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Volumn 43, Issue 3, 2008, Pages 613-620

Climbing exercise enhances osteoblast differentiation and inhibits adipogenic differentiation with high expression of PTH/PTHrP receptor in bone marrow cells

Author keywords

Adipocyte; Bone marrow cell; Mechanical loading; Osteoblast; PTH PTHrP receptor

Indexed keywords

ALKALINE PHOSPHATASE; CCAAT ENHANCER BINDING PROTEIN BETA; CCAAT ENHANCER BINDING PROTEIN DELTA; FATTY ACID BINDING PROTEIN; MESSENGER RNA; PARATHYROID HORMONE; PARATHYROID HORMONE RELATED PROTEIN RECEPTOR; PARATHYROID HORMONE[1-34]; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PTHR1 ANTIBODY; RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

EID: 49149084192     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2008.04.022     Document Type: Article
Times cited : (85)

References (38)
  • 1
    • 0030816572 scopus 로고    scopus 로고
    • On our age-related bone loss: insights from a new paradigm
    • Frost H.M. On our age-related bone loss: insights from a new paradigm. J Bone Miner Res 12 (1997) 1539-1546
    • (1997) J Bone Miner Res , vol.12 , pp. 1539-1546
    • Frost, H.M.1
  • 2
    • 0034621881 scopus 로고    scopus 로고
    • Effects of mechanical forces on maintenance and adaptation of form in trabecular bone
    • Huiskes R., Ruimerman R., van Lenthe G.H., and Janssen J.D. Effects of mechanical forces on maintenance and adaptation of form in trabecular bone. Nature 405 (2000) 704-706
    • (2000) Nature , vol.405 , pp. 704-706
    • Huiskes, R.1    Ruimerman, R.2    van Lenthe, G.H.3    Janssen, J.D.4
  • 3
    • 0242412974 scopus 로고    scopus 로고
    • Climbing exercise increases bone mass and trabecular bone turnover through transient regulation of marrow osteogenic and osteoclastogenic potentials in mice
    • Mori T., Okimoto N., Sakai A., Okazaki Y., Nakura N., Notomi T., et al. Climbing exercise increases bone mass and trabecular bone turnover through transient regulation of marrow osteogenic and osteoclastogenic potentials in mice. J Bone Miner Res 18 (2003) 2002-2009
    • (2003) J Bone Miner Res , vol.18 , pp. 2002-2009
    • Mori, T.1    Okimoto, N.2    Sakai, A.3    Okazaki, Y.4    Nakura, N.5    Notomi, T.6
  • 4
    • 22744432069 scopus 로고    scopus 로고
    • Stretch-induced PTH-related protein gene expression in osteoblasts
    • Chen X., Macica C.M., Ng K.W., and Broadus A.E. Stretch-induced PTH-related protein gene expression in osteoblasts. J Bone Miner Res 20 (2005) 1454-1461
    • (2005) J Bone Miner Res , vol.20 , pp. 1454-1461
    • Chen, X.1    Macica, C.M.2    Ng, K.W.3    Broadus, A.E.4
  • 5
    • 0032970789 scopus 로고    scopus 로고
    • Parathyroid hormone and mechanical usage have a synergistic effect in rat tibial diaphyseal cortical bone
    • Ma Y., Jee W.S., Yusan Z., Wei W., Chen H., Pun S., et al. Parathyroid hormone and mechanical usage have a synergistic effect in rat tibial diaphyseal cortical bone. J Bone Miner Res 14 (1999) 439-448
    • (1999) J Bone Miner Res , vol.14 , pp. 439-448
    • Ma, Y.1    Jee, W.S.2    Yusan, Z.3    Wei, W.4    Chen, H.5    Pun, S.6
  • 6
    • 0031934350 scopus 로고    scopus 로고
    • Role for parathyroid hormone in mechanical responsiveness of rat bone
    • Chow J.W., Fox S., Jagger C.J., and Chambers T.J. Role for parathyroid hormone in mechanical responsiveness of rat bone. Am J Physiol 274 (1998) E146-E154
    • (1998) Am J Physiol , vol.274
    • Chow, J.W.1    Fox, S.2    Jagger, C.J.3    Chambers, T.J.4
  • 7
    • 0037387070 scopus 로고    scopus 로고
    • Parathyroid hormone enhances mechanically induced bone formation, possibly involving L-type voltage-sensitive calcium channels
