CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination

Cell Cycle

Volumn 10, Issue 21, 2011, Pages 3719-3730

  Latini, Paolo ^a   Frontini, Mattia ^b   Caputo, Manuela ^a   Gregan, Juraj ^c   Cipak, Lubos ^c,d   Filippi, Silvia ^a   Kumar, Vivek ^a   Vélez Cruz, Renier ^e   Stefanini, Miria ^f   Palitti, Fabrizio ^a   Proietti De Santis, Luca ^a  

^a UNIVERSITY OF TUSCIA   (Italy)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c UNIVERSITY OF VIENNA   (Austria)

^d CANCER RESEARCH INSTITUTE   (Slovakia)

^e INSERM   (France)

^f Istituto di Genetica Molecolare   (Italy)

Author keywords

Aging; Apoptosis; Cancer; Cockayne syndrome; DNA repair; Mdm2; p53; Ubiquitination

Indexed keywords

COCKAYNE SYNDROME A PROTEIN; COCKAYNE SYNDROME B PROTEIN; PROTEIN; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; COCKAYNE SYNDROME; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PROTEIN BINDING; PROTEIN INTERACTION; UBIQUITINATION;

EID: 80655123583     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.21.17905     Document Type: Article

References (44)

1. Llanos S, Serrano M. Depletion of ribosomal protein L37 occurs in response to DNA damage and activates p53 through the L11/MDM2 pathway. Cell Cycle 2010; 9:4005-12; PMID:20935493; DOI:10.4161/ cc.9.19.13299.
2. Feng Z, Hu W, Rajagopal G, Levine AJ. The tumor suppressor p53: cancer and aging. Cell Cycle 2008; 7:842- 7; PMID:18414039; DOI:10.4161/cc.7.7.5657.
3. Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, et al. p53 mutant mice that display early ageing-associated phenotypes. Nature 2002; 415:45-53; PMID:11780111; DOI:10.1038/415045a.
4. Brown JG, Familiari U, Papotti M, Rosai J. Thymic basaloid carcinoma: a clinicopathologic study of 12 cases, with a general discussion of basaloid carcinoma and its relationship with adenoid cystic carcinoma. Am J Surg Pathol 2009; 33:1113-24; PMID:19461509; DOI:10.1097/PAS.0b013e3181a2443b.
5. Band M, Ashur-Fabian O, Avivi A. The expression of p53-target genes in the hypoxia-tolerant subterranean mole-rat is hypoxia-dependent and similar to expression patterns in solid tumors. Cell Cycle 2010; 9:3347- 52; PMID:20703075; DOI:10.4161/cc.9.16.12712.
6. Inuzuka H, Fukushima H, Shaik S, Wei W. Novel insights into the molecular mechanisms governing Mdm2 ubiquitination and destruction. Oncotarget 2010; 1:685-90; PMID:21317463.
7. Frontini M, Proietti-De-Santis L. Cockayne syndrome B protein (CSB): linking p53, HIF-1 and p300 to robustness, lifespan, cancer and cell fate decisions. Cell Cycle 2009; 8:693-6; PMID:19221478; DOI:10.4161/cc.8.5.7754.
8. Weidenheim KM, Dickson DW, Rapin I. Neuropathology of Cockayne syndrome: Evidence for impaired development, premature aging and neurodegeneration. Mech Ageing Dev 2009; 130:619-36; PMID:19647012; DOI:10.1016/j.mad.2009.07.006.
9. Troelstra C, van Gool A, de Wit J, Vermeulen W, Bootsma D, Hoeijmakers JH. ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes. Cell 1992; 71:939-53; PMID:1339317; DOI:10.1016/0092-8674(92)90390-X.
10. Henning KA, Li L, Iyer N, McDaniel LD, Reagan MS, Legerski R, et al. The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH. Cell 1995; 82:555-64; PMID:7664335; DOI:10.1016/0092-8674(95)90028-4.
