BE-I-PLA2, a novel acidic phospholipase A2 from Bothrops erythromelas venom: Isolation, cloning and characterization as potent anti-platelet and inductor of prostaglandin I2 release by endothelial cells

Biochemical Pharmacology

Volumn 72, Issue 3, 2006, Pages 377-384

  de Albuquerque Modesto, Jeanne Claine ^a,d   Spencer, Patrick J ^b   Fritzen, Márcio ^a   Valença, Renata C ^d   Oliva, Maria Luíza Vilela ^c   da Silva, Marcia Bezerra ^d   Chudzinski Tavassi, Ana Marisa ^a   Guarnieri, Miriam Camargo ^d  

^a INSTITUTO BUTANTAN   (Brazil)

^b INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES   (Brazil)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^d FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

Author keywords

Endothelial cells; Nitric oxide; Phospholipase A2; Platelet; Platelet receptors; Prostaglandin I2; Snake venoms

Indexed keywords

4 BROMOPHENACYL BROMIDE; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; COLLAGEN; COMPLEMENTARY DNA; PHOSPHOLIPASE A2; PROSTACYCLIN; SNAKE VENOM; THROMBOCYTE RECEPTOR; TOXIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BOTHROPS ERYTHROMELAS; CELL STIMULATION; CHEMICAL MODIFICATION; CONTROLLED STUDY; DNA LIBRARY; DNA SEQUENCE; DRUG ISOLATION; DRUG POTENCY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME ISOLATION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MOLECULAR CLONING; MOLECULAR WEIGHT; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; SNAKE; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE RICH PLASMA; UMBILICAL VEIN;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BOTHROPS; CELL PROLIFERATION; CELLS, CULTURED; CLONING, MOLECULAR; CROTALID VENOMS; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; EPOPROSTENOL; FEMALE; HUMANS; MALE; MOLECULAR SEQUENCE DATA; PHOSPHOLIPASES A; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; SEQUENCE ANALYSIS, DNA; SEQUENCE ANALYSIS, PROTEIN; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 33745641891     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.04.032     Document Type: Article

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