Lactam-stabilized helical analogues of the analgesic μ-conotoxin KIIIA

Journal of Medicinal Chemistry

Volumn 54, Issue 21, 2011, Pages 7558-7566

  Khoo, Keith K ^a,b,c   Wilson, Michael J ^d   Smith, Brian J ^b   Zhang, Min Min ^d   Gulyas, Joszef ^e   Yoshikami, Doju ^d   Rivier, Jean E ^e   Bulaj, Grzegorz ^d   Norton, Raymond S ^a  

^a MONASH UNIVERSITY   (Australia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSITY OF UTAH   (United States)

^e SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONOTOXIN; MU CONOTOXIN KIIIA; MU CONOTOXIN KIIIA DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL CELL; ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT;

ANALGESICS; ANIMALS; CONOTOXINS; FEMALE; LACTAMS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLECULAR DYNAMICS SIMULATION; MOLECULAR MIMICRY; OLIGOPEPTIDES; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, SECONDARY; RATS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 80455144785     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200839a     Document Type: Article

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