11. Licht CL, Stevnsner T, Bohr VA. Cockayne syndrome group B cellular and biochemical functions. Am J Hum Genet 2003; 73:1217-39; PMID:14639525; DOI:10.1086/380399.
12. Lainé JP, Egly JM. When transcription and repair meet: a complex system. Trends Genet 2006; 22:430-6; PMID:16797777; DOI:10.1016/j.tig.2006.06. 006.
13. Fousteri M, Vermeulen W, van Zeeland AA, Mullenders LH. Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo. Mol Cell 2006; 23:471-82; PMID:16916636; DOI:10.1016/j.molcel.2006.06.029.
14. Cleaver JE, Hefner E, Laposa RR, Karentz D, Marti T. Cockayne syndrome exhibits dysregulation of p21 and other gene products that may be independent of transcription-coupled repair. Neuroscience 2007; 145:1300-8; PMID:17055654; DOI:10.1016/j.neuroscience. 2006.08.074.
15. Brooks PJ, Cheng TF, Cooper L. Do all of the neurologic diseases in patients with DNA repair gene mutations result from the accumulation of DNA damage? DNA Repair (Amst) 2008; 7:834-48; PMID:18339586; DOI:10.1016/j.dnarep. 2008.01.017.
16. Selby CP, Sancar A. Cockayne syndrome group B protein enhances elongation by RNA polymerase II. Proc Natl Acad Sci USA 1997; 94:11205-9; PMID:9326587; DOI:10.1073/pnas.94.21.11205.
17. Tantin D, Kansal A, Carey M. Recruitment of the putative transcription-repair coupling factor CSB/ERCC6 to RNA polymerase II elongation complexes. Mol Cell Biol 1997; 17:6803-14; PMID:9372911.
18. van Gool AJ, van der Horst GT, Citterio E, Hoeijmakers JH. Cockayne syndrome: defective repair of transcription? EMBO J 1997; 16:4155-62; PMID:9250659; DOI:10.1093/emboj/16.14.4155.
19. Bradsher J, Auriol J, Proietti de Santis L, Iben S, Vonesch JL, Grummt I, et al. CSB is a component of RNA pol I transcription. Mol Cell 2002; 10:819-29; PMID:12419226; DOI:10.1016/S1097- 2765(02)00678-0.
20. Yuan X, Feng W, Imhof A, Grummt I, Zhou Y. Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a. Mol Cell 2007; 27:585- 95; PMID:17707230; DOI:10.1016/j.molcel. 2007.06.021.
21. Proietti-De-Santis L, Drane P, Egly JM. Cockayne syndrome B protein regulates the transcriptional program after UV irradiation. EMBO J 2006; 25:1915-23; PMID:16601682; DOI:10.1038/sj.emboj.7601071.
22. Filippi S, Latini P, Frontini M, Palitti F, Egly JM, Proietti-De-Santis L. CSB protein is (a direct target of HIF-1 and) a critical mediator of the hypoxic response. EMBO J 2008; 27:2545-56; PMID:18784753; DOI:10.1038/emboj. 2008.180.
23. Maki CG, Huibregtse JM, Howley PM. In vivo ubiquitination and proteasome-mediated degradation of p53(1). Cancer Res 1996; 56:2649-54; PMID:8653711.
24. Li M, Brooks CL, Wu-Baer F, Chen D, Baer R, Gu W. Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science 2003; 302:1972-5; PMID:14671306; DOI:10.1126/science.1091362.
25. Ljungman M, O'Hagan HM, Paulsen MT. Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation. Oncogene 2001; 20:5964- 71; PMID:11593403; DOI:10.1038/sj.onc.1204734.
26. Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000; 408:307-10; PMID:11099028; DOI:10.1038/35042675.
27. Zdzalik M, Pustelny K, Kedracka-Krok S, Huben K, Pecak A, Wladyka B, et al. Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73. Cell Cycle 2010; 9:4584-91; PMID:21088494; DOI:10.4161/cc.9.22.13871.
28. Miliani de Marval PL, Zhang Y. The RP-Mdm2-p53 pathway and tumorigenesis. Oncotarget 2011; 2:234- 8; PMID:21406728.
