Molecular characterization of an acidic phospholipase A 2 from Bothrops pirajai snake venom: Synthetic C-terminal peptide identifies its antiplatelet region

Archives of Toxicology

Volumn 85, Issue 10, 2011, Pages 1219-1233

  Teixeira, Sabrina S ^a   Silveira, Lucas B ^a   Da Silva, Franco M N ^a   Marchi Salvador, Daniela P ^a,b   Silva Jr , Floriano P ^c   Izidoro, Luiz Fernando M ^a,d   Fuly, André L ^e   Juliano, Maria A ^f   Dos Santos, Camila R ^g   Murakami, Mário T ^g   Sampaio, Suely V ^a   Da Silva, Saulo L ^h   Soares, Andreimar M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

^d FEDERAL UNIVERSITY OF UBERLÂNDIA   (Brazil)

^e FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^f FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^g BRAZILIAN CENTER FOR RESEARCH IN ENERGY AND MATERIALS CNPEM   (Brazil)

^h FEDERAL UNIVERSITY OF SÃO JOÃO DEL REI   (Brazil)

Author keywords

Acidic phospholipase A 2; Antiplatelet domain; Biochemical and pharmacological characterization; Bothrops pirajai; Snake venom

Indexed keywords

ACIDIC PHOSPHOLIPASE A2; CALCIUM ION; COMPLEMENTARY DNA; DNA FRAGMENT; PHOSPHOLIPASE A2; RNA; SNAKE VENOM; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; BOTHROPS PIRAJAI; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CLADISTICS; CONTROLLED STUDY; EDEMA; ELECTRIC POTENTIAL; ELECTROSTATIC SURFACE POTENTIAL; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ISOLATION; GENOME SIZE; HYPOTENSION; MALE; MOLECULAR BIOLOGY; MOLECULAR CLONING; MOUSE; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN DOMAIN; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SNAKE; TOXIN ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BAYES THEOREM; BOTHROPS; CLONING, MOLECULAR; CROTALID VENOMS; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYPOTENSION; MALE; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PHOSPHOLIPASES A2; PHYLOGENY; PLATELET AGGREGATION INHIBITORS; RABBITS;

BOTHROPS; BOTHROPS PIRAJAI;

EID: 80755175916     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0665-6     Document Type: Article

References (62)

