Cyclophosphamide-induced oxidative stress in brain: Protective effect of hot short pepper (Capsicum frutescens L. var. abbreviatum)

Experimental and Toxicologic Pathology

Volumn 62, Issue 3, 2010, Pages 227-233

  Oboh, Ganiyu ^a   Ogunruku, Omodesola O ^a  

^a FEDERAL UNIVERSITY OF TECHNOLOGY   (Nigeria)

Author keywords

Antioxidant; Brain; Cyclophosphamide; Pepper; Phenol

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CYCLOPHOSPHAMIDE; MALONALDEHYDE; PHENOL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BRAIN; CAPSICUM FRUTESCENS; CONTROLLED STUDY; ENZYME INHIBITION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PEPPER; PERICARP; PLANT SEED; RAT;

ANIMALS; ANTIOXIDANTS; BRAIN; BRAIN CHEMISTRY; CAPSICUM; CYCLOPHOSPHAMIDE; FRUIT; IMMUNOSUPPRESSIVE AGENTS; LIPID PEROXIDATION; MALONDIALDEHYDE; OXIDATIVE STRESS; PHENOLS; PLANT EXTRACTS; RATS; SEEDS;

CAPSICUM FRUTESCENS; RATTUS;

EID: 77952891808     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2009.03.011     Document Type: Article

References (37)