    • Li J., Duncan R.L., Burr D.B., Gattone V.H., and Turner C.H. Parathyroid hormone enhances mechanically induced bone formation, possibly involving L-type voltage-sensitive calcium channels. Endocrinology 144 (2003) 1226-1233
    • (2003) Endocrinology , vol.144 , pp. 1226-1233
    • Li, J.1    Duncan, R.L.2    Burr, D.B.3    Gattone, V.H.4    Turner, C.H.5
  • 8
    • 0015137446 scopus 로고
    • Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies
    • Meunier P., Aaron J., Edouard C., and Vignon G. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies. Clin Orthop 80 (1971) 147-154
    • (1971) Clin Orthop , vol.80 , pp. 147-154
    • Meunier, P.1    Aaron, J.2    Edouard, C.3    Vignon, G.4
  • 9
    • 0023276009 scopus 로고
    • Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study
    • Burkhardt R., Kettner G., Bohm W., Schmidmeier M., Schlag R., Frisch B., et al. Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study. Bone 8 (1987) 157-164
    • (1987) Bone , vol.8 , pp. 157-164
    • Burkhardt, R.1    Kettner, G.2    Bohm, W.3    Schmidmeier, M.4    Schlag, R.5    Frisch, B.6
  • 10
    • 0030700448 scopus 로고    scopus 로고
    • Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover osteopenia
    • Kajkenova O., Lecka-Czernik B., Gubrij I., Hauser S.P., Takahashi K., Parfitt A.M., et al. Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover osteopenia. J Bone Miner Res 12 (1997) 1772-1779
    • (1997) J Bone Miner Res , vol.12 , pp. 1772-1779
    • Kajkenova, O.1    Lecka-Czernik, B.2    Gubrij, I.3    Hauser, S.P.4    Takahashi, K.5    Parfitt, A.M.6
  • 11
    • 0033926146 scopus 로고    scopus 로고
    • Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?
    • Nuttall M.E., and Gimble J.M. Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?. Bone 27 (2000) 177-184
    • (2000) Bone , vol.27 , pp. 177-184
    • Nuttall, M.E.1    Gimble, J.M.2
  • 12
    • 0025865559 scopus 로고
    • Adipocytic cells cultured from marrow have osteogenic potential
    • Bennett J.H., Joyner C.J., Triffitt J.T., and Owen M.E. Adipocytic cells cultured from marrow have osteogenic potential. J Cell Sci 99 (1991) 131-139
    • (1991) J Cell Sci , vol.99 , pp. 131-139
    • Bennett, J.H.1    Joyner, C.J.2    Triffitt, J.T.3    Owen, M.E.4
  • 13
    • 0026718865 scopus 로고
    • Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures
    • Beresford J.N., Bennett J.H., Devlin C., Leboy P.S., and Owen M.E. Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J Cell Sci 102 (1992) 341-351
    • (1992) J Cell Sci , vol.102 , pp. 341-351
    • Beresford, J.N.1    Bennett, J.H.2    Devlin, C.3    Leboy, P.S.4    Owen, M.E.5
  • 14
    • 0029961204 scopus 로고    scopus 로고
    • The function of adipocytes in the bone marrow stroma: an update
    • Gimble J.M., Robinson C.E., Wu X., and Kelly K.A. The function of adipocytes in the bone marrow stroma: an update. Bone 19 (1996) 421-428
    • (1996) Bone , vol.19 , pp. 421-428
    • Gimble, J.M.1    Robinson, C.E.2    Wu, X.3    Kelly, K.A.4
  • 15
    • 2642674421 scopus 로고    scopus 로고
    • High fatty acid content in rabbit serum is responsible for the differentiation of osteoblasts into adipocyte-like cells
    • Diascro Jr. D.D., Vogel R.L., Johnson T.E., Witherup K.M., Pitzenberger S.M., Rutledge S.J., et al. High fatty acid content in rabbit serum is responsible for the differentiation of osteoblasts into adipocyte-like cells. J Bone Miner Res 13 (1998) 96-106
    • (1998) J Bone Miner Res , vol.13 , pp. 96-106
