A novel wound healing ointment: A formulation of Hypericum perforatum oil and sage and oregano essential oils based on traditional Turkish knowledge

Journal of Ethnopharmacology

Volumn 134, Issue 1, 2011, Pages 89-96

  Süntar, Ipek ^a   Akkol, Esra Küpeli ^a   Keleş, Hikmet ^b   Oktem, Alper ^c   Başer, Kemal Hüsnü Can ^d   Yeşilada, Erdem ^e  

^a GAZI UNIVERSITY   (Turkey)

^b AFYON KOCATEPE UNIVERSITY   (Turkey)

^c Anadolu University ^*  (Germany)

^d ANADOLU UNIVERSITY   (Turkey)

^e YEDITEPE UNIVERSITY   (Turkey)

Author keywords

Excision wound; Hypericum perforatum; Incision wound; Medicinal plants; Olive oil; Origanum majorana essential oil; Origanum minutiflorum essential oil; Salvia triloba essential oil; Tensiometer; Wound healing

Indexed keywords

ASIATICOSIDE; COLLAGENASE; ELASTASE; ESSENTIAL OIL; HYPERICUM PERFORATUM EXTRACT; OLIVE OIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG FORMULATION; DRUG MIXTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OINTMENT; OREGANO; ORIGANUM MAJORANA; ORIGANUM MINUTIFLORUM; PSEUDOMONAS AERUGINOSA; RAT; SALVIA; SALVIA TRILOBA; STAPHYLOCOCCUS AUREUS; WOUND; WOUND HEALING;

ANIMALS; HYPERICUM; MALE; MICE; OILS, VOLATILE; ORIGANUM; PLANT OILS; RATS; RATS, SPRAGUE-DAWLEY; WOUND HEALING;

CLUSIACEAE; HYPERICUM; HYPERICUM PERFORATUM; LAMIACEAE; MUS; OLEACEAE; ORIGANUM; ORIGANUM MAJORANA; ORIGANUM MINUTIFLORUM; RATTUS; SALVIA; SALVIA TRILOBA;

EID: 79952695113     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.11.061     Document Type: Article

References (30)

