Structural and functional characterization of an acidic platelet aggregation inhibitor and hypotensive phospholipase A2 from Bothrops jararacussu snake venom

Biochemical Pharmacology

Volumn 64, Issue 4, 2002, Pages 723-732

  Andrião Escarso, Sílvia H ^a   Soares, Andreimar M ^a,b   Fontes, Marcos R M ^c   Fuly, André L ^d   Corrêa, Fernando M A ^a   Rosa, José C ^a   Greene, Lewis J ^a   Giglio, José R ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF RIBEIRÃO PRETO   (Brazil)

^c SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^d FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Acidic phospholipase A2; Bothrops jararacussu; Hypotensive effect; N terminal sequence; Platelet aggregation inhibition; X ray crystallography

Indexed keywords

4 BROMOPHENACYL BROMIDE; ACID PROTEIN; AMINO ACID DERIVATIVE; ANTITHROMBOCYTIC AGENT; BATROXOBIN; EDETIC ACID; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR;

AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; CHEMICAL MODIFICATION; CONTROLLED STUDY; COVALENT BOND; CROSS REACTION; CRYSTAL; CYTOTOXICITY; DRUG ISOLATION; ION EXCHANGE CHROMATOGRAPHY; MYCOTOXICOSIS; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEQUENCE HOMOLOGY; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION;

AMINO ACID SEQUENCE; ANIMALS; ANTIHYPERTENSIVE AGENTS; BOTHROPS; CROTALID VENOMS; CRYSTALLOGRAPHY, X-RAY; MOLECULAR SEQUENCE DATA; PHOSPHOLIPASES A; PLATELET AGGREGATION INHIBITORS; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0037103457     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01210-8     Document Type: Article

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