Effect of marjoram extract treatment on the cytological and biochemical changes induced by cyclophosphamide in mice

Journal of Medicinal Plant Research

Volumn 5, Issue 23, 2011, Pages 5479-5485

  Al Harbi, Naif Obaid ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Bone marrow; Cyclophosphamide (CP); Marjoram (origanum majorana L.); Micronucleated polychromatic erythrocytes; Mitodepression; Protein and nucleic acid contents

Indexed keywords

CYCLOPHOSPHAMIDE; ORIGANUM MAJORANA EXTRACT;

ADVERSE OUTCOME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CELL PROTECTION; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG DOSE COMPARISON; DRUG EFFECT; MALE; MOUSE; MUTAGENIC ACTIVITY; NONHUMAN; PLANT LEAF;

LAMIACEAE; MUS; ORIGANUM MAJORANA;

EID: 80755182401     PISSN: None     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. Abd EMA, El-Metwally NY (2010). Effect of marjoram leaves on injured liver in experimental rats. Report and Opinion 2(12):181-191. (ISSN: 1553-9873). http://www.sciencepub.net
2. Abdel-Massih RM, Fares R, Bazzi S, El-Chami N, Baydoun E (2010). The apoptotic and anti-proferative activity of Origanum majorana extracts on human leukemic cell line. Leuk. Res., 34(8): 1052-1056.
3. Aheme SA, Kerry JP, O'Brien NM (2007). Effect of plant extracts on antioxidant status and oxidant-induced stress in Caco-2 cells. Br. J. Nutr., 97(2): 321-328.
4. Ahmed LA, Ramadan RS, Mohamed RA (2009). Biochemical and histopathological studies on the water extracts of Marjoram and chicory herbs and their mixture in obese rats. Pak. J. Nutr., 8(10): 1581-1587.
5. Alenzi FQ, El-Bolkiny Yel-S, Salem ML (2010). Protective effects of Nigella sativa oil and thymoquinone against toxicity induced by the anticancer drug cyclophosphamide. Br. J. Biomed. Sci., 67(1): 20-28.
6. Al-Harbi MM (1993). Effect of captopril on the cytological and biochemical changes induced by adriamycin. Food Chem. Toxicol., 31(3): 209-212.
7. Al-Harbi MM, Qureshi S, Ahmed MM, Rafatullah S, Shah AH (1994). Effect of Commiphora molmol (oleo-gum-resin) on the cytological and biochemical changes induced by cyclophosphamide in mice Am. J. Chin. Med., 22: 77-82.
8. Al-Bekairi AM, Qureshi S, Ahmed MM, Qazi NS, Khan ZA, Shah AH (1992). Effect of Caralluma tuberculata on the cytological and biochemical changes induced by cyclophosphamide in mice. Food Chem. Toxicol., 30: 719-722.
9. Akah PA, Onuogu E (1993). Hepatotoxic effects of Azadiractica indica leaf extracts in rabbits. Fitoterapia, 63(4): 311-319. Aromatherapy (2011). http://www.aromatherapybible.Com/marjoram.php
10. Arts IC, Hollman PC (2005). Polyphenols and disease risk in epidemiologic studies. Am. J. Clin. Nutr., 81: 317S-325S
11. Al-Howiriny T, Alsheikh A, Algasoumi S, Al-Yahya M, ElTahir K, Rafatullah S (2009). Protective effect of Origanum majorana L. 'Marjoram' on various models of gastric mucosal injury in rats. Am. J. Chin. Med., 37(3): 531-545.
12. Assaf MH, Ali AA, Makboul MA, Beck JP, Anton R (1987). Preliminary study of phenolic glycosides from Origanum majorana; quantitative estimation of arbutin; cytotoxic acitivity of hydroquinone. Planta Med., 53(4): 343-345.
13. Babili FE, Bouajila J, Souchard JP, Bertrand C, Bellvert F, Fouraste I, Moulis C, Valentin A (2011). Oregano: chemical analysis and evaluation of its antimalarial, antioxidant, and cytotoxic activities. J. Food Sci., 76(3): C512-C518
