Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974)

British Journal of Clinical Pharmacology

Volumn 69, Issue 1, 2010, Pages 15-22

  Sinclair, Simon R ^a   Kane, Stefanie A ^b   Van Der Schueren, Bart J ^c   Xiao, Alan ^b   Willson, Kenneth J ^b   Boyle, Janet ^a   De Lepeleire, Inge ^d   Xu, Yang ^b   Hickey, Lisa ^a   Denney, William S ^b   Li, Chi Chung ^b   Palcza, John ^a   Vanmolkot, Floris H M ^c   Depré, Marleen ^c   Van Hecken, Anne ^c   Murphy, M Gail ^a   Ho, Tony W ^a   De Hoon, Jay N ^c  

^a Merck Research Laboratory   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^d MSD Europe Inc   (Belgium)

Author keywords

Blood flow; Capsaicin; CGRP; Migraine; Telcagepant

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; CAPSAICIN; TELCAGEPANT;

ACUTE DISEASE; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG INHIBITION; FEMALE; HUMAN; LASER DOPPLER FLOWMETRY; MALE; MIGRAINE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN BLOOD FLOW;

ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; AZEPINES; CAPSAICIN; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FOREARM; HUMANS; IMIDAZOLES; LASER-DOPPLER FLOWMETRY; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; REGIONAL BLOOD FLOW; SKIN; VASODILATOR AGENTS; YOUNG ADULT;

EID: 72949106255     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2009.03543.x     Document Type: Article

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