Rethinking Ramoplanin: The role of substrate binding in inhibition of peptidoglycan biosynthesis

Journal of the American Chemical Society

Volumn 124, Issue 47, 2002, Pages 13970-13971

  Helm, Jeremiah S ^a   Chen, Lan ^a   Walker, Suzanne ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; PEPTIDOGLYCAN; PROTEIN MURG; RAMOPLANIN; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CONCENTRATION RESPONSE; DRUG BINDING; DRUG MECHANISM; ENZYME ACTIVITY; ESCHERICHIA COLI; GRAM POSITIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; POLARIZATION;

EID: 0037184490     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja021097n     Document Type: Article

References (25)

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11. It has recently been shown, however, that ramoplanin binds to Lipid I analogues. See: (a) Lo, M.-C. Ph.D. Thesis. Princeton University, 2000. (b) Cudic, P.; Kranz, J. K.; Behenna, D. C.; Kruger, R. G.; Tadesse, H.; Wand, A. J.; Veklich, Y. I.; Weisel, J. W.; McCafferty, D. G. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 7384-7389. (c) Cudic, P.: Behenna, D. C.; Kranz, J. K.; Kruger, R. G.; Wand, A. J.; Veklich, Y. I.; Weisel, J. W.; McCafferty, D. G. Chem. Biol. 2002, 9, 897-906.
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