Pharmacophore modeling and in silico screening for new KDR kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 8, 2007, Pages 2126-2133

  Yu, Hui ^a   Wang, Zhanli ^b   Zhang, Liangren ^c   Zhang, Jufeng ^a   Huang, Qian ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b NeoTrident Technology Ltd   (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

CATALYST; Conformational analysis; KDR kinase; Pharmacophore

Indexed keywords

3 (4 BROMO 2,6 DIFLUOROBENZYLOXY) 5 [3 [4 (1 PYRROLIDINYL)BUTYL]UREIDO] 4 ISOTHIAZOLECARBOXAMIDE; SEMAXANIB; VASCULOTROPIN INHIBITOR; VATALANIB;

ARTICLE; BINDING AFFINITY; DRUG SCREENING; DRUG STRUCTURE; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; VALIDATION PROCESS;

COMPUTER SIMULATION; DATABASES, FACTUAL; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 33947594733     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.01.089     Document Type: Article

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