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Volumn 4, Issue 1, 2011, Pages 127-140

Current and future role of biomarkers in Crohn's disease risk assessment and treatment

Author keywords

Biomarkers; Complicated disease; Crohn's disease; Inflammatory bowel disease; Serologic testing

Indexed keywords

ANTIBIOTIC AGENT; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CALGRANULIN; CORTICOSTEROID; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INFLIXIMAB; LACTOFERRIN; MESALAZINE; NEUTROPHIL CYTOPLASMIC ANTIBODY; OUTER MEMBRANE PROTEIN C; OUTER MEMBRANE PROTEIN C ANTIBODY; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG;

EID: 80955139672     PISSN: None     EISSN: 11787023     Source Type: Journal    
DOI: 10.2147/CEG.S18187     Document Type: Review
Times cited : (15)

References (124)
  • 1
    • 0002063230 scopus 로고    scopus 로고
    • A simple classifcation of Crohn's disease: Report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998
    • Gasche C, Scholmerich J, Brynskov J, et al. A simple classifcation of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998. Infamm Bowel Dis. 2000;6(1): 8-15.
    • (2000) Infamm Bowel Dis , vol.6 , Issue.1 , pp. 8-15
    • Gasche, C.1    Scholmerich, J.2    Brynskov, J.3
  • 2
    • 58149090725 scopus 로고    scopus 로고
    • The evolution of Crohn's disease (CD) behavior in a population-based cohort [abstract 1135]
    • Thia K, Sandborn W, Harmsen W, Zinmeister A. The evolution of Crohn's disease (CD) behavior in a population-based cohort [abstract 1135]. Am J Gastroenterol. 2008;103 Suppl 5: S443-S444.
    • (2008) Am J Gastroenterol , vol.103 , Issue.SUPPL. 5
    • Thia, K.1    Sandborn, W.2    Harmsen, W.3    Zinmeister, A.4
  • 3
    • 0021266269 scopus 로고
    • Natural history of recurrent Crohn's disease at the ileoco-lonic anastomosis after curative surgery
    • Rutgeerts P, Geboes K, Vantrappen G, Kerremans R, Coenegrachts JL, Coremans G. Natural history of recurrent Crohn's disease at the ileoco-lonic anastomosis after curative surgery. Gut. 1984;25(6):665-672.
    • (1984) Gut , vol.25 , Issue.6 , pp. 665-672
    • Rutgeerts, P.1    Geboes, K.2    Vantrappen, G.3    Kerremans, R.4    Coenegrachts, J.L.5    Coremans, G.6
  • 4
    • 0033022146 scopus 로고    scopus 로고
    • Clinical course and costs of care for Crohn's disease: Markov model analysis of a population-based cohort
    • Silverstein MD, Loftus E V, Sandborn WJ, et al. Clinical course and costs of care for Crohn's disease: Markov model analysis of a population-based cohort. Gastroenterology. 1999;117(1):49-57.
    • (1999) Gastroenterology , vol.117 , Issue.1 , pp. 49-57
    • Silverstein, M.D.1    Loftus, E.V.2    Sandborn, W.J.3
  • 5
    • 59749093368 scopus 로고    scopus 로고
    • For the Practice Parameters Committee of the American College of Gastroenterology. Management of Crohn's disease in adults
    • Lichtenstein GR, Hanauer SB, Sandborn WJ; For the Practice Parameters Committee of the American College of Gastroenterology. Management of Crohn's disease in adults. Am J Gastroenterol. 2009;104(2): 465-483.
    • (2009) Am J Gastroenterol , vol.104 , Issue.2 , pp. 465-483
    • Lichtenstein, G.R.1    Hanauer, S.B.2    Sandborn, W.J.3
  • 6
    • 4344602852 scopus 로고    scopus 로고
    • Guidelines for the management of Inflammatory bowel disease in adults
    • Carter MJ, Lobo AJ, Travis S P. Guidelines for the management of Inflammatory bowel disease in adults. Gut. 2004; 53 Suppl 5: 6-66.
    • (2004) Gut , vol.53 , Issue.SUPPL. 5 , pp. 6-66
    • Carter, M.J.1    Lobo, A.J.2    Travis, S.P.3
  • 7
    • 70449469801 scopus 로고    scopus 로고
    • Positioning biologic agents in the treatment of Crohn's disease
    • Hanauer SB. Positioning biologic agents in the treatment of Crohn's disease. Infamm Bowel Dis. 2009;15(10):1570-1582.
    • (2009) Infamm Bowel Dis , vol.15 , Issue.10 , pp. 1570-1582
    • Hanauer, S.B.1
  • 9
    • 0029134702 scopus 로고
    • Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis
    • Pearson DC, May GR, Fick GH, Sutherland LR. Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis. Ann Intern Med. 1995;123(2):132-142.
    • (1995) Ann Intern Med , vol.123 , Issue.2 , pp. 132-142
    • Pearson, D.C.1    May, G.R.2    Fick, G.H.3    Sutherland, L.R.4
  • 10
    • 0018290191 scopus 로고
    • National Cooperative Crohn's Disease Study: Results of drug treatment
    • Summers RW, Switz DM, Sessions JT, et al. National Cooperative Crohn's Disease Study: results of drug treatment. Gastroenterology. 1979;77(4 Pt 2):847-869.
    • (1979) Gastroenterology , vol.77 , Issue.4 Pt 2 , pp. 847-869
    • Summers, R.W.1    Switz, D.M.2    Sessions, J.T.3
  • 11
    • 33845384834 scopus 로고    scopus 로고
    • Review article: Altering the natural history of Crohn's disease - evidence for and against current therapies
    • Vermeire S, Van Assche G, Rutgeerts P. Review article: altering the natural history of Crohn's disease - evidence for and against current therapies. Aliment Pharmacol Ther. 2007;25(1):3-12.
    • (2007) Aliment Pharmacol Ther , vol.25 , Issue.1 , pp. 3-12
    • Vermeire, S.1    van Assche, G.2    Rutgeerts, P.3
  • 12
    • 0034903792 scopus 로고    scopus 로고
    • The natural history of corticosteroid therapy for infam-matory bowel disease: A population-based study
    • Faubion WA Jr, Loftus EV Jr, Harmsen WS, Zinsmeister AR, Sandborn WJ. The natural history of corticosteroid therapy for infam-matory bowel disease: a population-based study. Gastroenterology. 2001;121(2):255-260.
    • (2001) Gastroenterology , vol.121 , Issue.2 , pp. 255-260
    • Faubion, W.A.1    Loftus, E.V.2    Harmsen, W.S.3    Zinsmeister, A.R.4    Sandborn, W.J.5
  • 13
    • 12344291265 scopus 로고    scopus 로고
    • Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery
    • Cosnes J, Nion-Larmurier I, Beaugerie L, Afchain P, Tiret E, Gendre JP. Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery. Gut. 2005;54(2):237-241.
    • (2005) Gut , vol.54 , Issue.2 , pp. 237-241
    • Cosnes, J.1    Nion-Larmurier, I.2    Beaugerie, L.3    Afchain, P.4    Tiret, E.5    Gendre, J.P.6
  • 14
    • 33645067210 scopus 로고    scopus 로고
    • The natural history of surgery for Crohn's disease in a population-based cohort from Olmsted County, Minnesota [abstract 825]
    • Dhillon SL, Loftus E V, Tremaine WJ. The natural history of surgery for Crohn's disease in a population-based cohort from Olmsted County, Minnesota [abstract 825]. Am J Gastroenterol. 2005; 100 Suppl: S305.
    • (2005) Am J Gastroenterol , vol.100 , Issue.SUPPL.
    • Dhillon, S.L.1    Loftus, E.V.2    Tremaine, W.J.3
  • 15
    • 0036061640 scopus 로고    scopus 로고
    • Long-term evolution of disease behavior of Crohn's disease
    • Cosnes J, Cattan S, Blain A, et al. Long-term evolution of disease behavior of Crohn's disease. Infamm Bowel Dis. 2002;8(4):244-250.
