Effects of long-term silymarin oral supplementation on the blood biochemical profile of rainbow trout (Oncorhynchus mykiss)

Fish Physiology and Biochemistry

Volumn 37, Issue 4, 2011, Pages 885-896

  Banaee, Mahdi ^a   Sureda, Antoni ^b   Mirvaghefi, Ali Reza ^c   Rafei, Golam Reza ^c  

^a Industrial University of Behbahan   (Iran)

^b UNIVERSITAT DE LES ILLES BALEARS   (Spain)

^c UNIVERSITY OF TEHRAN   (Iran)

Author keywords

Biochemical parameters; Herbal drug; Rainbow trout; Silymarin

Indexed keywords

CHOLESTEROL; SERUM GLOBULIN; SILYMARIN;

ANIMAL; ARTICLE; BLOOD; DIET SUPPLEMENTATION; DRUG EFFECT; GLUCOSE BLOOD LEVEL; LIVER; METABOLISM; RAINBOW TROUT;

ANIMALS; BLOOD GLUCOSE; CHOLESTEROL; DIETARY SUPPLEMENTS; LIVER; ONCORHYNCHUS MYKISS; SERUM GLOBULINS; SILYMARIN;

ONCORHYNCHUS MYKISS; PISCES; SILYBUM MARIANUM;

EID: 80355132253     PISSN: 09201742     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10695-011-9486-z     Document Type: Article

References (56)