14. Bhatia K, Kaur M, Atif F, Ali M, Rehman H, Rahman S, Raisuddin S (2006). Aqueous extract of Trigonella foenum-graecum L. ameliorates additive urotoxicity of buthionine sulfoximine and cyclophosphamide in mice. Food Chem. Toxicol., 44(10): 1744-1750.
15. Bhatia K, Rahman S, Ali M, Raisuddin S (2006). In vitro antioxidant activity of Juglans regia L. bark extract and its protective effect on cyclophosphamide-induced urotoxicity in mice. Redox Rep., 11(6): 273-279.
16. Barbosa LN, Rall VL, Fernandes AA, Ushimaru PI, Da SPI, Fernandes A Jr (2009). Essential oils against foodborne pathogens and spoilage bacteria in minced meat. Foodborne Pathog. Dis., 6(6): 725-728.
17. Bremness L (1994). The Complete Book of Herbs: A Practical Guide to Growing and Using Herbs-Fifth edition; Studio; Seattle Goodwill, WA, USA. ISBN 0140238026
18. Bermejo JL, Sundquist J, Hemminiki K (2009). Bladder cancer in cancer patients: population-based estimates from a large Swedish study. Br. J. Cancer, 101(7): 1091-1099.
19. Busatta C, Vidal RS, Popiolski AS, Mossi AJ, Dariva C, Rodringues MR, Corazza FC, Corazza ML, Vladimir-Oliveira J, Cansian RL (2008). Application of Origanum majorana L. essential oil as an antimicrobial agent in sausage. Food Microbiol., 25(1): 207-211.
20. Christman S (2010). Origanum majoranum. Flori-Data, Tallahassee, Florida, USA
21. Chung YK, Heo HJ, Kim EK, Kim HK, Huh TL, Lim Y, Kim SK, Shin DH (2001). Inhibitory effect of ursolic acid furified from Origanum majorana L. on the acetylcholinesterase. Mol. Cells, 11(2): 137-143.
22. Cohen SM (1998). Urinary bladder carcinogenesis. Toxicol. Pathol., 26(1): 121-127.
23. Coleman RE (2003). Current and future status of adjuvant therapy for breast cancer. Cancer 97(3 Suppl): 880-886.
24. D'Antuono LF, Elementi S (2006). Facts and perspectives of edible Lamiaceae: flavor and health, industrial exploitation, and the consumer. Acta Hortic., 723. http://www.actahort.org/books/723/723_2.htm
25. Deans SG, Svoboda KP (1990). The antimicrobial properties of marjoram (Origanum majorana L.) volatile oil. Flav. Frag. J., 5(3): 187-190.
26. DeLair SM, White RW, Kurzrock EA (2005). Secondary transitional cell carcinoma and nitrogen mustard treatment. Urology, 65(6): 1226-1227.
27. Dragano NR, De VVP, Paula FB, Della LF, Fonseca MJ, Azevedo L (2010). Influence of Marolo (Annona crassiflora Mart.) pulp intake on the modulation of mutagenic/antimutagenic processes and its action on oxidative stress in vivo. Plant Foods Hum. Nutr., 65(4): 319-325.
28. Dragland S, Senoo H, Wake K, Holte K, Blomhoff R (2003). Several culinary and medicinal herbs are important sources of dietary antioxidants. J. Nutr., 133(5): 1286-1290.
29. El-Ashmawy IM, El-Nahas AF, Salama OM (2005). Protective effect of volatile oil, alcoholic and aqueous extracts of Origanum majorana on lead acetate toxicity in mice. Basic Clin. Pharmacol. Toxicol., 97(4): 238-243.
30. El-Ashmawy IM, Amal S, Salama OM (2007a). Acute and long term safety evaluation of Origanum majorana essential oil. Alex. J. Pharm. Sci., 21: 29-35.
31. El-Ashmawy IM, Saleh A, Salama OM (2007b). Effects of marjoram volatile oil and grape seed extract on ethanol toxicity in male rats. Basic Clin. Pharmacol. Toxicol., 101(5): 320-327.
32. Faleiro L, Miguel G, Gomes S, Costa L, Venancio F, Teixeira A, Cristina-Figueiredo A, Barroso JG, Pedro LG (2005). Antibacterial and Antioxidant Activities of Essential Oils Isolated from Thymbra capitata L. (Cav.) and Origanum vulgare L. J. Agric. Food Chem., 53(21): 8162-8168
