The novel Angiotensin-Converting Enzyme (ACE) homolog, ACE2, is selectively expressed by adult leydig cells of the testis

Endocrinology

Volumn 145, Issue 10, 2004, Pages 4703-4711

  Douglas, Gabrielle C ^a,b   O'Bryan, Moira K ^b,c   Hedger, Mark P ^b   Lee, David K L ^a   Yarski, Michael A ^a   Smith, A Ian ^a,b   Lew, Rebecca A ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c Australian Government Australian Research Council   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; DIPEPTIDYL CARBOXYPEPTIDASE; ETHYLENE GLYCOL DIMESYLATE; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL MATURATION; CONTROLLED STUDY; HYPOPHYSIS TESTIS SYSTEM; IMMUNOHISTOCHEMISTRY; INTERSTITIUM; LEYDIG CELL; MALE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUBERTY; RAT; SERTOLI CELL; SOMATIC CELL; TESTIS; TESTIS FUNCTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CARBOXYPEPTIDASES; CATALYSIS; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; CRICETULUS; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; LEYDIG CELLS; MALE; PEPTIDYL-DIPEPTIDASE A; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; STAINING AND LABELING; SUBCELLULAR FRACTIONS; TISSUE DISTRIBUTION;

EID: 4644300547     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-0443     Document Type: Article

References (33)

1. Corvol P, Williams TA, Soubrier F 1995 Peptidyl dipeptidase A: angiotensin I-converting enzyme. Methods Enzymol 248:283-305
2. Erdos EG, Deddish PA, Marcic BM 1999 Potentiation of bradykinin actions by ACE inhibitors. Trends Endocrinol Metab 10:223-229
3. Turner AJ, Hooper NM 2002 The angiotensin-converting enzyme gene family: genomics and pharmacology. Trends Pharmacol Sci 23:177-183
4. Sibony M, Gasc JM, Soubrier F, Alhenc-Gelas F, Corvol P 1993 Gene expression and tissue localization of the two isoforms of angiotensin I converting enzyme. Hypertension 21:827-835
5. Krege JH, John SW, Langenbach LL, Hodgin JB, Hagaman JR, Bachman ES, Jennette JC, O'Brien DA, Smithies O 1995 Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature 375:146-148
6. Esther Jr CR, Howard TE, Marino EM, Goddard JM, Capecchi MR, Bernstein KE 1996 Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab Invest 74:953-965
7. Hagaman JR, Moyer JS, Bachman ES, Sibony M, Magyar PL, Welch JE, Smithies O, Krege JH, O'Brien DA 1998 Angiotensin-converting enzyme and male fertility. Proc Natl Acad Sci USA 95:2552-2557
8. Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S 2000 A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res 87:E1-E9
9. Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G, Turner AJ 2000 A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem 275:33238-33243
10. Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, Godbout K, Parsons T, Baronas E, Hsieh F, Acton S, Patane M, Nichols A, Tummino P 2002 Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J Biol Chem 277:14838-14843
11. Zisman LS, Keller RS, Weaver B, Lin Q, Speth R, Bristow MR, Canver CC 2003 Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin-converting enzyme homologue ACE2. Circulation 108:1707-1712
12. Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, Oliveira-dos-Santos AJ, da Costa J, Zhang L, Pei Y, Scholey J, Ferrario CM, Manoukian AS, Chappell MC, Backx PH, Yagil Y, Penninger JM 2002 Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature 417:822-828
13. Edwards K, Craig AW, Jackson H 1969 Studies with alkylating esters. I. The fate of ethylene dimethanesulphonate. Biochem Pharmacol 18:1693-1700
14. al-Moslih MI, Dubes GR 1973 The kinetics of DEAE-dextran-induced cell sensitization to transfection. J Gen Virol 18:189-193
15. Hedger MP, Eddy EM 1990 Leydig cell cooperation in vitro: evidence for communication between adult rat Leydig cells. J Androl 11:9-16
16. Sun YT, Irby DC, Robertson DM, de Kretser DM 1989 The effects of exogenously administered testosterone on spermatogenesis in intact and hypophysectomized rats. Endocrinology 125:1000-1010
17. Wang J, Wreford NG, Lan HY, Atkins R, Hedger MP 1994 Leukocyte populations of the adult rat testis following removal of the Leydig cells by treatment with ethane dimethane sulfonate and subcutaneous testosterone implants. Biol Reprod 51:551-561
18. Lerner RA, Green N, Alexander H, Liu FT, Sutcliffe JG, Shinnick TM 1981 Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles. Proc Natl Acad Sci USA 78:3403-3407
19. Berndt MC, Gregory C, Kabral A, Zola H, Fournier D, Castaldi PA 1985 Purification and preliminary characterization of the glycoprotein Ib complex in the human platelet membrane. Eur J Biochem 151:637-649
20. Andrews RK, Harris SJ, McNally T, Berndt MC 1998 Binding of purified 14-3-3 ζ signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex. Biochemistry 37:638-647
21. Berndt MC, Chong BH, Bull HA, Zola H, Castaldi PA 1985b Molecular characterization of quinine/quinidine drug-dependent antibody platelet interaction using monoclonal antibodies. Blood 66:1292-1301
22. Balanathan P, Ball EM, Wang H, Harris SE, Shelling AN, Risbridger GP 2004 Epigenetic regulation of inhibin α-subunit gene in prostate cancer cell lines. J Mol Endocrinol 32:55-67
23. O'Bryan MK, Schlatt S, Gerdprasert O, Phillips DJ, de Kretser DM, Hedger MP 2000 Inducible nitric oxide synthase in the rat testis: evidence for potential roles in both normal function and inflammation-mediated infertility. Biol Reprod 63:1285-1293
24. Molenaar R, de Rooij DG, Rommerts FF, van der Molen HJ 1986 Repopulation of Leydig cells in mature rats after selective destruction of the existent Leydig cells with ethylene dimethane sulfonate is dependent on luteinizing hormone and not follicle-stimulating hormone. Endocrinology 118:2546-2554
25. 3H]captopril. Endocrinology 115:2332-2341
26. Vanha-Perttula T, Mather JP, Bardin CW, Moss SB, Bellve AR 1985 Localization of the angiotensin-converting enzyme activity in testis and epididymis. Biol Reprod 33:870-877
27. Millan MA, Aguilera G 1988 Angiotensin II receptors in testes. Endocrinology 122:1984-1990
28. Khanum A, Dufau ML 1988 Angiotensin II receptors and inhibitory actions in Leydig cells. J Biol Chem 263:5070-5074
29. Dufau ML, Khanum A, Winters CA, Tsai-Morris CH 1987 Multistep regulation of Leydig cell function. J Steroid Biochem 27:343-350
30. Widmark A, Damber JE, Bergh A 1986 Relationship between human chorionic gonadotrophin-induced changes in testicular microcirculation and the formation of testicular interstitial fluid. J Endocrinol 109:419-425
31. Damber JE, Bergh A, Widmark A 1987 Testicular blood flow and microcirculation in rats after treatment with ethane dimethyl sulfonate. Biol Reprod 37:1291-1296
32. Maddocks S, Sharpe RM 1989 Interstitial fluid volume in the rat testis: androgen-dependent regulation by the seminiferous tubules? J Endocrinol 120:215-222
33. Collin O, Bergh A, Damber JE, Widmark A 1993 Control of testicular vasomotion by testosterone and tubular factors in rats. J Reprod Fertil 97:115-121