메뉴 건너뛰기




Volumn 15, Issue 10, 2009, Pages 1570-1582

Positioning biologic agents in the treatment of Crohn's disease

Author keywords

Biologic therapies; Crohn's disease; Immunomodulators

Indexed keywords

ADALIMUMAB; AZATHIOPRINE; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CERTOLIZUMAB PEGOL; CORTICOSTEROID; INFLIXIMAB; MERCAPTOPURINE; METHOTREXATE; NATALIZUMAB; PLACEBO; STEROID;

EID: 70449469801     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.20918     Document Type: Review
Times cited : (18)

References (72)
  • 1
    • 33847684264 scopus 로고    scopus 로고
    • Turning traditional treatment strategies on their heads: Current evidence for 'step-up' versus 'top-down.'
    • Hanauer SB. Turning traditional treatment strategies on their heads: current evidence for 'step-up' versus 'top-down.' Rev Gastroenterol Disord. 2007;7(suppl 2):S17-S22.
    • (2007) Rev Gastroenterol Disord , vol.7 , Issue.SUPPL. 2
    • Hanauer, S.B.1
  • 2
    • 33747337737 scopus 로고    scopus 로고
    • Biological therapy in the management of recent-onset Crohn's disease: Why, when and how?
    • DOI 10.2165/00003495-200666110-00002
    • Löwenberg M, Peppelenbosch M, Hommes D. Biological therapy in the management of recent-onset Crohn's disease: why, when and how? Drugs. 2006;66:1431-1439. (Pubitemid 44246602)
    • (2006) Drugs , vol.66 , Issue.11 , pp. 1431-1439
    • Lowenberg, M.1    Peppelenbosch, M.2    Hommes, D.3
  • 5
    • 17144388945 scopus 로고    scopus 로고
    • Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn's disease
    • DOI 10.1053/j.gastro.2005.01.048
    • Lichtenstein GR, Yan S, Bala M, et al. Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn's disease. Gastroenterology. 2005;128:862-869. (Pubitemid 40523539)
    • (2005) Gastroenterology , vol.128 , Issue.4 , pp. 862-869
    • Lichtenstein, G.R.1    Yan, S.2    Bala, M.3    Blank, M.4    Sands, B.E.5
  • 7
    • 0036161786 scopus 로고    scopus 로고
    • The epidemiology and natural history of Crohn's disease in population-based patient cohorts from North America: A systematic review
    • DOI 10.1046/j.1365-2036.2002.01140.x
    • Loftus EV Jr, Schoenfeld P, Sandborn WJ. The epidemiology and natural history of Crohn's disease in population-based patient cohorts from North America: a systematic review. Aliment Pharmacol Ther. 2002;16:51-60. (Pubitemid 34123864)
    • (2002) Alimentary Pharmacology and Therapeutics , vol.16 , Issue.1 , pp. 51-60
    • Loftus Jr., E.V.1    Schoenfeld, P.2    Sandborn, W.J.3
  • 8
    • 0029014305 scopus 로고
    • Disease activity courses in a regional cohort of Crohn's disease patients
    • Munkholm P, Langholz E, Davidsen M, et al. Disease activity courses in a regional cohort of Crohn's disease patients. Scand J Gastroenterol. 1995;30:699-706.