1. Alqasoumi SI, Al-Howiriny TA, Abdel-Kaer MS (2008) Evaluation of the hepatoprotective effect of Aloe vera, Clematis hirsute and bee propolis against experimentally induced liver injury in rats. Int J Pharmacol 4(3): 213-217.
2. Banaee M (2010) Influence of silymarin in decline of sub-lethal diazinon-induced oxidative stress in rainbow trout (Oncorhynchus mykiss). Ph. D. Thesis, Aquaculture and Environmental Department, Natural Resource Faculty, Natural Resource and Agriculture Collage, Tehran University, Iran, 149 pp.
3. Basiglio CL, Sánchez Pozzi EJ, Mottino AD, Roma MG (2009) Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis. Chemico-Biological Interact 179: 297-303. doi: 10. 1016/j. cbi. 2008. 12. 008.
4. Beckmann-Knopp S, Rietbrock S, Weyhenmeyer R, Böcker RH, Beckurts KT, Lang W, Hunz M, Fuhr U (2000) Inhibitory effects of silibinin on cytochrome P-450 enzymes in human liver microsomes. Pharmacol Toxicol 86(6): 250-256. doi: 10. 1111/j. 0901-9928. 2000. 860602. x.
5. Borsari M, Gabbi C, Ghelfi F, Grandi R, Saladini M, Severi S, Borella F (2001) Silybin, a new iron-chelating agent. J Inorg Biochem 85: 123-129.
6. Canbek M, Uyanoglu M, Bayramoglu G, Senturk H, Erkasap N, Koken T, Uslu S, Demirustu C, Aral E, Can Baser KH (2008) Effects of carvacrol on defects of ischemia-reperfusion in the rat liver. Phytomedicine 15(6-7): 447-452. doi: 10. 1016/j. phymed. 2007. 11. 022.
7. Christybapita D, Divyagnaneswari M, Dinakaran Michael R (2007) Oral administration of Eclipta alba leaf aqueous extract enhances the non-specific immune responses and disease resistance of Oreochromis mossambicus. Fish Shellfish Immunol 23: 840-852. doi: 10. 1016/j. fsi. 2007. 03. 010.
8. Citarasu T, Sivaram V, Immanuel G, Rout N, Murugan V (2006) Influence of selected Indian immunostimulant herbs against white spot syndrome virus (WSSV) infection in black tiger shrimp, Penaeus monodon with reference to haematological, biochemical and immunological changes. Fish Shellfish Immunol 21: 372-384. doi: 10. 1016/j. fsi. 2006. 01. 002.
9. D'Andrea V, Perez LM, Pozzi EJS (2005) Inhibition of rat liver UDP-glucuronosyltransferase by silymarin and the metabolite silibinin-glucuronide. Life Sci 77: 683-692. doi: 10. 1016/j. lfs. 2005. 01. 011.
10. Divyagnaneswari M, Christybapita D, Dinakaran Michael R (2007) Enhancement of nonspecific immunity and disease resistance in Oreochromis mossambicus by Solanum trilobatum leaf fractions. Fish Shellfish Immunol 23: 249-259. doi: 10. 1016/j. fsi. 2006. 09. 015.
11. Dügenci SK, Arda N, Candan A (2003) Some medicinal plants as immunostimulant for fish. J Ethnopharmacol 88: 99-106. doi: 10. 1016/S0378-8741(03)00182-X.
12. El-Kamary SS, Shardell MD, Abdel-Hamid M, Ismail S, El-Ateek M, Metwally M, Mikhail N, Hashem M, Mousa A, Aboul-Fotouh A, El-Kassas M, Esmat G, Strickland GT (2009) A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis. Phytomedicine 16: 391-400. doi: 10. 1016/j. phymed. 2009. 02. 002.
13. El-Shitany NA, El-Haggar S, El-desoky K (2008) Silymarin prevents adriamycin-induced cardiotoxicity and nephrotoxicity in rats. Food Chem Toxicol 46: 2422-2428. doi: 10. 1016/j. fct. 2008. 03. 033.
14. Fallah Huseini H, Larijani B, Heshmat R, Fakhrzadeh H, Radjabipour B, Toliat T, Mohsin R (2006) The efficacy of Silybum marianum (L.) Gaertn. (Silymarin) in the treatment of type II diabetes: A randomized, double-blind, placebo-controlled, clinical trial. Phytother Res 20(12): 1036-1039. doi: 10. 1002/ptr. 1988.
15. Flora K, Hahn M, Rosen H, Benner K (1998) Milk thistle (Silybum matinum) for the therapy of liver disease. Am J Gastroenterol 93(2): 139-143 PII: S0002-9270(97)00082-8.
16. Gilbert SC, Emmett M, Menter A, Silverman A, Klintmalm G (1989) Cyclosporine therapy for psoriasis: serum creatinine measurements are an unreliable predictor of decreased renal function. J Am Acad Dermatol 21: 470-474 PII: S0190-9622(89)70209-7.
17. Han MH, Yoon WK, Lee H, Han SB, Lee K, Park SK, Yang KH, Kim HM, Kang JS (2007) Topical application of silymarin reduces chemical-induced irritant contact dermatitis in BALB/c mice. Int Immunopharmacol 7: 1651-1658. doi: 10. 1016/j. intimp. 2007. 08. 019.
