EW-7195, a novel inhibitor of ALK5 kinase inhibits EMT and breast cancer metastasis to lung

European Journal of Cancer

Volumn 47, Issue 17, 2011, Pages 2642-2653

  Park, Chul Yong ^a   Son, Jee Yeon ^a   Jin, Cheng Hua ^a   Nam, Jeong Suk ^b   Kim, Dae Kee ^a   Sheen, Yhun Yhong ^a  

^a Ewha Womans University   (South Korea)

^b Gachon University College of Medicine   (South Korea)

Author keywords

ALK5 inhibitor; Breast cancer; Epithelial to mesenchymal transition; Metastasis; TGF

Indexed keywords

3 [[4 ([1,2,4]TRIAZOLO[1,5 ALPHA-PYRIDIN 6 YL) 5 (6 METHYLPYRIDIN 2 YL) 1H IMIDAZOL 2 YL]METHYLAMINO]BENZONITRILE; ANTIMETASTATIC AGENT; EW 7195; PROTEIN SERINE THREONINE KINASE INHIBITOR; SMAD2 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL CULTURE; CELL ASSAY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VIVO STUDY; INTRACELLULAR SIGNALING; LUNG METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TRANSACTIVATION; TUMOR XENOGRAFT; WOUND HEALING;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HEP G2 CELLS; HUMANS; LUCIFERASES; LUNG NEOPLASMS; MICE; MICE, TRANSGENIC; NEOPLASM INVASIVENESS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SMAD2 PROTEIN; TRIAZOLES;

EID: 80755163620     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2011.07.007     Document Type: Article

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