29. Conforti G, Nardo T, D'Incalci M, Stefanini M. Proneness to UV-induced apoptosis in human fibroblasts defective in transcription coupled repair is associated with the lack of Mdm2 transactivation. Oncogene 2000; 19:2714-20; PMID:10851071; DOI:10.1038/ sj.onc.1203583.
30. Wang XW, Yeh H, Schaeffer L, Roy R, Moncollin V, Egly JM, et al. p53 modulation of TFIIH-associated nucleotide excision repair activity. Nat Genet 1995; 10:188-95; PMID:7663514; DOI:10.1038/ng0695-188.
31. Newman JC, Bailey AD, Fan HY, Pavelitz T, Weiner AM. An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome. PLoS Genet 2008; 4:1000031; PMID:18369450; DOI:10.1371/journal.pgen. 1000031.
32. Wu X, Bayle JH, Olson D, Levine AJ. The p53- mdm-2 autoregulatory feedback loop. Genes Dev 1993; 7:1126-32; PMID:8319905; DOI:10.1101/ gad.7.7a.1126.
33. Leng RP, Lin Y, Ma W, Wu H, Lemmers B, Chung S, et al. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell 2003; 112:779-91; PMID:12654245; DOI:10.1016/S0092- 8674(03)00193-4.
34. Dornan D, Wertz I, Shimizu H, Arnott D, Frantz GD, Dowd P, et al. The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature 2004; 429:86-92; PMID:15103385; DOI:10.1038/nature02514.
35. Fuchs SY, Adler V, Buschmann T, Yin Z, Wu X, Jones SN, et al. JNK targets p53 ubiquitination and degradation in nonstressed cells. Genes Dev 1998; 12:2658-63; PMID:9732264; DOI:10.1101/gad.12.17.2658.
36. Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T, et al. L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes. Cell Cycle 2006; 5:1719-29; PMID:16861890; DOI:10.4161/cc.5.15.3150.
37. Groisman R, Kuraoka I, Chevallier O, Gaye N, Magnaldo T, Tanaka K, et al. CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome. Genes Dev 2006; 20:1429- 34; PMID:16751180; DOI:10.1101/gad.378206.
38. Wee S, Geyer RK, Toda T, Wolf DA. CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability. Nat Cell Biol 2005; 7:387-91; PMID:15793566; DOI:10.1038/ ncb1241.
39. Wu JT, Chan YR, Chien CT. Protection of cullin- RING E3 ligases by CSN-UBP12. Trends Cell Biol 2006; 16:362-9; PMID:16762551; DOI:10.1016/j. tcb.2006.05.001.
40. Li M, Brooks CL, Kon N, Gu W. A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell 2004; 13:879-86; PMID:15053880; DOI:10.1016/S1097- 2765(04)00157-1.
41. Yanagawa Y, Sullivan JA, Komatsu S, Gusmaroli G, Suzuki G, Yin J, et al. Arabidopsis COP10 forms a complex with DDB1 and DET1 in vivo and enhances the activity of ubiquitin conjugating enzymes. Genes Dev 2004; 18:2172-81; PMID:15342494; DOI:10.1101/gad.1229504.
42. Anindya R, Mari PO, Kristensen U, Kool H, Giglia- Mari G, Mullenders LH, et al. A ubiquitin-binding domain in Cockayne syndrome B required for transcription- coupled nucleotide excision repair. Mol Cell 2010; 38:637-48; PMID:20541997; DOI:10.1016/j. molcel.2010.04.017.
43. Ljungman M. The transcription stress response. Cell Cycle 2007; 6:2252-7; PMID:17700065; DOI:10.4161/cc.6.18.4751.
44. Charlet-Berguerand N, Feuerhahn S, Kong SE, Ziserman H, Conaway JW, Conaway R, et al. RNA polymerase II bypass of oxidative DNA damage is regulated by transcription elongation factors. EMBO J 2006; 25:5481-91; PMID:17110932; DOI:10.1038/ sj.emboj.7601403.