    • (2002) Infamm Bowel Dis , vol.8 , Issue.4 , pp. 244-250
    • Cosnes, J.1    Cattan, S.2    Blain, A.3
  • 17
    • 0029014305 scopus 로고
    • Disease activity courses in a regional cohort of Crohn's disease patients
    • Munkholm P, Langholz E, Davidsen M, Binder V. Disease activity courses in a regional cohort of Crohn's disease patients. Scand J Gastroenterol. 1995;30(7):699-706.
    • (1995) Scand J Gastroenterol , vol.30 , Issue.7 , pp. 699-706
    • Munkholm, P.1    Langholz, E.2    Davidsen, M.3    Binder, V.4
  • 18
    • 76949095663 scopus 로고    scopus 로고
    • Top-down therapy for IBD: Rationale and requisite evidence
    • D'Haens GR. Top-down therapy for IBD: rationale and requisite evidence. Nat Rev Gastroenterol Hepatol. 2010;7(2):86-92.
    • (2010) Nat Rev Gastroenterol Hepatol , vol.7 , Issue.2 , pp. 86-92
    • D'haens, G.R.1
  • 19
    • 34848887711 scopus 로고    scopus 로고
    • Early Crohn's disease shows high levels of remission to therapy with adalimumab: Sub-analysis of CHARM [abstract 985]
    • Schreiber S, Reinisch W, Colombel JF, et al. Early Crohn's disease shows high levels of remission to therapy with adalimumab: sub-analysis of CHARM [abstract 985]. Gastroenterology. 2007; 132 Suppl 1: A147.
    • (2007) Gastroenterology , vol.132 , Issue.SUPPL. 1
    • Schreiber, S.1    Reinisch, W.2    Colombel, J.F.3
  • 20
    • 33846464903 scopus 로고    scopus 로고
    • Higher remission and maintenance of response rates with subcutaneous monthly certolizumab pegol in patients with recent-onset Crohn's disease: Data from PRECiSE 2 [abstract 1109]
    • Sandborn WJ, Colombel J F, Panes J, Scholmerich J, McConnell J, Schreiber S. Higher remission and maintenance of response rates with subcutaneous monthly certolizumab pegol in patients with recent-onset Crohn's disease: data from PRECiSE 2 [abstract 1109]. Am J Gastroenterol. 2006;101:S454-S455.
    • (2006) Am J Gastroenterol , vol.101
    • Sandborn, W.J.1    Colombel, J.F.2    Panes, J.3    Scholmerich, J.4    McConnell, J.5    Schreiber, S.6
  • 21
    • 55249088369 scopus 로고    scopus 로고
    • SONIC: A randomized, double-blind, controlled trial comparing infiximab and infiximab plus azathioprine in patients with Crohn's disease naive to immuno-modulators and biologic therapy [late-breaking abstract 29]
    • Sandborn WJ, Rutgeerts P, Reinisch W, et al. SONIC: a randomized, double-blind, controlled trial comparing infiximab and infiximab plus azathioprine in patients with Crohn's disease naive to immuno-modulators and biologic therapy [late-breaking abstract 29]. Am J Gastroenterol. 2008;103 Suppl 1: S423.
    • (2008) Am J Gastroenterol , vol.103 , Issue.SUPPL. 1
    • Sandborn, W.J.1    Rutgeerts, P.2    Reinisch, W.3
  • 22
    • 39449085441 scopus 로고    scopus 로고
    • Early combined immunosup-pression or conventional management in patients with newly diagnosed Crohn's disease: An open randomised trial
    • D'Haens G, Baert F, Van Assche G, et al. Early combined immunosup-pression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial. Lancet. 2008;371(9613): 660-667.
    • (2008) Lancet , vol.371 , Issue.9613 , pp. 660-667
    • D'haens, G.1    Baert, F.2    van Assche, G.3
  • 23
    • 0033770169 scopus 로고    scopus 로고
    • A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease
    • Markowitz J, Grancher K, Kohn N, Lesser M, Daum F. A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease. Gastroenterolog y. 2000;119(4):895-902.
    • (2000) Gastroenterolog Y , vol.119 , Issue.4 , pp. 895-902
    • Markowitz, J.1    Grancher, K.2    Kohn, N.3    Lesser, M.4    Daum, F.5
  • 24
    • 33751360290 scopus 로고    scopus 로고
    • Infiximab drug and infusion costs among patients with Crohn's disease in a commercially-insured setting
    • Ollendorf DA, Lidsky L. Infiximab drug and infusion costs among patients with Crohn's disease in a commercially-insured setting. Am J Ther. 2006;13(6):502-506.
    • (2006) Am J Ther , vol.13 , Issue.6 , pp. 502-506
    • Ollendorf, D.A.1    Lidsky, L.2
  • 25
    • 24944514548 scopus 로고    scopus 로고
    • Economic implications of biological therapies for Crohn's disease: Review of infliximab
    • Bodger K. Economic implications of biological therapies for Crohn's disease: review of infliximab. Pharmacoeconomics. 2005;23(9): 875-888.
    • (2005) Pharmacoeconomics , vol.23 , Issue.9 , pp. 875-888
    • Bodger, K.1
  • 28
    • 0028044925 scopus 로고
    • Smoking habits and recurrence in Crohn's disease
    • Cottone M, Rosselli M, Orlando A, et al. Smoking habits and recurrence in Crohn's disease. Gastroenterolog y. 1994;106(3):643-648.
    • (1994) Gastroenterolog Y , vol.106 , Issue.3 , pp. 643-648
    • Cottone, M.1    Rosselli, M.2    Orlando, A.3
  • 29
    • 9144228789 scopus 로고    scopus 로고
    • Risk of early surgery for Crohn's disease: Implications for early treatment strategies
    • Sands BE, Arsenault JE, Rosen MJ, et al. Risk of early surgery for Crohn's disease: implications for early treatment strategies. Am J Gastroenterol. 2003;98(12):2712-2718.
    • (2003) Am J Gastroenterol , vol.98 , Issue.12 , pp. 2712-2718
    • Sands, B.E.1    Arsenault, J.E.2    Rosen, M.J.3
  • 30
    • 84894353884 scopus 로고    scopus 로고
    • Toward an integrated clinical, molecular and serological classifcation of Inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology
    • Silverberg MS, Satsangi J, Ahmad T, et al. Toward an integrated clinical, molecular and serological classifcation of Inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol. 2005; 19 Suppl A: 5-36.
    • (2005) Can J Gastroenterol , vol.19 , Issue.SUPPL. A , pp. 5-36
    • Silverberg, M.S.1    Satsangi, J.2    Ahmad, T.3
  • 31
    • 53049110159 scopus 로고    scopus 로고
    • Natural history of pediatric Crohn's disease: A population-based cohort study
    • Vernier-Massouille G, Balde M, Salleron J, et al. Natural history of pediatric Crohn's disease: a population-based cohort study. Gastroenterology. 2008;135(4):1106-1113.
    • (2008) Gastroenterology , vol.135 , Issue.4 , pp. 1106-1113
    • Vernier-Massouille, G.1    Balde, M.2    Salleron, J.3
  • 32
    • 0033971379 scopus 로고    scopus 로고
    • Risk factors for surgery and postoperative recurrence in Crohn's disease
    • Bernell O, Lapidus A, Hellers G. Risk factors for surgery and postoperative recurrence in Crohn's disease. Ann Surg. 2000;231(1):38-45.
    • (2000) Ann Surg , vol.231 , Issue.1 , pp. 38-45
    • Bernell, O.1    Lapidus, A.2    Hellers, G.3
  • 33
    • 36549071038 scopus 로고    scopus 로고
    • Clinical course in Crohn's disease: Results of a Norwegian population-based ten-year follow-up study
    • Solberg IC, Vatn MH, Hoie O, et al. Clinical course in Crohn's disease: results of a Norwegian population-based ten-year follow-up study. Clin Gastroenterol Hepatol. 2007;5(12):1430-1438.
