CDH13 is associated with working memory performance in attention deficit/hyperactivity disorder

Genes, Brain and Behavior

Volumn 10, Issue 8, 2011, Pages 844-851

  Arias Vasquez A ^a,b   Altink, M E ^a,c   Rommelse, N N J ^a   Slaats Willemse, D I E ^c   Buschgens, C J M ^a   Fliers, E A ^a   Faraone, S V ^d   Sergeant, J A ^e   Oosterlaan, J ^e   Franke, B ^a,b   Buitelaar, J K ^a  

^a RADBOUD UNIVERSITY   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^d SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^e VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Attention deficit hyperactivity disorder; CDH13 gene; Executive functioning; Haplotype analysis; Working memory

Indexed keywords

CADHERIN; CADHERIN 13; UNCLASSIFIED DRUG;

ADOLESCENT; ARTICLE; ATTENTION DEFICIT DISORDER; CELL ADHESION; CHILD; COGNITION; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENETIC ASSOCIATION; GENETIC CODE; GENETIC SUSCEPTIBILITY; HUMAN; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; NERVE CELL GROWTH; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; REGULATORY SEQUENCE; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; TASK PERFORMANCE; WORKING MEMORY;

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CADHERINS; CHILD; CHILD, PRESCHOOL; DNA; FEMALE; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; INHIBITION (PSYCHOLOGY); MALE; MEMORY, SHORT-TERM; NETHERLANDS; NEUROPSYCHOLOGICAL TESTS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHOMOTOR PERFORMANCE; REGRESSION ANALYSIS; SPACE PERCEPTION; VISUAL PERCEPTION; WECHSLER SCALES;

EID: 80755128395     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2011.00724.x     Document Type: Article

References (63)

