Apoptosis: A key effector mechanism of lymphocyte action in human nonseminomatous testicular carcinoma?

BJU International

Volumn 96, Issue 1, 2005, Pages 158-163

  Schmelz, Hans U ^a,d   Port, Matthias ^c   Hauck, Ekkehard W ^d   Schwerer, Michael J ^b   Weidner, Wolfgang ^d   Sparwasser, Christoph ^a   Abend, Michael ^c  

^a BUNDESWEHRKRANKENHAUS ULM   (Germany)

^b Department of Pathology ^*  (Germany)

^c Institute of Radiobiology   (Germany)

^d JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Apoptosis; Testicular cancer; Tumour infiltrating lymphocytes

Indexed keywords

BLEOMYCIN; CISPLATIN; ETOPOSIDE; IFOSFAMIDE;

APOPTOSIS; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CELL INTERACTION; CELL NUCLEUS; CELL STRUCTURE; CHROMATIN CONDENSATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DNA STRAND BREAKAGE; EMBRYONAL CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE COUNT; LYMPHOCYTIC INFILTRATION; MALE; NON SEMINOMATOUS GERMINOMA; PRIORITY JOURNAL; PROGNOSIS; SEMINOMA; SIGNAL TRANSDUCTION; TESTIS CANCER; TESTIS NONSEMINOMA CANCER; TUMOR ASSOCIATED LEUKOCYTE;

APOPTOSIS; HUMANS; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; NEOPLASMS, GERM CELL AND EMBRYONAL; TESTICULAR NEOPLASMS;

EID: 21744449215     PISSN: 14644096     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2005.05587.x     Document Type: Article

References (34)