1. 2 in Bothrops snake venoms: effects of chemical modifications on the enzymatic and pharmacological properties of Bothropstoxins from Bothrops jararacussu Biochimie 82 755 763 11018293 10.1016/S0300-9084(00)01150-0
2. 2 from Bothrops jararacussu snake venom Biochem Pharmacol 64 723 732 12167491 10.1016/S0006-2952(02)01210-8
3. 2-a structural review Toxicon 34 827 841 8875770 10.1016/0041-0101(96)00036-0 1:CAS:528: DyaK28XlsFalsr0%3D (Pubitemid 26273993)
4. JU Bowie R Luthy D Eisenberg 1991 A method to identify protein sequences that fold into a known three-dimensional structure Science 253 164 169 1853201 10.1126/science.1853201 1:CAS:528:DyaK3MXltV2qsbk%3D
5. 2 from the venom of Bothrops insularis (jararaca ilhoa) Biochimie 88 1947 1959 17140721 10.1016/j.biochi.2006.10.006 1:CAS:528:DC%2BD28Xhtlarur3P (Pubitemid 44889271)
6. 2+-independent catalytic mechanism Biochim Biophys Acta 1784 591 599 18261474 1:CAS:528: DC%2BD1cXjtlChur4%3D
7. 2 isolated from Bothrops brazili snake venom and synthetic peptides derived from their C-terminal region: cytotoxic effect on microorganism and tumor cells Peptides 29 10 1645 1656 18602430 10.1016/j.peptides.2008.05.021 1:CAS:528:DC%2BD1cXhtFCkur3N
8. 2 release by endothelial cells Biochem Pharmacol 72 377 384 16750518 10.1016/j.bcp.2006.04.032 (Pubitemid 43975087)
9. GH De Haas NM Postema W Nieuwenhuizen LLM van Deenen 1968 Purification and properties of Phospholipase A from porcine pancreas Biochim Biophys Acta 159 103 117 4967810
10. 2 from snake venoms Protein Pept Lett 16 899 907 19689416 10.2174/092986609788923365
11. 2 from Bothrops genus reveal their myotoxic site J Struct Biol 167 106 116 19401234 10.1016/j.jsb.2009.04.003 1:CAS:528:DC%2BD1MXosVGhurk%3D
12. RC Edgar 2004 MUSCLE: multiple sequence alignment with high accuracy and high throughput Nucleic Acids Res 32 1792 1797 15034147 10.1093/nar/gkh340 1:CAS:528:DC%2BD2cXisF2ks7w%3D (Pubitemid 38832724)
13. 2 from the venom of the snake Bothrops asper of Costa Rica: biochemical and toxicological characterization Biochimie 92 273 283 20026168 10.1016/j.biochi.2009.12.006
14. 2 isoenzyme isolated from Lachesis muta snake venom Biochem Pharmacol 63 1589 1597 12007562 10.1016/S0006-2952(02)00873-0 1:CAS:528:DC%2BD38XjsVSksbk%3D (Pubitemid 34457998)
15. 2-like BthTX-I and a synthetic peptide derived from its C-terminal region Biologicals 37 4 222 229 19264509 10.1016/j.biologicals.2009.01.010 1:CAS:528:DC%2BD1MXptVShsrs%3D
16. GH Gonnet MA Cohen SA Benner 1992 Exhaustive matching of the entire protein sequence database Science 256 1443 1445 1604319 10.1126/science.1604319 1:CAS:528:DyaK38Xks12hs7k%3D
17. C Guda ED Scheeff PE Bourne IN Shindyalov 2001 A new algorithm for the alignment of multiple protein structures using Monte Carlo optimization Pac Symp Biocomput 6 275 286
18. 2 enzymes: structure, function and mechanism. Wiley, Chichester, pp 321-352
19. JM Gutiérrez C Avila E Rojas L Cerdas 1988 An alternative in vitro method for testing the potency of the polyvalent antivenom produced in Costa Rica Toxicon 26 411 413 3406951 10.1016/0041-0101(88)90010-4
20. TA Hall 1999 BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT Nucl Acids Symp Ser 41 95 98 1:CAS:528:DC%2BD3cXhtVyjs7Y%3D
21. 2; notexin and taipoxin Exp Neurol 161 517 526 10686073 10.1006/exnr.1999.7275 1:CAS:528:DC%2BD3cXht1OntLw%3D (Pubitemid 30137011)
22. 2, from Vipera russelli (Russell's viper) snake venom Toxicon 22 207 217 6729839 10.1016/0041-0101(84)90021-7 1:CAS:528: DyaL2cXktFykt7o%3D (Pubitemid 14143412)
23. DT Jones WR Taylor JM Thornton 1992 The rapid generation of mutation data matrices from protein sequences Comp Appl Biosci 8 275 282 1633570 1:CAS:528:DyaK38Xlt1Okt7w%3D
