U., Stockinger M., et al. Gene expression profiling in seminoma and nonseminoma. J Clin Oncol 2005, 23:58-69.
14. Honecker F., Oosterhuis J.W., Mayer F., et al. New insights into the pathology and molecular biology of human germ cell tumors. World J Urol 2004, 22:15-24.
15. Biermann K., Heukamp L.C., Steger K., et al. Gene expression profiling identifies new biological markers of neoplastic germ cells. Anticancer Res 2007, 27:3091-3100.
16. Almstrup K., Leffers H., Lothe R.A., et al. Improved gene expression signature of testicular carcinoma in situ. Int J Androl 2007, 30:292-302.
17. Seidl C., Port M., Gilbertz K.P., et al. 213Bi-induced death of HSC45-M2 gastric cancer cells is characterized by G2 arrest and up-regulation of genes known to prevent apoptosis but induce necrosis and mitotic catastrophe. Mol Cancer Ther 2007, 6:2346-2359.
18. Port M., Boltze C., Wang Y., et al. A radiation-induced gene signature distinguishes post-Chernobyl from sporadic papillary thyroid cancers. Radiat Res 2007, 168:639-649.
19. Fritz G., Kaina B. Rho GTPases: Promising cellular targets for novel anticancer drugs. Curr Cancer Drug Targets 2006, 6:1-14.
20. Li S., Huang S., Peng S.B. Overexpression of G protein-coupled receptors in cancer cells: Involvement in tumor progression. Int J Oncol 2005, 27:1329-1339.
21. Okegawa T., Pong R.C., Li Y., et al. The role of cell adhesion molecule in cancer progression and its application in cancer therapy. Acta Biochim Pol 2004, 51:445-457.
22. Yamazaki D., Kurisu S., Takenawa T. Regulation of cancer cell motility through actin reorganization. Cancer Sci 2005, 96:379-386.
23. Pages F., Vives V., Sautes-Fridman C., et al. Control of tumor development by intratumoral cytokines. Immunol Lett 1999, 68:135-139.
24. Sierra A. Metastases and their microenvironments: Linking pathogenesis and therapy. Drug Resist Update 2005, 8:247-257.
25. Fujii T., Otsuki T., Moriya T., et al. Effect of hypoxia on human seminoma cells. Int J Oncol 2002, 20:955-962.
26. Viglietto G., Romano A., Maglione D., et al. Neovascularization in human germ cell tumors correlates with a marked increase in the expression of the vascular endothelial growth factor but not the placenta-derived growth factor. Oncogene 1996, 13:577-587.
27. Koshida K., Konaka H., Kato H., et al. Correlation between expression of metastasis-related genes and lymph node metastasis in testicular cancer. Hinyokika Kiyo 2000, 46:775-781.
28. VanMeter T.E., Rooprai H.K., Kibble M.M., et al. The role of matrix metalloproteinase genes in glioma invasion: Codependent and interactive proteolysis. J Neurooncol 2001, 53:213-235.
29. Schmelz H.U., Port M., Hauck E.W., et al. Apoptosis: A key effector mechanism of lymphocyte action in human nonseminomatous testicular carcinoma?. BJU Int 2005, 96:158-163.
30. Sugimura J., Foster R.S., Cummings O.W., et al. Gene expression profiling of early- and late-relapse nonseminomatous germ cell tumor and primitive neuroectodermal tumor of the testis. Clin Cancer Res 2004, 10:2368-2378.
31. Michael H., Hull M.T., Ulbright T.M., et al. Primitive neuroectodermal tumors arising in testicular germ cell neoplasms. Am J Surg Pathol 1997, 21:896-904.
32. Schmelz H.U., Albers P. Klinik und Diagnostik maligner Keimzelltumoren des Hodens. Facharztwissen Urologie, Differenzierte Diagnostik und Therapie 2006, 261-266.
33. Zhang H., Wang Y., Chen Y., et al. Identification and validation of S100A7 associated with lung squamous cell carcinoma metastasis to brain. Lung Cancer 2007, 57:37-45.
34. Payne S.L., Hendrix M.J., Kirschmann D.A. Paradoxical roles for lysyl oxidases in cancer-a prospect. J Cell Biochem 2007, 101:1338-1354.
35. Erler J.T., Giaccia A.J. Lysyl oxidase mediates hypoxic control of metastasis. Cancer Res 2006, 66:10238-10241.
36. L'Esperance S., Popa I., Bachvarova M., et al. Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: Molecular signatures of chemoresistant tumors. Int J Oncol 2006, 29:5-24.
37. Madi L., Ochaion A., Rath-Wolfson L., et al. The A3 adenosine receptor is highly expressed in tumor versus normal cells: Potential target for tumor growth inhibition. Clin Cancer Res 2004, 10:4472-4479.
38. Bar-Yehuda S., Barer F., Volfsson L., et al. Resistance of muscle to tumor metastases: A role for a3 adenosine receptor agonists. Neoplasia 2001, 3:125-131.
39. Feng Y., Huang T., Gao J., et al. Inhibition of metastatic progression of SSTR2 gene transfection mediated by adenovirus in human pancreatic carcinoma cells. J Huazhong Univ Sci Technolog Med Sci 2006, 26:68-71.
40. Li L., Miyamoto M., Ebihara Y., et al. DRD2/DARPP-32 expression correlates with lymph node metastasis and tumor progression in patients with esophageal squamous cell carcinoma. World J Surg 2006, 30:1672-1679.
41. Cheng Y., Buffone M.G., Kouadio M., et al. Abnormal sperm in mice lacking the Taf7l gene. Mol Cell Biol 2007, 27:2582-2589.
42. Kimmins S., Kotaja N., Davidson I., et al. Testis-specific transcription mechanisms promoting male germ-cell differentiation. Reproduction 2004, 128:5-12.
43. Mitra A.P., Almal A.A., George B., et al. The use of genetic programming in the analysis of quantitative gene expression profiles for identification of nodal status in bladder cancer. BMC Cancer 2006, 6:159.
44. Ren Y., Chan H.M., Fan J., et al. Inhibition of tumor growth and metastasis in vitro and in vivo by targeting macrophage migration inhibitory factor in human neuroblastoma. Oncogene 2006, 25:3501-3508.
45. Muller-Tidow C., Diederichs S., Bulk E., et al. Identification of metastasis-associated receptor tyrosine kinases in non-small cell lung cancer. Cancer Res 2005, 65:1778-1782.
46. Douglas G.C., O'Bryan M.K., Hedger M.P., et al. The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis. Endocrinology 2004, 145:4703-4711.