1. Mostofi FK, Sesterhenn I. Plenary lecture: lymphocytic infiltration in relationship to urologic tumors. Natl Cancer Inst Monogr 1987; 49: 133-41
2. Torres A, Casanova JF, Nistal M, Regadera J. Quantification of immunocompetent cells in testicular germ cell tumors. Histopathology 1997; 30: 23-30
3. Ansell SM, Stenson M, Habermann TM, Jelinek DF, Witzig TE. CD 4+ T-cell immune response to large B-cell non-Hodgkin's lymphoma predicts patient outcome. J Clin Oncol 2001; 19: 720-6
4. Schumancher K, Haensch W, Roefzaad C, Schlag PM. Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas. Cancer Res 2001; 61: 3932-6
5. Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava E, Kosma VM. Prognostic value of tumor infiltrating and transforming growth factor beta as prognostic factors in breast carcinoma. Int J Cancer 1997; 74: 492-501
6. Bell DA, Flotte TJ, Bhan AK. Immunohistochemical characterization of seminoma and its inflammatory cell infiltrate. Hum Pathol 1987; 18: 511-20
7. Parker C, Milosevic M, Panzarella T et al. The prognostic significance of the tumor infiltrating lymphocyte count in stage I testicular seminoma managed by surveillance. Eur J Cancer 2002; 38: 2014-9
8. Schmelz HU, Abend M, Kraft K, Van Beuningen D, Pust R, Sparwasser C. Apoptosis in human embryonal cell carcinoma: preliminary results. Urol Res 1999; 27: 368-75
9. Schmelz HU, Abend M, Kraft K et al. Fas/Fas ligand system and apoptosis induction in testicular carcinoma. Cancer 2002; 95: 73-81
10. Podack E. Execution and suicide: cytotoxic lymphocytes enforce Draconian laws through separate molecular mechanisms. Curr Opin Immunol 1995; 7: 11-6
11. Abend M, Port M, Schmelz HU, Kraft K, Sparwasser C. Significance of apoptosis in metastasizing testis tumors. Urol Res 2004; 32: 28-35
12. Fernandez Y, Gu B, Martinez A, Torregrosa A, Sierra A. Inhibition of apoptosis in human breast cancer cells: role in tumor progression to the metastatic state. Int J Cancer 2002; 101: 317-26
13. Richter EN, Oevermann K, Buentig N, Storkel S, Dallmann I, Atzpodien J. Primary apoptosis as a prognostic index for the classification of metastatic renal cell carcinoma. J Urol 2002; 168: 460-4
14. Scaife CL, Kuang J, Wills JC et al. Nuclear factor kappaB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis. Cancer Res 2002; 62: 6870-8
15. Naito Y, Saito K, Shiiba K et al. CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res 1998; 58: 3491-4
16. Oudejans JJ, Jiwa NM, Kummer JA et al. Analysis of major histocompatibility complex class I expression on Reed-Sternberg cells in relation to the cytotoxic T-cell response in Epstein-Barr virus positive and negative Hodgkin's disease. Blood 1996; 87: 3844-51
17. Yakirevich E, Ben Izhak O, Rennert G, Kovacs ZG, Resnick MB. Cytotoxic phenotype of tumor infiltrating lymphocytes in medullary carcinoma of the breast. Mod Pathol 1999; 12: 1050-6
18. Bols B, Jensen A, Braendstrup O. Immunopathology of in situ seminoma. Int J Exp Pathol 2000; 81: 211-7
19. Abend M, Schmelz HU, Kraft K, Rhein AP, van Beuningen D, Sparwasser C. Intercomparison of apoptosis morphology with DNA cleavage on single cells in vitro and on testis tumors. J Pathol 1998; 185: 419-26
20. Schmelz HU, Abend M, Port M et al. Comparative analysis of different apoptosis detection methods in human testicular cancer. Urol Res 2004; 32: 332-7
21. Schmoll HJ, Souchon R, Krege S et al. European consensus on diagnosis and treatment of germ cell cancer: a report of the European Germ Cell Cancer Consensus Group (EGCCCG). Ann Oncol 2004; 15: 1377-99
22. Schulze-Osthoff K, Walczak H, Droge W, Krammer PH. Cell nucleus and DNA fragmentation are not required for apoptosis. J Cell Biol 1994; 127: 15-20
23. Cohen GM, Sun XM, Snowden RT, Dinsdale D, Skilleter DN. Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation. Biochem J 1992; 286: 331-40
24. Port M, Schmelz HU, Sparwasser C, Albers P, Pottek T, Abend M. Gene expression profiling in seminoma and nonseminoma. J Clin Oncol 2005; 23: 58-69
25. Grossmann J. Molecular mechanisms of 'detachment-induced apoptosis-Anoikis'. Apoptosis 2002; 7: 247-60
26. Coles HSR, Brune JF, Raff MC. Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor. Development 1993; 118: 777-84
27. Saraste A. Morphologic criteria and detection of apoptosis. Herz 1999; 24: 189-95
28. Nouri AM, Hussain RF, Oliver RT, Handy AM, Bartkova I, Bodmer JG. Immunological paradox in testicular tumours, the presence of a large number of activated T-cells despite the complete absence of MHC antigens. Eur J Cancer 1993; 29A: 1895-9
29. Yakirevich E, Lefel O, Sova Y et al. Activated status of tumour-infiltrating lymphocytes and apoptosis in testicular seminoma. J Pathol 2002; 196: 67-75
30. Nagata S, Goldstein P. The Fas death factor. Science 1995; 267: 1449-56
31. Suda T, Okazaki T, Naito Y et al. Expression of the Fas ligand in cells of T cell lineage. J Immunol 1995; 154: 3806-13
32. Alderson MR, Armitage RJ, Maraskowsky E et al. Fas transduces activation signals in normal human T-lymphocytes. J Exp Med 1993; 178: 2231-5
33. Braendstrup O, Bols B, Jensen L. Fas and Fas-ligand expression in seminomatous testes. APMIS 1999; 107: 431-6
34. Sugihara A, Saiki S, Tsuji M et al. Expression of Fas and Fas ligand in the testes and testicular germ cell tumors: an immunhistochemical study. Anticancer Res 1997; 17: 3861-5