    • (1995) Scand J Gastroenterol , vol.30 , pp. 699-706
    • Munkholm, P.1    Langholz, E.2    Davidsen, M.3
  • 11
    • 12344291265 scopus 로고    scopus 로고
    • Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery
    • DOI 10.1136/gut.2004.045294
    • Cosnes J, Nion-Larmurier I, Beaugerie L, et al. Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery. Gut. 2005;54:237-241. (Pubitemid 40139240)
    • (2005) Gut , vol.54 , Issue.2 , pp. 237-241
    • Cosnes, J.1    Nion-Larmurier, I.2    Beaugerie, L.3    Afchain, P.4    Tiret, E.5    Gendre, J.-P.6
  • 12
    • 33845405908 scopus 로고    scopus 로고
    • Long-term prognosis in Crohn's disease: An epidemiological study of patients diagnosed more than 20 years ago in Cardiff
    • DOI 10.1111/j.1365-2036.2006.03132.x
    • Canavan C, Abrams KR, Hawthorne B, et al. Long-term prognosis in Crohn's disease: an epidemiological study of patients diagnosed more than 20 years ago in Cardiff. Aliment Pharmacol Ther. 2007;25:59-65. (Pubitemid 44902864)
    • (2007) Alimentary Pharmacology and Therapeutics , vol.25 , Issue.1 , pp. 59-65
    • Canavan, C.1    Abrams, K.R.2    Hawthorne, B.3    Mayberry, J.F.4
  • 14
    • 10444225399 scopus 로고    scopus 로고
    • Long-term prognosis of early-onset Crohn's disease diagnosed in childhood or adolescence
    • Freeman HJ. Long-term prognosis of early-onset Crohn's disease diagnosed in childhood or adolescence. Can J Gastroenterol. 2004;18:661-665.
    • (2004) Can J Gastroenterol , vol.18 , pp. 661-665
    • Freeman, H.J.1
  • 15
    • 33845384834 scopus 로고    scopus 로고
    • Review article: Altering the natural history of Crohn's disease - Evidence for and against current therapies
    • DOI 10.1111/j.1365-2036.2006.03134.x
    • Vermeire S, van Assche G, Rutgeerts P. Altering the natural history of Crohn's disease - evidence for and against current therapies. Aliment Pharmacol Ther. 2007;25:3-12. (Pubitemid 44902859)
    • (2007) Alimentary Pharmacology and Therapeutics , vol.25 , Issue.1 , pp. 3-12
    • Vermeire, S.1    Van Assche, G.2    Rutgeerts, P.3
  • 16
    • 33646486116 scopus 로고    scopus 로고
    • Risk factors for initial surgery in pediatric patients with Crohn's disease
    • Gupta N, Cohen SA, Bostrom AG, et al. Risk factors for initial surgery in pediatric patients with Crohn's disease. Gastroenterology. 2006;130:1069-1077.
    • (2006) Gastroenterology , vol.130 , pp. 1069-1077
    • Gupta, N.1    Cohen, S.A.2    Bostrom, A.G.3
  • 17
    • 0036120291 scopus 로고    scopus 로고
    • Long term outcome of patients with active Crohn's disease exhibiting extensive and deep ulcerations at colonoscopy
    • DOI 10.1016/S0002-9270(02)03970-9, PII S0002927002039709
    • Allez M, Lemann M, Bonnet J, et al. Long term outcome of patients with active Crohn's disease exhibiting extensive and deep ulcerations at colonoscopy. Am J Gastroenterol. 2002;97:947-953. (Pubitemid 34408253)
    • (2002) American Journal of Gastroenterology , vol.97 , Issue.4 , pp. 947-953
    • Allez, M.1    Lemann, M.2    Bonnet, J.3    Cattan, P.4    Jian, R.5    Modigliani, R.6
  • 20
    • 34548118412 scopus 로고    scopus 로고
    • Risks and benefits of combining immunosuppressives and biological agents in inflammatory bowel disease: Is the synergy worth the risk?
    • Hanauer SB. Risks and benefits of combining immunosuppressives and biological agents in inflammatory bowel disease: is the synergy worth the risk? Gut. 2007;56:1181-1183.
    • (2007) Gut , vol.56 , pp. 1181-1183
    • Hanauer, S.B.1
  • 21
    • 55249088369 scopus 로고    scopus 로고
    • SONIC: A randomized, double-blind, controlled trial comparing infliximab and infliximab and azathioprine to azathioprine in patients with Crohn's disease naïve to immunomodulators and biologic therapy
    • Abstract 29
    • Sandborn WJ, Rugeerts P, Reinisch W, et al. SONIC: a randomized, double-blind, controlled trial comparing infliximab and infliximab and azathioprine to azathioprine in patients with Crohn's disease naïve to immunomodulators and biologic therapy. Am J Gastroenterol. 2008; Abstract 29.
