Optimization of human Th17 cell differentiation in vitro: Evaluating different polarizing factors

In Vitro Cellular and Developmental Biology - Animal

Volumn 47, Issue 8, 2011, Pages 581-592

  Ganjalikhani Hakemi, Mazdak ^a,b   Ghaedi, Kamran ^c   Andalib, Alireza ^a   Hosseini, Mohsen ^a   Rezaei, Abbas ^a,b  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UNIVERSITY OF ISFAHAN   (Iran)

Author keywords

IL 17; RORC2; TGF ; Th17

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 21; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 6; INTERLEUKIN DERIVATIVE; INTERLEUKIN-22; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL DEDIFFERENTIATION; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; EVALUATION; HUMAN; METABOLISM; TH17 CELL;

CELL DEDIFFERENTIATION; CELLS, CULTURED; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKIN-1BETA; INTERLEUKIN-23; INTERLEUKIN-6; INTERLEUKINS; TH17 CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 80855138032     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11626-011-9444-1     Document Type: Article

References (44)

1. EV Acosta-Rodriguez G Napolitani A Lanzavecchia F Sallusto 2007 Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells Nat. Immunol. 8 942 949 17676045 10.1038/ni1496 1:CAS:528:DC%2BD2sXptlSku7w%3D (Pubitemid 47300008)
2. EV Acosta-Rodriguez L Rivino J Geginat D Jarossay M Gattorno 2007 Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells Nat. Immunol. 8 639 46 17486092 10.1038/ni1467 1:CAS:528: DC%2BD2sXlsVSrsLo%3D (Pubitemid 46785128)
3. S Aggarwal N Ghilardi MH Xie FJ de Sauvage AL Gurney 2003 Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17 J. Biol. Chem. 278 1910 1914 12417590 10.1074/jbc.M207577200 1:CAS:528:DC%2BD3sXisFyksA%3D%3D (Pubitemid 36801431)
4. F Annunziato L Cosmi F Liotta E Maggi S Romagnani 2009 Human Th17 cells: are they different from murine Th17 cells? Eur. J. Immunol. 39 637 640 19283714 10.1002/eji.200839050 1:CAS:528:DC%2BD1MXktVaisrc%3D
5. F Annunziato L Cosmi V Santarlasci L Maggi F Liotta B Mazzinghi E Parente 2007 Phenotypic and functional features of human Th17 cells J. Exp. Med. 204 1849 1861 17635957 10.1084/jem.20070663 1:CAS:528:DC%2BD2sXptVyjsLs%3D (Pubitemid 47240944)
6. E Bettelli Y Carrier W Gao T Korn T Storm M Oukka 2006 Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells Nature 441 235 8 16648838 10.1038/nature04753 1:CAS:528:DC%2BD28XksVGns7g%3D
7. S Burgler PY Mantel C Bassin N Ouaked CA Akdis CB Schmidt-Weber 2010 RORC2 is involved in T cell polarization through interaction with the FOXP3 promoter J. Immunol. 184 6161 6169 20427770 10.4049/jimmunol.0903243 1:CAS:528:DC%2BC3cXmtFyqtrw%3D
8. S Burgler N Ouaked C Bassin TM Basinski PY Mantel K Siegmund N Meyer CA Akdis CB Schmidt-Weber 2009 Differentiation and functional analysis of human T(H)17 cells J. Allergy Clin. Immunol. 123 588-95 595
9. CR Cardoso GP Garlet GE Crippa AL Rosa WM Junior MA Rossi JS Silva 2009 Evidence of the presence of T helper type 17 cells in chronic lesions of human periodontal disease Oral Microbiol. Immunol. 24 1 6 19121062 10.1111/j.1399-302X.2008.00463.x 1:CAS:528:DC%2BD1MXitF2hurc%3D
10. L Cosmi R De Palma V Santarlasci L Maggi M Capone F Frosali G Rodolico 2008 Human interleukin-17-producing cells originate from a CD161+ CD4+ T-cell precursor J. Exp. Med. 205 1903 1916 18663128 10.1084/jem.20080397 1:CAS:528:DC%2BD1cXpsFOjsbg%3D
11. SQ Crome AY Wang CY Kang MK Levings 2009 The role of retinoic acid-related orphan receptor variant 2 and IL-17 in the development and function of human CD4+ T cells Eur. J. Immunol. 39 1480 1493 19449310 10.1002/eji.200838908 1:CAS:528:DC%2BD1MXntFCiurk%3D
