Analysis of biomarkers in rats and dogs exposed to polymeric methylenediphenyl diisocyanate (pMDI) and its glutathione adduct

Toxicology

Volumn 222, Issue 3, 2006, Pages 202-212

  Pauluhn, Jürgen ^a   Brown, William E ^b   Hext, Paul ^c   Leibold, Edgar ^d   Leng, Gabriele ^e  

^a Institute of Toxicology   (Germany)

^b CARNEGIE MELLON UNIVERSITY   (United States)

^c JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^d BASF SE   (Germany)

^e B   (Germany)

Author keywords

Diphenylmethane diisocyanate; Dosimetry; Exposure biomarker; Glutathione adduct; MDI

Indexed keywords

BIOLOGICAL MARKER; CYANIC ACID DERIVATIVE; DIAMINE; DIPHENYLMETHANE 4,4' DIAMINE; GLUTATHIONE DERIVATIVE; HEMOGLOBIN; METHYLENEDIPHENYL DIISOCYANATE; PLASMA PROTEIN; POLYMER; UNCLASSIFIED DRUG;

ACETYLATION; AEROSOL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD; CONTROLLED STUDY; DOG; FEEDING; HYDROLYSIS; MALE; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETANILIDES; ANILINE COMPOUNDS; ANIMALS; BENZHYDRYL COMPOUNDS; BIOLOGICAL MARKERS; BLOOD PROTEINS; DOGS; GLUTATHIONE; HEMOGLOBINS; ISOCYANATES; MALE; POLYURETHANES; PROTEIN BINDING; RATS; RATS, WISTAR;

ANIMALIA; CANIS FAMILIARIS;

EID: 33646507894     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.02.014     Document Type: Article

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