Incomplete aerobic degradation of the antidiabetic drug Metformin and identification of the bacterial dead-end transformation product Guanylurea

Chemosphere

Volumn 85, Issue 5, 2011, Pages 765-773

  Trautwein, Christoph ^a,b,c   Kümmerer, Klaus ^c  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c LEUPHANA UNIVERSITY OF LÜNEBURG   (Germany)

Author keywords

Aquatic environment; Biodegradation; Dead end metabolite; Photodegradation; Toxicity; Water treatment

Indexed keywords

BIODEGRADABILITY; BIODEGRADATION; BOTTLES; DEGRADATION; DRUG PRODUCTS; EFFLUENT TREATMENT; GROUNDWATER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MAMMALS; MASS SPECTROMETRY; METABOLITES; METADATA; PHOTODEGRADATION; SEWAGE TREATMENT PLANTS; SURFACE WATERS; TOXICITY; WATER TREATMENT;

ACTIVE PHARMACEUTICAL INGREDIENTS; AQUATIC ENVIRONMENTS; DEAD-END METABOLITES; ECONOMIC COOPERATION AND DEVELOPMENT; ENVIRONMENTAL COMPARTMENT; ENVIRONMENTAL CONCENTRATION; MULTIPLE STAGE MASS SPECTROMETRY; PREDICTED ENVIRONMENTAL CONCENTRATIONS;

EFFLUENTS;

AMIDE; DICYANDIAMIDINE; GUANIDINECARBOXAMIDE; METFORMIN; SURFACE WATER; UNCLASSIFIED DRUG; UREA;

ACTIVATED SLUDGE; AQUATIC ENVIRONMENT; BACTERIUM; BIODEGRADATION; DOSE-RESPONSE RELATIONSHIP; DRUG; ENVIRONMENTAL FATE; EXPERIMENTAL STUDY; GROUNDWATER POLLUTION; LIQUID CHROMATOGRAPHY; MAMMAL; OXIC CONDITIONS; PHOTODEGRADATION; SOIL POLLUTION; SURFACE WATER; TOXICITY TEST; WASTE TREATMENT;

ACTIVATED SLUDGE; AEROBIC METABOLISM; ARTICLE; BACTERIUM TRANSFORMATION; BIODEGRADABILITY; BIODEGRADATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DEGRADATION; GERMANY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PHOTODEGRADATION; SEWAGE EFFLUENT; SEWAGE TREATMENT PLANT; SIMULATION; TOXICITY TESTING;

GERMANY;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 80555126786     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2011.06.057     Document Type: Article

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