Thermoregulation and its influence on toxicity assessment

Toxicology

Volumn 244, Issue 2-3, 2008, Pages 87-97

  Gordon, Christopher J ^a   Spencer, Pamela J ^b   Hotchkiss, Jon ^b   Miller, Diane B ^c   Hinderliter, Paul M ^d   Pauluhn, Juergen ^e  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b DOW CHEMICAL COMPANY   (United States)

^c NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^d PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^e BAYER PHARMA AG   (Germany)

Author keywords

Core temperature; Inhalation; Metabolic rate; Pesticide; Radiotelemetry; Restraint; Rodent; Skin temperature; Stress

Indexed keywords

HEAVY METAL; INSECTICIDE; ISOCYANATE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SOLVENT;

BODY TEMPERATURE; CALORIMETRY; ENVIRONMENTAL TEMPERATURE; GEL ELECTROPHORESIS; HEAT EXCHANGE; HEAT LOSS; HUMAN; HUMIDITY; HYPERTHERMIA; HYPOTHERMIA; LIPID PEROXIDATION; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; RAT STRAIN; RECTUM TEMPERATURE; REVIEW; RODENT; SKIN TEMPERATURE; THERMAL CONDUCTIVITY; THERMOGRAPHY; THERMOMETRY; THERMOREGULATION; TOXICOLOGY;

ANIMALS; ANIMALS, NEWBORN; BODY TEMPERATURE REGULATION; HUMANS; HYPOTHERMIA; THERMOMETERS; TOXICITY TESTS;

RODENTIA;

EID: 38949140216     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.10.030     Document Type: Review

References (25)

1. Doull J. The effect of physical environmental factors on drug response. Essays Toxicol. 3 (1972) 37-63
2. Gordon C.J. Thermal biology of the laboratory rat. Physiol. Behav. 47 (1990) 963-991
3. Gordon C.J. Toxic-induced hypothermia and hypometabolism: Do they increase uncertainty in the extrapolation of toxicological data from experimental animals to humans?. Neurosci. Biobehav. Rev. 15 (1991) 95-98
4. Gordon C.J., Mohler F.S., Watkinson W.P., and Rezvani A.H. Temperature regulation in laboratory mammals following acute toxic insult. Toxicology 53 (1988) 161-178
5. Gordon C.J. Temperature Regulation in Laboratory Rodents (1993), Cambridge University Press, New York
6. Gordon C.J. Homeothermy: does it impede the response to cellular injury. J. Thermal Biol. 21 (1996) 29-36
7. Gordon C.J. Temperature and Toxicology: An Integrative, Comparative, and Environmental Approach (2005), CRC Press, Boca Raton, FL
8. Hartinger J., Kulbs D., Volkers P., and Cussler K. Suitability of temperature-sensitive transponders to measure body temperature during animal experiments required for regulatory tests. Altex 20 (2003) 65-70
9. IUPS Thermal Commission. Glossary of terms for thermal physiology. Third edition. Revised by The Commission for Thermal Physiology of the International Union of Physiological Sciences. Jpn. J. Physiol. 51 245-280 (2001) 2001
10. Kaiyala K.J., Butt S., and Ramsay D.S. Systems-level adaptations explain chronic tolerance development to nitrous oxide hypothermia in young and mature rats. Psychopharmacy 191 (2007) 233-242
11. Kaiyala K.J., Butt S., and Ramsay D.S. Direct evidence for systems-level modulation of initial drug (in)sensitivity in rats. Psychopharmacy 191 (2007) 243-251
12. Lovinger D.M., and Crabbe J.C. Laboratory models of alcoholism: treatment target identification and insight into mechanisms. Nat. Neurosci. 8 (2005) 1471-1480
13. Mack C.M., and Gordon C.J. Differential sensitivity to anticholinesterase insecticides in the juvenile rat: effects on thermoregulation. J. Toxicol. Environ. Health A 70 (2007) 439-444
14. Narciso S.P., Nadziejko E., Chen L.C., Gordon T., and Nadziejko C. Adaptation to stress induced by restraining rats and mice in nose-only inhalation holders. Inhal. Toxicol. 15 (2003) 1133-1143
15. OECD (1981) Test Guideline 403. OECD Guideline for Testing of Chemicals. Acute Inhalation Toxicity Testing. Available: http://www.oecd.org/document/22/0,2340,en_2649_34377_1916054_1_1_1_1,00. html.
16. Palmer A.A., Moyer M.R., Crabbe J.C., and Phiilips T.J. Initial sensitivity, tolerance and cross-tolerance to allopregnanolone- and ethanol-induced hypothermia in selected mouse lines. Psychopharmacy 162 (2002) 313-322
17. Pauluhn J., and Machemer L.H. Assessment of pyrethroid-induced paraesthesias: comparison of animal model and human data. Toxicol. Lett. 96-97 (1998) 361-368
18. Pauluhn J., and Mohr U. Repeated 4-week inhalation exposure of rats: effect of low-, intermediate, and high-humidity chamber atmospheres. Exp. Toxicol. Pathol. 51 (1999) 178-187
19. Pauluhn J., and Mohr U. Inhalation studies in laboratory animals-current concepts and alternatives. Review. Toxicol. Pathol. 28 (2000) 734-753
20. Pauluhn J. Overview of testing methods used in inhalation toxicity: from facts to artifacts. Toxicol. Lett. 140-141 (2003) 183-193
21. Pauluhn J., and Schmuck G. Critical analysis of potential body temperature confounders on neurochemical endpoints caused by direct dosing and maternal separation in neonatal mice: a study of bioallethrin and deltamethrin interactions with temperature on brain muscarinic receptors. J. Appl. Toxicol. 23 (2003) 9-18
22. Pauluhn J. Pulmonary irritant potency of polyisocyanate aerosols in rats: comparative assessment of irritant-threshold concentrations by bronchoalveolar lavage. J. Appl. Toxicol. 24 (2004) 231-247
23. Schmidt-Nielsen K. Animal Physiology-Adaptation and Environment (1975), Cambridge University Press, London
24. Van Eijl S., van Oorschot R., Olivier B., Nijkamp F.P., and Bloksma N. Stress and hypothermia in mice in a nose-only cigarette smoke exposure system. Inhal. Toxicol. 18 (2006) 911-918
25. Watkinson W.P., and Gordon C.J. Caveats regarding the use of the laboratory rat as a model for acute toxicological studies: modulation of the toxic response via physiological and behavioral mechanisms. Toxicology 81 (1993) 15-31