12. N Ghilardi W Ouyang 2007 Targeting the development and effector functions of TH17 cells Semin. Immunol. 19 383 393 18083530 10.1016/j.smim.2007.10.016 1:CAS:528:DC%2BD1cXisVSrsLY%3D
13. AR Gocke PD Cravens LH Ben RZ Hussain SC Northrop MK Racke AE Lovett-Racke 2007 T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity J. Immunol. 178 1341 1348 17237380 1:CAS:528:DC%2BD2sXntVGiug%3D%3D (Pubitemid 46154603)
14. LE Harrington RD Hatton PR Mangan H Turner TL Murphy KM Murphy CT Weaver 2005 Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages Nat. Immunol. 6 1123 1132 16200070 10.1038/ni1254 1:CAS:528:DC%2BD2MXhtFamsb7J (Pubitemid 41541790)
15. K Hirota B Martin M Veldhoen 2010 Development, regulation and functional capacities of Th17 cells Semin. Immunopathol. 32 3 16 20107806 10.1007/s00281-009-0187-y 1:CAS:528:DC%2BC3cXjtFyisrs%3D
16. II Ivanov BS McKenzie L Zhou CE Tadokoro A Lepelley JJ Lafaille DJ Cua DR Littman 2006 The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells Cell 126 1121 1133 16990136 10.1016/j.cell.2006.07.035 1:CAS:528:DC%2BD28XhtVCnsrrE (Pubitemid 44380299)
17. -ddCt Method Methods 25 402 408 10.1006/meth.2001.1262 (Pubitemid 34164012)
18. I Kryczek S Wei L Vatan J Escara-Wilke W Szeliga ET Keller W Zou 2007 Cutting edge: opposite effects of IL-1 and IL-2 on the regulation of IL-17+ T cell pool IL-1 subverts IL-2-mediated suppression J. Immunol. 179 1423 1426 17641006 1:CAS:528:DC%2BD2sXnvVyntr0%3D
19. A Laurence CM Tato TS Davidson Y Kanno Z Chen Z Yao RB Blank F Meylan R Siegel L Hennighausen EM Shevach JJ O'Shea 2007 Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation Immunity. 26 371 381 17363300 10.1016/j.immuni.2007.02.009 1:CAS:528:DC%2BD2sXjvVSnsL8%3D (Pubitemid 46413906)
20. YK Lee H Turner CL Maynard JR Oliver D Chen CO Elson CT Weaver 2009 Late developmental plasticity in the T helper 17 lineage Immunity. 30 92 107 19119024 10.1016/j.immuni.2008.11.005 1:CAS:528:DC%2BD1MXhtlCnsLk%3D
21. L Maggi V Santarlasci M Capone A Peired F Frosali SQ Crome V Querci M Fambrini F Liotta M Levings E Maggi L Cosmi S Romagnani F Annunziato 2010 CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC Eur. J. Immunol. 40 2174 2181 20486123 10.1002/eji.200940257 1:CAS:528:DC%2BC3cXpsF2rtro%3D
22. N Manel D Unutmaz DR Littman 2008 The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgamma Nat. Immunol. 9 641 49 18454151 10.1038/ni.1610 1:CAS:528:DC%2BD1cXmtVWqurg%3D (Pubitemid 351714729)
23. PR Mangan LE Harrington D O'quinn W Helms D Bullard C Elson 2006 Transforming growth factor- induces development of TH17 lineage Nature 441 231 4 16648837 10.1038/nature04754 1:CAS:528:DC%2BD28XksVGns7k%3D
24. N Martin-Orozco Y Chung SH Chang YH Wang C Dong 2009 Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells Eur. J. Immunol. 39 216 224 19130584 10.1002/eji.200838475 1:CAS:528:DC%2BD1MXhs1Siurc%3D
25. MJ McGeachy DJ Cua 2008 Th17 cell differentiation: the long and winding road Immunity. 28 445 453 18400187 10.1016/j.immuni.2008.03.001 1:CAS:528:DC%2BD1cXkvV2itrk%3D (Pubitemid 351467042)
26. WP Michael 2001 A new mathematical model for relative quantification in real-time RT-PCR Nucleic Acids Res. 29 2002 2007
27. AM Mus F Cornelissen PS Asmawidjaja JP van Hamburg L Boon RW Hendriks E Lubberts 2010 Interleukin-23 promotes Th17 differentiation by inhibiting T-bet and FoxP3 and is required for elevation of interleukin-22, but not interleukin-21, in autoimmune experimental arthritis Arthritis Rheum. 62 1043 1050 20131264 10.1002/art.27336 1:CAS:528:DC%2BC3cXhtFGnu7rK
28. Naive CD4+ T cell isolation kit II human. [130-094-131]. 2008. Miltenyi Biotec GmbH. Ref Type: Catalog.
