The lantibiotic mersacidin inhibits peptidoglycan synthesis by targeting lipid II

Antimicrobial Agents and Chemotherapy

Volumn 42, Issue 1, 1998, Pages 154-160

  Brötz, Heike ^a   Bierbaum, Gabriele ^a   Leopold, Klaus ^b   Reynolds, Peter E ^c   Sahl, Hans Georg ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LANTIBIOTIC; LIPID; MERSACIDIN; PEPTIDOGLYCAN;

ANTIBIOTIC THERAPY; ARTICLE; BACTERICIDAL ACTIVITY; DRUG BINDING; DRUG MECHANISM; GLYCOSYLATION; MICELLE; NONHUMAN; PRIORITY JOURNAL;

EID: 0038026361     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.42.1.154     Document Type: Article

References (41)

1. Anderson, J. S., M. Matsuhashi, M. A. Haskin, and J. L. Strominger. 1967. Biosynthesis of the peptidoglycan of bacterial cell walls. II. Phospholipid carriers in the reaction sequence. J. Biol. Chem. 242:3180-3190.
2. Barrett, M. S., R. P. Wenzel, and R. N. Jones. 1992. In vitro activity of mersacidin (M87-1551), an investigational peptide antibiotic tested against gram-positive bloodstream isolates. Diagn. Microbiol. Infect. Dis. 15:641-644.
3. Best, G. K., and N. N. Durham. 1965. Vancomycin adsorption to Bacillus subtilis cell walls. Arch. Biochem. Biophys. 111:685-692.
4. Bierbaum, G., and H.-G. Sahl. 1987. Autolytic system of Staphylococcus simulans 22: influence of cationic peptides on activity of N-acetylmuramoyl-L-alanine amidase. J. Bacteriol. 169:5452-5458.
5. Bierbaum, G., H. Brötz, K.-P. Koller, and H.-G. Sahl. 1995. Cloning, sequencing and production of the lantibiotic mersacidin. FEMS Lett. 127:121-126.
6. Blumberg, P. M., and J. L. Strominger. 1974. Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes. Bacteriol. Rev. 38:291-335.
7. Brötz, H., G. Bierbaum, A. Markus, E. Molitor, and H.-G. Sahl. 1995. Mode of action of the lantibiotic mersacidin: inhibition of peptidoglycan biosynthesis via a novel mechanism? Antimicrob. Agents Chemother. 39:714-719.
8. Brötz, H., G. Bierbaum, P. E. Reynolds, and H.-G. Sahl. 1997. The lantibiotic mersacidin inhibits peptidoglycan biosynthesis at the level of transglycosylation. Eur. J. Biochem. 246:193-199.
9. Chatterjee, S., D. K. Chatterjee, R. H. Jani, J. Blumbach, B. N. Ganguli, N. Klesel, M. Limbert, and G. Seibert. 1992. Mersacidin, a new antibiotic from Bacillus: in vitro and in vivo antibacterial activity. J. Antibiot. 45:839-845.
10. Chatterjee, S., S. Chatterjee, S. J. Lad, M. S. Phansalkar, R. H. Rupp, B. N. Ganguli, H.-W. Fehlhaber, and H. Kogler. 1992. Mersacidin, a new antibiotic from Bacillus, fermentation, isolation, purification and chemical characterization. J. Antibiot. 45:832-838.
11. Chen, P. S., Jr., T. Y. Toribara, and H. Warner. 1956. Microdetermination of phosphorus. Anal. Chem. 28:1756-1758.
12. Dankert, M., A. Wright, W. S. Kelley, and P. W. Robbins. 1966. Isolation, purification, and properties of the lipid-linked intermediates of O-antigen biosynthesis. Arch. Biochem. Biophys. 116:425-435.
13. Davidson, V. L., W. A. Cramer, L. J. Bishop, and K. R. Brunden. 1984. Dependence of the activity of colicin E1 in artificial membrane vesicles on pH, membrane potential, and vesicle size. J. Biol. Chem. 259:594-600.
14. Dougherty, T. J., K. Kennedy, R. E. Kessler, and M. J. Pucci. 1996. Direct quantitation of the number of individual penicillin-binding proteins per cell in Escherichia coli. J. Bacteriol. 178:6110-6115.
15. 2, and structural revision of duramycin and cinnamycin, p. 131-140. In G. Jung and H.-G. Sahl (ed.), Nisin and novel lantibiotics. ESCOM, Leiden, The Netherlands.
16. Gale, E. F., E. Cundliffe, P. E. Reynolds, M. H. Richmond, and M. J. Waring. 1972. The molecular basis of antibiotic action, p. 77-80. John Wiley & Sons, London, United Kingdom.
17. Gale, E. F., E. Cundliffe, P. E. Reynolds, M. H. Richmond, and M. J. Waring. 1981. The molecular basis of antibiotic action, p. 147-153. John Wiley & Sons, London, United Kingdom.