24. 2 isoforms from Bothrops jararacussu snake venom Biochimie 85 983 991 14644553 10.1016/j.biochi.2003.09. 011 1:CAS:528:DC%2BD3sXptlOls78%3D (Pubitemid 38008092)
25. B Korkmaz S Attucci MA Juliano T Kalupov ML Jourdan L Juliano F Gauthier 2008 Measuring elastase, proteinase 3 and cathepsin G activities at the surface of human neutrophils with fluorescence resonance energy transfer substrates Nat Protoc 3 991 1000 18536646 10.1038/nprot.2008.63 1:CAS:528:DC%2BD1cXmvVemtrc%3D (Pubitemid 351818687)
26. UK Laemmli 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 680 685 5432063 10.1038/227680a0 1:CAS:528:DC%2BD3MXlsFags7s%3D
27. RA Laskowski MW MacArthur DS Moss JM Thornton 1993 PROCHECK: a program to check the stereochemical quality of protein structures J Appl Cryst 26 283 291 10.1107/S0021889892009944 1:CAS:528:DyaK3sXit12lurY%3D
28. 2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action Toxicon 42 885 901 15019489 10.1016/j.toxicon.2003.11.008 1:CAS:528:DC%2BD2cXhtVehsL8%3D (Pubitemid 38201490)
29. 2 from snake venoms Toxicon 42 307 312 14559083 10.1016/S0041-0101(03)00149-1 1:CAS:528:DC%2BD3sXnvFGmtLc%3D (Pubitemid 37338168)
30. B Lomonte Y Angulo E Moreno 2010 Synthetic peptides derived from the C-terminal region of Lys49 phospholipase A2 homologues from viperidae snake venoms: biomimetic activities and potential applications Curr Pharm 16 28 3224 3230 10.2174/138161210793292456 1:CAS:528:DC%2BC3cXhsVKlurvI
31. 2 J Nat Toxins 11 25 33 11829058 (Pubitemid 34128544)
32. R Luthy JU Bowie D Eisenberg 1992 Assessment of protein models with three-dimensional profiles Nature 356 83 85 1538787 10.1038/356083a0 1:STN:280:DyaK387mvVWluw%3D%3D
33. MacKerell AD Jr, Brooks B, Brooks CL III, Nilsson L, Roux B, Won Y, Karplus M (1998) CHARMM: the energy function and its paramerization with an overview of the program. In: Schleyer PVR, Allinger NL, Clark T, Gasteiger J, Kollman PA, Schaefer HF III, Schreiner PR (eds) Encyclopedia of computational chemistry. Wiley, Chichester, pp 271-277
34. AJ Magro AAS Takeda AM Soares MRM Fontes 2005 Structure of BthA-I complexed with p-bromophenacyl bromide: possible correlations with lack of pharmacological activity Acta Crystallogr D 61 1670 1677 16301802 10.1107/S0907444905029598 (Pubitemid 43943127)
35. 2 from Bothrops jararacussu venom complexed with p-bromophenacyl bromide Acta Crystallogr 62F 600 603 (Pubitemid 43892151)
36. 2 formed by two isoforms of crotoxin B from Crotalus durissus terrificus venom Proteins 72 883 891 18275084 10.1002/prot.21980 1:CAS:528:DC%2BD1cXos1Grtbs%3D (Pubitemid 352000866)
37. 2 homologue complexed with p-bromophenacyl bromide reveals important structural changes associated with the inhibition of myotoxic activity Biochim Biophys Acta 1794 1583 1590 19616648 1:CAS:528:DC%2BD1MXhtFGqsb%2FE
38. 2+ free and bound states Biochimie 88 543 549 16376474 10.1016/j.biochi.2005.10.014 1:CAS:528:DC%2BD28XmtVOksLc%3D (Pubitemid 43867904)
39. LA Murillo CY Lan NM Agabian S Larios B Lomonte 2007 Fungicidal activity of a phospholipase-A2-derived synthetic peptide variant against Candida albicans Rev Esp Quimioter 20 3 330 333 18080030 (Pubitemid 350240492)
40. C Notredame DG Higgins J Heringa 2000 T-Coffee: a novel method for fast and accurate multiple sequence alignment J Mol Biol 302 205 217 10964570 10.1006/jmbi.2000.4042 1:CAS:528:DC%2BD3cXmtVGntr8%3D
41. T Ogawa K-I Nakashima I Nobuhisa M Deshimaru Y Shimohigashi Y Fukumak Y Sakaki S Hattori M Ohno 1996 Accelerated evolution of snake venom phospholipase a, isozymes for acquisition of diverse physiological functions Toxicon 34 1229 1236 9027978 10.1016/S0041-0101(96)00112-2 1:CAS:528:DyaK2sXhtVWqt7o%3D (Pubitemid 27051446)
