An ‘injury-time integral’ model for extrapolating from acute to chronic effects of phosgene

Toxicology and Industrial Health

Volumn 17, Issue 10, 2001, Pages 285-293

  Hatch, Ge ^a   Kodavanti, U ^a   Crissman, K ^a   Slade, R ^a   Costa, D ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

chronic lung injury; dose response models; extrapolation; phosgene toxicity; risk assessment

Indexed keywords

COLLAGEN; DYE; HYDROXYPROLINE; PHOSGENE; TRICHROME; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ADAPTATION; AIR POLLUTANT; ANIMAL EXPERIMENT; CHRONIC TOXICITY; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; EXPERIMENTAL MODEL; LUNG LAVAGE; MALE; NONHUMAN; PROTEIN DETERMINATION; RAT; RISK ASSESSMENT; STAINING; SUPERNATANT; TIME;

ANIMALS; BRONCHOALVEOLAR LAVAGE; CHEMICAL WARFARE AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; HUMANS; LUNG; MALE; MODELS, THEORETICAL; PHOSGENE; RATS; RATS, INBRED F344; RISK ASSESSMENT; TIME FACTORS;

ANIMALIA; RODENTIA;

EID: 0035384509     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1191/0748233701th123oa     Document Type: Article

References (24)

1. Clay, J. R. and Rossing, R. G. 1964: Histopathology of exposure to phosgene-an attempt to produce pulmonary emphysema experimentally. Arch Pathol 78, 544-551.
2. Currie, W. D., Hatch, G. E. and Frosolono, M. F. 1987: Pulmonary alterations due to phosgene inhalation. Fundam Appl Toxicol 8, 107-114.
3. Dubin, N., Moseson, M. and Pasternack, B. S. May 1989: Sun exposure and malignant melanoma among susceptible individuals. Environ Health Perspect 81, 139-151.
4. Dunnett, C. W. 1955: A multiple comparison procedure for comparing several treatments with a control. J Am Stat Assoc 50, 1096-1121.
5. EPA (1998): Science Advisory Board Report: Development of the Acute Reference Exposure. Review of draft document methods for exposure-response analysis for acute inhalation exposure to chemicals. Development of the acute reference exposure. EPA/600/R-68/051. National Technical Information System.
6. Evans, M. J., Dekker, N. P., Cabral-Anderson, L. J. and Shami, S. G. 1985: Morphological basis of tolerance to ozone. Exp Mol Pathol 42, 366-376.
7. Franch, S. and Hatch, G. E. 1986: Pulmonary biochemical effects of inhaled phosgene in rats. J Toxicol Environ Health 19, 413-423.
8. Ghio, A. J. and Hatch, G. E. 1996: Tolerance to phosgene is associated with a neutrophilic influx into the rat lung. Am J Respir Crit Care Med 153, 1064-1071.
9. Gross, P., Rinehart, W. E. and Hatch, T. 1965: Chronic pneumonitis caused by phosgene. Arch Environ Health 10, 768-775.
10. Hatch, G. E. 1992: Comparative biochemistry of airway lining fluid. In Parent, R. A., editor, Comparative biology of the normal lung. Boca Raton, FL: CRC Press, 631-717.
11. Hatch, G. E., Slade, R., Stead, A. G. and Graham, J. A. 1986: Species comparison of acute inhalation toxicity of ozone and phosgene. J Toxicol Environ Health 19, 43-53.
12. Hu, P. C., Miller, F. J., Daniels, M. J., Hatch, G. E., Graham, J. A. and Gardner, D. L. 1982: Protein accumulation in lung lavage fluid following ozone exposure. Environ Res 299, 377-388.
13. Jarabek, A. M. 1995: Consideration of the temporal toxicity challenges current default assumptions. Inhal Toxicol 7, 927-946.
14. Kodavanti, U. P., Costa, D. L., Giri, S. N., Starcher, B. and Hatch, G. E. 1997: Pulmonary structural and extracellular matrix alterations in Fischer 344 rats following subchronic phosgene exposure. Fundam Appl Toxicol 37, 54-63.
15. Lowry, O. H., Rosebrogh, N. J., Farr, A. L. and Randall, R. J. 1951: Protein measurement with the Folin phenol reagent. J Biol Chem 193, 265-275.
16. Miller, F. J., Schlosser, P. M. and Janszen, D. B. Aug 14 2000: Haber's rule: a special case in a family of curves relating concentration and duration of exposure to a fixed level of response for a given endpoint. Toxicology 149, 21-34.
17. NIOSH (2001): Pocket guide to chemical hazards. National Institute for Occupational Safety and Health, Department of Health and Human Services, Centers for Disease Control and Prevention. 2001 CD ROM, www.cdc.gov.niosh
18. Selgrade, M. J. K., Gilmour, M. I., Yang, Y. G., Burleson, G. R. and Hatch, G. E. 1995: Pulmonary host defenses and resistance to infection following subchronic exposure to phosgene. Inhal Toxicol 7, 1257-1268.
19. Singh, H. B. 1976: Phosgene in ambient air. Nature 264, 428-429.
20. Tyler, W. S., Tyler, N. K., Last, J. A., Gillespie, M. J. and Barstow, T. J. 1988: Comparisons of daily and seasonal exposures of young monkeys to ozone. Toxicology 50(2), 131-144.
21. US E.P.A. (1997): Acute Reference Exposure (ARE) Methods Document. http://www.epa.gov/sab/ared029.htm
22. US E.P.A. (2002): United States Environmental Protection Agency Air Toxics Network Website. http://www.epa.gov/ttnatw01/hlthef/phosgene.html%23ref1
23. Williams, D. A. 1972: The comparison of several dose levels with a zero dose control. Biometrics 28, 519-531.
24. Yang, Y. G., Gilmour, M. I., Lange, R., Burleson, G. R. and Selgrade, M. J. K. 1995: Effect of acute exposure to phosgene on pulmonary host defenses and resistance to infection. Inhal Toxicol 7, 393-404.