18. Hammes, W. P., J. Winter, and O. Kandler. 1979. The sensitivity of the pseudomurein-containing genus Methanobacterium to inhibitors of murein synthesis. Arch. Microbiol. 123:275-279.
19. Jung, G. 1991. Lantibiotics - ribosomally synthesized biologically active polypeptides containing sulfide bridges and α,β-didehydroamino acids. Angew. Chem. Int. Ed. Engl. 30:1051-1068.
20. Katz, W., M. Matsuhashi, C. P. Dietrich, and J. L. Strominger. 1967. Biosynthesis of the peptidoglycan of bacterial cell walls. IV. Incorporation of glycine in Micrococcus lysodeikticus. J. Biol. Chem. 242:3207-3217.
21. Kohlrausch, U., and J.-V. Höltje. 1991. One-step purification procedure for UDP-N-acetylmuramyl-peptide murein precursors from Bacillus cereus. FEMS Lett. 78:253-258.
22. König, H. Personal communication.
23. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680-685.
24. Malabarba, A., R. Pallanza, M. Berti, and B. Cavalleri. 1990. Synthesis and biological activity of some amide derivatives of the lantibiotic actagardine. J. Antibiot. 43:1089-1097.
25. Molitor, E., C. Kluczny, H. Brötz, G. Bierbaum, R. Jack, and H.-G. Sahl. 1996. Effects of the lantibiotic mersacidin on the morphology of staphylococci. Zentralbl. Bakteriol. 284:318-328.
26. Moll, G. N., G. C. K. Roberts, W. N. Konings, and A. J. M. Driessen. 1996. Mechanism of lantibiotic-induced pore-formation. Antonie Leeuwenhoek 69:185-191.
27. Perkins, H. R. 1969. Specificity of combination between mucopeptide precursors and vancomycin or ristocetin. Biochem. J. 111:195-205.
28. Reynolds, P. E. 1971. Peptidoglycan synthesis in bacilli. I. Effect of temperature on the in vitro system from Bacillus megaterium and Bacillus stearothermophilus. Biochim. Biophys. Acta 237:239-254.
29. Reynolds, P. E. 1971. Peptidoglycan synthesis in bacilli. II. Characteristics of protoplast membrane preparations. Biochim. Biophys. Acta 237:255-272.
30. Reynolds, P. E. 1989. Structure, biochemistry and mechanism of action of glycopeptide antibiotics. Eur. J. Clin. Microbiol. 8:943-950.
31. Sahl, H.-G. 1991. Pore formation in bacterial membranes by cationic lantibiotics, p. 347-358. In G. Jung and H.-G. Sahl (ed.), Nisin and novel lantibiotics. ESCOM, Leiden, The Netherlands.
32. Sahl, H.-G., R. W. Jack, and G. Bierbaum. 1995. Biosynthesis and biological activities of lantibiotics with unique post-translational modifications. Eur. J. Biochem. 230:827-853.
33. Sinha, R. K., and F. C. Neuhaus. 1968. Reversal of the vancomycin inhibition of peptidoglycan synthesis by cell walls. J. Bacteriol. 96:374-382.
34. Somma, S., W. Merati, and F. Parenti. 1977. Gardimycin, a new antibiotic inhibiting peptidoglycan synthesis. Antimicrob. Agents Chemother. 11:396-401.
35. Somner, E. A., and P. E. Reynolds. 1990. Inhibition of peptidoglycan biosynthesis by ramoplanin. Antimicrob. Agents Chemother. 34:413-419.
36. 55-isoprenyl pyrophosphate. Proc. Natl. Acad. Sci. USA 68:3223-3227.
37. Storm, D. R. 1974. Mechanism of bacitracin action: a specific lipid-peptide interaction. Ann. N.Y. Acad. Sci. 235:387-398.
38. Storm, D. R., and J. L. Strominger. 1974. Binding of bacitracin to cells and protoplasts of Micrococcus lysodeikticus. J. Biol. Chem. 249:1823-1827.
39. van Heijenoort, J., Y. van Heijenoort, and P. Welzel. 1988. Moenomycin: inhibitor of peptidoglycan polymerization in Escherichia coli, p. 549-557. In P. Actor, L. Daneo-Moore, M. L. Higgins, M. R. J. Salton, and G. D. Shockman (ed.), Antibiotic inhibition of bacterial cell surface assembly and function. American Society for Microbiology, Washington, D.C.
40. van Heijenoort, Y., M. Gómez, M. Derrien, J. Ayala, and J. van Heijenoort. 1992. Membrane intermediates in the peptidoglycan metabolism of Escherichia coli: possible roles of PBP 1b and PBP 3. J. Bacteriol. 174:3549-3557.
41. 13C-NMR assignments and revised primary structure. Eur. J. Biochem. 228:786-797.