1. Arumugam N., Sivakumar V., Thanislass J., Devaraj H. Effects of acrolein on rat liver antioxidant defense system. Indian J Exp Biol 1997, 35:1373-1374.
2. Belle N.A.V., Dalmolin G.D., Fonini G., Rubim M.A., Rocha J.B.T. Polyamines reduces lipid peroxidation induced by different pro-oxidant agents. Brain Res 2004, 1008:245-251.
3. Bhatia A.L., Manda K., Patni S., Sharma A.L. Prophylactic action of linseed (Linum usitatissimum) oil against cyclophosphamide-induced oxidative stress on mouse brain. J Med Food 2006, 9:21-264.
4. Chu Y., Sun J., Wu X., Liu R.H. Antioxidant and antiproliferation activity of common vegetables. J Agric Food Chem 2002, 50:6910-6916.
5. Conforti F., Giancarlo A., Statti G.A., Menichini F. Chemical and biological variability of hot pepper fruits (Capsicum annuum var. acuminatum L.) in relation to maturity stage. Food Chem 2007, 102:1096-1104.
6. Daood H.G., Vinkler M., Markus F., Hebshi E.A., Biacs P.A. Antioxidant vitamin content of spice red pepper (paprika) as affected by technological and varietal factors. Food Chem 1996, 55:365-372.
7. Dasmalchi K., Dorman H.J.D., Kosar M., Hiltunen R. Chemical composition and in vitro antioxidant evaluation of a water soluble Moldavian balm (Dracocephalum moldavica L.) extract. Lebensm Wiss Technol 2007, 40:239-248.
8. Doblado R., Zielinski H., Piskula M., Kozlowska H., Munoz R., Friäas J., et al. Effect of processing on the antioxidant vitamins and antioxidant capacity of Vigna sinensis var. carilla. J Agric Food Chem 2005, 53:1215-1222.
9. Dollery C. Cyclophosphamide. Therapeutic drugs 1999, 349-353. Churchill Livingstone, Edinburg. C. Dollery (Ed.).
10. Gyamfi M.A., Yonamine M., Aniya Y. Free-radical scavenging action of medicinal herbs from Ghana: Thonningia sanguinea on experimentally-induced liver injuries. Genet Pharmacol 1999, 32:661-667.
11. Kern J.C., Kehrer J.P. Acrolein-induced cell death: a caspase influenced decision between apoptosis and oncosis/necrosis. Chem Biol Interact 2002, 139:79-95.
12. Krinsky N.I. Carotenoids as antioxidants. Nutrition 2001, 17:815-817.
13. Krinsky N.I. The biological properties of carotenoids. Pure Appl Chem 1994, 66:1003-1010.
14. Ludeman S.M. The chemistry of the metabolites of cyclophosphamide. Curr Pharm Des 1999, 5:627-643.
15. Marin A., Ferreres F., Tomas-Barberan F.A., Gil M.J. Characterization and quantitation of antioxidant constituents of sweet pepper (Capsicum annuum L.). J Agric Food Chem 2004, 52:3861-3869.
16. Markus T., Daood H.G., Kapitany J., Biacs P.A. Changes in the carotenoid and antioxidant content of spice red pepper (paprika) as a function of ripening and some technological factors. J Agric Food Chem 1999, 47:100-107.
17. Materska M., Perucka I. Antioxidant activity of the main phenolic compounds isolated from hot pepper fruits (Capsicum annuum L.). J Agric Food Chem 2005, 53:1730-1758.
18. Matsufuji H., Nakamura H., Chino M., Takeda M. Antioxidant activity of capsantin and the fatty acid esters in paprika (Capsicum annuum). J Agric Food Chem 1998, 46:3468-3472.
19. Mythili Y., Sudharsan P.T., Sulvakumar E., Varalakshmi P. Protective effect of dl-α-lipoic acid on cyclophosphamide induced oxidative cardiac injury. Chem Biol Interact 2004, 15:13-19.
20. Oboh G., Rocha J.B.T. Distribution and antioxidant activity of polyphenols in ripe and unripe tree pepper (Capsicum pubescens). J Food Biochem 2007, 31:456-473.
21. Oboh G., Akindahunsi A.A. Nutritional and toxicological evaluation of Saccharomyces cerevisae fermented cassava flour. J Food Compos Anal 2005, 18:731-738.
22. Oboh G., Rocha J.B.T. Distribution and antioxidant activity of polyphenols in ripe and unripe tree pepper (Capsicum pubescens). J Food Biochem 2007, 31:456-473.
23. Oboh G., Rocha J.B.T. Polyphenols in red pepper [Capsicum annuum var. aviculare (Tepin)] and their protective effect on some pro-oxidant induced lipid peroxidation in brain and liver. Eur Food Res Technol 2007, 225:239-247.
24. Oboh G., Akindahunsi A.A. Changes in the ascorbic acid, total phenol content and antioxidant activity of some sun dried green leafy vegetables in Nigeria. Nutr Health 2004, 18:29-36.
25. 2+-induced lipid peroxidation in brain - in vitro. Food Chem 2007, 102:178-185.
26. Oboh G. Antioxidant properties of some commonly consumed and underutilized tropical legumes. Eur Food Res Technol 2006, 244:61-65.
27. Oboh G. Hepatoprotective property of ethanolic and aqueous extracts of fluted pumpkin (Telfaria occidentalis) leaves against garlic-induced oxidative stress. J Med Food 2006, 8:560-563.
28. Odeigah P.G.C., Oboh B., Aghalolepe I.O. The characterization of Nigerian varieties of pepper, Capsicum annuum and Capsicum frutescens by SDS-polyacrylamide gel electrophoresis of seed protein. Genet Resour Crop Evol 1999, 46:127-131.
29. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reactions. Anal Biochem 1979, 95:351-358.
30. Oyaizu M. Studies on products of browning reaction: antioxidative activity of products of browning reaction prepared from glucosamine. Japan J Nutr 1986, 44:307-315.
31. Perry S.W., Norman J.P., Litzburg A., Gelbard H A. Antioxidants are required during the early critical period, but not later, for neuronal survival. J Neurosci Res 2004, 78:485-492.
32. Senthilkumar S., Yogerta S.K., Subashini R., Deraki T. Attenuation of cyclophosphamide induced toxicity by squalene in experimental rats. Chem Biol Interact 2006, 160:252-260.
33. Shulman R.G., Rothman D.L., Behar K.L., Hyder F. Energetic basis of brain activity: implications for neuroimaging. Trends Neurosci 2004, 27:489-495.
34. Singleton V.L., Orthofor R., Lamuela-Raventos R.M. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocaltau reagent. Methods Enzymol 1999, 299:152-178.
35. Sulkowska M., Skrzydlewska E., Sobaniec-Łotowska M., Famulski W.S., Terlikowski S., Kańczuga-Koda L., et al. Effect of cyclophosphamide-induced generation reactive oxygen forms on ultrastructure of the liver and lung. Bull Vet Inst Pulawy 2002, 46:239-246.
36. Sun J., Chu Y.F., Wu X., Liu R.H. Antioxidant and antiproliferation activities of common fruits. J Agric Food Chem 2002, 50:7449-7454.
37. Zar J.H. Biostatistical analysis 1984, Prentice-Hall, Upper Saddle River, NJ.