Haloduracin α binds the peptidoglycan precursor lipid II with 2:1 stoichiometry

Journal of the American Chemical Society

Volumn 133, Issue 44, 2011, Pages 17544-17547

  Oman, Trent J ^a   Lupoli, Tania J ^b   Wang, Tsung Shing Andrew ^c   Kahne, Daniel ^b   Walker, Suzanne ^c   Van Der Donk, Wilfred A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b HARVARD UNIVERSITY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL WALL BIOSYNTHESIS; DATA SUPPORT; GRAM-POSITIVE BACTERIUM; LANTIBIOTICS; MEMBRANE POTENTIALS; PEPTIDOGLYCAN PRECURSORS; PEPTIDOGLYCANS; PORE FORMATION; POTASSIUM EFFLUX; POTENT INHIBITOR; TRANSGLYCOSYLATION REACTION;

BACTERIA; BIOCHEMISTRY; BIOSYNTHESIS; PEPTIDES; POTASSIUM;

STOICHIOMETRY;

ANTIINFECTIVE AGENT; HALODURACIN ALPHA; LANTIBIOTIC; LIPID; PEPTIDOGLYCAN; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BINDING AFFINITY; BIOSYNTHESIS; CHANNEL GATING; GLYCOSYLATION; IC 50; MEMBRANE POTENTIAL; MUTATION; NONHUMAN; POLYMERIZATION; POTASSIUM TRANSPORT; PROTEIN BINDING; PROTEIN SYNTHESIS; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; BACTERIOCINS; BINDING SITES; LACTOCOCCUS LACTIS; MICROBIAL SENSITIVITY TESTS; PEPTIDOGLYCAN; STEREOISOMERISM;

EID: 80455168091     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja206281k     Document Type: Article

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