18. Harikrishnan R, Balasundaram C, Heo MS (2010a) Herbal supplementation diets on hematology and innate immunity in goldfish against Aeromonas hydrophila. Fish Shellfish Immunol 28: 354-361. doi: 10. 1016/j. fsi. 2009. 11. 013.
19. Harikrishnan R, Heo J, Balasundaram C, Kim MC, Kim JS, Han YJ, Heo MS (2010b) Effect of Punica granatum solvent extracts on immune system and disease resistance in Paralichthys olivaceus against lymphocystis disease virus (LDV). Fish Shellfish Immunol 29: 668-673. doi: 10. 1016/j. fsi. 2010. 07. 006.
20. Haroun EM, Mahmoud OM, Adam SE (2002) Effect of feeding Cuminum cyminum fruits, Thymus vulgaris leaves or their mixture to rats. Vet Hum Toxicol 44(2): 67-69 PMID: 11933909 [PubMed-indexed for MEDLINE].
21. Hinshaw JM (1999) Trout production (feeds and feeding methods). SRAC publication no. 223.
22. Iris F, Benzie F, Strain JJ (1996) The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: the FRAP assay. Anal Biochem 239: 70-76.
23. Iwashima M, Mori J, Ting X, Matsunaga T, Hayashi K, Shinoda D, Saito H, Sankawa U, Hayashi T (2005) Antioxidant and antiviral activities of plastoquinones from the brown alga Sargassum micracanthum, and a new chromene derivative converted from the plastoquinones. Biol Pharm Bull 28: 374-377.
24. Jeney G, Yin G, Ardó L, Jeney Z (2009) The use of immunostimulating herbs in fish. An overview of research. Fish Physiol Biochem 35: 669-676. doi: 10. 1007/s10695-009-9304-z.
25. Jia JD, Bauer M, Cho JJ, Ruehl M, Milani S, Boigk G, Riecken OE, Schuppan D (2001) Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by downregulation of procollagen α1(I) and TIMP-1. J Hepatol 35: 392-398 PII: S0l68-8278(01)00148-9.
26. Kaur M, Agarwal R (2007) Silymarin and epithelial cancer chemoprevention: how close we are to bedside? Toxicol Appl Pharmacol 224(3): 350-359. doi: 10. 1016/j. taap. 2006. 11. 011.
27. Kiruthiga PV, Beema Shafreen R, Karutha Pandian S, Arun S, Govindu S, Pandima Devi K (2007) Protective effect of silymarin on erythrocyte haemolysate against benzo(a) pyrene and exogenous reactive oxygen species (H2O2) induced oxidative stress. Chemosphere 68: 1511-1518. doi: 10. 1016/j. chemosphere. 2007. 03. 015.
28. Kohno H, Tanaka T, Kawabata K, Hirose Y, Sugie S, Tsuda H, Mori H (2002) Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats. Int J Cancer 101: 461-468. doi: 10. 1002/ijc. 10625.
29. Kumar RS, Sivakumar T, Sivakumar P, Nethaji R, Vijayabasker M, Perumal P, Gupta M, Mazumder UK (2005) Hepatoprotective and in vivo antioxidant effects of Careya arbrorea against carbon tetrachloride induced liver damage in rats. Int J Mol Med Adv Sci 1(4): 418-424.
30. Nencini C, Giorgi G, Micheli L (2007) Protective effect of silymarin on oxidative stress in rat brain. Phytomedicine 14: 129-135. doi: 10. 1016/j. phymed. 2006. 02. 005.
31. Oliveira CPMS, Lopasso FP, Laurindo FRM, Leitão RMC, Laudanna AA (2001) Protection against liver ischemia-reperfusion injury in rats by silymarin or verapamil. Transpl Proc 33(6): 3010-3014 PII: S0041-1345(01)02288-6.
32. Palanisamy D, Syamala S, Kannan E, Bhojraj S (2007) Protective and therapeutic effects of the Indian medicinal plant Pterocarpus santalinus on d-Galactosamine induced liver damage. Asian J Tradit Med 2(2): 51-57.
33. Pradeep K, Mohan CVR, Gobianand K, Karthikeyan S (2007) Silymarin modulates the oxidant-antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats. Eur J Pharmacol 560: 110-116. doi: 10. 1016/j. ejphar. 2006. 12. 023.
34. Premalakshmi V, Thenmozhi CD (2011) Hepatoprotective effect of hyroethanolic extract of Hybanthus enneaspermus against paracetamol induced liver damage in rats. Int J Biotechnol Biochem 7(2): 239-244.
35. Ramadan LA, Roushdy HM, Abu-Senna GM, Amin NE (2002) Radio-protective effect of silymarin against radiation induced hepatotoxicity. Pharmacol Res 45(6): 447-454. doi: 10. 1006/phrs. 2002. 990.
36. Ramasamy K, Agarwal R (2008) Multitargeted therapy of cancer by silymarin. Cancer Lett 269: 352-362. doi: 10. 1016/j. canlet. 2008. 03. 053.
37. Rao YV, Chakrabarti R (2005) Stimulation of immunity in Indian major carp Catla catla with herbal feed ingredients. Fish Shellfish Immunol 18: 327-334. doi: 10. 1016/j. fsi. 2004. 08. 005.
38. Rao YV, Das BK, Jyotyrmayee P, Chakrabarti R (2006) Effect of Achyranthes aspera on the immunity and survival of Labeo rohita infected with Aeromonas hydrophila. Fish Shellfish Immunol 20: 263-273. doi: 10. 1016/j. fsi. 2005. 04. 006.