29. W Ouyang JK Kolls Y Zheng 2008 The biological functions of T helper 17 cell effector cytokines in inflammation Immunity. 28 454 467 18400188 10.1016/j.immuni.2008.03.004 1:CAS:528:DC%2BD1cXkvV2itrY%3D (Pubitemid 351471762)
30. H Park Z Li XO Yang SH Chang R Nurieva YH Wang Y Wang L Hood Z Zhu Q Tian C Dong 2005 A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 Nat. Immunol. 6 1133 1141 16200068 10.1038/ni1261 1:CAS:528:DC%2BD2MXhtFamsb%2FO (Pubitemid 41541791)
31. A Peck ED Mellins 2009 Plasticity of T-cell phenotype and function: the T helper type 17 example Immunology 129 147 153 19922424 10.1111/j.1365-2567. 2009.03189.x
32. G Shi CA Cox BP Vistica C Tan EF Wawrousek I Gery 2008 Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells J. Immunol. 181 7205 7213 18981142 1:CAS:528:DC%2BD1cXhtlaisrjP
33. H Streeck KW Cohen JS Jolin MA Brockman A Meier KA Power MT Waring G Alter M Altfeld 2008 Rapid ex vivo isolation and long-term culture of human Th17 cells J. Immunol. Methods 333 115 125 18314131 10.1016/j.jim.2008.01.018 1:CAS:528:DC%2BD1cXktlWku7g%3D
34. D Unutmaz 2009 RORC2: the master of human Th17 cell programming Eur. J. Immunol. 39 1452 1455 19499530 10.1002/eji.200939540 1:CAS:528: DC%2BD1MXntFCiur8%3D
35. D Valmori C Raffin I Raimbaud M Ayyoub 2010 Human ROR{gamma}t+TH17 cells preferentially differentiate from naive FOXP3+Treg in the presence of lineage-specific polarizing factors Proc. Natl. Acad. Sci. U. S. A 107 19402 19407 20962281 10.1073/pnas.1008247107 1:CAS:528:DC%2BC3cXhsVGltr%2FL
36. M Veldhoen K Hirota J Christensen 2009 Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells J. Exp. Med. 206 43 49 19114668 10.1084/jem.20081438 1:CAS:528:DC%2BD1MXhtVOhtbo%3D
37. M Veldhoen K Hirota A Westendorf 2010 The aryl hydrocarbon receptor links Th17-cell-mediated autoimmunity to invironmental toxins Nature 453 106 109 10.1038/nature06881 (Pubitemid 351630329)
38. M Veldhoen R Hocking C Atkins R Locksley B Stockinger 2006 TGF- in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells Immunity 24 179 189 16473830 10.1016/j.immuni.2006.01. 001 1:CAS:528:DC%2BD28XitVOks7s%3D (Pubitemid 43214587)
39. E Volpe N Servant R Zollinger SI Bogiatzi P Hupe E Barillot V Soumelis 2008 A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses Nat. Immunol. 9 650 657 18454150 10.1038/ni.1613 1:CAS:528:DC%2BD1cXmtVWqurc%3D (Pubitemid 351712635)
40. Vyakarnam A. Human CD4 Culture. In: Rowland-Jones S. L.; McMichael A. (eds) Lymphocytes: a practical approach. Oxford University Press, Oxford, pp 136-142; 2000.
41. NJ Wilson K Boniface JR Chan BS McKenzie WM Blumenschein JD Mattson B Basham K Smith T Chen F Morel JC Lecron RA Kastelein DJ Cua TK McClanahan EP Bowman MR de Waal 2007 Development, cytokine profile and function of human interleukin 17-producing helper T cells Nat. Immunol. 8 950 957 17676044 10.1038/ni1497 1:CAS:528:DC%2BD2sXptlSku7o%3D (Pubitemid 47300009)
42. L Yang DE Anderson C Baecher-Allan WD Hastings E Bettelli M Oukka VK Kuchroo DA Hafler 2008 IL-21 and TGF-beta are required for differentiation of human T(H)17 cells Nature 454 350 352 18469800 10.1038/nature07021 1:CAS:528:DC%2BD1cXosFCqs7o%3D
43. XO Yang BP Pappu R Nurieva A Akimzhanov HS Kang Y Chung L Ma B Shah AD Panopoulos KS Schluns SS Watowich Q Tian AM Jetten C Dong 2008 T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma Immunity. 28 29 39 18164222 10.1016/j.immuni.2007.11.016 1:CAS:528:DC%2BD1cXht1Ontrs%3D
44. J Zhu WE Paul 2008 CD4 T cells: fates, functions, and faults Blood 112 1557 1569 18725574 10.1182/blood-2008-05-078154 1:CAS:528:DC%2BD1cXhtVylurbK