    • (2007) Clin Gastroenterol Hepatol , vol.5 , Issue.12 , pp. 1430-1438
    • Solberg, I.C.1    Vatn, M.H.2    Hoie, O.3
  • 34
    • 59749102408 scopus 로고    scopus 로고
    • Infuence of phenotype at diagnosis and of other potential prognostic factors on the course of Inflammatory bowel disease
    • Romberg-Camps MJ, Dagnelie PC, Kester AD, et al. Infuence of phenotype at diagnosis and of other potential prognostic factors on the course of Inflammatory bowel disease. Am J Gastroenterol. 2009;104(2):371-383.
    • (2009) Am J Gastroenterol , vol.104 , Issue.2 , pp. 371-383
    • Romberg-Camps, M.J.1    Dagnelie, P.C.2    Kester, A.D.3
  • 35
    • 70349924123 scopus 로고    scopus 로고
    • Disease behavior in adult patients: Are there predictors for stricture or fstula formation?
    • Dotan I. Disease behavior in adult patients: are there predictors for stricture or fstula formation? Dig Dis. 2009;27(3):206-211.
    • (2009) Dig Dis , vol.27 , Issue.3 , pp. 206-211
    • Dotan, I.1
  • 36
    • 37849053698 scopus 로고    scopus 로고
    • Noninvasive markers in the assessment of intestinal infam-mation in Inflammatory bowel diseases: Performance of fecal lactofer-rin, calprotectin, and PMN-elastase, CRP, and clinical indices
    • Langhorst J, Elsenbruch S, Koelzer J, Rueffer A, Michalsen A, Dobos GJ. Noninvasive markers in the assessment of intestinal infam-mation in Inflammatory bowel diseases: performance of fecal lactofer-rin, calprotectin, and PMN-elastase, CRP, and clinical indices. Am J Gastroenterol. 2008;103(1):162-169.
    • (2008) Am J Gastroenterol , vol.103 , Issue.1 , pp. 162-169
    • Langhorst, J.1    Elsenbruch, S.2    Koelzer, J.3    Rueffer, A.4    Michalsen, A.5    Dobos, G.J.6
  • 37
    • 54049150524 scopus 로고    scopus 로고
    • Fecal calprotectin, lacto-ferrin, and endoscopic disease activity in monitoring anti- TNF-alpha therapy for Crohn's disease
    • Sipponen T, Savilahti E, Kärkkäinen P, et al. Fecal calprotectin, lacto-ferrin, and endoscopic disease activity in monitoring anti- TNF-alpha therapy for Crohn's disease. Inflamm Bowel Dis. 2008;14(10): 1392-1398.
    • (2008) Inflamm Bowel Dis , vol.14 , Issue.10 , pp. 1392-1398
    • Sipponen, T.1    Savilahti, E.2    Kärkkäinen, P.3
  • 38
    • 34447523749 scopus 로고    scopus 로고
    • Certolizumab pegol for the treatment of Crohn's disease
    • Sandborn WJ, Feagan BG, Stoinov S, et al. Certolizumab pegol for the treatment of Crohn's disease. N Engl J Med. 2007;357(3):228-238.
    • (2007) N Engl J Med , vol.357 , Issue.3 , pp. 228-238
    • Sandborn, W.J.1    Feagan, B.G.2    Stoinov, S.3
  • 39
    • 54349117795 scopus 로고    scopus 로고
    • C-reactive protein: A predictive factor and marker of infammation in Inflammatory bowel disease. Results from a prospective population-based study
    • Henriksen M, Jahnsen J, Lygren I, et al. C-reactive protein: a predictive factor and marker of infammation in Inflammatory bowel disease. Results from a prospective population-based study. Gut. 2008;57(11): 1518-1523.
    • (2008) Gut , vol.57 , Issue.11 , pp. 1518-1523
    • Henriksen, M.1    Jahnsen, J.2    Lygren, I.3
  • 40
    • 38849194737 scopus 로고    scopus 로고
    • Discriminating IBD from IBS: Comparison of the test performance of fecal markers, blood leukocytes, CRP, and IBD antibodies
    • Schoepfer AM, Trummler M, Seeholzer P, Seibold-Schmid B, Seibold F. Discriminating IBD from IBS: comparison of the test performance of fecal markers, blood leukocytes, CRP, and IBD antibodies. Infamm Bowel Dis. 2008;14(1):32-39.
    • (2008) Infamm Bowel Dis , vol.14 , Issue.1 , pp. 32-39
    • Schoepfer, A.M.1    Trummler, M.2    Seeholzer, P.3    Seibold-Schmid, B.4    Seibold, F.5
  • 41
    • 38849204268 scopus 로고    scopus 로고
    • Crohn's disease activity assessed by fecal calprotectin and lactoferrin: Correlation with Crohn's disease activity index and endoscopic fndings
    • Sipponen T, Savilahti E, Kolho KL, Nuutinen H, Turunen U, Farkkila M. Crohn's disease activity assessed by fecal calprotectin and lactoferrin: correlation with Crohn's disease activity index and endoscopic fndings. Infamm Bowel Dis. 2008;14(1):40-46.
    • (2008) Infamm Bowel Dis , vol.14 , Issue.1 , pp. 40-46
    • Sipponen, T.1    Savilahti, E.2    Kolho, K.L.3    Nuutinen, H.4    Turunen, U.5    Farkkila, M.6
  • 42
    • 0025145696 scopus 로고
    • A distinct subset of antineutrophil cytoplasmic antibodies is associated with Inflammatory bowel disease
    • Saxon A, Shanahan F, Landers C, Ganz T, Targan S. A distinct subset of antineutrophil cytoplasmic antibodies is associated with Inflammatory bowel disease. J Allergy Clin Immunol. 1990;86(2):202-210.
    • (1990) J Allergy Clin Immunol , vol.86 , Issue.2 , pp. 202-210
    • Saxon, A.1    Shanahan, F.2    Landers, C.3    Ganz, T.4    Targan, S.5
  • 43
    • 0023698058 scopus 로고
    • Antibody to Saccharomyces cerevisiae (bakers' yeast) in Crohn's disease
    • Main J, McKenzie H, Yeaman GR, et al. Antibody to Saccharomyces cerevisiae (bakers' yeast) in Crohn's disease. BMJ. 1988;297(6656): 1105-1106.
    • (1988) BMJ , vol.297 , Issue.6656 , pp. 1105-1106
    • Main, J.1    McKenzie, H.2    Yeaman, G.R.3
  • 45
    • 0029781078 scopus 로고    scopus 로고
    • Antineutrophil cytoplasmic antibodies in relatives of patients with Inflammatory bowel disease
    • Papo M, Quer JC, Pastor RM, et al. Antineutrophil cytoplasmic antibodies in relatives of patients with Inflammatory bowel disease. Am J Gastroenterol. 1996;91(8):1512-1515.
    • (1996) Am J Gastroenterol , vol.91 , Issue.8 , pp. 1512-1515
    • Papo, M.1    Quer, J.C.2    Pastor, R.M.3
  • 46
    • 0031807506 scopus 로고    scopus 로고
    • Anti-neutrophil and pancreatic autoantibodies in frst-degree relatives of patients with Inflammatory bowel disease
    • Folwaczny C, Noehl N, Endres S P, Loeschke K, Fricke H. Anti-neutrophil and pancreatic autoantibodies in frst-degree relatives of patients with Inflammatory bowel disease. Scand J Gastroenterol. 1998;33(5):523-528.
    • (1998) Scand J Gastroenterol , vol.33 , Issue.5 , pp. 523-528
    • Folwaczny, C.1    Noehl, N.2    Endres, S.P.3    Loeschke, K.4    Fricke, H.5
  • 47
    • 0029924944 scopus 로고    scopus 로고
    • Perinuclear antineutrophil cytoplasmic antibodies in patients with Crohn's disease defne a clinical subgroup
    • Vasiliauskas EA, Plevy SE, Landers CJ, et al. Perinuclear antineutrophil cytoplasmic antibodies in patients with Crohn's disease defne a clinical subgroup. Gastroenterolog y. 1996;110(6):1810-1819.
