Impact of Toll-like receptor 2 deficiency on immune responses to mycobacterial antigens

Infection and Immunity

Volumn 79, Issue 11, 2011, Pages 4649-4656

  Rahman, Muhammad J ^a   Chuquimia, Olga D ^a   Petursdottir, Dagbjort H ^a   Periolo, Natalia ^a   Singh, Mahavir ^b   Fernández, Carmen ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b LIONEX DIAGNOSTICS AND THERAPEUTICS GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; GAMMA INTERFERON; MYCOBACTERIUM ANTIGEN; TOLL LIKE RECEPTOR 2;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIGEN PRESENTING CELL; ARTICLE; BONE MARROW; CELL COMPARTMENTALIZATION; CELL STIMULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; IMMUNIZATION; IN VITRO STUDY; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SERUM; SPLEEN; SPLEEN CELL; T LYMPHOCYTE; UPREGULATION;

ANIMALS; ANTIGENS, BACTERIAL; INTERFERON-GAMMA; MACROPHAGES; MACROPHAGES, ALVEOLAR; MICE; MICE, KNOCKOUT; MYCOBACTERIUM; SPLEEN; TOLL-LIKE RECEPTOR 2;

EID: 80855144656     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.05724-11     Document Type: Article

References (38)

1. Aliprantis, A. O., et al. 1999. Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor-2. Science 285:736-739.
2. Arko-Mensah, J., E. Julian, M. Singh, and C. Fernandez. 2007. TLR2 but not TLR4 signalling is critically involved in the inhibition of IFN-gammainduced killing of mycobacteria by murine macrophages. Scand. J. Immunol. 65:148-157. doi:10.1111/j.1365-3083.2006.01888.x.
3. Blander, J. M., and R. Medzhitov. 2004. Regulation of phagosome maturation by signals from toll-like receptors. Science 304:1014-1018. doi:10.1126/science.1096158.
4. Brightbill, H. D., et al. 1999. Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors. Science 285:732-736.
5. Clatza, A., L. C. Bonifaz, D. A. Vignali, and J. Moreno. 2003. CD40-induced aggregation of MHC class II and CD80 on the cell surface leads to an early enhancement in antigen presentation. J. Immunol. 171:6478-6487.
6. Cooper, A. M., L. B. Adams, D. K. Dalton, R. Appelberg, and S. Ehlers. 2002. IFN-gamma and NO in mycobacterial disease: new jobs for old hands. Trends Microbiol. 10:221-226.
7. Corti, M., A. R. Brody, and J. H. Harrison. 1996. Isolation and primary culture of murine alveolar type II cells. Am. J. Respir. Cell Mol. Biol. 14:309-315.
8. Drennan, M. B., et al. 2004. Toll-like receptor 2-deficient mice succumb to Mycobacterium tuberculosis infection. Am. J. Pathol. 164:49-57. doi:10.1016/S0002-9440(10)63095-7.
9. Dustin, M. L., S. Y. Tseng, R. Varma, and G. Campi. 2006. T cell-dendritic cell immunological synapses. Curr. Opin. Immunol. 18:512-516. doi:10.1016/j.coi.2006.05.017.
10. Flynn, J. L., et al. 1995. Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 2:561-572.
11. Giri, P. K., and J. S. Schorey. 2008. Exosomes derived from M. Bovis BCG infected macrophages activate antigen-specific CD4+ and CD8+ T cells in vitro and in vivo. PLoS One 3:e2461. doi:10.1371/journal.pone.0002461.
12. Goldrath, A. W., et al. 2002. Cytokine requirements for acute and basal homeostatic proliferation of naive and memory CD8+ T cells. J. Exp. Med. 195:1515-1522.
13. Hou, B., B. Reizis, and A. L. DeFranco. 2008. Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms. Immunity 29:272-282. doi:10.1016/j.immuni.2008.05.016.
14. Jeannin, P., et al. 2000. Soluble CD86 is a costimulatory molecule for human T lymphocytes. Immunity 13:303-312.
15. Kabelitz, D. 2007. Expression and function of Toll-like receptors in T lymphocytes. Curr. Opin. Immunol. 19:39-45. doi:10.1016/j.coi.2006.11.007.
16. Kaneko, H., et al. 1999. Role of tumor necrosis factor-alpha in Mycobacterium-induced granuloma formation in tumor necrosis factor-alpha-deficient mice. Lab. Invest. 79:379-386.
