Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein

Journal of Biological Chemistry

Volumn 286, Issue 45, 2011, Pages 39450-39456

  Case, Natasha ^a   Thomas, Jacob ^a   Sen, Buer ^a   Styner, Maya ^a   Xie, Zhihui ^a   Galior, Kornelia ^a   Rubin, Janet ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOGENESIS; DOWNSTREAM TARGET; GLYCOGEN SYNTHASE KINASE-3; GROWTH FACTOR; INSULIN TREATMENT; KINASE INHIBITORS; MAMMALIAN TARGET; MECHANICAL SIGNALS; MECHANICAL STRAIN; MESENCHYMAL STEM CELL; SIGNALING CASCADES; SIGNALING MOLECULES;

AMINO ACIDS; ANTIBIOTICS; CELL CULTURE; CHEMICAL ACTIVATION; ENZYME ACTIVITY; INSULIN; MAMMALS; SIGNALING; STEM CELLS;

PHOSPHORYLATION;

GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; KU 0063794; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C; UNCLASSIFIED DRUG;

AMINO ACID COMPOSITION; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; INSULIN RESPONSE; MECHANICAL STRAIN; MESENCHYMAL STEM CELL; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; ENZYME ACTIVATION; GLYCOGEN SYNTHASE KINASE 3; MECHANOTRANSDUCTION, CELLULAR; MESENCHYMAL STEM CELLS; MICE; MORPHOLINES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRIMIDINES; SERINE; TOR SERINE-THREONINE KINASES; TRANS-ACTIVATORS;

MAMMALIA;

EID: 80655144734     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.265330     Document Type: Article

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