Local use of antibiotics and their input and fate in a small sewage treatment plant - Significance of balancing and analysis on a local scale vs. nationalwide scale

Acta Hydrochimica et Hydrobiologica

Volumn 34, Issue 6, 2006, Pages 587-592

  Alexy, Radka ^a   Sommer, Alexander ^a   Lange, Frank T ^b   Kümmerer, Klaus ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b DVGW Technologiezentrum Wasser   (Germany)

Author keywords

Effluent; Elimination; Mass balance; STP

Indexed keywords

ANTIBIOTICS; CONCENTRATION (PROCESS); EFFLUENTS; ENVIRONMENTAL IMPACT; SEWAGE TREATMENT PLANTS;

ANTIBIOTICS; EFFLUENT; ENVIRONMENTAL FATE; MASS BALANCE; SEWAGE TREATMENT;

CENTRAL EUROPE; EURASIA; EUROPE; GERMANY;

EID: 33846870798     PISSN: 03234320     EISSN: 1521401X     Source Type: Journal    
DOI: 10.1002/aheh.200400657     Document Type: Article

References (28)

1. Kümmerer, K. (Ed.): Pharmaceuticals in the Environment. Sources, Fate, Effects and Risks. 2nd Edition. Springer, Heidelberg, 2004.
2. Wise, R.: Antimicrobial resistance: priorities for action. J. Antimicrob. Chemother. 49, 585-86 (2002).
3. European Federation of Animal Health (FEDESA): Antibiotic use in farm animals does not threaten human health. FEDESA/FEFANA Press Release, Brussels, 13 July 2001.
4. Greiner, P., Rönnefahrt, I.: Management of environmental risks in the life cycle of pharmaceuticals. European Conference on Human and Veterinary Pharmaceuticals in the Environment, Lyon, April 14-16, 2003.
5. Kümmerer, K., Henninger, A.: Promoting resistance by the emission of antibiotics from hospitals and households into effluents. Clin. Microbiol. Infect. 9, 1203-1214 (2003).
6. Halling-Sørensen, B., Holten Lüzhøft, H.-C., Andersen, H. R., Ingerslev, F.: Environmental risk assessment of antibiotics: comparison of mecillinam, trimethoprim and ciprofloxacin. J. Antimicrob. Chemother. 46 (Suppl 1), 53-58 (2002).
7. Al-Ahmad, A., Daschner, F. D., Kümmerer, K.: Biodegradability of cefotiam, ciprofloxacin, meropenem, penicillin G, and sulfamethoxazole and inhibition of waste water bacteria. Arch. Environ. Contam. Toxicol. 37, 158-163 (1999).
8. Kümmerer, K., Al-Ahmad, A., Mersch-Sundermann, V.: Biodegradability of some antibiotics, elimination of their genotoxicity and affection of waste water bacteria in a simple test. Chemosphere 40, 701-710 (2000).
9. Alexy, R., Schöll, A., Kümmerer, K.: Elimination and degradability of 18 antibiotics studied with simple tests. Chemosphere 57, 505-512 (2004).
10. Wetenkamp, K.: Wasser. Wie gut und rein ist unser Leitungswasser? Ein Test im Labor zeigt: In einigen Städten gibt es bedenkliche Rückstände. Der Feinschmecker 9, 74-79 (2006).
11. Golet, E. M., Alder, A. C., Hartmann, A., Ternes, T. A., Giger, W.: Trace determination of fluoroquinolone antibacterial agents in urban wastewater by solid-phase extraction and liquid chromatography with fluorescence detection. Anal. Chem. 73, 3632-3638 (2001).
12. Zuccato, E., Calamari, D., Natangelo, M., Fanelli, R.: Presence of therapeutic drugs in the environment. Lancet 335, 1789-1790 (2000).
13. Richardson, M. L., Bowron, J. M.: The fate of pharmaceutical chemicals in the aquatic environment. J. Pharmacy Pharmacol. 37, 1-12 (1985).
14. Kolpin, D., Furlong, E. T., Meyer, M. T., Thurman, E. M., Zaugg, S. D., Barber, L. B.: Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: A national reconnaissance. Environ. Sci. Technol. 36, 1202-1211 (2002).