    • Diascro Jr., D.D.1    Vogel, R.L.2    Johnson, T.E.3    Witherup, K.M.4    Pitzenberger, S.M.5    Rutledge, S.J.6
  • 17
    • 0031893494 scopus 로고    scopus 로고
    • Development and characterization of conditionally immortalized osteoblast precursor cell lines from human bone marrow stroma
    • Hicok K.C., Thomas T., Gori F., Rickard D.J., Spelsberg T.C., and Riggs B.L. Development and characterization of conditionally immortalized osteoblast precursor cell lines from human bone marrow stroma. J Bone Miner Res 13 (1998) 205-217
    • (1998) J Bone Miner Res , vol.13 , pp. 205-217
    • Hicok, K.C.1    Thomas, T.2    Gori, F.3    Rickard, D.J.4    Spelsberg, T.C.5    Riggs, B.L.6
  • 18
    • 0034748575 scopus 로고    scopus 로고
    • PTHrP inhibits adipocyte differentiation by down-regulating PPAR gamma activity via a MAPK-dependent pathway
    • Chan G.K., Deckelbaum R.A., Bolivar I., Goltzman D., and Karaplis A.C. PTHrP inhibits adipocyte differentiation by down-regulating PPAR gamma activity via a MAPK-dependent pathway. Endocrinology 142 (2001) 4900-4909
    • (2001) Endocrinology , vol.142 , pp. 4900-4909
    • Chan, G.K.1    Deckelbaum, R.A.2    Bolivar, I.3    Goltzman, D.4    Karaplis, A.C.5
  • 19
    • 0345688670 scopus 로고    scopus 로고
    • Parathyroid hormone-related peptide interacts with bone morphogenetic protein 2 to increase osteoblastogenesis and decrease adipogenesis in pluripotent C3H10T 1/2 mesenchymal cells
    • Chan G.K., Miao D., Deckelbaum R., Bolivar I., Karaplis A., and Goltzman D. Parathyroid hormone-related peptide interacts with bone morphogenetic protein 2 to increase osteoblastogenesis and decrease adipogenesis in pluripotent C3H10T 1/2 mesenchymal cells. Endocrinology 144 (2003) 5511-5520
    • (2003) Endocrinology , vol.144 , pp. 5511-5520
    • Chan, G.K.1    Miao, D.2    Deckelbaum, R.3    Bolivar, I.4    Karaplis, A.5    Goltzman, D.6
  • 20
    • 34248506892 scopus 로고    scopus 로고
    • Intermittent treatment with parathyroid hormone (PTH) as well as a non-peptide small molecule agonist of the PTH1 receptor inhibits adipocyte differentiation in human bone marrow stromal cells
    • Rickard D.J., Wang F.L., Rodriguez-Rojas A.M., Wu Z., Trice W.J., Hoffman S.J., et al. Intermittent treatment with parathyroid hormone (PTH) as well as a non-peptide small molecule agonist of the PTH1 receptor inhibits adipocyte differentiation in human bone marrow stromal cells. Bone 39 (2006) 1361-1372
    • (2006) Bone , vol.39 , pp. 1361-1372
    • Rickard, D.J.1    Wang, F.L.2    Rodriguez-Rojas, A.M.3    Wu, Z.4    Trice, W.J.5    Hoffman, S.J.6
  • 21
    • 6344261898 scopus 로고    scopus 로고
    • Teriparatide [PTH(1-34)] strengthens the proximal femur of ovariectomized nonhuman primates despite increasing porosity
    • Sato M., Westmore M., Ma Y.L., Schmidt A., Zeng Q.Q., Glass E.V., et al. Teriparatide [PTH(1-34)] strengthens the proximal femur of ovariectomized nonhuman primates despite increasing porosity. J Bone Miner Res 19 (2004) 623-629
    • (2004) J Bone Miner Res , vol.19 , pp. 623-629
    • Sato, M.1    Westmore, M.2    Ma, Y.L.3    Schmidt, A.4    Zeng, Q.Q.5    Glass, E.V.6
  • 22
    • 0034915161 scopus 로고    scopus 로고
    • Troglitazone treatment increases bone marrow adipose tissue volume but does not affect trabecular bone volume in mice
    • Tornvig L., Mosekilde L.I., Justesen J., Falk E., and Kassem M. Troglitazone treatment increases bone marrow adipose tissue volume but does not affect trabecular bone volume in mice. Calcif Tissue Int 69 (2001) 46-50
    • (2001) Calcif Tissue Int , vol.69 , pp. 46-50
    • Tornvig, L.1    Mosekilde, L.I.2    Justesen, J.3    Falk, E.4    Kassem, M.5