    • (1996) Gastroenterolog Y , vol.110 , Issue.6 , pp. 1810-1819
    • Vasiliauskas, E.A.1    Plevy, S.E.2    Landers, C.J.3
  • 48
    • 0004200689 scopus 로고    scopus 로고
    • Anti-Saccharomyces cerevisiae mannan antibodies in familial Crohn's disease
    • Sendid B, Quinton JF, Charrier G, et al. Anti-Saccharomyces cerevisiae mannan antibodies in familial Crohn's disease. Am J Gastroenterol. 1998;93(8):1306-1310.
    • (1998) Am J Gastroenterol , vol.93 , Issue.8 , pp. 1306-1310
    • Sendid, B.1    Quinton, J.F.2    Charrier, G.3
  • 49
    • 0035015975 scopus 로고    scopus 로고
    • Anti-Saccharomyces cerevi-siae antibodies (ASCA), phenotypes of IBD, and intestinal permeability: A study in IBD families
    • Vermeire S, Peeters M, Vlietinck R, et al. Anti-Saccharomyces cerevi-siae antibodies (ASCA), phenotypes of IBD, and intestinal permeability: a study in IBD families. Infamm Bowel Dis. 2001;7(1):8-15.
    • (2001) Infamm Bowel Dis , vol.7 , Issue.1 , pp. 8-15
    • Vermeire, S.1    Peeters, M.2    Vlietinck, R.3
  • 50
    • 0034235501 scopus 로고    scopus 로고
    • Identification of a novel bacterial sequence associated with Crohn's disease
    • Sutton CL, Kim J, Yamane A, et al. Identification of a novel bacterial sequence associated with Crohn's disease. Gastroenterology. 2000;119(1):23-31.
    • (2000) Gastroenterology , vol.119 , Issue.1 , pp. 23-31
    • Sutton, C.L.1    Kim, J.2    Yamane, A.3
  • 51
    • 23944516248 scopus 로고    scopus 로고
    • Anti-Saccharomyces cerevisiae antibodies in twins with Inflammatory bowel disease
    • Halfvarson J, Standaert-Vitse A, Jarnerot G, et al. Anti-Saccharomyces cerevisiae antibodies in twins with Inflammatory bowel disease. Gut. 2005;54(9):1237-1243.
    • (2005) Gut , vol.54 , Issue.9 , pp. 1237-1243
    • Halfvarson, J.1    Standaert-Vitse, A.2    Jarnerot, G.3
  • 52
    • 5144227750 scopus 로고    scopus 로고
    • Genetic variants of the mannan-binding lectin are associated with immune reactivity to mannans in Crohn's disease
    • Seibold F, Konrad A, Flogerzi B, et al. Genetic variants of the mannan-binding lectin are associated with immune reactivity to mannans in Crohn's disease. Gastroenterolog y. 2004;127(4):1076-1084.
    • (2004) Gastroenterolog Y , vol.127 , Issue.4 , pp. 1076-1084
    • Seibold, F.1    Konrad, A.2    Flogerzi, B.3
  • 53
    • 78049515838 scopus 로고    scopus 로고
    • Mannan-binding lectin defciency results in unusual antibody production and excessive experimental colitis in response to mannose-expressing mild gut pathogens
    • Muller S, Schaffer T, Flogerzi B, et al. Mannan-binding lectin defciency results in unusual antibody production and excessive experimental colitis in response to mannose-expressing mild gut pathogens. Gut. 2010;59(11):1493-1500.
    • (2010) Gut , vol.59 , Issue.11 , pp. 1493-1500
    • Muller, S.1    Schaffer, T.2    Flogerzi, B.3
  • 54
    • 33645998461 scopus 로고    scopus 로고
    • Familial expression of anti-Escherichia coli outer membrane porin C in relatives of patients with Crohn's disease
    • Mei L, Targan SR, Landers CJ, et al. Familial expression of anti-Escherichia coli outer membrane porin C in relatives of patients with Crohn's disease. Gastroenterolog y. 2006;130(4):1078-1085.
    • (2006) Gastroenterolog Y , vol.130 , Issue.4 , pp. 1078-1085
    • Mei, L.1    Targan, S.R.2    Landers, C.J.3
  • 55
    • 27144516402 scopus 로고    scopus 로고
    • Serum antibodies in frst-degree relatives of patients with IBD: A marker of disease susceptibility? A follow-up pilot-study after 7 years
    • Torok H P, Glas J, Hollay HC, et al. Serum antibodies in frst-degree relatives of patients with IBD: a marker of disease susceptibility? A follow-up pilot-study after 7 years. Digestion. 2005;72(2-3):119-123.
    • (2005) Digestion , vol.72 , Issue.2-3 , pp. 119-123
    • Torok, H.P.1    Glas, J.2    Hollay, H.C.3
  • 56
    • 23744480856 scopus 로고    scopus 로고
    • Anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies as predictors of Inflammatory bowel disease
    • Israeli E, Grotto I, Gilburd B, et al. Anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies as predictors of Inflammatory bowel disease. Gut. 2005;54(9):1232-1236.
    • (2005) Gut , vol.54 , Issue.9 , pp. 1232-1236
    • Israeli, E.1    Grotto, I.2    Gilburd, B.3
  • 57
    • 33646381860 scopus 로고    scopus 로고
    • Candida albicans is an immunogen for anti-Saccharomyces cerevisiae antibody markers of Crohn's disease
    • Standaert-Vitse A, Jouault T, Vandewalle P, et al. Candida albicans is an immunogen for anti-Saccharomyces cerevisiae antibody markers of Crohn's disease. Gastroenterolog y. 2006;130(6):1764-1775.
    • (2006) Gastroenterolog Y , vol.130 , Issue.6 , pp. 1764-1775
    • Standaert-Vitse, A.1    Jouault, T.2    Vandewalle, P.3
  • 58
    • 34948828006 scopus 로고    scopus 로고
    • Autoantibodies in nonautoimmune individuals during infections
    • Berlin T, Zandman-Goddard G, Blank M, et al. Autoantibodies in nonautoimmune individuals during infections. Ann N Y Acad Sci. 2007; 1108:584-593.
    • (2007) Ann N Y Acad Sci , vol.1108 , pp. 584-593
    • Berlin, T.1    Zandman-Goddard, G.2    Blank, M.3
  • 59
    • 22044443705 scopus 로고    scopus 로고
    • Frequency of ASCA seropositivity in children with cystic fbrosis
    • Condino AA, Hoffenberg EJ, Accurso F, et al. Frequency of ASCA seropositivity in children with cystic fbrosis. J Pediatr Gastroenterol Nurs. 2005;41(1):23-26.
    • (2005) J Pediatr Gastroenterol Nurs , vol.41 , Issue.1 , pp. 23-26
    • Condino, A.A.1    Hoffenberg, E.J.2    Accurso, F.3
  • 60
    • 71049125383 scopus 로고    scopus 로고
    • Prevalence and clinical signifcance of auto-antibodies in adults with cystic fbrosis
    • Lachenal F, Nkana K, Nove-Josserand R, Fabien N, Durieu I. Prevalence and clinical signifcance of auto-antibodies in adults with cystic fbrosis. Eur Respir J. 2009;34(5):1079-1085.
    • (2009) Eur Respir J , vol.34 , Issue.5 , pp. 1079-1085
    • Lachenal, F.1    Nkana, K.2    Nove-Josserand, R.3    Fabien, N.4    Durieu, I.5
  • 61
    • 33846267363 scopus 로고    scopus 로고
    • Anti-Saccharomyces cerevisiae antibody does not differentiate between Crohn's disease and intestinal tuberculosis
    • Makharia GK, Sachdev V, Gupta R, Lal S, Pandey RM. Anti-Saccharomyces cerevisiae antibody does not differentiate between Crohn's disease and intestinal tuberculosis. Dig Dis Sci. 2007;52(1):33-39.
    • (2007) Dig Dis Sci , vol.52 , Issue.1 , pp. 33-39
    • Makharia, G.K.1    Sachdev, V.2    Gupta, R.3    Lal, S.4    Pandey, R.M.5
  • 62
    • 20144388512 scopus 로고    scopus 로고
    • Anti-Saccharomyces cerevisiae and perinuclear anti-neutrophil cytoplasmic antibodies in coeliac disease before and after gluten-free diet
    • Granito A, Zauli D, Muratori P, et al. Anti-Saccharomyces cerevisiae and perinuclear anti-neutrophil cytoplasmic antibodies in coeliac disease before and after gluten-free diet. Aliment Pharmacol Ther. 2005;21(7): 881-887.