33. Force M, Sparks WS, Ronzio RA (2000). Inhibition of enteric parasites by emulsified oil of oregano in vivo. Phytother. Res., 14(3): 213-214.
34. Hamsa TP, Kuttan G (2011). Protective role of Ipomoea obscura (L.) on cyclophosphamide-induced uro-and nephrotoxicities by modulating antioxidant status and pro-inflammatory cytokine levels. Inflammopharmacology, 19(3): 155-167.
35. Hazzit M, Baaliouamer A, Leonor-Faleiro M, Graca MM (2006). Compostion of the essential oils of Thymus and Origanum species from Algeria and their antioxidant and antimicrobial activities. J. Agric. Food Chem., 54(17): 6314-6321.
36. Heo HJ, Cho HY, Hong B, Kim HK, Heo TR, Kim EK, Kim SK, Kim CJ, Shin DH (2002). Ursolic acid of Origanum majorana L. reduces Abeta-induced oxidative injury. Mol. Cells, 13(1): 5-11.
37. Hossain MB, Brunton NP, Barry-Ryan C, Martin-Diana AB, Wilkinson M (2008). Antioxidant activity of spice extracts and phenolics in comparison to synthetic antioxidants. Rasayan J. Chem., 1: 751-756.
38. Hossain MB, Brunton NP, Barry-Ryan C, Martin-Diana AB, Wilkinson M (2010a). Characterization of phenolics composition in Lamiaceae spices by LC-ESI-MS/MS. J. Agric. Food Chem., 58(19): 10576-10581. DOI: 10.1021/jf102042g
39. Hossain MB, Rai DK, Brunton NP, Martin-Diana AB, Barry-Ryan C (2010b). Characterization of phenolic compounds in marjoram (Origanum majorana L.) by LC-ESI-MS/MS. Intern. Conf. on Food Innovation, Food Innova-2010, Universidad Politechica De Valencia. [http://www.foodinnova.com/foodInnova/docu2/331.pdf]
40. Jankovic S, Radosavljevic V (2007). Risk factors for bladder cancer. Tumori, 93(1): 4-12.
41. Kelly WJ (2004). Herbal medicine handbook. Lippincott Williams Wilkins A Wolters, Kluwer Co. Pp. 289-290.
42. Leeja L, Thoppil JE (2007). Antimicrobial activity of methanol extract of Origanum majorana L. (Sweet marjoram). J. Environ. Biol., 28(1): 145-146.
43. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193(1): 265-275.
44. Machado M, Dinis AM, Salgueiro L, Cavaleiro C, Custodio JB, Sousa MC (2010). Anti-Giardia activity of phenolic-rich essential oils: effect of Thymbra capitata, Origanum virens, Thymus zygis subsp, sylvestris, and Lippia granveolens on trophozoites growth, viability, adherence, and ultrastructure. Parasitol. Res., 106(5): 1205-1215.
45. Maihail NS, Brazauskas R, Rizzo JD, Sobecks RM, Wang Z, Horowitz MM, Bolwell B, Wingard JR, Socie G (2011). Secondary solid cancers after allogeneic hematopoietic cell transplantation using busulfan-cyclophosphamide conditioning. Blood, 117(1): 316-322.
46. McCarroll N, Keshava N, Cimino M, Chu M, Dearfield K, Keshava C, Kligerman A, Owen R, Protzel A, Putzrath R, Schoeny R (2008). An evaluation of the mode of action framework for mutagenic carcinogens case study: Cyclophosphamide. Environ. Mol. Mutagen, 49(2): 117-131.
47. Meschino J (2005). Oil of Oregano: Nature's antibiotic and anti-fungal supplement. Dynamic Chiropractic Canada, www.renaisante.com 23(10): 1
48. Miron TL, Plaza M, Bahrim G, Ibariez E, Herrero M (2011). Chemical composition of biocactive pressurized extracts of Romanian aromatic plants. J. Chromatogr. A. PMID: 21163488 [ahead of print]
49. Misharina TA, Terenina MB, Krikunova NI (2009). Antioxidant properties of essential oils. Prikl. Biokhim. Mikrobiol., 45(6): 710-716.