1. Arnsten, A.F. (2011) Catecholamine influences on dorsolateral prefrontal cortical networks. Biol Psychiatry 69, e89-e99.
2. Aron, A.R. & Poldrack, R.A. (2005) The cognitive neuroscience of response inhibition: relevance for genetic research in attention-deficit/hyperactivity disorder. Biol Psychiatry 57, 1285-1292.
3. Asherson, P., Zhou, K., Anney, R.J. et al. (2008) A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16. Mol Psychiatry 13, 514-521.
4. Baddeley, A. (2010) Working memory. Curr Biol 20, R136-R140.
5. Berx, G. & van Roy, F. (2009) Involvement of members of the cadherin superfamily in cancer. Cold Spring Harb Perspect Biol 1, a003129.
6. Brookes, K., Xu, X., Chen, W. et al. (2006) The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry 11, 934-953.
7. Castellanos, F.X., Sonuga-Barke, E.J., Milham, M.P. & Tannock, R. (2006) Characterizing cognition in ADHD: beyond executive dysfunction. Trends Cogn Sci 10, 117-123.
8. Collette, F. & Van der Linden, M. (2002) Brain imaging of the central executive component of working memory. Neurosci Biobehav Rev 26, 105-125.
9. Conners, C.K., Epstein, J.N., Angold, A. & Klaric, J. (2003) Continuous performance test performance in a normative epidemiological sample. J Abnorm Child Psychol 31, 555-562.
10. Crone, E.A., Wendelken, C., Donohue, S., van Leijenhorst, L. & Bunge, S.A. (2006) Neurocognitive development of the ability to manipulate information in working memory. Proc Natl Acad Sci U S A 103, 9315-9320.
11. D'Esposito, M., Detre, J.A., Alsop, D.C., Shin, R.K., Atlas, S. & Grossman, M. (1995) The neural basis of the central executive system of working memory. Nature 378, 279-281.
12. Faraone, S.V., Perlis, R.H., Doyle, A.E., Smoller, J.W., Goralnick, J.J., Holmgren, M.A. & Sklar, P. (2005) Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry 57, 1313-1323.
13. Frank, M.J., Santamaria, A., O'Reilly, R.C. & Willcutt, E. (2007) Testing computational models of dopamine and noradrenaline dysfunction in attention deficit/hyperactivity disorder. Neuropsychopharmacology 32, 1583-1599.
14. Franke, B., Neale, B.M. & Faraone, S.V. (2009) Genome-wide association studies in ADHD. Hum Genet 126, 13-50.
15. Gathercole, S.E. (1998) The development of memory. J Child Psychol Psychiatry 39, 3-27.
16. Gathercole, S.E. (1999) Cognitive approaches to the development of short-term memory. Trends Cogn Sci 3, 410-419.
17. Gathercole, S.E. & Pickering, S.J. (2000) Working memory deficits in children with low achievements in the national curriculum at 7 years of age. Br J Educ Psychol 70, 177-194.
18. Goldman-Rakic, P.S. (1996) Regional and cellular fractionation of working memory. Proc Natl Acad Sci U S A 93, 13473-13480.
19. Goodman, R. (2001) Psychometric properties of the strengths and difficulties questionnaire. J Am Acad Child Adolesc Psychiatry 40, 1337-1345.
20. Gottesman, I.I. & Gould, T.D. (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160, 636-645.
21. Jacobson, L.A., Ryan, M., Martin, R.B., Ewen, J., Mostofsky, S.H., Denckla, M.B. & Mahone, E.M. (2011) Working memory influences processing speed and reading fluency in ADHD. Child Neuropsychol, 17, 209-224.
22. Karatekin, C. (2004) A test of the integrity of the components of Baddeley's model of working memory in attention-deficit/hyperactivity disorder (ADHD). J Child Psychol Psychiatry 45, 912-926.
23. Kempton, S., Vance, A., Maruff, P., Luk, E., Costin, J. & Pantelis, C. (1999) Executive function and attention deficit hyperactivity disorder: stimulant medication and better executive function performance in children. Psychol Med 29, 527-538.
24. Kofler, M.J., Rapport, M.D., Bolden, J., Sarver, D.E., Raiker, J.S. & Alderson, R.M. (2011) Working memory deficits and social problems in children with ADHD. J Abnorm Child Psychol 39, 805-817.
25. Kuntsi, J., Neale, B.M., Chen, W., Faraone, S.V. & Asherson, P. (2006) The IMAGE project: methodological issues for the molecular genetic analysis of ADHD. Behav Brain Funct 2, 27.
26. Lasky-Su, J., Neale, B.M., Franke, B. et al. (2008) Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. Am J Med Genet B Neuropsychiatr Genet 147B, 1345-1354.
27. Logan, G.D., Cowan, W.B. & Davis, K.A. (1984) On the ability to inhibit simple and choice reaction time responses: a model and a method. J Exp Psychol Hum Percept Perform 10, 276-291.
28. Manolio, T.A., Brooks, L.D. & Collins, F.S. (2008) A HapMap harvest of insights into the genetics of common disease. J Clin Invest 118, 1590-1605.
29. Manolio, T.A., Collins, F.S., Cox, N.J. et al. (2009) Finding the missing heritability of complex diseases. Nature 461, 747-753.
30. Martinussen, R., Hayden, J., Hogg-Johnson, S. & Tannock, R. (2005) A meta-analysis of working memory impairments in children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 44, 377-384.
31. McInnes, A., Humphries, T., Hogg-Johnson, S. & Tannock, R. (2003) Listening comprehension and working memory are impaired in attention-deficit hyperactivity disorder irrespective of language impairment. J Abnorm Child Psychol 31, 427-443.
32. Neale, B.M., Lasky-Su, J., Anney, R. et al. (2008) Genome-wide association scan of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 147B, 1337-1344.
33. Neale, B.M., Medland, S.E., Ripke, S. et al. (2010) Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 49, 884-897.
34. Nigg, J.T., Willcutt, E.G., Doyle, A.E. & Sonuga-Barke, E.J. (2005) Causal heterogeneity in attention-deficit/hyperactivity disorder: do we need neuropsychologically impaired subtypes? Biol Psychiatry 57, 1224-1230.
35. Nikolas, M.A. & Burt, S.A. (2010) Genetic and environmental influences on ADHD symptom dimensions of inattention and hyperactivity: a meta-analysis. J Abnorm Psychol 119, 1-17.