42. 2 from snake venom Toxicon 42 841 854 15019486 10.1016/j.toxicon.2003.11.003 1:CAS:528:DC%2BD2cXhtVehs7Y%3D (Pubitemid 38201487)
43. 2 proteins Toxicon 37 411 445 10080349 10.1016/S0041-0101(98)00188-3 1:CAS:528:DyaK1MXht1aru7w%3D (Pubitemid 29088240)
44. 2 from bovine pancreas and Crotalus atrox venom J Biol Chem 260 11627 11636 4044572 1:CAS:528: DyaL2MXlsFKnsrs%3D
45. 2 cDNA from Bothrops jararacussu venom gland Protein Expr Purif 37 102 108 15294287 10.1016/j.pep.2004.05.020 1:CAS:528:DC%2BD2cXmt1Cmu78%3D (Pubitemid 39027249)
46. W Rocchia E Alexov B Honig 2001 Extending the applicability of the nonlinear poisson-boltzmann equation: multiple dielectric constants and multivalent ions J Phys Chem 105B 6507 6514 (Pubitemid 35339019)
47. 2 from Bothrops pauloensis snake venom Toxicon 50 153 165 17451767 10.1016/j.toxicon.2007.03.005 1:CAS:528:DC%2BD2sXmtVSksbY%3D (Pubitemid 46836720)
48. F Ronquist JP Huelsenbeck 2003 MRBAYES 3: Bayesian phylogenetic inference under mixed models Bioinformatics 19 1572 1574 12912839 10.1093/bioinformatics/ btg180 1:CAS:528:DC%2BD3sXntlKms7k%3D (Pubitemid 37038874)
49. A Sali TL Blundell 1993 Comparative protein modelling by satisfaction of spatial restraints J Mol Biol 234 779 815 8254673 10.1006/jmbi.1993.1626 1:CAS:528:DyaK2cXnt1ylug%3D%3D (Pubitemid 24007801)
50. 2 isolated from Bothrops moojeni snake venom Toxicon 52 908 917 18929590 10.1016/j.toxicon.2008.08.020 1:CAS:528:DC%2BD1cXhsVKntbjE
51. 2 superfamily and its group numbering system Biochim Biophys Acta 1761 1246 1259 16973413 1:CAS:528:DC%2BD28Xht1CisLvM (Pubitemid 44755364)
52. 2, from the venom of the snake Bothrops jararaca: purification, primary structure analysis, and its characterization as a platelet-aggregation- inhibiting factor Arch Biochem Biophys 367 26 32 10375395 10.1006/abbi.1999.1230 1:CAS:528:DyaK1MXjvVOgtbo%3D (Pubitemid 29394189)
53. MY Shen A Sali 2006 Statistical potential for assessment and prediction of protein structures Protein Sci 15 2507 2524 17075131 10.1110/ps.062416606 1:CAS:528:DC%2BD28XhtFygsrfO (Pubitemid 44771688)
54. K Simons D Toomre 2000 Lipid rafts and signal transduction Nat Rev Mol Cell Biol 1 31 39 11413487 10.1038/35036052 1:CAS:528:DC%2BD3MXivVGjtbo%3D
55. D Sitkoff KA Sharp B Honig 1994 Accurate calculation of hydration free energies using macroscopic solvent models J Phys Chem 98 1978 1988 10.1021/j100058a043 1:CAS:528:DyaK2cXhsVGrsrs%3D
56. D Sitkoff DJ Lockhart KA Sharp B Honig 1994 Calculation of electrostatic effects at the amino terminus of an alpha helix Biophys J 67 2251 2260 7696466 10.1016/S0006-3495(94)80709-X 1:CAS:528:DyaK2MXisVajtb8%3D (Pubitemid 24369647)
57. 2 from snake venoms: effects on catalytic and pharmacological properties Toxicon 42 855 868 15019487 10.1016/j.toxicon.2003.11.004 1:CAS:528:DC%2BD2cXhtVehs7c%3D (Pubitemid 38201488)
58. 2 myotoxins from Bothrops snake venoms: structure-function relationship Curr Org Chem 8 1 14 10.2174/1385272043369610 (Pubitemid 39377879)
59. 2? Biochimie 82 815 831 11086212 10.1016/S0300-9084(00)01168-8 1:CAS:528:DC%2BD3cXovFahsbk%3D
60. O Vesterberg 1972 Isoelectric focusing of proteins in polyacrylamide gels Biochim Biophys Acta 257 11 13 4109859 1:CAS:528:DyaE38Xps1Gntw%3D%3D
61. S Whelan N Goldman 2001 A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach Mol Biol Evol 18 691 699 11319253 1:CAS:528:DC%2BD3MXjtFyktr4%3D (Pubitemid 32372940)
62. Zuccon A, Zuccon D (2008) Program distributed by the authors. http://www.mrent.org