SCOPUS 정보 검색 플랫폼

Volumn 46, Issue 12, 2011, Pages 5949-5958

Pharmacophore identification, virtual screening and biological evaluation of prenylated flavonoids derivatives as PKB/Akt1 inhibitors

(8) Dong, Xiaowu a Zhou, Xinglu a Jing, Hui a Chen, Jianzhong a Liu, Tao a Yang, Bo a He, Qiaojun a Hu, Yongzhou a

a ZHEJIANG UNIVERSITY (China)

Author keywords

HypoGen; Molecular docking; Pharmacophore model; PKB Akt1; Virtual screening

Indexed keywords

2',4',5,7 TETRAHYDROXY 6 (3,3 DIMETHYLALLYL)FLAVONE; 2',4',7 TRIHYDROXY 6 (3,3 DIMETHYLALLYL)FLAVONE; 3',4',5,7, TETRAHYDROXY 6 (3,3 DIMETHYLALLYL)FLAVONE; BTB 14740; FLAVONOID; GLYCOGEN SYNTHASE KINASE 3BETA; HTS 02143; HTS 08006; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE B INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; COST BENEFIT ANALYSIS; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FLOW CYTOMETRY; MOLECULAR DOCKING; MOLECULAR MODEL; PHARMACOPHORE; PRENYLATION; RELIABILITY; VALIDITY; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DRUG DESIGN; FLAVONOIDS; HUMANS; MODELS, MOLECULAR; NEOPLASMS; PRENYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 80955151802 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2011.10.006 Document Type: Article

Times cited : (45)

References (40)

1
- 0035872199
- J. Brognard, A.S. Clark, Y. Ni, and P.A. Dennis Cancer Res. 61 2001 3986 3997
- (2001) Cancer Res. , vol.61 , pp. 3986-3997
- Brognard, J.¹ Clark, A.S.² Ni, Y.³ Dennis, P.A.⁴

2
- 0001457668
- J.Q. Cheng, B. Ruggeri, W.M. Klein, G. Sonoda, D.A. Altomare, D.K. Watson, and J.R. Testa Proc. Natl. Acad. Sci. U.S.A 93 1996 3636 3641
- (1996) Proc. Natl. Acad. Sci. U.S.A , vol.93 , pp. 3636-3641
- Cheng, J.Q.¹ Ruggeri, B.² Klein, W.M.³ Sonoda, G.⁴ Altomare, D.A.⁵ Watson, D.K.⁶ Testa, J.R.⁷

3
- 0032558822
- D. Haas-Kogan, N. Shalev, M. Wong, G. Mills, G. Yount, and D. Stokoe Curr. Biol. 8 1998 1195 1198
- (1998) Curr. Biol. , vol.8 , pp. 1195-1198
- Haas-Kogan, D.¹ Shalev, N.² Wong, M.³ Mills, G.⁴ Yount, G.⁵ Stokoe, D.⁶

4
- 0001582482
- S.P. Staal Proc. Natl. Acad. Sci. U.S.A 84 1987 5034 5037
- (1987) Proc. Natl. Acad. Sci. U.S.A , vol.84 , pp. 5034-5037
- Staal, S.P.¹

5
- 30544453564
- E. Fayard, L. Tintignac, A. Baudry, and B. Hemmings J. Cell. Sci. 118 2005 5675 5678
- (2005) J. Cell. Sci. , vol.118 , pp. 5675-5678
- Fayard, E.¹ Tintignac, L.² Baudry, A.³ Hemmings, B.⁴

6
- 0033214101
- S. Masure, B. Haefner, J.J. Wesselink, E. Hoefnagel, E. Mortier, P. Verhasselt, A. Tuytelaars, R. Gordon, and A. Richardson Eur. J. Biochem. 265 1999 353 360
- (1999) Eur. J. Biochem. , vol.265 , pp. 353-360
- Masure, S.¹ Haefner, B.² Wesselink, J.J.³ Hoefnagel, E.⁴ Mortier, E.⁵ Verhasselt, P.⁶ Tuytelaars, A.⁷ Gordon, R.⁸ Richardson, A.⁹