39. Šeršeň F, Vencel T, Annus J (2006) Silymarin and its components scavenge phenylglyoxylic ketyl radicals. Fitoterapia 77: 525-529. doi: 10. 1016/j. fitote. 2006. 06. 005.
40. Shaarawy SM, Tohamy AA, Elgendy SM, Abd Elmageed ZY, Bahnasy A, Mohamed MS, Kandil E, Kh Matrougui (2009) Protective effects of garlic and silymarin on NDEA-induced rats hepatotoxicity. Int J Biol Sci 5(6): 549-557 PMID: 19742242 [PubMed-indexed for MEDLINE].
41. Shaker E, Mahmoud H (2010) Mnaa S (2010) Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage. Food Chem Toxicol 48: 803-806. doi: 10. 1016/j. fct. 2009. 12. 011.
42. Sivaram V, Babu MM, Citarasu T, Immanuel G, Murugadass S, Marian MP (2004) Growth and immune response of juvenile greasy groupers (Epinephelus tauvina) fed with herbal antibacterial active principle supplemented diets against Vibrio harveyi infections. Aquaculture 237: 9-20. doi: 10. 1016/j. aquaculture. 2004. 03. 014.
43. Škottová N, Večeřa R, Urbánek K, Vána P, Walterová D, Cvak L (2003) Effects of polyphenolic fraction of silymarin on lipoprotein profile in rats fed cholesterol-rich diets. Pharmacol Res 47: 17-26 PII: S1043-6618(02)00252-9.
44. Sobolová L, Škottová N, Večeřa R, Urbánek K (2006) Effect of silymarin and its polyphenolic fraction on cholesterol absorption in rats. Pharmacol Res 53: 104-112. doi: 10. 1016/j. phrs. 2005. 09. 004.
45. Soto C, Recoba R, Barrón H, Alvarez C, Favari L (2003) Silymarin increases antioxidant enzymes in alloxan-induced diabetes in rat pancreas. Compar Biochem Physiol Part C Toxicol Pharmacol 136(3): 205-212. doi: 10. 1016/S1532-0456(03)00214-X.
46. Soto C, Mena R, Luna J, Cerbón M, Larrieta E, Vital P, Uría E, Sánchez M, Recoba R, Barrón H, Favari L, Lara A (2004) Silymarin induces recovery of pancreatic function after alloxan damage in rats. Life Sci 75: 2167-2180. doi: 10. 1016/j. lfs. 2004. 04. 019.
47. Soto C, Pérez J, García V, Uría E, Vadillo M, Raya L (2010) Effect of silymarin on kidneys of rats suffering from alloxan-induced diabetes mellitus. Phytomedicine 17(14): 1090-1094. doi: 10. 1016/j. phymed. 2010. 04. 011.
48. Stickel F, Patsenker E, Schuppan D (2005) Herbal hepatotoxicity. J Hepatol 43: 901-910. doi: 10. 1016/j. jhep. 2005. 08. 002.
49. Toklu HZ, Tunali-Akbay T, Erkanli G, Yüksel M, Ercan F, Şener G (2007) Silymarin, the antioxidant component of Silybum marianum, protects against burn-induced oxidative skin injury burns. 33: 908-916. doi: 10. 1016/j. burns. 2006. 10. 407.
50. Toklu HZ, Tunali{dotless}-Akbay T, Velioglu-Ogunc A, Ercan F, Gedik N, Keyer-Uysal M, Sener G (2008) Silymarin, the antioxidant component of Silybum marianum, prevents sepsis-induced acute lung and brain injury. J Surg Res 145: 214-222. doi: 10. 1016/j. jss. 2007. 03. 072.
51. Valenzuela A, Monica A, Soledad V, Ricardo G (1989) Selectivity of silymarin on the increase of the glutathione content in different tissues of the rats. Planta Med 55: 420-422.
52. Venkataramanan R, Ramachandran V, Komoroski BJ, Zhang S, Schiff PL, Strom SC (2000) Milk thistle, an herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures. Drug Metab Dispos 28: 1270-1273.
53. Wu CC, Liu CH, Chang YP, Hsieh SL (2010) Effects of hot-water extract of Toona sinensis on immune response and resistance to Aeromonas hydrophila in Oreochromis mossambicus. Fish Shellfish Immunol 29: 258-263. doi: 10. 1016/j. fsi. 2010. 04. 021.
54. Yadava NP, Pal A, Shanker K, Bawankule DU, Gupta AK, Darokar MP, Khanuja SPS (2008) Synergistic effect of silymarin and standardized extract of Phyllanthus amarus against CCl4-induced hepatotoxicity in Rattus norvegicus. Phytomedicine 15: 1053-1061. doi: 10. 1016/j. phymed. 2008. 08. 002.
55. Yin G, Ardo L, Thompson KD, Adams A, Jeney Z, Jeney G (2009) Chinese herbs (Astragalus radix and Ganoderma lucidum) enhance immune response of carp, Cyprinus carpio, and protection against Aeromonas hydrophila. Fish Shellfish Immunol 26: 140-145. doi: 10. 1016/j. fsi. 2008. 08. 015.
56. Zuber R, Modrianský M, Dvořák Z, Rohovský P, Ulrichová J, Šimánek V, Anzenbacher P (2002) Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities. Phytother Res 16(7): 632-638. doi: 10. 1002/ptr. 1000.