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Volumn 13, Issue 6, 2011, Pages 745-755

Dynamic metabolic flux analysis (DMFA): A framework for determining fluxes at metabolic non-steady state

Author keywords

Data reconciliation; Dynamic analysis; Fed batch fermentation; Metabolic fluxes; Process monitoring

Indexed keywords

1 ,3 PROPANEDIOL; DATA RECONCILIATION; DATA SMOOTHING; DYNAMIC BEHAVIORS; ELECTRON-BALANCE; EXTRACELLULAR; FED-BATCH FERMENTATION; FLUX ESTIMATION; GLUCOSE LIMITED FED BATCHES; IN-VIVO; METABOLIC FLUX; METABOLIC FLUX ANALYSIS; METABOLIC NETWORK; METABOLITE CONCENTRATIONS; STEADY STATE;

EID: 80555149221     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2011.09.010     Document Type: Article
Times cited : (95)

References (20)
  • 1
    • 80052032471 scopus 로고    scopus 로고
    • Metabolic flux analysis of CHO cells at growth and non-growth phases using isotopic tracers and mass spectrometry
    • Ahn W.S., Antoniewicz M.R. Metabolic flux analysis of CHO cells at growth and non-growth phases using isotopic tracers and mass spectrometry. Metab. Eng. 2011, 13:598-609.
    • (2011) Metab. Eng. , vol.13 , pp. 598-609
    • Ahn, W.S.1    Antoniewicz, M.R.2
  • 2
    • 80555131272 scopus 로고    scopus 로고
    • Towards dynamic metabolic flux analysis in CHO cell cultures. Biotechnol. J., accepted for publication.
    • Ahn, W. S., Antoniewicz, M. R.. Towards dynamic metabolic flux analysis in CHO cell cultures. Biotechnol. J., accepted for publication.
    • Ahn, W.S.1    Antoniewicz, M.R.2
  • 3
    • 33745155105 scopus 로고    scopus 로고
    • Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements
    • Antoniewicz M.R., Kelleher J.K., Stephanopoulos G. Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements. Metab. Eng. 2006, 8:324-337.
    • (2006) Metab. Eng. , vol.8 , pp. 324-337
    • Antoniewicz, M.R.1    Kelleher, J.K.2    Stephanopoulos, G.3
  • 4
    • 35348941242 scopus 로고    scopus 로고
    • Accurate assessment of amino acid mass isotopomer distributions for metabolic flux analysis
    • Antoniewicz M.R., Kelleher J.K., Stephanopoulos G. Accurate assessment of amino acid mass isotopomer distributions for metabolic flux analysis. Anal. Chem. 2007, 79:7554-7559.
    • (2007) Anal. Chem. , vol.79 , pp. 7554-7559
    • Antoniewicz, M.R.1    Kelleher, J.K.2    Stephanopoulos, G.3
  • 5
    • 33845679072 scopus 로고    scopus 로고
    • Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions
    • Antoniewicz M.R., Kelleher J.K., Stephanopoulos G. Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions. Metab. Eng. 2007, 9:68-86.
    • (2007) Metab. Eng. , vol.9 , pp. 68-86
    • Antoniewicz, M.R.1    Kelleher, J.K.2    Stephanopoulos, G.3
  • 6
    • 79954522565 scopus 로고    scopus 로고
    • Measuring deuterium enrichment of glucose hydrogen atoms by gas chromatography/mass spectrometry
    • Antoniewicz, M. R., Kelleher, J. K., Stephanopoulos, G., 2011. Measuring deuterium enrichment of glucose hydrogen atoms by gas chromatography/mass spectrometry. Anal. Chem. 83, 3211-3216.
    • (2011) Anal. Chem. , vol.83 , pp. 3211-3216
    • Antoniewicz, M.R.1    Kelleher, J.K.2    Stephanopoulos, G.3
  • 7
    • 34249297627 scopus 로고    scopus 로고
    • Metabolic flux analysis in a nonstationary system: fed-batch fermentation of a high yielding strain of E. coli producing 1,3-propanediol
    • Antoniewicz M.R., Kraynie D.F., Laffend L.A., Gonzalez-Lergier J., Kelleher J.K., Stephanopoulos G. Metabolic flux analysis in a nonstationary system: fed-batch fermentation of a high yielding strain of E. coli producing 1,3-propanediol. Metab. Eng. 2007, 9:277-292.
    • (2007) Metab. Eng. , vol.9 , pp. 277-292
    • Antoniewicz, M.R.1    Kraynie, D.F.2    Laffend, L.A.3    Gonzalez-Lergier, J.4    Kelleher, J.K.5    Stephanopoulos, G.6
  • 8
    • 79952104485 scopus 로고    scopus 로고
    • Tandem mass spectrometry: a novel approach for metabolic flux analysis
    • Choi J., Antoniewicz M.R. Tandem mass spectrometry: a novel approach for metabolic flux analysis. Metab. Eng. 2011, 13:225-233.
    • (2011) Metab. Eng. , vol.13 , pp. 225-233
    • Choi, J.1    Antoniewicz, M.R.2
  • 9
    • 79952145912 scopus 로고    scopus 로고
    • Resolving the TCA cycle and pentose-phosphate pathway of Clostridium acetobutylicum ATCC 824: isotopomer analysis, in vitro activities and expression analysis