    • (2005) Aliment Pharmacol Ther , vol.21 , Issue.7 , pp. 881-887
    • Granito, A.1    Zauli, D.2    Muratori, P.3
  • 63
    • 77955857730 scopus 로고    scopus 로고
    • Anti-Saccharomyces cerevisiae antibodies are frequent in type 1 diabetes
    • Sakly W, Mankai A, Sakly N, et al. Anti-Saccharomyces cerevisiae antibodies are frequent in type 1 diabetes. Endocr Pathol. 2010;21(2): 108-114.
    • (2010) Endocr Pathol , vol.21 , Issue.2 , pp. 108-114
    • Sakly, W.1    Mankai, A.2    Sakly, N.3
  • 64
    • 0038472392 scopus 로고    scopus 로고
    • Anti-Saccharomyces cerevisiae antibodies (ASCA) and autoimmune liver diseases
    • Muratori P, Muratori L, Guidi M, et al. Anti-Saccharomyces cerevisiae antibodies (ASCA) and autoimmune liver diseases. Clin Exp Immunol. 2003;132(3):473-476.
    • (2003) Clin Exp Immunol , vol.132 , Issue.3 , pp. 473-476
    • Muratori, P.1    Muratori, L.2    Guidi, M.3
  • 65
    • 2342507708 scopus 로고    scopus 로고
    • Antibodies to tissue transglu-taminase and Saccharomyces cerevisiae in ankylosing spondylitis and psoriatic arthritis
    • Riente L, Chimenti D, Pratesi F, et al. Antibodies to tissue transglu-taminase and Saccharomyces cerevisiae in ankylosing spondylitis and psoriatic arthritis. J Rheumatol. 2004;31(5):920-924.
    • (2004) J Rheumatol , vol.31 , Issue.5 , pp. 920-924
    • Riente, L.1    Chimenti, D.2    Pratesi, F.3
  • 66
    • 0029883566 scopus 로고    scopus 로고
    • Specifc antibody response to oligomannosidic epitopes in Crohn's disease
    • Sendid B, Colombel J F, Jacquinot PM, et al. Specifc antibody response to oligomannosidic epitopes in Crohn's disease. Clin Diagn Lab Immunol. 1996;3(2):219-226.
    • (1996) Clin Diagn Lab Immunol , vol.3 , Issue.2 , pp. 219-226
    • Sendid, B.1    Colombel, J.F.2    Jacquinot, P.M.3
  • 67
    • 67650429655 scopus 로고    scopus 로고
    • Candida albicans colonization and ASCA in familial Crohn's disease
    • Standaert-Vitse A, Sendid B, Joossens M, et al. Candida albicans colonization and ASCA in familial Crohn's disease. Am J Gastroenterol. 2009;104(7):1745-1753.
    • (2009) Am J Gastroenterol , vol.104 , Issue.7 , pp. 1745-1753
    • Standaert-Vitse, A.1    Sendid, B.2    Joossens, M.3
  • 68
    • 0028522160 scopus 로고
    • Diagnosis of gastrointestinal tuberculosis
    • Anand BS. Diagnosis of gastrointestinal tuberculosis. Trop Gastroenterol. 1994;15(4):179-185.
    • (1994) Trop Gastroenterol , vol.15 , Issue.4 , pp. 179-185
    • Anand, B.S.1
  • 69
    • 0037404927 scopus 로고    scopus 로고
    • Anti-Saccharomyces cerevisiae IgA antibodies are raised in ankylosing spondylitis and undifferentiated spondyloarthropathy
    • Hoffman IE, Demetter P, Peeters M, et al. Anti-Saccharomyces cerevisiae IgA antibodies are raised in ankylosing spondylitis and undifferentiated spondyloarthropathy. Ann Rheum Dis. 2003;62(5): 455-459.
    • (2003) Ann Rheum Dis , vol.62 , Issue.5 , pp. 455-459
    • Hoffman, I.E.1    Demetter, P.2    Peeters, M.3
  • 70
    • 0030612342 scopus 로고    scopus 로고
    • Anti-neutrophil cytoplasmic antibodies in type 1 and 2 autoimmune hepatitis
    • Zauli D, Ghetti S, Grassi A, et al. Anti-neutrophil cytoplasmic antibodies in type 1 and 2 autoimmune hepatitis. Hepatology. 1997;25(5): 1105-1107.
    • (1997) Hepatology , vol.25 , Issue.5 , pp. 1105-1107
    • Zauli, D.1    Ghetti, S.2    Grassi, A.3
  • 71
    • 10744228695 scopus 로고    scopus 로고
    • Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease
    • Mow WS, Vasiliauskas EA, Lin YC, et al. Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease. Gastroenterolog y. 2004;126(2):414-424.
    • (2004) Gastroenterolog Y , vol.126 , Issue.2 , pp. 414-424
    • Mow, W.S.1    Vasiliauskas, E.A.2    Lin, Y.C.3
  • 72
    • 11144266571 scopus 로고    scopus 로고
    • Sero-reactivity to microbial components in Crohn's disease is associated with disease severity and progression, but not NOD2/CARD15 genotype
    • Arnott ID, Landers CJ, Nimmo EJ, et al. Sero-reactivity to microbial components in Crohn's disease is associated with disease severity and progression, but not NOD2/CARD15 genotype. Am J Gastroenterol. 2004;99(12):2376-2384.
    • (2004) Am J Gastroenterol , vol.99 , Issue.12 , pp. 2376-2384
    • Arnott, I.D.1    Landers, C.J.2    Nimmo, E.J.3
  • 73
    • 33847664069 scopus 로고    scopus 로고
    • Anti-fagellin (CBir1) phe-notypic and genetic Crohn's disease associations
    • Papadakis KA, Yang H, Ippoliti A, et al. Anti-fagellin (CBir1) phe-notypic and genetic Crohn's disease associations. Infamm Bowel Dis. 2007;13(5):524-530.
    • (2007) Infamm Bowel Dis , vol.13 , Issue.5 , pp. 524-530
    • Papadakis, K.A.1    Yang, H.2    Ippoliti, A.3
  • 74
    • 33644908022 scopus 로고    scopus 로고
    • Serum immune responses predict rapid disease progression among children with Crohn's disease: Immune responses predict disease progression
    • Dubinsky MC, Lin YC, Dutridge D, et al. Serum immune responses predict rapid disease progression among children with Crohn's disease: immune responses predict disease progression. Am J Gastroenterol. 2006;101(2):360-367.
    • (2006) Am J Gastroenterol , vol.101 , Issue.2 , pp. 360-367
    • Dubinsky, M.C.1    Lin, Y.C.2    Dutridge, D.3
  • 75
    • 52949145981 scopus 로고    scopus 로고
    • Increased immune reactivity predicts aggressive complicating Crohn's disease in children
    • Dubinsky MC, Kugathasan S, Mei L, et al. Increased immune reactivity predicts aggressive complicating Crohn's disease in children. Clin Gastroenterol Hepatol. 2008;6(10):1105-1111.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , Issue.10 , pp. 1105-1111
    • Dubinsky, M.C.1    Kugathasan, S.2    Mei, L.3
  • 76
    • 77955738032 scopus 로고    scopus 로고
    • Combination of innate and adaptive immune alterations increased the likelihood of fbrostenosis in Crohn's disease
    • Ippoliti A, Devlin S, Mei L, et al. Combination of innate and adaptive immune alterations increased the likelihood of fbrostenosis in Crohn's disease. Infamm Bowel Dis. 2010;16(8):1279-1285.