15. Sacher, F., Lange, F. T., Brauch, H. J., Blankenhorn, I.: Pharmaceuticals in groundwaters analytical methods and results of a monitoring program in Baden-Württemberg, Germany. J. Chromatogr. A 938, 199-210 (2001).
16. Hirsch, R., Ternes, T., Haberer, K., Kratz, K L.: Occurrence of antibiotics in the aquatic environment. Sci. Total Environ. 225, 109-118 (1999).
17. Golet, E. M., Alder, A. C., Giger, W.: Environmental exposure and risk assessment of fluoroquinolone antibacterial agents in wastewater and river water of the Glatt Valley Watershed, Switzerland. Environ. Sci. Technol. 36, 3645-3651 (2002).
18. Landesumweltamt Brandenburg: Ökotoxikologische Bewertung von Arzneimitteln. Studien und Tagungsberichte Bd. 39, 2002.
19. Simon, C., Stille, W.: Antibiotikatherapie in Klinik und Praxis. 8th Edition. Schlattauer, Stuttgart, 1993.
20. Gerding, D. N., Peterson, L. R., Hughes, C. E., Bamberger, D. M. Larson, T. A.: Extravascular antimicrobial distribution and the respective blood concentrations in human. In: Lorian, V. (Ed.): Antibiotics in Laboratory Medicine. 3rd Edition. Williams & Wilkins, Baltimore, 1991, pp. 880-961.
21. Lange, F. T., Sacher, F., Metzinger, M., Wenz, M.: Quantitative Spurenanalytik von Antibiotika-Wirkstoffen in Wasser mittels HPLC-ESI-MS/ MS - gibt es eine Multimethode? Schriftenreihe Biologische Abwasserreinigung 16, 193-212 (2001).
22. Alexy, R., Kümpel, T., Schöll, A., Kümmerer, K., Kalsch, W., Junker, T., Moltmann, F., Knocker, T., Theis, W., Weihs, C., Urich, E., Gartiser, S., Metzinger, M., Wenz, M., Lange, T., Beimfohr, C.: Eintrag von Antibiotika in die aquatische Umwelt. Prüfung der biologischen Abbaubarkeit ausgewdählter Antibiotika, ihr Vorkommen im Abwasser und ihr möglicher Einfluss auf die Reinigungsleistung kommunaler Kläranlagen. Identifizierung von Risikofeldern. Abschlussbericht, F&E-Vorhaben 298 63 722, 2003.
23. European Agency for the Evaluation of Medicinal Products (EMEA): Draft Discussion Paper on Environmental Risk Assessment of Non-genetically Modified Organism (non-GMO) Containing Medicinal Products for Human Use. London, 2001.
24. European Commission: Technical Guidance Document in Support of Commission Directive 93/67/EEC on Risk Assessment for New Notified Substances and Commission Regulation (EC) No 1488/94 on Risk Assessment for Existing Substances Part II (1996).
25. Günther, J., Kern, W. V., Nink, K., Schröder, H., de With, K.: Solange sie noch wirken...Kommentare und Analysen zum Antibiotikaverbrauch in Deutschland. Wissenschaftliches Institut der AOK (WldO), Bonn und Universitätsklinikum Freiburg, 2003.
26. Christian, T., Schneider, R. J., Färber, H. A., Skutlarek, D., Meyer, M. T., Goldbach, H. E.: Determination of antibiotic residues in manure, soil, and surface waters. Acta Hydrochim. Hydrobiol. 31, 36-44 (2003).
27. Göbel, A., Thomsen, A., McArdell, C. S., Joss, A., Giger, W.: Occurrence and sorption behavior of sulfonamides, macrolides, and trimethoprim in activated sludge treatment. Environ. Sci. Technol. 39, 3981-89 (2005).
28. Volmer, D. A., Hui, J. P. M.: Study of erythromycin A decomposition products in aqueous solution by solid-phase microextraction/liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrometry 12, 123-129 (1998).