    • (2008) Am J Gastroenterol
    • Sandborn, W.J.1    Rugeerts, P.2    Reinisch, W.3
  • 24
    • 0033770169 scopus 로고    scopus 로고
    • A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease
    • Markowitz J, Grancher K, Kohn N, et al. A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease. Gastroenterology. 2000;119:895-902. (Pubitemid 30777909)
    • (2000) Gastroenterology , vol.119 , Issue.4 , pp. 895-902
    • Markowitz, J.1    Grancher, K.2    Kohn, N.3    Lesser, M.4    Daum, F.5
  • 25
    • 84894353884 scopus 로고    scopus 로고
    • Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology
    • Silverberg MS, Satsangi J, Ahmad T, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol. 2005;19(suppl A):5-36.
    • (2005) Can J Gastroenterol , vol.19 , Issue.SUPPL. A , pp. 5-36
    • Silverberg, M.S.1    Satsangi, J.2    Ahmad, T.3
  • 27
    • 33748139307 scopus 로고    scopus 로고
    • Step-up versus top-down: Application of new biological agents in pediatric inflammatory bowel disease
    • Faubion WA. Step-up versus top-down: application of new biological agents in pediatric inflammatory bowel disease. Clin Gastroenterol Hepatol. 2006;4:1094-1096.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 1094-1096
    • Faubion, W.A.1
  • 28
    • 33748194334 scopus 로고    scopus 로고
    • A population-based study of the frequency of corticosteroid resistance and dependence in pediatric patients with Crohn's disease and ulcerative colitis
    • Tung J, Loftus EV, Freese DK, et al. A population-based study of the frequency of corticosteroid resistance and dependence in pediatric patients with Crohn's disease and ulcerative colitis. Gastroenterology. 2005;4(suppl 2):A327.
    • (2005) Gastroenterology , vol.4 , Issue.SUPPL. 2
    • Tung, J.1    Loftus, E.V.2    Freese, D.K.3
  • 31
    • 0028790186 scopus 로고
    • A controlled double blind study of azathioprine in the management of Crohn's disease
    • Candy S, Wright J, Gerber M, et al. A controlled double blind study of azathioprine in the management of Crohn's disease. Gut. 1995;37:674-678.
    • (1995) Gut , vol.37 , pp. 674-678
    • Candy, S.1    Wright, J.2    Gerber, M.3
  • 32
    • 33645958908 scopus 로고    scopus 로고
    • Infliximab plus azathioprine for steroid-dependent Crohn's disease patients: A randomized placebo-controlled trial
    • and the Groupe d'Etude Therapeutique des Affections Inflammatoires du Tube Digestif (GETAID)
    • Lémann M, Mary JY, Duclos B, et al, and the Groupe d'Etude Therapeutique des Affections Inflammatoires du Tube Digestif (GETAID). Infliximab plus azathioprine for steroid-dependent Crohn's disease patients: a randomized placebo-controlled trial. Gastroenterology. 2006;130:1054-1061.
    • (2006) Gastroenterology , vol.130 , pp. 1054-1061
    • Lémann, M.1    Mary, J.Y.2    Duclos, B.3
  • 33
    • 0030954732 scopus 로고    scopus 로고
    • A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease
    • on behalf of the Crohn's Disease cA2 Study Group
    • Targan SR, Hanauer SB, van Deventer SJ, et al, on behalf of the Crohn's Disease cA2 Study Group. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease. N Engl J Med. 1997;337:1029-1035.
    • (1997) N Engl J Med , vol.337 , pp. 1029-1035
    • Targan, S.R.1    Hanauer, S.B.2    Van Deventer, S.J.3
  • 38
    • 39449085441 scopus 로고    scopus 로고
    • Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: An open randomised trial
    • for the Belgian Inflammatory Bowel Disease Research Group; North-Holland Gut Club
    • D'Haens G, Baert F, van Assche G, et al, for the Belgian Inflammatory Bowel Disease Research Group; North-Holland Gut Club. Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial. Lancet. 2008;371:660-667.