    • (2010) Infamm Bowel Dis , vol.16 , Issue.8 , pp. 1279-1285
    • Ippoliti, A.1    Devlin, S.2    Mei, L.3
  • 77
    • 0034887447 scopus 로고    scopus 로고
    • Evaluation of serologic disease markers in a population-based cohort of patients with ulcerative colitis and Crohn's disease
    • Sandborn WJ, Loftus EV, Colombel J F, et al. Evaluation of serologic disease markers in a population-based cohort of patients with ulcerative colitis and Crohn's disease. Infamm Bowel Dis. 2001;7(3):192-201.
    • (2001) Infamm Bowel Dis , vol.7 , Issue.3 , pp. 192-201
    • Sandborn, W.J.1    Loftus, E.V.2    Colombel, J.F.3
  • 78
    • 0035069547 scopus 로고    scopus 로고
    • Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in Inflammatory bowel disease
    • Peeters M, Joossens S, Vermeire S, Vlietinck R, Bossuyt X, Rutgeerts P. Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in Inflammatory bowel disease. Am J Gastroenterol. 2001;96(3):730-734.
    • (2001) Am J Gastroenterol , vol.96 , Issue.3 , pp. 730-734
    • Peeters, M.1    Joossens, S.2    Vermeire, S.3    Vlietinck, R.4    Bossuyt, X.5    Rutgeerts, P.6
  • 79
    • 3042725140 scopus 로고    scopus 로고
    • Optimising the diagnostic value of anti-Saccharomyces cerevisiae-antibodies (ASCA) in Crohn's disease
    • Klebl FH, Bataille F, Hofstadter F, Herfarth H, Scholmerich J, Rogler G. Optimising the diagnostic value of anti-Saccharomyces cerevisiae-antibodies (ASCA) in Crohn's disease. Int J Colorectal Dis. 2004;19(4):319-324.
    • (2004) Int J Colorectal Dis , vol.19 , Issue.4 , pp. 319-324
    • Klebl, F.H.1    Bataille, F.2    Hofstadter, F.3    Herfarth, H.4    Scholmerich, J.5    Rogler, G.6
  • 80
    • 33749181545 scopus 로고    scopus 로고
    • Diagnostic precision of anti-Saccharomyces cerevisiae antibodies and perinuclear antineu-trophil cytoplasmic antibodies in Inflammatory bowel disease
    • Reese GE, Constantinides VA, Simillis C, et al. Diagnostic precision of anti-Saccharomyces cerevisiae antibodies and perinuclear antineu-trophil cytoplasmic antibodies in Inflammatory bowel disease. Am J Gastroenterol. 2006;101(10):2410-2422.
    • (2006) Am J Gastroenterol , vol.101 , Issue.10 , pp. 2410-2422
    • Reese, G.E.1    Constantinides, V.A.2    Simillis, C.3
  • 81
    • 66149100143 scopus 로고    scopus 로고
    • Predictive value of serologic markers in a population-based Norwegian cohort with Inflammatory bowel disease
    • Solberg IC, Lygren I, Cvancarova M, et al. Predictive value of serologic markers in a population-based Norwegian cohort with Inflammatory bowel disease. Infamm Bowel Dis. 2009;15(3):406-414.
    • (2009) Infamm Bowel Dis , vol.15 , Issue.3 , pp. 406-414
    • Solberg, I.C.1    Lygren, I.2    Cvancarova, M.3
  • 82
    • 34948854194 scopus 로고    scopus 로고
    • New serological markers in Inflammatory bowel disease are associated with complicated disease behaviour
    • Ferrante M, Henckaerts L, Joossens M, et al. New serological markers in Inflammatory bowel disease are associated with complicated disease behaviour. Gut. 2007;56(10):1394-1403.
    • (2007) Gut , vol.56 , Issue.10 , pp. 1394-1403
    • Ferrante, M.1    Henckaerts, L.2    Joossens, M.3
  • 83
    • 66049137260 scopus 로고    scopus 로고
    • Fecal calprotectin levels and serological responses to microbial antigens among children and adolescents with Inflammatory bowel disease
    • Ashorn S, Honkanen T, Kolho KL, et al. Fecal calprotectin levels and serological responses to microbial antigens among children and adolescents with Inflammatory bowel disease. Infamm Bowel Dis. 2009;15(2):199-205.
    • (2009) Infamm Bowel Dis , vol.15 , Issue.2 , pp. 199-205
    • Ashorn, S.1    Honkanen, T.2    Kolho, K.L.3
  • 87
    • 0036726184 scopus 로고    scopus 로고
    • Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens
    • Landers CJ, Cohavy O, Misra R, et al. Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens. Gastroenterolog y. 2002;123(3):689-699.
    • (2002) Gastroenterolog Y , vol.123 , Issue.3 , pp. 689-699
    • Landers, C.J.1    Cohavy, O.2    Misra, R.3
  • 88
    • 2342646956 scopus 로고    scopus 로고
    • Bacterial fagellin is a dominant antigen in Crohn disease
    • Lodes MJ, Cong Y, Elson CO, et al. Bacterial fagellin is a dominant antigen in Crohn disease. J Clin Invest. 2004;113(9):1296-1306.
    • (2004) J Clin Invest , vol.113 , Issue.9 , pp. 1296-1306
    • Lodes, M.J.1    Cong, Y.2    Elson, C.O.3
  • 89
    • 20444441016 scopus 로고    scopus 로고
    • Antibodies to CBir1 fagellin defne a unique response that is associated independently with complicated Crohn's disease
    • Targan SR, Landers CJ, Yang H, et al. Antibodies to CBir1 fagellin defne a unique response that is associated independently with complicated Crohn's disease. Gastroenterology. 2005;128(7):2020-2028.
    • (2005) Gastroenterology , vol.128 , Issue.7 , pp. 2020-2028
    • Targan, S.R.1    Landers, C.J.2    Yang, H.3
  • 90
    • 33746542174 scopus 로고    scopus 로고
    • Antibodies against laminaribio-side and chitobioside are novel serologic markers in Crohn's disease
    • Dotan I, Fishman S, Dgani Y, et al. Antibodies against laminaribio-side and chitobioside are novel serologic markers in Crohn's disease. Gastroenterology. 2006;131(2):366-378.
    • (2006) Gastroenterology , vol.131 , Issue.2 , pp. 366-378
    • Dotan, I.1    Fishman, S.2    Dgani, Y.3
  • 91
    • 0036242774 scopus 로고    scopus 로고
    • The value of serologic markers in indeterminate colitis: A prospective follow-up study
    • Joossens S, Reinisch W, Vermeire S, et al. The value of serologic markers in indeterminate colitis: a prospective follow-up study. Gastroenterology. 2002;122(5):1242-1247.
    • (2002) Gastroenterology , vol.122 , Issue.5 , pp. 1242-1247
    • Joossens, S.1    Reinisch, W.2    Vermeire, S.3
  • 92
    • 3242698642 scopus 로고    scopus 로고
    • Anti-Saccharomyces cerevisiae antibody (ASCA) positivity is associated with increased risk for early surgery in Crohn's disease
    • Forcione DG, Rosen MJ, Kisiel JB, Sands BE. Anti-Saccharomyces cerevisiae antibody (ASCA) positivity is associated with increased risk for early surgery in Crohn's disease. Gut. 2004;53(8):1117-1122.
    • (2004) Gut , vol.53 , Issue.8 , pp. 1117-1122
    • Forcione, D.G.1    Rosen, M.J.2    Kisiel, J.B.3    Sands, B.E.4
  • 93
    • 0141519369 scopus 로고    scopus 로고
    • Association of perinuclear anti-neutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae antibodies with Vienna classifcation subtypes of Crohn's disease
    • Klebl FH, Bataille F, Bertea CR, et al. Association of perinuclear anti-neutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae antibodies with Vienna classifcation subtypes of Crohn's disease. Infamm Bowel Dis. 2003;9(5):302-307.
    • (2003) Infamm Bowel Dis , vol.9 , Issue.5 , pp. 302-307
    • Klebl, F.H.1    Bataille, F.2    Bertea, C.R.3
  • 94
    • 0033805362 scopus 로고    scopus 로고
    • Marker antibody expression stratifes Crohn's disease into immuno-logically homogeneous subgroups with distinct clinical characteristics
    • Vasiliauskas EA, Kam LY, Karp LC, Gaiennie J, Yang H, Targan SR. Marker antibody expression stratifes Crohn's disease into immuno-logically homogeneous subgroups with distinct clinical characteristics. Gut. 2000;47(4):487-496.