36. O'Brien, J.W., Dowell, L.R., Mostofsky, S.H., Denckla, M.B. & Mahone, E.M. (2010) Neuropsychological profile of executive function in girls with attention-deficit/hyperactivity disorder. Arch Clin Neuropsychol 25, 656-670.
37. Oosterlaan, J. & Sergeant, J.A. (1998) Response inhibition and response re-engagement in attention-deficit/hyperactivity disorder, disruptive, anxious and normal children. Behav Brain Res 94, 33-43.
38. Oosterlaan, J., Logan, G.D. & Sergeant, J.A. (1998) Response inhibition in AD/HD, CD, comorbid AD/HD + CD, anxious, and control children: a meta-analysis of studies with the stop task. J Child Psychol Psychiatry 39, 411-425.
39. Org, E., Eyheramendy, S., Juhanson, P. et al. (2009) Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. Hum Mol Genet 18, 2288-2296.
40. Patel, S.D., Chen, C.P., Bahna, F., Honig, B. & Shapiro, L. (2003) Cadherin-mediated cell-cell adhesion: sticking together as a family. Curr Opin Struct Biol 13, 690-698.
41. Pauli-Pott, U. & Becker, K. (2011) Neuropsychological basic deficits in preschoolers at risk for ADHD: a meta-analysis. Clin Psychol Rev 31, 626-637.
42. Pennington, B.F. & Ozonoff, S. (1996) Executive functions and developmental psychopathology. J Child Psychol Psychiatry 37, 51-87.
43. Rommelse, N.N., Altink, M.E., de Sonneville, L.M., Buschgens, C.J., Buitelaar, J., Oosterlaan, J. & Sergeant, J.A. (2007a) Are motor inhibition and cognitive flexibility dead ends in ADHD? J Abnorm Child Psychol 35, 957-967.
44. Rommelse, N.N., Altink, M.E., Oosterlaan, J., Buschgens, C.J., Buitelaar, J., de Sonneville, L.M. & Sergeant, J.A. (2007b) Motor control in children with ADHD and non-affected siblings: deficits most pronounced using the left hand. J Child Psychol Psychiatry 48, 1071-1079.
45. Rommelse, N.N., Oosterlaan, J., Buitelaar, J., Faraone, S.V. & Sergeant, J.A. (2007c) Time reproduction in children with ADHD and their nonaffected siblings. J Am Acad Child Adolesc Psychiatry 46, 582-590.
46. Rommelse, N.N., Altink, M.E., Martin, N.C., Buschgens, C.J., Faraone, S.V., Buitelaar, J.K., Sergeant, J.A. & Oosterlaan, J. (2008a) Relationship between endophenotype and phenotype in ADHD. Behav Brain Funct 4, 4.
47. Rommelse, N.N., Altink, M.E., Oosterlaan, J., Beem, L., Buschgens, C.J., Buitelaar, J. & Sergeant, J.A. (2008b) Speed, variability, and timing of motor output in ADHD: which measures are useful for endophenotypic research? Behav Genet 38, 121-132.
48. Rommelse, N.N., Altink, M.E., Oosterlaan, J., Buschgens, C.J., Buitelaar, J. & Sergeant, J.A. (2008c) Support for an independent familial segregation of executive and intelligence endophenotypes in ADHD families. Psychol Med 38, 1595-1606.
49. Rommelse, N.N., Van der Stigchel, S., Witlox, J., Geldof, C., Deijen, J.B., Theeuwes, J., Oosterlaan, J. & Sergeant, J.A. (2008d) Deficits in visuo-spatial working memory, inhibition and oculomotor control in boys with ADHD and their non-affected brothers. J Neural Transm (Vienna, Austria: 1996) 115, 249-260.
50. Schaid, D.J., Rowland, C.M., Tines, D.E., Jacobson, R.M. & Poland, G.A. (2002) Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 70, 425-434.
51. Scheres, A., Dijkstra, M., Ainslie, E., Balkan, J., Reynolds, B., Sonuga-Barke, E. & Castellanos, F.X. (2006) Temporal and probabilistic discounting of rewards in children and adolescents: effects of age and ADHD symptoms. Neuropsychologia 44, 2092-2103.
52. Schweitzer, J.B., Hanford, R.B. & Medoff, D.R. (2006) Working memory deficits in adults with ADHD: is there evidence for subtype differences? Behav Brain Funct 2, 43.
53. Seidman, L.J., Biederman, J., Monuteaux, M.C., Valera, E., Doyle, A.E. & Faraone, S.V. (2005) Impact of gender and age on executive functioning: do girls and boys with and without attention deficit hyperactivity disorder differ neuropsychologically in preteen and teenage years? Dev Neuropsychol 27, 79-105.
54. Solanto, M.V., Gilbert, S.N., Raj, A., Zhu, J., Pope-Boyd, S., Stepak, B., Vail, L. & Newcorn, J.H. (2007) Neurocognitive functioning in AD/HD, predominantly inattentive and combined subtypes. J Abnorm Child Psychol 35, 729-744.
55. Takeuchi, T., Misaki, A., Liang, S.B., Tachibana, A., Hayashi, N., Sonobe, H. & Ohtsuki, Y. (2000) Expression of T-cadherin (CDH13, H-Cadherin) in human brain and its characteristics as a negative growth regulator of epidermal growth factor in neuroblastoma cells. J Neurochem 74, 1489-1497.
56. Taylor, E., Schachar, R., Thorley, G. & Wieselberg, M. (1986) Conduct disorder and hyperactivity: I. Separation of hyperactivity and antisocial conduct in British child psychiatric patients. Br J Psychiatry J Mental Sci 149, 760-767.
57. Thomason, M.E., Race, E., Burrows, B., Whitfield-Gabrieli, S., Glover, G.H. & Gabrieli, J.D. (2009) Development of spatial and verbal working memory capacity in the human brain. J Cogn Neurosci 21, 316-332.
58. Treutlein, J., Cichon, S., Ridinger, M. et al. (2009) Genome-wide association study of alcohol dependence. Arch Gen Psychiatry 66, 773-784.
59. Uhl, G.R., Drgon, T., Liu, Q.-R., Johnson, C., Walther, D., Komiyama, T., Harano, M., Sekine, Y., Inada, T., Ozaki, N., Iyo, M., Iwata, N., Yamada, M., Sora, I., Chen, C.-K., Liu, H.-C., Ujike, H. & Lin, S.-K. (2008) Genome-wide association for methamphetamine dependence: convergent results from 2 samples. Arch Gen Psychiatry 65, 345-355.
60. Wechsler, D. (2000) WAIS-III Nederlandstalige Bewerking. Technische Handleiding.
61. Wechsler, D. (2002) WISC-III Handleiding.
62. Willcutt, E.G., Doyle, A.E., Nigg, J.T., Faraone, S.V. & Pennington, B.F. (2005) Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review. Biol Psychiatry 57, 1336-1346.
63. Zhou, K., Dempfle, A., rcos-Burgos, M. et al. (2008) Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 147B, 1392-1398.