    • (2008) Lancet , vol.371 , pp. 660-667
    • D'Haens, G.1    Baert, F.2    Van Assche, G.3
  • 39
    • 53049083113 scopus 로고    scopus 로고
    • A randomized trial of methotrexate in combination with infliximab for the treatment of Crohn's disease
    • Feagan B, McDonald JW, Panaccione R, et al. A randomized trial of methotrexate in combination with infliximab for the treatment of Crohn's disease. Gastroenterology. 2008;135:294-295.
    • (2008) Gastroenterology , vol.135 , pp. 294-295
    • Feagan, B.1    McDonald, J.W.2    Panaccione, R.3
  • 46
    • 34548130215 scopus 로고    scopus 로고
    • Effectiveness of concomitant immunosuppressive therapy in suppressing the formation of antibodies to infliximab in Crohn's disease
    • DOI 10.1136/gut.2006.099978
    • Vermeire S, Noman M, Van Assche G, et al. Effectiveness of concomitant immunosuppressive therapy in suppressing the formation of antibodies to infliximab in Crohn's disease. Gut. 2007;56:1226-1231. (Pubitemid 47300423)
    • (2007) Gut , vol.56 , Issue.9 , pp. 1226-1231
    • Vermeire, S.1    Noman, M.2    Van Assche, G.3    Baert, F.4    D'Haens, G.5    Rutgeerts, P.6
  • 48
    • 27644441529 scopus 로고    scopus 로고
    • Natalizumab induction and maintenance therapy for Crohn's disease
    • on behalf of the International Efficacy of Natalizumab as Active Crohn's Therapy (ENACT-1) Trial Group; and Evaluation of Natalizumab as Continuous Therapy (ENACT-2) Trial Group
    • Sandborn WJ, Colombel JF, Enns R, et al, on behalf of the International Efficacy of Natalizumab as Active Crohn's Therapy (ENACT-1) Trial Group; and Evaluation of Natalizumab as Continuous Therapy (ENACT-2) Trial Group. Natalizumab induction and maintenance therapy for Crohn's disease. N Engl J Med. 2005;353:1912-1925.
    • (2005) N Engl J Med , vol.353 , pp. 1912-1925
    • Sandborn, W.J.1    Colombel, J.F.2    Enns, R.3
  • 49
    • 34247884424 scopus 로고    scopus 로고
    • Natalizumab for the treatment of active Crohn's disease: Results of the ENCORE Trial
    • on behalf of the International Efficacy of Natalizumab in Crohn's Disease Response and Remission (ENCORE) Trial Group
    • Targan SR, Feagan BG, Fedorak RN, et al, on behalf of the International Efficacy of Natalizumab in Crohn's Disease Response and Remission (ENCORE) Trial Group. Natalizumab for the treatment of active Crohn's disease: results of the ENCORE Trial. Gastroenterology. 2007;132:1672-1683.
    • (2007) Gastroenterology , vol.132 , pp. 1672-1683
    • Targan, S.R.1    Feagan, B.G.2    Fedorak, R.N.3
  • 51
    • 33646379583 scopus 로고    scopus 로고
    • The safety of infliximab, combined with background treatments, among patients with rheumatoid arthritis and various comorbidities
    • Westhovens R, Yocum D, Han J, et al. The safety of infliximab, combined with background treatments, among patients with rheumatoid arthritis and various comorbidities. Arthritis Rheum. 2006;54:1075-1086.
    • (2006) Arthritis Rheum , vol.54 , pp. 1075-1086
    • Westhovens, R.1    Yocum, D.2    Han, J.3
  • 52
    • 0032848211 scopus 로고    scopus 로고
    • Safety of infliximab in clinical trials
    • Hanauer SB. Safety of infliximab in clinical trials. Aliment Pharmacol Ther. 1999;13(suppl 4):16-22.
    • (1999) Aliment Pharmacol Ther , vol.13 , Issue.SUPPL. 4 , pp. 16-22
    • Hanauer, S.B.1
  • 53
    • 41349088375 scopus 로고    scopus 로고
    • Risk factors for opportunistic infections in patients with inflammatory bowel disease
    • Toruner M, Loftus EV Jr, Harmsen WS, et al. Risk factors for opportunistic infections in patients with inflammatory bowel disease. Gastroenterology. 2008;134:926-936.