    • (2000) Gut , vol.47 , Issue.4 , pp. 487-496
    • Vasiliauskas, E.A.1    Kam, L.Y.2    Karp, L.C.3    Gaiennie, J.4    Yang, H.5    Targan, S.R.6
  • 95
    • 0034775034 scopus 로고    scopus 로고
    • High level perinuclear antineutrophil cytoplasmic antibody (pANCA) in ulcerative colitis patients before colectomy predicts the development of chronic pouchi-tis after ileal pouch-anal anastomosis
    • Fleshner PR, Vasiliauskas EA, Kam LY, et al. High level perinuclear antineutrophil cytoplasmic antibody (pANCA) in ulcerative colitis patients before colectomy predicts the development of chronic pouchi-tis after ileal pouch-anal anastomosis. Gut. 2001;49(5):671-677.
    • (2001) Gut , vol.49 , Issue.5 , pp. 671-677
    • Fleshner, P.R.1    Vasiliauskas, E.A.2    Kam, L.Y.3
  • 96
    • 43049128099 scopus 로고    scopus 로고
    • Both preoperative peri-nuclear antineutrophil cytoplasmic antibody and anti-CBir1 expression in ulcerative colitis patients infuence pouchitis development after ileal pouch-anal anastomosis
    • Fleshner P, Ippoliti A, Dubinsky M, et al. Both preoperative peri-nuclear antineutrophil cytoplasmic antibody and anti-CBir1 expression in ulcerative colitis patients infuence pouchitis development after ileal pouch-anal anastomosis. Clin Gastroenterol Hepatol. 2008;6(5):561-568.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , Issue.5 , pp. 561-568
    • Fleshner, P.1    Ippoliti, A.2    Dubinsky, M.3
  • 97
    • 0036725827 scopus 로고    scopus 로고
    • Mutations in NOD2 are associated with fbrostenosing disease in patients with Crohn's disease
    • Abreu MT, Taylor KD, Lin YC, et al. Mutations in NOD2 are associated with fbrostenosing disease in patients with Crohn's disease. Gastroenterology. 2002;123(3):679-688.
    • (2002) Gastroenterology , vol.123 , Issue.3 , pp. 679-688
    • Abreu, M.T.1    Taylor, K.D.2    Lin, Y.C.3
  • 98
    • 10744230291 scopus 로고    scopus 로고
    • Defning complex contributions of NOD2/CARD15 gene mutations, age at onset, and tobacco use on Crohn's disease phenotypes
    • Brant SR, Picco MF, Achkar J P, et al. Defning complex contributions of NOD2/CARD15 gene mutations, age at onset, and tobacco use on Crohn's disease phenotypes. Infamm Bowel Dis. 2003;9(5):281-289.
    • (2003) Infamm Bowel Dis , vol.9 , Issue.5 , pp. 281-289
    • Brant, S.R.1    Picco, M.F.2    Achkar, J.P.3
  • 99
    • 70449713617 scopus 로고    scopus 로고
    • Phenotypic associations of Crohn's disease with antibodies to fagellins A4-Fla2 and Fla-X, ASCA, p-ANCA, PAB, and NOD2 mutations in a Swiss Cohort
    • Schoepfer AM, Schaffer T, Mueller S, et al. Phenotypic associations of Crohn's disease with antibodies to fagellins A4-Fla2 and Fla-X, ASCA, p-ANCA, PAB, and NOD2 mutations in a Swiss Cohort. Infamm Bowel Dis. 2009;15(9):1358-1367.
    • (2009) Infamm Bowel Dis , vol.15 , Issue.9 , pp. 1358-1367
    • Schoepfer, A.M.1    Schaffer, T.2    Mueller, S.3
  • 100
    • 0036201577 scopus 로고    scopus 로고
    • CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with infam-matory bowel disease
    • Lesage S, Zouali H, Cezard J P, et al. CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with infam-matory bowel disease. Am J Hum Genet. 2002;70(4):845-857.
    • (2002) Am J Hum Genet , vol.70 , Issue.4 , pp. 845-857
    • Lesage, S.1    Zouali, H.2    Cezard, J.P.3
  • 101
    • 80955157123 scopus 로고    scopus 로고
    • The relationship between abnormal innate and adaptive immune function and fbrostenosis in Crohn's disease patients [abstract 127]
    • Ippoliti AF, Devlin S, Yang H, et al. The relationship between abnormal innate and adaptive immune function and fbrostenosis in Crohn's disease patients [abstract 127]. Gastroenterology. 2006;130:A24-A25.
    • (2006) Gastroenterology , vol.130
    • Ippoliti, A.F.1    Devlin, S.2    Yang, H.3
  • 102
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot J P, Chamaillard M, Zouali H, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature. 2001;411(6837):599-603.
    • (2001) Nature , vol.411 , Issue.6837 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 103
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 2001; 411(6837):603-606.
    • (2001) Nature , vol.411 , Issue.6837 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 104
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confrmed Crohn's disease susceptibility loci
    • Franke A, McGovern D P, Barrett JC, et al. Genome-wide meta-analysis increases to 71 the number of confrmed Crohn's disease susceptibility loci. Nat Genet. 2010;42(12):1118-1125.
    • (2010) Nat Genet , vol.42 , Issue.12 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.2    Barrett, J.C.3
  • 105
    • 11144279151 scopus 로고    scopus 로고
    • Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: A metaanalysis
    • Economou M, Trikalinos TA, Loizou KT, Tsianos E V, Ioannidis J P. Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis. Am J Gastroenterol. 2004;99(12):2393-2404.
    • (2004) Am J Gastroenterol , vol.99 , Issue.12 , pp. 2393-2404
    • Economou, M.1    Trikalinos, T.A.2    Loizou, K.T.3    Tsianos, E.V.4    Ioannidis, J.P.5
  • 106
    • 77953297458 scopus 로고    scopus 로고
    • Penetrance of NOD2/CARD15 genetic variants in the general population
    • Yazdanyar S, Kamstrup PR, Tybjaerg-Hansen A, Nordestgaard BG. Penetrance of NOD2/CARD15 genetic variants in the general population. CMAJ. 2010;182(7):661-665.
    • (2010) CMAJ , vol.182 , Issue.7 , pp. 661-665
    • Yazdanyar, S.1    Kamstrup, P.R.2    Tybjaerg-Hansen, A.3    Nordestgaard, B.G.4
  • 107
    • 0037379286 scopus 로고    scopus 로고
    • CARD15/NOD2 gene variants are associated with familially occurring and complicated forms of Crohn's disease
    • Helio T, Halme L, Lappalainen M, et al. CARD15/NOD2 gene variants are associated with familially occurring and complicated forms of Crohn's disease. Gut. 2003;52(4):558-562.
    • (2003) Gut , vol.52 , Issue.4 , pp. 558-562
    • Helio, T.1    Halme, L.2    Lappalainen, M.3
  • 108
    • 0036202336 scopus 로고    scopus 로고
    • The molecular classifcation of the clinical manifestations of Crohn's disease
    • Ahmad T, Armuzzi A, Bunce M, et al. The molecular classifcation of the clinical manifestations of Crohn's disease. Gastroenterology. 2002;122(4):854-866.
    • (2002) Gastroenterology , vol.122 , Issue.4 , pp. 854-866
    • Ahmad, T.1    Armuzzi, A.2    Bunce, M.3
  • 109
    • 61649123125 scopus 로고    scopus 로고
    • Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort
    • Weersma RK, Stokkers PC, van Bodegraven AA, et al. Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort. Gut. 2009;58(3):388-395.