  • 23
    • 0027185702 scopus 로고
    • Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells
    • Wang E.A., Israel D.I., Kelly S., and Luxenberg D.P. Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells. Growth Factors 9 (1993) 57-71
    • (1993) Growth Factors , vol.9 , pp. 57-71
    • Wang, E.A.1    Israel, D.I.2    Kelly, S.3    Luxenberg, D.P.4
  • 24
    • 0034705835 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 stimulates adipogenic differentiation of mesenchymal precursor cells in synergy with BRL 49653 (rosiglitazone)
    • Sottile V., and Seuwen K. Bone morphogenetic protein-2 stimulates adipogenic differentiation of mesenchymal precursor cells in synergy with BRL 49653 (rosiglitazone). FEBS Lett 475 (2000) 201-204
    • (2000) FEBS Lett , vol.475 , pp. 201-204
    • Sottile, V.1    Seuwen, K.2
  • 25
    • 0023749677 scopus 로고    scopus 로고
    • In vivo distribution of parathyroid hormone receptors in bone: evidence that a predominant osseous target cell is not the mature osteoblast
    • Rouleau M.F., Mitchell J., and Goltzman D. In vivo distribution of parathyroid hormone receptors in bone: evidence that a predominant osseous target cell is not the mature osteoblast. Endocrinology 123 (1998) 187-191
    • (1998) Endocrinology , vol.123 , pp. 187-191
    • Rouleau, M.F.1    Mitchell, J.2    Goltzman, D.3
  • 26
    • 0025047391 scopus 로고
    • Characterization of the major parathyroid hormone target cell in the endosteal metaphysis of rat long bones
    • Rouleau M.F., Mitchell J., and Goltzman D. Characterization of the major parathyroid hormone target cell in the endosteal metaphysis of rat long bones. J Bone Miner Res 5 (1990) 1043-1053
    • (1990) J Bone Miner Res , vol.5 , pp. 1043-1053
    • Rouleau, M.F.1    Mitchell, J.2    Goltzman, D.3
  • 28
    • 0031435337 scopus 로고    scopus 로고
    • Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene
    • Tanaka T., Yoshida N., Kishimoto T., and Akira S. Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene. EMBO J 16 (1997) 7432-7443
    • (1997) EMBO J , vol.16 , pp. 7432-7443
    • Tanaka, T.1    Yoshida, N.2    Kishimoto, T.3    Akira, S.4
  • 29
    • 34249776946 scopus 로고    scopus 로고
    • Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis
    • David V., Martin A., Lafage-Proust M.H., Malaval L., Peyroche S., Jones D.B., et al. Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology 148 (2007) 2553-2562
    • (2007) Endocrinology , vol.148 , pp. 2553-2562
    • David, V.1    Martin, A.2    Lafage-Proust, M.H.3    Malaval, L.4    Peyroche, S.5    Jones, D.B.6
  • 30
    • 0035167777 scopus 로고    scopus 로고
    • Effects of tower climbing exercise on bone mass, strength, and turnover in growing rats
    • Notomi T., Okimoto N., Okazaki Y., Tanaka Y., Nakamura T., and Suzuki M. Effects of tower climbing exercise on bone mass, strength, and turnover in growing rats. J Bone Miner Res 16 (2001) 166-174
    • (2001) J Bone Miner Res , vol.16 , pp. 166-174
    • Notomi, T.1    Okimoto, N.2    Okazaki, Y.3    Tanaka, Y.4    Nakamura, T.5    Suzuki, M.6
  • 31
    • 0034688213 scopus 로고    scopus 로고
    • The physiology of parathyroid hormonerelated protein
    • Strewler G.J. The physiology of parathyroid hormonerelated protein. N Engl J Med 342 (2000) 177-185
    • (2000) N Engl J Med , vol.342 , pp. 177-185
    • Strewler, G.J.1
  • 32
    • 0033570107 scopus 로고    scopus 로고
    • Endocytosis of ligand-human parathyroid hormone receptor 1 complexes is protein kinase C-dependent and involves beta-arrestin2. Real-time monitoring by fluorescence microscopy