50. Moretti M, Bonfiglioli R, Feretti D, Pavanello S, Mussi F, Villarini M, Mossa AH, Nawwar GA (2011). Free radical scavenging and antiacetylcholinestrerase activities of Origanum majorana L. essential oil. Hum. Exp. Toxicol., PMID: 21239482 [Epub ahead of print], doi: 10.1177/0960327110391686
51. Nakatani N (2000). Phenolic antioxidants from herbs and spices. Biofactors, 13(1-4): 5-11.
52. Novak J, Bitsch C, Langbehn J, Pank F, Skoula M, Gotsiou Y, Franz CM (2000). Ratios of cis-and trans-sabinene hydrate in Origanum majorana L. and Origanum microphyllum (Bentham) Vogel. Biochem. System Ecol., 28(7): 697-704.
53. Oboh G, Ogunruku OO (2010). Cyclophosphamide-induced oxidative stress in brain: protective effect of hot short pepper (Capsicum frutescens L. var. abbreviatum) Exp. Toxicol. Pathol., 62(3): 227-233.
54. Oboh G, Akomolafe TL, Adefegha SA, Adetuyi AO (2011). Attenuation of cyclophosphamide-induced neurotoxicity in rat by yellow dye extract from root of Brimstone tree (Morinda lucida). Exp. Toxicol. Pathol., PMID: 21227669. [as given by publisher]
55. Papageorgiou V, Mallouchos A, Komaitis M (2008). Investigation of the antioxidant behavior of air-and freeze-dried aromatic plant materials in relation to their phenolic content and vegetative cycle. J. Agric. Food Chem., 56(14): 5743-5752.
56. Renner HW (1986). The anticlastogenic potential of fatty acid methyl esters. Mutat. Res., 172(3): 265-269.
57. Tanira MOM, Shah AH, Khatibi A, Ageel AM (1988). Phytochemical and antimicrobial screening of some plants used in Saudi folk medicine. Pak. J. Pham. Sci., 2: 53-60.
58. Shan B, Cai YZ, Sun M, Corke H (2005). Antioxidant capacity of 26 spice extracts and characterization of their phenolic constituents. J. Agric. Food Chem., 53: 7749-7759.
59. Sladek NE (1972). Therapeutic efficacy of cyclophosphamide as a function of its metabolism. Cancer Res., 32(3): 535-542.
60. Suntar I, Akkol EK, Keles H, Oktem A, Baser KH, Yesilada E (2011). A novel wound healing ointment: a formulation of Hypericum perforatum oil and sage and oregano essential oils based on traditional Turkish knowledge. J. Ethnopharmacol., 134(1): 89-96.
61. Travis LB, Curtis RE, Climelius B, Holowaty EJ, Van LFE, Lynch CF, Hagenbeek A, Stovall M, Banks PM, Adami J (1995). Bladder and kidney cancer following cyclophosphamide therapy for non-Hodgkin's lymphoma. J. Natl. Cancer Inst., 87(7): 524-530.
62. Vagi E, Rapavi E, Hadolin M, Vasarhelyine PK, Balazs A, Biazovics A, Simandi B (2005). Phenolic and triterpenoid antioxidants from Origanum majorana L. herb and extracts obtained with different solvents. J. Agric. Food Chem., 53(1): 17-21.
63. Watanabe K, Taquchi K, Yamamoto M, Jotoku H, Tamura M (2010). Safety and tolerance of docetaxel (especially 75 mg/m2) with cyclophosphamide as adjuvant chemotherapy for Japanese patients with operable breast cancer. Gan. To Kagaku Ryoho, 37(7): 1265-1269.
64. Winters M (2006). Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology. Altern. Med. Rev. 11(4): 269-277.
65. www.renaisante.com.http://dcpracticeinsights.org/pdf_out/DCPracticeIn sights.com-Oil-of-Oregano-Natures-Antibiotic-and-Anti-Fungal-Supplement-1317836099.pdf
66. Yanishlieva NY, Marinova E, Pokorny J (2006). Natural antioxidants from herbs and spices. Eur. J. Lipid Sci. Technol., 108(9): 776-793.
67. Yazdanparast R, Shahriyary L (2008). Comparative effects of Artemisia dracunculus, Satureja hortensis and Origanum majorana on inhibition of blood platelet adhesion, aggregation and secretion. Vascul. Pharmacol., 48(1): 32-37.