7
- 80955153870
- R.T. Joseph, and B. Alfonso Proc. Natl. Acad. Sci. U.S.A 98 2001 10983 10985
- (2001) Proc. Natl. Acad. Sci. U.S.A , vol.98 , pp. 10983-10985
- Joseph, R.T.¹ Alfonso, B.²

8
- 26444503696
- E. Oki, H. Baba, E. Tokunaga, T. Nakamura, N. Ueda, M. Futatsugi, K. Mashino, M. Yamamoto, M. Ikebe, Y. Kakeji, and Y. Maehara Int. J. Cancer 117 2005 376 380
- (2005) Int. J. Cancer , vol.117 , pp. 376-380
- Oki, E.¹ Baba, H.² Tokunaga, E.³ Nakamura, T.⁴ Ueda, N.⁵ Futatsugi, M.⁶ Mashino, K.⁷ Yamamoto, M.⁸ Ikebe, M.⁹ Kakeji, Y.¹⁰ Maehara, Y.¹¹

9
- 33744902875
- C. Sourbier, V. Lindner, H. Lang, A. Agouni, E. Schordan, S. Danilin, S. Rothhut, D. Jacqmin, J. Helwig, and T. Massfelder Cancer Res. 66 2006 5130 5142
- (2006) Cancer Res. , vol.66 , pp. 5130-5142
- Sourbier, C.¹ Lindner, V.² Lang, H.³ Agouni, A.⁴ Schordan, E.⁵ Danilin, S.⁶ Rothhut, S.⁷ Jacqmin, D.⁸ Helwig, J.⁹ Massfelder, T.¹⁰

10
- 33644755478
- E. Tokunaga, A. Kataoka, Y. Kimura, E. Oki, K. Mashino, K. Nishida, T. Koga, M. Morita, Y. Kakeji, H. Baba, S. Ohno, and Y. Maehar Eur. J. Cancer 42 2006 629 635
- (2006) Eur. J. Cancer , vol.42 , pp. 629-635
- Tokunaga, E.¹ Kataoka, A.² Kimura, Y.³ Oki, E.⁴ Mashino, K.⁵ Nishida, K.⁶ Koga, T.⁷ Morita, M.⁸ Kakeji, Y.⁹ Baba, H.¹⁰ Ohno, S.¹¹ Maehar, Y.¹²

11
- 54049116732
- D. Mahadevan, G. Powis, E.A. Mash, B. George, V.M. Gokhale, S. Zhang, K. Shakalya, L. Du-Cuny, M. Berggren, M.A. Ali, U. Jana, N. Ihle, S. Moses, C. Franklin, S. Narayan, N. Shirahatti, and E.J. Meuillet Mol. Cancer Ther. 7 2008 2621 2632
- (2008) Mol. Cancer Ther. , vol.7 , pp. 2621-2632
- Mahadevan, D.¹ Powis, G.² Mash, E.A.³ George, B.⁴ Gokhale, V.M.⁵ Zhang, S.⁶ Shakalya, K.⁷ Du-Cuny, L.⁸ Berggren, M.⁹ Ali, M.A.¹⁰ Jana, U.¹¹ Ihle, N.¹² Moses, S.¹³ Franklin, C.¹⁴ Narayan, S.¹⁵ Shirahatti, N.¹⁶ Meuillet, E.J.¹⁷

12
- 34548844487
- C.W. Lindsley, S.F. Barnett, M. Yaroschak, M.T. Bilodeau, and M.E. Layton Curr. Top. Med. Chem. 7 2007 1349 1363
- (2007) Curr. Top. Med. Chem. , vol.7 , pp. 1349-1363
- Lindsley, C.W.¹ Barnett, S.F.² Yaroschak, M.³ Bilodeau, M.T.⁴ Layton, M.E.⁵