17. Komai-Koma, M., L. Jones, G. S. Ogg, D. Xu, and F. Y. Liew. 2004. TLR2 is expressed on activated T cells as a costimulatory receptor. Proc. Natl. Acad. Sci. U. S. A. 101:3029-3034. doi:10.1073/pnas.0400171101.
18. Lazarevic, V., D. J. Yankura, S. J. DiVito, and J. L. Flynn. 2005. Induction of Mycobacterium tuberculosis-specific primary and secondary T-cell responses in interleukin-15-deficient mice. Infect. Immun. 73:2910-2922. doi:10.1128/IAI.73.5.2910-2922.2005.
19. Liu, P. T., et al. 2006. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311:1770-1773. doi:10.1126/science.1123933.
20. Means, T. K., et al. 1999. Human Toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J. Immunol. 163:3920-3927.
21. Muzio, M., et al. 2000. Differential expression and regulation of Toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J. Immunol. 164:5998-6004.
22. Nicod, L. P. 2007. Immunology of tuberculosis. Swiss Med. Wkly. 137:357-362. doi:2007/25/smw-11499.
23. Noss, E. H., et al. 2001. Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosis. J. Immunol. 167:910-918.
24. Pasare, C., and R. Medzhitov. 2005. Toll-like receptors: linking innate and adaptive immunity. Adv. Exp. Med. Biol. 560:11-18. doi:10.1007/0-387-24180-9_2.
25. Pathan, A. A., et al. 2007. Boosting BCG with recombinant modified vaccinia Ankara expressing antigen 85A: different boosting intervals and implications for efficacy trials. PLoS One 2:e1052. doi:10.1371/journal.pone.0001052.
26. Post, F. A., et al. 2001. Mycobacterium tuberculosis 19-kilodalton lipoprotein inhibits Mycobacterium smegmatis-induced cytokine production by human macrophages in vitro. Infect. Immun. 69:1433-1439. doi:10.1128/IAI.69.3.1433-1439.2001.
27. Prlic, M., L. Lefrancois, and S. C. Jameson. 2002. Multiple choices: regulation of memory CD8 T cell generation and homeostasis by interleukin (IL)-7 and IL-15. J. Exp. Med. 195:F49-F52.
28. Rothfuchs, A. G., et al. 2001. IFN-alpha beta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection. J. Immunol. 167:6453-6461.
29. Sato, M., et al. 2003. Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are downregulated by lung collectin surfactant protein A. J. Immunol. 171:417-425.
30. Takeda, K., and S. Akira. 2005. Toll-like receptors in innate immunity. Int. Immunol. 17:1-14. doi:10.1093/intimm/dxh186.
31. Tjärnlund, A., E. Guirado, E. Julian, P. J. Cardona, and C. Fernandez. 2006. Determinant role for Toll-like receptor signalling in acute mycobacterial infection in the respiratory tract. Microbes Infect. 8:1790-1800. doi:10.1016/j.micinf.2006.02.017.
32. Tsuji, S., et al. 2000. Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guerin: involvement of toll-like receptors. Infect. Immun. 68:6883-6890.
33. Wang, B., et al. 2007. A Toll-like receptor-2-directed fusion protein vaccine against tuberculosis. Clin. Vaccine Immunol. 14:902-906. doi:10.1128/CDLI.00077-07.
34. Weeratna, R. D., S. R. Makinen, M. J. McCluskie, and H. L. Davis. 2005. TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848). Vaccine 23:5263-5270. doi:10.1016/j.vaccine.2005.06.024.
35. Xing, Z., A. Zganiacz, and M. Santosuosso. 2000. Role of IL-12 in macrophage activation during intracellular infection: IL-12 and mycobacteria syn-ergistically release TNF-alpha and nitric oxide from macrophages via IFNgamma induction. J. Leukoc. Biol. 68:897-902.
36. Yeremeev, V. V., et al. 2000. The 19-kD antigen and protective immunity in a murine model of tuberculosis. Clin. Exp. Immunol. 120:274-279.
37. Zhang, F. X., et al. 1999. Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J. Biol. Chem. 274: 7611-7614.
38. Zhang, W. W., and G. Matlashewski. 2008. Immunization with a Toll-like receptor 7 and/or 8 agonist vaccine adjuvant increases protective immunity against Leishmania major in BALB/c mice. Infect. Immun. 76:3777-3783. doi:10.1128/IAI.01527-07.