Crystal structure of a phospholipase A2 homolog complexed with p-bromophenacyl bromide reveals important structural changes associated with the inhibition of myotoxic activity

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1794, Issue 11, 2009, Pages 1583-1590

  Marchi Salvador, Daniela P ^a   Fernandes, Carlos A H ^a   Silveira, Lucas B ^b   Soares, Andreimar M ^b   Fontes, Marcos R M ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bothrops pirajai venom; Myotoxicity; p Bromophenacyl bromide inhibitor; Phospholipase A2 homolog; X ray crystallography

Indexed keywords

4 BROMOPHENACYL BROMIDE; ALPHA TOCOPHEROL; CALCIUM; HISTIDINE DERIVATIVE; HYDROGEN; LYSINE DERIVATIVE; MONOMER; PHOSPHOLIPASE A2; SNAKE VENOM; TYROSINE DERIVATIVE;

ARTICLE; CALCIUM BINDING; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; COMPARATIVE STUDY; CRYSTAL STRUCTURE; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; HYDROGEN BOND; MUSCLE NECROSIS; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ACETOPHENONES; ANIMALS; BOTHROPS; CROTALID VENOMS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; LYSINE; MODELS, MOLECULAR; PHOSPHOLIPASES A2; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION;

BOTHROPS PIRAJAI; VIPERIDAE;

EID: 70349169826     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2009.07.005     Document Type: Article

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