Synthesis and anticonvulsant properties of 1-(amino-N-arylmethanethio)-3- (1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2011, Pages 2236-2242

  Siddiqui, Nadeem ^a   Alam, M Shamsher ^a   Stables, James P ^b  

^a HAMDARD UNIVERSITY   (India)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Anticonvulsants; Isatin; Neurotoxicity

Indexed keywords

1 (AMINO N 2 TOLYLMETHANETHIO) 3 (1 BENZYL 2, 3 DIOXOINDOLIN 5 YL)UREA; 1 (AMINO N 3 TOLYLMETHANETHIO) 3 (1 BENZYL 2, 3 DIOXOINDOLIN 5 YL)UREA; 1 (AMINO N 4 TOLYLMETHANETHIO) 3 (1 BENZYL 2, 3 DIOXOINDOLIN 5 YL)UREA; 1 (AMINO N PHENYLMETHANETHIO) 3 (1 BENZYL 2, 3 DIOXOINDOLIN 5 YL)UREA; 1 [1 (2 CHLOROBENZYL) 2,3 DIOXOINDOLIN 5 YL] 3 (AMINO N 2 TOLYLMETHANETHIO)UREA; 1 [1 (2 CHLOROBENZYL) 2,3 DIOXOINDOLIN 5 YL] 3 (AMINO N 3 TOLYLMETHANETHIO)UREA; 1 [1 (2 CHLOROBENZYL) 2,3 DIOXOINDOLIN 5 YL] 3 (AMINO N 4 TOLYLMETHANETHIO)UREA; 1 [1 (2 CHLOROBENZYL) 2,3 DIOXOINDOLIN 5 YL] 3 [AMINO N (2 CHLOROPHENYL)METHANETHIO]UREA; 1 [1 (2 CHLOROBENZYL) 2,3 DIOXOINDOLIN 5 YL] 3 [AMINO N (2 METHOXYPHENYL)METHANETHIO]UREA; 1 [1 (2 CHLOROBENZYL) 2,3 DIOXOINDOLIN 5 YL] 3 [AMINO N (3 METHOXYPHENYL)METHANETHIO]UREA; 1 [1 (2 CHLOROBENZYL) 2,3 DIOXOINDOLIN 5 YL] 3 [AMINO N (4 METHOXYPHENYL)METHANETHIO]UREA; 1 [AMINO N (2 CHLOROPHENYL)METHANETHIO] 3 (1 BENZYL 2, 3 DIOXOINDOLIN 5 YL)UREA; 1 [AMINO N (2 METHOXYPHENYL)METHANETHIO] 3 (1 BENZYL 2,3 DIOXOINDOLIN 5 YL)UREA; 1 [AMINO N (3 METHOXYPHENYL)METHANETHIO] 3 (1 BENZYL 2,3 DIOXOINDOLIN 5 YL)UREA; 1 [AMINO N(4 METHOXYPHENYL)METHANETHIO] 3 (1 BENZYL 2,3 DIOXOINDOLIN 5 YL)UREA; 1[1 (2 CHLOROBENZYL) 2,3 DIOXOINDOLIN 5 YL] 3 (AMINO N PHENYLMETHANETHIO)UREA; ANTICONVULSIVE AGENT; PENTETRAZOLE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CLONIC SEIZURE; CONTROLLED STUDY; DRUG DESIGN; DRUG DOSE COMPARISON; DRUG SCREENING; DRUG SYNTHESIS; ELECTRIC SHOCK; IN VIVO STUDY; MOUSE; NEUROTOXICITY; NONHUMAN; PHARMACOPHORE; PROTON NUCLEAR MAGNETIC RESONANCE; SUBSTITUTION REACTION; TONIC CLONIC SEIZURE;

ANIMALS; ANTICONVULSANTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ELECTROSHOCK; MICE; MOLECULAR STRUCTURE; PENTYLENETETRAZOLE; RATS; SEIZURES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 79955590371     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.03.004     Document Type: Article

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