13
- 19944431003
- C.W. Lindsley, Z. Zhao, W.H. Leister, R.G. Robinson, S.F. Barnett, D. Defeo-Jones, R.E. Jones, G.D. Hartman, J.R. Huff, H.E. Huber, and M.E. Duggan Bioorg. Med. Chem. Lett. 15 2005 761 764
- (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 761-764
- Lindsley, C.W.¹ Zhao, Z.² Leister, W.H.³ Robinson, R.G.⁴ Barnett, S.F.⁵ Defeo-Jones, D.⁶ Jones, R.E.⁷ Hartman, G.D.⁸ Huff, J.R.⁹ Huber, H.E.¹⁰ Duggan, M.E.¹¹

14
- 32044433797
- Q. Li, T. Li, G. Zhu, J. Gong, A. Claibone, C. Dalton, Y. Luo, E.F. Johnson, Y. Shi, X. Liu, V. Klinghofer, J.L. Bauch, K.C. Marsh, J.J. Bousk, S. Arries, R. de Jong, T. Oltersdorf, V.S. Stoll, C.G. Jakob, S.H. Rosenberg, and V.L. Giranda Bioorg. Med. Chem. Lett. 16 2006 1679 1685
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 1679-1685
- Li, Q.¹ Li, T.² Zhu, G.³ Gong, J.⁴ Claibone, A.⁵ Dalton, C.⁶ Luo, Y.⁷ Johnson, E.F.⁸ Shi, Y.⁹ Liu, X.¹⁰ Klinghofer, V.¹¹ Bauch, J.L.¹² Marsh, K.C.¹³ Bousk, J.J.¹⁴ Arries, S.¹⁵ De Jong, R.¹⁶ Oltersdorf, T.¹⁷ Stoll, V.S.¹⁸ Jakob, C.G.¹⁹ Rosenberg, S.H.²⁰ Giranda, V.L.²¹ more..

15
- 33646184153
- G. Zhu, J. Gong, A. Claiborne, K.W. Woods, V.B. Gandhi, S. Thomas, Y. Luo, X. Liu, Y. Shi, R. Guan, S.R. Magnone, V. Klinghofer, E.F. Johnson, J. Bouska, A. Shoemaker, A. Oleksijew, V.S. Stoll, R. de Jong, T. Oltersdorf, Q. Li, S.H. Rosenberga, and V.L. Giranda Bioorg. Med. Chem. Lett. 16 2006 3150 3155
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 3150-3155
- Zhu, G.¹ Gong, J.² Claiborne, A.³ Woods, K.W.⁴ Gandhi, V.B.⁵ Thomas, S.⁶ Luo, Y.⁷ Liu, X.⁸ Shi, Y.⁹ Guan, R.¹⁰ Magnone, S.R.¹¹ Klinghofer, V.¹² Johnson, E.F.¹³ Bouska, J.¹⁴ Shoemaker, A.¹⁵ Oleksijew, A.¹⁶ Stoll, V.S.¹⁷ De Jong, R.¹⁸ Oltersdorf, T.¹⁹ Li, Q.²⁰ more..

16
- 33748102816
- K.W. Woods, J.P. Fischer, A. Claiborne, T. Li, S.A. Thomas, G. Zhu, R.B. Diebold, X. Liu, Y. Shi, V. Klinghofer, E.K. Han, R. Guan, S.R. Magnone, E.F. Johnson, J.J. Bouska, A.M. Olson, R. de Jong, T. Oltersdorf, Y. Luo, S.H. Rosenberg, V.L. Giranda, and Q. Li Bioorg. Med. Chem. Lett. 14 2006 6832 6848
- (2006) Bioorg. Med. Chem. Lett. , vol.14 , pp. 6832-6848
- Woods, K.W.¹ Fischer, J.P.² Claiborne, A.³ Li, T.⁴ Thomas, S.A.⁵ Zhu, G.⁶ Diebold, R.B.⁷ Liu, X.⁸ Shi, Y.⁹ Klinghofer, V.¹⁰ Han, E.K.¹¹ Guan, R.¹² Magnone, S.R.¹³ Johnson, E.F.¹⁴ Bouska, J.J.¹⁵ Olson, A.M.¹⁶ De Jong, R.¹⁷ Oltersdorf, T.¹⁸ Luo, Y.¹⁹ Rosenberg, S.H.²⁰ Giranda, V.L.²¹ Li, Q.²² more..