    • (2008) Gastroenterology , vol.134 , pp. 926-936
    • Toruner, M.1    Loftus Jr., E.V.2    Harmsen, W.S.3
  • 54
    • 52649134405 scopus 로고    scopus 로고
    • JC viral loads in patients with Crohn's disease treated with immunosuppression: Can we screen for elevated risk of progressive multifocal leukoencephalopathy?
    • Verbeeck J, Van Assche G, Ryding J, et al. JC viral loads in patients with Crohn's disease treated with immunosuppression: can we screen for elevated risk of progressive multifocal leukoencephalopathy? Gut. 2008;57:1393-1397.
    • (2008) Gut , vol.57 , pp. 1393-1397
    • Verbeeck, J.1    Van Assche, G.2    Ryding, J.3
  • 55
    • 33846592386 scopus 로고    scopus 로고
    • Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease
    • DOI 10.1097/MPG.0b013e31802f6424, PII 0000517620070200000019
    • Mackey AC, Green L, Liang L, et al. Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease. J Pediatr Gastro Nutr. 2007;44:265-267. (Pubitemid 46175082)
    • (2007) Journal of Pediatric Gastroenterology and Nutrition , vol.44 , Issue.2 , pp. 265-267
    • Mackey, A.C.1    Green, L.2    Liang, L.-C.3    Dinndorf, P.4    Avigan, M.5
  • 56
    • 34347369156 scopus 로고    scopus 로고
    • Hepatosplenic T-cell lymphoma in adolescents and young adults with Crohn's disease: A cautionary tale?
    • DOI 10.1002/ibd.20169
    • Rosh JR, Gross T, Mamula P, et al. Hepatosplenic T-cell lymphoma in adolescents and young adults with Crohn's disease: a cautionary tale? Inflamm Bowel Dis. 2007;13:1024-1030. (Pubitemid 47309975)
    • (2007) Inflammatory Bowel Diseases , vol.13 , Issue.8 , pp. 1024-1030
    • Rosh, J.R.1    Gross, T.2    Mamula, P.3    Griffiths, A.4    Hyams, J.5
  • 57
    • 33746239695 scopus 로고    scopus 로고
    • Safety issues with biological therapies for inflammatory bowel disease
    • DOI 10.1097/01.mog.0000231810.87901.e8, PII 0000157420060700000008
    • Van Assche G, Vermeire S, Rutgeerts P. Safety issues with biological therapies for inflammatory bowel disease. Curr Opin Gastroenterol. 2006;22:370-376. (Pubitemid 44090191)
    • (2006) Current Opinion in Gastroenterology , vol.22 , Issue.4 , pp. 370-376
    • Van Assche, G.1    Vermeire, S.2    Rutgeerts, P.3
  • 58
    • 35448971037 scopus 로고    scopus 로고
    • Medical therapy for Crohn's disease: Top-down or step-up?
    • DOI 10.1159/000103897
    • Baert F, Caprilli R, Angelucci E. Medical therapy for Crohn's disease: top:down or step-up? Dig Dis. 2007;25:260-266. (Pubitemid 350194180)
    • (2007) Digestive Diseases , vol.25 , Issue.3 , pp. 260-266
    • Baert, F.1    Caprilli, R.2    Angelucci, E.3
  • 60
    • 0037378890 scopus 로고    scopus 로고
    • Isolation of peptides useful for differential diagnosis of Crohn's disease and ulcerative colitis
    • DOI 10.1136/gut.52.4.535
    • Saito H, Fukuda Y, Katsuragi K, et al. Isolation of peptides useful for differential diagnosis of Crohn's disease and ulcerative colitis. Gut. 2003;52:535-540. (Pubitemid 36363407)
    • (2003) Gut , vol.52 , Issue.4 , pp. 535-540
    • Saito, H.1    Fukuda, Y.2    Katsuragi, K.3    Tanaka, M.4    Satomi, M.5    Shimoyama, T.6    Saito, T.7    Tachikawa, T.8
  • 62
    • 10944261455 scopus 로고    scopus 로고
    • Serologic markers in inflammatory bowel disease: State of the art
    • Sandborn WJ. Serologic markers in inflammatory bowel disease: state of the art. Rev Gastroenterol Disord. 2004;4:167-174. (Pubitemid 40012216)
    • (2004) Reviews in Gastroenterological Disorders , vol.4 , Issue.4 , pp. 167-174
    • Sandborn, W.J.1
  • 63
    • 0033805362 scopus 로고    scopus 로고
    • Marker antibody expression stratifies Crohn's disease into immunologically homogeneous subgroups with distinct clinical characteristics
    • Vasiliauskas EA, Kam LY, Karp LC, et al. Marker antibody expression stratifies Crohn's disease into immunologically homogeneous subgroups with distinct clinical characteristics. Gut. 2000;47:487-496.
