μ-Conotoxin KIIIA derivatives with divergent affinities versus efficacies in blocking voltage-gated sodium channels

Biochemistry

Volumn 49, Issue 23, 2010, Pages 4804-4812

  Zhang, Min Min ^a   Han, Tiffany S ^a   Olivera, Baldomero M ^a   Bulaj, Grzegorz ^a   Yoshikami, Doju ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOCKING VOLTAGE; CHEMICAL SYNTHESIS; CONOPEPTIDES; CONOTOXINS; CORE STRUCTURE; DISULFIDE BRIDGE; PORE BLOCKER; RESIDUAL CURRENT; SATURATING CONCENTRATION; SELENOCYSTEINE; SIDE CHAINS; SODIUM CHANNEL; SODIUM CURRENT; XENOPUS OOCYTE;

AMINO ACIDS; ORGANIC ACIDS; PEPTIDES; SYNTHESIS (CHEMICAL); TOXIC MATERIALS;

SODIUM;

CONOTOXIN; MU CONOTOXIN KIIIA; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; HYDROPHOBICITY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STABILITY; STRUCTURE ANALYSIS; SYNTHESIS; XENOPUS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CONOTOXINS; DISULFIDES; INDICATORS AND REAGENTS; MOLECULAR SEQUENCE DATA; MUSCLE PROTEINS; OOCYTES; PROTEIN BINDING; PROTONS; RATS; SELENOCYSTEINE; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; XENOPUS;

RATTUS;

EID: 77953262644     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100207k     Document Type: Article

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