1. Altiok, D., Altiok, E., Tihminlioǧlu, F., 2010. Physical, antibacterial and antioxidant properties of chitosan films incorporated with tyme oil for potential wound healing applications. Journal of Materials Science: Materials in Medicine 21, 2227-2236.
2. Baytop, T., 1999. Therapy with Plants in Turkey; Today and in Future, vol. 3255. Istanbul University Publications, Istanbul, Turkey, pp. 142-144 and 166-167.
3. Chvapil, M., Chvapil, T.A., Owen, J.A., 1986. Reaction of various skin wounds in the rat to collagen sponge dressing. Journal of Surgical Research 41, 410-418. (Pubitemid 17179672)
4. Cuttle, L., Pearn, J., McMilla, J.R., Kimble, R.M., 2009. A review of first aid treatment for burn injuries. Burns 35, 768-775.
5. Dursun, N., Liman, N., Özyazgan, I., Güneş, I., Saraymen, R., 2003. Role of thymus oil in burn wound healing. Journal of Burn Care and Rehabilitation 24, 395-399. (Pubitemid 37444518)
6. Ehrlich, H.P., Hunt, T.K., 1968. The effect of cortisone and anabolic steroids on the tensile strength of healing wounds. Annals of Surgery 57, 117.
7. ESO 2000, 1999. The Complete Database of Essential Oils. Boelens Aroma Chemical Information Service, The Netherlands.
8. Fujita, T., Sezik, E., Tabata, M., Yeşilada, E., Honda, G., Takeda, Y., Tanaka, T., Takaishi, Y., 1995. Traditional medicine in Turkey. VII. Folk medicine in Middle and West Black Sea regions. Economic Botany 49, 406-422.
9. Honda, G., Yeşilada, E., Tabata, M., Sezik, E., Fujita, T., Takeda, Y., Takaishi, Y., Tanaka, T., 1996. Traditional medicine in Turkey. VI. Folk medicine in West Anatolia: Afyon, Kütahya, Denizli, Muǧla, Aydin provinces. Journal of Ethnopharmacology 53, 75-87. (Pubitemid 26257079)
10. Joulain, D., Koenig, W.A., 1998. The Atlas of Spectra Data of Sesquiterpene Hydrocarbons. EB-Verlag, Hamburg.
11. Koenig, W.A., Joulain, D., Hochmuth, D.H., 2004. Terpenoids and Related Constituents of Essential Oils. In: Hochmuth, D.H. (Ed.), Convenient and Rapid Analysis of GCMS. MassFinder 3, Hamburg, Germany.
12. Kondo, T., 2007. Timing of skin wounds. Legal Medicine 9, 109-114. (Pubitemid 46274468)
13. Küpeli Akkol, E., Koca, U., Peşin, I., Yilmazer, D., Toker, G., Yeşilada, E., 2009. Exploring the wound healing activity of Arnebia densiflora (Nordm.) Ledeb. by in vivo models. Journal of Ethnopharmacology 124, 137-141.
14. Leporatti, M.L., Ivancheva, S., 2003. Preliminary comparative analysis of medicinal plants used in the traditional medicine of Bulgaria and Italy. Journal of Ethnopharmacology 87, 123-142. (Pubitemid 36809141)
15. Lodhi, S., Pawar, R.S., Jain, A.P., Singhai, A.K., 2006. Wound healing potential of Tephrosia purpurea (Linn.) Pers. in rats. Journal of Ethnopharmacology 108, 204-210. (Pubitemid 44635026)
16. McLafferty, F.W., Stauffer, D.B., 1989. The Wiley/NBS Registry of Mass Spectral Data. J Wiley and Sons, New York.
17. Motta, G., Ratto, G.B., De Barbieri, A., Corte, G., Zardi, L., Sacco, A., Castagnola, M., 1983. Can heterologous collagen enhance the granulation tissue growth? An experimental study. The Italian Journal of Surgical Sciences 13, 101-108. (Pubitemid 14226532)
18. Neves, J.M., Matosa, C., Moutinho, C., Queirozd, G., Gomesa, L.R., 2009. Ethnopharmacological notes about ancient uses of medicinal plants in Trás-os-Montes (northern of Portugal). Journal of Ethnopharmacology 124, 270-283.
19. Peşin Süntar, I., Küpeli Akkol, E., Yilmazer, D., Baykal, T., Kirmizibekmez, H., Alper, M., Yesilada, E., 2010a. Investigations on the in vivo wound healing potential of Hypericum perforatum L. Journal of Ethnopharmacology 127, 468-477.
20. Peşin Süntar, I., Küpeli Akkol, E., Yalçin, F.N., Koca, U., Keleş, H., Yeşilada, E., 2010b. Wound healing potential of Sambucus ebulus L. leaves and isolation of an active component, quercetin 3-O-glucoside. Journal of Ethnopharmacology 129, 106-114.
21. Pilcher, B.K., Sudbeck, B.D., Dumin, J.A., Welgus, H.G., Parks, W.C., 1998. Collagenase- 1 and collagen in epidermal repair. Archives of Dermatological Research 290, 37-46.
22. Sadaf, F., Saleem, R., Ahmed, M., Ahmad, S.I., Navaid-ul, Z., 2006. Healing potential of cream containing extract of Sphaeranthus indicius on dermal wounds in guinea pigs. Journal of Ethnopharmacology 107, 161-163. (Pubitemid 44247437)
23. Sezik, E., Yeşilada, E., Tabata, M., Honda, G., Takaishi, Y., Tetsuro, F., Tanaka, T., Takeda, Y., 1997. Traditional medicine in Turkey. VIII. Folk medicine in East Anatolia; Erzurum, Erzincan, Aǧri, Kars, Iǧdir provinces. Economic Botany 51, 195-211.
24. Steflictsch, W., 2009. Wound care with essential oils after enucleation of a chronic abscess. Forschende Komplementaermedizin 16, 400-403.
25. Suguna, L., Singh, S., Sivakumar, P., Sampath, P., Chandrakasan, G., 2002. Influence of Terminalia chebula on dermal wound healing in rats. Phytotherapy Research 16, 227-231. (Pubitemid 34534947)
26. Tabanca, N., Demirci, F., Ozek, T., Tumen, G., Baser, K.H.C., 2001. Composition and antimicrobial activity of the essential oil of Origanum dolichosiphon P.H. Davis. Chemistry of Natural Products 37, 238-241.
27. Tramontina, V.A., Machado, M.A., Nogueira Filho Gda, R., Kim, S.H., Vizzioli, M.R., Toledo, S., 2002. Effect of bismuth subgallate (local hemostatic agent) on wound healing in rats. Histological and histometric findings. Brazilian Dental Journal 13, 11-16.
28. Yesilada, E., Honda, G., Sezik, E., Tabata, M., Goto, K., Ikeshiro, Y., 1993. Traditional Medicine in Turkey. IV. Folk Medicine in the Mediterranean subdivision. Journal of Ethnopharmacology 39, 31-38. (Pubitemid 23191351)
29. Yesilada, E., Honda, G., Sezik, E., Tabata, M., Fujita, T., Tanaka, T., Takeda, Y., Takaishi, Y., 1995. Traditional medicine in Turkey. V. Folk medicine in the inner Taurus Mountains. Journal of Ethnopharmacology 46, 133-152.
30. Yesilada, E., Sezik, E., Honda, G., Takaishi, Y., Takeda, Y., Tanaka, T., 1999. Traditional medicine in Turkey. IX. Folk medicine in north-west Anatolia. Journal of Ethnopharmacology 64, 195-210. (Pubitemid 29170204)