    • (2009) Gut , vol.58 , Issue.3 , pp. 388-395
    • Weersma, R.K.1    Stokkers, P.C.2    van Bodegraven, A.A.3
  • 110
    • 34249313972 scopus 로고    scopus 로고
    • Antibodies to Saccharomyces cerevisiae in Crohn's disease: Higher titers are associated with a greater frequency of mutant NOD2/CARD15 alleles and with a higher probability of complicated disease
    • Dassopoulos T, Frangakis C, Cruz-Correa M, et al. Antibodies to Saccharomyces cerevisiae in Crohn's disease: higher titers are associated with a greater frequency of mutant NOD2/CARD15 alleles and with a higher probability of complicated disease. Infamm Bowel Dis. 2007;13(2):143-151.
    • (2007) Infamm Bowel Dis , vol.13 , Issue.2 , pp. 143-151
    • Dassopoulos, T.1    Frangakis, C.2    Cruz-Correa, M.3
  • 111
    • 33847016160 scopus 로고    scopus 로고
    • NOD2 variants and antibody response to microbial antigens in Crohn's disease patients and their unaffected relatives
    • Devlin SM, Yang H, Ippoliti A, et al. NOD2 variants and antibody response to microbial antigens in Crohn's disease patients and their unaffected relatives. Gastroenterolog y. 2007;132(2):576-586.
    • (2007) Gastroenterolog Y , vol.132 , Issue.2 , pp. 576-586
    • Devlin, S.M.1    Yang, H.2    Ippoliti, A.3
  • 112
    • 74049121872 scopus 로고    scopus 로고
    • Familial aggregation and antimicrobial response dose-dependently affect the risk for Crohn's disease
    • Joossens M, Van Steen K, Branche J, et al. Familial aggregation and antimicrobial response dose-dependently affect the risk for Crohn's disease. Infamm Bowel Dis. 2010;16(1):58-67.
    • (2010) Infamm Bowel Dis , vol.16 , Issue.1 , pp. 58-67
    • Joossens, M.1    van Steen, K.2    Branche, J.3
  • 113
    • 58249085435 scopus 로고    scopus 로고
    • Linkage of Crohn's disease-related serological phenotypes: NFKB1 haplotypes are associated with anti-CBir1 and ASCA, and show reduced NF-kappaB activation
    • Takedatsu H, Taylor KD, Mei L, et al. Linkage of Crohn's disease-related serological phenotypes: NFKB1 haplotypes are associated with anti-CBir1 and ASCA, and show reduced NF-kappaB activation. Gut. 2009;58(1):60-67.
    • (2009) Gut , vol.58 , Issue.1 , pp. 60-67
    • Takedatsu, H.1    Taylor, K.D.2    Mei, L.3
  • 114
    • 1542299293 scopus 로고    scopus 로고
    • Anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn's disease are associated with disease severity but not NOD2/CARD15 mutations
    • Walker LJ, Aldhous MC, Drummond HE, et al. Anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn's disease are associated with disease severity but not NOD2/CARD15 mutations. Clin Exp Immunol. 2004;135(3):490-496.
    • (2004) Clin Exp Immunol , vol.135 , Issue.3 , pp. 490-496
    • Walker, L.J.1    Aldhous, M.C.2    Drummond, H.E.3
  • 116
    • 0037560163 scopus 로고    scopus 로고
    • An analysis of factors infuencing short-term and sustained response to infiximab treatment for Crohn's disease
    • Arnott ID, McNeill G, Satsangi J. An analysis of factors infuencing short-term and sustained response to infiximab treatment for Crohn's disease. Aliment Pharmacol Ther. 2003;17(12):1451-1457.
    • (2003) Aliment Pharmacol Ther , vol.17 , Issue.12 , pp. 1451-1457
    • Arnott, I.D.1    McNeill, G.2    Satsangi, J.3
  • 117
    • 33749432435 scopus 로고    scopus 로고
    • Association of trough serum infiximab to clinical outcome after scheduled maintenance treatment for Crohn's disease
    • Maser EA, Villela R, Silverberg MS, Greenberg GR. Association of trough serum infiximab to clinical outcome after scheduled maintenance treatment for Crohn's disease. Clin Gastroenterol Hepatol. 2006;4(10):1248-1254.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , Issue.10 , pp. 1248-1254
    • Maser, E.A.1    Villela, R.2    Silverberg, M.S.3    Greenberg, G.R.4
  • 118
    • 0029913679 scopus 로고    scopus 로고
    • Association of antineutrophil cytoplasmic antibodies with resistance to treatment of left-sided ulcerative colitis: Results of a pilot study
    • Sandborn WJ, Landers CJ, Tremaine WJ, Targan SR. Association of antineutrophil cytoplasmic antibodies with resistance to treatment of left-sided ulcerative colitis: results of a pilot study. Mayo Clin Proc. 1996;71(5):431-436.
    • (1996) Mayo Clin Proc , vol.71 , Issue.5 , pp. 431-436
    • Sandborn, W.J.1    Landers, C.J.2    Tremaine, W.J.3    Targan, S.R.4
  • 119
    • 4444349841 scopus 로고    scopus 로고
    • High-level serum antibodies to bacterial antigens are associated with antibiotic-induced clinical remission in Crohn's disease: A pilot study
    • Mow WS, Landers CJ, Steinhart AH, et al. High-level serum antibodies to bacterial antigens are associated with antibiotic-induced clinical remission in Crohn's disease: a pilot study. Dig Dis Sci. 2004;49(7-8): 1280-1286.
    • (2004) Dig Dis Sci , vol.49 , Issue.7-8 , pp. 1280-1286
    • Mow, W.S.1    Landers, C.J.2    Steinhart, A.H.3
  • 120
    • 0036084752 scopus 로고    scopus 로고
    • Serological markers for prediction of response to anti-tumor necrosis factor treatment in Crohn's disease
    • Esters N, Vermeire S, Joossens S, et al. Serological markers for prediction of response to anti-tumor necrosis factor treatment in Crohn's disease. Am J Gastroenterol. 2002;97(6):1458-1462.
    • (2002) Am J Gastroenterol , vol.97 , Issue.6 , pp. 1458-1462
    • Esters, N.1    Vermeire, S.2    Joossens, S.3
  • 121
    • 34247140485 scopus 로고    scopus 로고
    • Predictors of early response to infiximab in patients with ulcerative colitis
    • Ferrante M, Vermeire S, Katsanos KH, et al. Predictors of early response to infiximab in patients with ulcerative colitis. Infamm Bowel Dis. 2007;13(2):123-128.
    • (2007) Infamm Bowel Dis , vol.13 , Issue.2 , pp. 123-128
    • Ferrante, M.1    Vermeire, S.2    Katsanos, K.H.3
  • 122
    • 34247638361 scopus 로고    scopus 로고
    • Predictive model for the outcome of infiximab therapy in Crohn's disease based on apoptotic pharmacogenetic index and clinical predictors
    • Hlavaty T, Ferrante M, Henckaerts L, Pierik M, Rutgeerts P, Vermeire S. Predictive model for the outcome of infiximab therapy in Crohn's disease based on apoptotic pharmacogenetic index and clinical predictors. Infamm Bowel Dis. 2007;13(4):372-379.
    • (2007) Infamm Bowel Dis , vol.13 , Issue.4 , pp. 372-379
    • Hlavaty, T.1    Ferrante, M.2    Henckaerts, L.3    Pierik, M.4    Rutgeerts, P.5    Vermeire, S.6
  • 123
    • 77953787089 scopus 로고    scopus 로고
    • Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric Inflammatory bowel disease
    • Dubinsky MC, Mei L, Friedman M, et al. Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric Inflammatory bowel disease. Infamm Bowel Dis. 2009;16(8): 1357-1366.
    • (2009) Infamm Bowel Dis , vol.16 , Issue.8 , pp. 1357-1366
    • Dubinsky, M.C.1    Mei, L.2    Friedman, M.3
  • 124
    • 38849134889 scopus 로고    scopus 로고
    • Determination of serologic and genetic markers aid in the determination of the clinical course and severity of patients with IBD
    • Devlin SM, Dubinsky MC. Determination of serologic and genetic markers aid in the determination of the clinical course and severity of patients with IBD. Infamm Bowel Dis. 2008;14(1):125-128.
    • (2008) Infamm Bowel Dis , vol.14 , Issue.1 , pp. 125-128
    • Devlin, S.M.1    Dubinsky, M.C.2


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