Liquid chromatographic/electrospray ionization mass spectrometric identification of the oxidation end-products of metformin in aqueous solutions

Journal of Mass Spectrometry

Volumn 39, Issue 8, 2004, Pages 890-902

  Collin, Fabrice ^a   Khoury, H ^a   Bonnefont Rousselot, D ^b   Therond P ^b   Legrand, A ^b   Jore, D ^a   Gardes Albert M ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

HO free radicals; Liquid chromatography electrospray ionization; Mass spectrometry; Metformin; Oxidative stress

Indexed keywords

ELUCIDATION; GAMMA RADIOLYSIS; METAFORMALIN;

ANTIOXIDANTS; AROMATIC COMPOUNDS; DEUTERIUM; DIMERS; GAMMA RAYS; HYDROGEN; IONIZATION; MASS SPECTROMETERS; MASS SPECTROMETRY; OXIDATION; SOLUTIONS; WATER; WATER AERATION;

DRUG PRODUCTS;

2 AMINO 4 IMINO 1 [2 (1 METHYLBIGUANID 1 YL)ETHYL] 1,2 DIHYDRO 1,3,5 TRIAZINE; 2 AMINO 4 IMINO 5 METHYL 1,3,5 TRIAZINE; ANTIDIABETIC AGENT; BIGUANIDE; DEUTERIUM; DIMER; DRUG METABOLITE; FORMOGUANAMINE; FREE RADICAL; HYDROGEN; HYDROPEROXIDE DERIVATIVE; HYPEROXOMETFORMIN; METFORMIN; METHYLBIGUANIDE; N DEMETHYLDIMETFORMIN; UNCLASSIFIED DRUG; WATER;

AERATION; ANALYTIC METHOD; ANTIOXIDANT ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG OXIDATION; ELECTRON; ELECTROSPRAY MASS SPECTROMETRY; FRAGMENTATION REACTION; GAMMA RADIATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS; PRIORITY JOURNAL; RADIATION DOSE; RADIATION RESPONSE; RADIOLYSIS; REACTION ANALYSIS; STRUCTURE ANALYSIS; SYNTHESIS;

ANTIOXIDANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROXYL RADICAL; HYPOGLYCEMIC AGENTS; METFORMIN; OXIDATION-REDUCTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; WATER;

EID: 4444298087     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/jms.656     Document Type: Article

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