17
- 33846936007
- G. Zhu, J. Gong, V.B. Gandhi, K. Woods, Y. Luo, X. Liu, R. Guan, V. Klinghofer, E.F. Johnson, V.S. Stoll, M. Mamo, Q. Li, S.H. Rosenberg, and V.L. Giranda Bioorg. Med. Chem. Lett. 15 2007 2441 2452
- (2007) Bioorg. Med. Chem. Lett. , vol.15 , pp. 2441-2452
- Zhu, G.¹ Gong, J.² Gandhi, V.B.³ Woods, K.⁴ Luo, Y.⁵ Liu, X.⁶ Guan, R.⁷ Klinghofer, V.⁸ Johnson, E.F.⁹ Stoll, V.S.¹⁰ Mamo, M.¹¹ Li, Q.¹² Rosenberg, S.H.¹³ Giranda, V.L.¹⁴

18
- 33646841168
- G. Zhu, V.B. Gandhi, R. de Jong, Y. Luo, X. Liu, Y. Shi, R. Guan, S.R. Magnone, V. Klinghofer, E.F. Johnson, J. Bouska, A. Shoemaker, A. Oleksijew, K. Jarvis, C. Park, R. de Jong, T. Oltersdorf, Q. Li, S.H. Rosenberg, and V.L. Giranda Bioorg. Med. Chem. Lett. 16 2006 3424 3429
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 3424-3429
- Zhu, G.¹ Gandhi, V.B.² De Jong, R.³ Luo, Y.⁴ Liu, X.⁵ Shi, Y.⁶ Guan, R.⁷ Magnone, S.R.⁸ Klinghofer, V.⁹ Johnson, E.F.¹⁰ Bouska, J.¹¹ Shoemaker, A.¹² Oleksijew, A.¹³ Jarvis, K.¹⁴ Park, C.¹⁵ De Jong, R.¹⁶ Oltersdorf, T.¹⁷ Li, Q.¹⁸ Rosenberg, S.H.¹⁹ Giranda, V.L.²⁰ more..

19
- 0347755449
- O. Dror, A. Shulman-Peleg, R. Nussinov, and H.L. Wolfson Curr. Med. Chem. 11 2004 71 90
- (2004) Curr. Med. Chem. , vol.11 , pp. 71-90
- Dror, O.¹ Shulman-Peleg, A.² Nussinov, R.³ Wolfson, H.L.⁴

20
- 37449006536
- S. Vadivelan, B.N. Sinha, G. Rambabu, K. Boppana, and S.A. Jagarlapudi J. Mol. Graph. Model. 26 2008 935 946
- (2008) J. Mol. Graph. Model. , vol.26 , pp. 935-946
- Vadivelan, S.¹ Sinha, B.N.² Rambabu, G.³ Boppana, K.⁴ Jagarlapudi, S.A.⁵

21
- 55549130812
- A. Rinaldi EMBO Rep. 9 2008 1073 1077
- (2008) EMBO Rep. , vol.9 , pp. 1073-1077
- Rinaldi, A.¹

22
- 21444435047
- L. Di, and E.H. Kerns Curr. Opin. Drug Discov. Devel. 8 2005 495 504
- (2005) Curr. Opin. Drug Discov. Devel. , vol.8 , pp. 495-504
- Di, L.¹ Kerns, E.H.²