    • Ferrari S.L., Behar V., Chorev M., Rosenblatt M., and Bisello A. Endocytosis of ligand-human parathyroid hormone receptor 1 complexes is protein kinase C-dependent and involves beta-arrestin2. Real-time monitoring by fluorescence microscopy. J Biol Chem 274 (1999) 29968-29975
    • (1999) J Biol Chem , vol.274 , pp. 29968-29975
    • Ferrari, S.L.1    Behar, V.2    Chorev, M.3    Rosenblatt, M.4    Bisello, A.5
  • 33
    • 0030817807 scopus 로고    scopus 로고
    • Temporal changes of mRNA expression of matrix proteins and parathyroid hormone and parathyroid hormone-related protein (PTH/PTHrP) receptor in bone development
    • Kondo H., Ohyama T., Ohya K., and Kasugai. Temporal changes of mRNA expression of matrix proteins and parathyroid hormone and parathyroid hormone-related protein (PTH/PTHrP) receptor in bone development. J Bone Miner Res 12 (1997) 2089-2097
    • (1997) J Bone Miner Res , vol.12 , pp. 2089-2097
    • Kondo, H.1    Ohyama, T.2    Ohya, K.3    Kasugai4
  • 34
    • 0037073709 scopus 로고    scopus 로고
    • Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice
    • Takeuchi Y., Watanabe S., Ishii G., Takeda S., Nakayama K., Fukumoto S., et al. Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice. J Biol Chem 277 (2002) 49011-49018
    • (2002) J Biol Chem , vol.277 , pp. 49011-49018
    • Takeuchi, Y.1    Watanabe, S.2    Ishii, G.3    Takeda, S.4    Nakayama, K.5    Fukumoto, S.6
  • 35
    • 0033387265 scopus 로고    scopus 로고
    • Fluid shear stress increases interleukin-11 expression in human osteoblast-like cells: its role in osteoclast induction
    • Sakai K., Mohtai M., Shida J., Harimaya K., Benvenuti S., Brandi M.L., et al. Fluid shear stress increases interleukin-11 expression in human osteoblast-like cells: its role in osteoclast induction. J Bone Miner Res 14 (1999) 2089-2098
    • (1999) J Bone Miner Res , vol.14 , pp. 2089-2098
    • Sakai, K.1    Mohtai, M.2    Shida, J.3    Harimaya, K.4    Benvenuti, S.5    Brandi, M.L.6
  • 36
    • 9644303172 scopus 로고    scopus 로고
    • Transcriptional induction of FosB/DeltaFosB gene by mechanical stress in osteoblasts
    • Inoue D., Kido S., and Matsumoto T. Transcriptional induction of FosB/DeltaFosB gene by mechanical stress in osteoblasts. J Biol Chem 279 (2004) 49795-49803
    • (2004) J Biol Chem , vol.279 , pp. 49795-49803
    • Inoue, D.1    Kido, S.2    Matsumoto, T.3
  • 37
    • 49149128432 scopus 로고    scopus 로고
    • BMP-2 enhances mechanical stress-Induced osteobalstic differentiation via formation of Smad1/Delta-FosB/JunD complex on IL-11 gene promoter
    • Kido S., Kuriwaka R., Miyamoto T., Taniguchi H., and Matsumoto1 T. BMP-2 enhances mechanical stress-Induced osteobalstic differentiation via formation of Smad1/Delta-FosB/JunD complex on IL-11 gene promoter. J Bone Miner Res 21 suppl 1 (2006) S371
    • (2006) J Bone Miner Res , vol.21 , Issue.SUPPL. 1
    • Kido, S.1    Kuriwaka, R.2    Miyamoto, T.3    Taniguchi, H.4    Matsumoto1, T.5
  • 38
    • 0034786751 scopus 로고    scopus 로고
    • Interleukin-11 induces osteoblast differentiation and acts synergistically with bone morphogenetic protein-2 in C3H10T1/2 cells
    • Suga K., Saitoh M., Fukushima S., Takahashi K., Nara H., Yasuda S., et al. Interleukin-11 induces osteoblast differentiation and acts synergistically with bone morphogenetic protein-2 in C3H10T1/2 cells. J Interferon Cytokine Res 21 (2001) 695-707
    • (2001) J Interferon Cytokine Res , vol.21 , pp. 695-707
    • Suga, K.1    Saitoh, M.2    Fukushima, S.3    Takahashi, K.4    Nara, H.5    Yasuda, S.6


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