    • (2000) Gut , vol.47 , pp. 487-496
    • Vasiliauskas, E.A.1    Kam, L.Y.2    Karp, L.C.3
  • 65
    • 33746612051 scopus 로고    scopus 로고
    • Anti-glycan antibodies as biomarkers for diagnosis and prognosis
    • DOI 10.1191/0961203306lu2331oa
    • Dotan N, Altstock RT, Schwarz M, et al. Anti-glycan antibodies as biomarkers for diagnosis and prognosis. Lupus. 2006;15:442-450. (Pubitemid 44147091)
    • (2006) Lupus , vol.15 , Issue.7 , pp. 442-450
    • Dotan, N.1    Altstock, R.T.2    Schwarz, M.3    Dukler, A.4
  • 66
    • 10744228695 scopus 로고    scopus 로고
    • Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease
    • Mow WS, Vasiliauskas EA, Lin Y-C, et al. Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease. Gastroenterology. 2004;126:414-424.
    • (2004) Gastroenterology , vol.126 , pp. 414-424
    • Mow, W.S.1    Vasiliauskas, E.A.2    Lin, Y.-C.3
  • 68
    • 35648976612 scopus 로고    scopus 로고
    • Genetic factors associated with the development of inflammatory bowel disease
    • Yamamoto-Furusho JK. Genetic factors associated with the development of inflammatory bowel disease. World J Gastroenterol. 2007;13:5594-5597. (Pubitemid 350031479)
    • (2007) World Journal of Gastroenterology , vol.13 , Issue.42 , pp. 5594-5597
    • Yamamoto-Furusho, J.K.1
  • 69
    • 33747063077 scopus 로고    scopus 로고
    • Genetic variants and the risk of Crohn's disease: What does it mean for future disease management?
    • DOI 10.1517/14656566.7.12.1591
    • Torok HP, Glas J, Lohse P, et al. Genetic variants and the risk of Crohn's disease: what does it mean for future disease management? Expert Opin Pharmacother. 2006;7:1591-1602. (Pubitemid 44209603)
    • (2006) Expert Opinion on Pharmacotherapy , vol.7 , Issue.12 , pp. 1591-1602
    • Torok, H.-P.1    Glas, J.2    Lohse, P.3    Folwaczny, C.4
  • 71
    • 70450165330 scopus 로고    scopus 로고
    • Clinical and molecular characteristics of isolated colonic Crohn's disease (CD)
    • Hancock L, Ahmad T, Reckley JB, et al. Clinical and molecular characteristics of isolated colonic Crohn's disease (CD). Gastroenterology. 2006;130(suppl 2):A589.
    • (2006) Gastroenterology , vol.130 , Issue.SUPPL. 2
    • Hancock, L.1    Ahmad, T.2    Reckley, J.B.3
  • 72
    • 44349124113 scopus 로고    scopus 로고
    • The genetics and immunopathogenesis of inflammatory bowel disease
    • DOI 10.1038/nri2340, PII NRI2340
    • Cho JH. The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol. 2008;8:458-466. (Pubitemid 351733422)
    • (2008) Nature Reviews Immunology , vol.8 , Issue.6 , pp. 458-466
    • Cho, J.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.