23
- 33745213575
- S.L. Dixon Chem. Biol. Drug Des. 67 2006 370 372
- (2006) Chem. Biol. Drug Des. , vol.67 , pp. 370-372
- Dixon, S.L.¹

24
- 20144376337
- T.A. Esbenshade, G.B. Fox, K.M. Krueger, T.R. Miller, C.H. Kang, L.I. Denny, D.G. Witte, B.B. Yao, L. Pan, J. Wetter, K. Marsh, Y.L. Bennani, M.D. Cowart, J.P. Sullivan, and A.A. Hancock J. Pharmacol. Exp. Ther. 313 2005 165 175
- (2005) J. Pharmacol. Exp. Ther. , vol.313 , pp. 165-175
- Esbenshade, T.A.¹ Fox, G.B.² Krueger, K.M.³ Miller, T.R.⁴ Kang, C.H.⁵ Denny, L.I.⁶ Witte, D.G.⁷ Yao, B.B.⁸ Pan, L.⁹ Wetter, J.¹⁰ Marsh, K.¹¹ Bennani, Y.L.¹² Cowart, M.D.¹³ Sullivan, J.P.¹⁴ Hancock, A.A.¹⁵

25
- 1642288258
- H.J. Boehm, M. Boehringer, D. Bur, H. Gmuender, W. Huber, W. Klaus, D. Kostrewa, H. Kuehne, T. Luebbers, N. Meunier-Keller, and F. Mueller J. Med. Chem. 43 2000 2664 2674
- (2000) J. Med. Chem. , vol.43 , pp. 2664-2674
- Boehm, H.J.¹ Boehringer, M.² Bur, D.³ Gmuender, H.⁴ Huber, W.⁵ Klaus, W.⁶ Kostrewa, D.⁷ Kuehne, H.⁸ Luebbers, T.⁹ Meunier-Keller, N.¹⁰ Mueller, F.¹¹

26
- 33947594733
- H. Yu, Z. Wang, L. Zhang, J. Zhang, and Q. Huang Bioorg. Med. Chem. Lett. 17 2007 2126 2133
- (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 2126-2133
- Yu, H.¹ Wang, Z.² Zhang, L.³ Zhang, J.⁴ Huang, Q.⁵

27
- 34347219022
- G. Zhu, V.B. Gandhi, J. Gong, S. Thomas, K.W. Woods, X. Song, T. Li, R.B. Diebold, Y. Luo, X. Liu, R. Guan, V. Klinghofer, E.F. Johnson, J. Bouska, A. Olson, K.C. Marsh, V.S. Stoll, M. Mamo, J. Polakowski, T.J. Campbell, R.L. Martin, G.A. Gintant, T.D. Penning, Q. Li, S.H. Rosenberg, and V.L. Giranda J. Med. Chem. 50 2007 2990 3003
- (2007) J. Med. Chem. , vol.50 , pp. 2990-3003
- Zhu, G.¹ Gandhi, V.B.² Gong, J.³ Thomas, S.⁴ Woods, K.W.⁵ Song, X.⁶ Li, T.⁷ Diebold, R.B.⁸ Luo, Y.⁹ Liu, X.¹⁰ Guan, R.¹¹ Klinghofer, V.¹² Johnson, E.F.¹³ Bouska, J.¹⁴ Olson, A.¹⁵ Marsh, K.C.¹⁶ Stoll, V.S.¹⁷ Mamo, M.¹⁸ Polakowski, J.¹⁹ Campbell, T.J.²⁰ more..