    • Crown S.B., Indurthi D.C., Ahn W.S., Choi J., Papoutsakis E.T., Antoniewicz M.R. Resolving the TCA cycle and pentose-phosphate pathway of Clostridium acetobutylicum ATCC 824: isotopomer analysis, in vitro activities and expression analysis. Biotechnol. J. 2011, 6:300-305.
    • (2011) Biotechnol. J. , vol.6 , pp. 300-305
    • Crown, S.B.1    Indurthi, D.C.2    Ahn, W.S.3    Choi, J.4    Papoutsakis, E.T.5    Antoniewicz, M.R.6
  • 10
    • 34447308322 scopus 로고    scopus 로고
    • Genome-scale analysis of Saccharomyces cerevisiae metabolism and ethanol production in fed-batch culture
    • Hjersted J.L., Henson M.A., Mahadevan R. Genome-scale analysis of Saccharomyces cerevisiae metabolism and ethanol production in fed-batch culture. Biotechnol. Bioeng. 2007, 97:1190-1204.
    • (2007) Biotechnol. Bioeng. , vol.97 , pp. 1190-1204
    • Hjersted, J.L.1    Henson, M.A.2    Mahadevan, R.3
  • 12
    • 38749117205 scopus 로고    scopus 로고
    • A procedure for the estimation over time of metabolic fluxes in scenarios where measurements are uncertain and/or insufficient
    • Llaneras F., Pico J. A procedure for the estimation over time of metabolic fluxes in scenarios where measurements are uncertain and/or insufficient. BMC Bioinf. 2007, 8:421.
    • (2007) BMC Bioinf. , vol.8 , pp. 421
    • Llaneras, F.1    Pico, J.2
  • 13
    • 76749149000 scopus 로고    scopus 로고
    • Application of dynamic flux balance analysis to an industrial Escherichia coli fermentation
    • Meadows A.L., Karnik R., Lam H., Forestell S., Snedecor B. Application of dynamic flux balance analysis to an industrial Escherichia coli fermentation. Metab. Eng. 2010, 12:150-160.
    • (2010) Metab. Eng. , vol.12 , pp. 150-160
    • Meadows, A.L.1    Karnik, R.2    Lam, H.3    Forestell, S.4    Snedecor, B.5
  • 15
    • 79956205237 scopus 로고    scopus 로고
    • Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis
    • Niklas, J., Schrader, E., Sandig, V., Noll, T., Heinzle, E., 2011. Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis. Bioprocess. Biosyst. Eng..
    • (2011) Bioprocess. Biosyst. Eng.
    • Niklas, J.1    Schrader, E.2    Sandig, V.3    Noll, T.4    Heinzle, E.5
  • 16
    • 34249934691 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for the production of l-valine based on transcriptome analysis and in silico gene knockout simulation
    • Park J.H., Lee K.H., Kim T.Y., Lee S.Y. Metabolic engineering of Escherichia coli for the production of l-valine based on transcriptome analysis and in silico gene knockout simulation. Proc. Natl. Acad. Sci. USA 2007, 104:7797-7802.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 7797-7802
    • Park, J.H.1    Lee, K.H.2    Kim, T.Y.3    Lee, S.Y.4
  • 18
    • 0029146299 scopus 로고
    • Biosynthetically directed fractional 13C-labeling of proteinogenic amino acids. An efficient analytical tool to investigate intermediary metabolism
    • Szyperski T. Biosynthetically directed fractional 13C-labeling of proteinogenic amino acids. An efficient analytical tool to investigate intermediary metabolism. Eur. J. Biochem. 1995, 232:433-448.
    • (1995) Eur. J. Biochem. , vol.232 , pp. 433-448
    • Szyperski, T.1
  • 19
    • 38449111120 scopus 로고    scopus 로고
    • An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis
    • Young J.D., Walther J.L., Antoniewicz M.R., Yoo H., Stephanopoulos G. An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis. Biotechnol. Bioeng. 2008, 99:686-699.
    • (2008) Biotechnol. Bioeng. , vol.99 , pp. 686-699
    • Young, J.D.1    Walther, J.L.2    Antoniewicz, M.R.3    Yoo, H.4    Stephanopoulos, G.5
  • 20
    • 0028859430 scopus 로고
    • Kinetic analysis of dynamic 13C NMR spectra: metabolic flux, regulation, and compartmentation in hearts
    • Yu X., White L.T., Doumen C., Damico L.A., LaNoue K.F., Alpert N.M., Lewandowski E.D. Kinetic analysis of dynamic 13C NMR spectra: metabolic flux, regulation, and compartmentation in hearts. Biophys. J. 1995, 69:2090-2102.
    • (1995) Biophys. J. , vol.69 , pp. 2090-2102
    • Yu, X.1    White, L.T.2    Doumen, C.3    Damico, L.A.4    LaNoue, K.F.5    Alpert, N.M.6    Lewandowski, E.D.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.