28
- 84986512474
- B.R. Brooks, R.E. Brucolleri, B.D. Olafson, D.J. States, S.S., and M. Karplus J. Comput. Chem. 4 1983 187 214
- (1983) J. Comput. Chem. , vol.4 , pp. 187-214
- Brooks, B.R.¹ Brucolleri, R.E.² Olafson, B.D.³ States, D.J.⁴ Karplus, M.⁵

29
- 0029277503
- A. Smellie, S.D. Kahn, and S.L. Teig J. Chem. Inf. Comp. Sci. 35 1995 285 294
- (1995) J. Chem. Inf. Comp. Sci. , vol.35 , pp. 285-294
- Smellie, A.¹ Kahn, S.D.² Teig, S.L.³

30
- 0037011895
- A.K. Debnath J. Med. Chem. 45 2002 41 53
- (2002) J. Med. Chem. , vol.45 , pp. 41-53
- Debnath, A.K.¹

31
- 5144222589
- W.M. Kazmierski, W. Andrews, E. Furfine, A. Spaltenstein, and L. Wright Bioorg. Med. Chem. Lett. 14 2004 5689 5692
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 5689-5692
- Kazmierski, W.M.¹ Andrews, W.² Furfine, E.³ Spaltenstein, A.⁴ Wright, L.⁵

32
- 33646023117
- T. Fawcett Pattern. Recogn. Lett. 27 2006 861 874
- (2006) Pattern. Recogn. Lett. , vol.27 , pp. 861-874
- Fawcett, T.¹

33
- 80955153871
- Sybyl6.9 Tripos Associates: St. Louis, MO, USA
- Sybyl6.9 (2002), Molecular Modelling System, Tripos Associates: St. Louis, MO, USA.
- (2002) Molecular Modelling System

34
- 0030599010
- M. Rarey, B. Kramer, T. Lengauer, and G. Klebe J. Mol. Biol. 261 1996 470 489
- (1996) J. Mol. Biol. , vol.261 , pp. 470-489
- Rarey, M.¹ Kramer, B.² Lengauer, T.³ Klebe, G.⁴

35
- 0037212102
- C.M. Venkatachalam, X. Jiang, T. Oldfield, and M. Waldman J. Mol. Graphics Model. 21 2003 289 307
- (2003) J. Mol. Graphics Model. , vol.21 , pp. 289-307
- Venkatachalam, C.M.¹ Jiang, X.² Oldfield, T.³ Waldman, M.⁴

36
- 0041781898
- G. Wu, D.H. Robertson, C.L. Brooks 3rd, and M. Vieth J. Comput. Chem. 24 2003 1549 1562
- (2003) J. Comput. Chem. , vol.24 , pp. 1549-1562
- Wu, G.¹ Robertson, D.H.² Brooks III, C.L.³ Vieth, M.⁴

37
- 37249060328
- S.N. Rao, M.S. Head, A. Kulkarni, and J.M. LaLonde J. Chem. Inf. Model. 47 2007 2159 2171
- (2007) J. Chem. Inf. Model. , vol.47 , pp. 2159-2171
- Rao, S.N.¹ Head, M.S.² Kulkarni, A.³ Lalonde, J.M.⁴

38
- 67650095165
- X. Dong, J. Chen, C. Jiang, T. Liu, and Y. Hu Arch. Pharm. 342 2009 428 432
- (2009) Arch. Pharm. , vol.342 , pp. 428-432
- Dong, X.¹ Chen, J.² Jiang, C.³ Liu, T.⁴ Hu, Y.⁵

39
- 65749118365
- X. Dong, L. Qi, C. Jiang, J. Chen, E. Wei, and Y. Hu Bioorg. Med. Chem. Lett. 19 2009 3196 3198
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 3196-3198
- Dong, X.¹ Qi, L.² Jiang, C.³ Chen, J.⁴ Wei, E.⁵ Hu, Y.⁶

40
- 27844553839
- AKT crystal structure and AKT-specific inhibitors
- C.K. Chandra, and M. Vincent AKT crystal structure and AKT-specific inhibitors Oncogene 24 2005 7493 7501
- (2005) Oncogene , vol.24 , pp. 7493-7501
- Chandra, C.K.¹ Vincent, M.²

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