Evaluation of the hepatoprotective effect of Aloe vera, Clematis hirsute, Cucumis prophetarum and Bee Propolis against experimentally induced liver injury in rats

International Journal of Pharmacology

Volumn 4, Issue 3, 2008, Pages 213-217

  Alqasoumi, Saleh I ^a   Al Howiriny, Tawfik A ^a   Abdel Kader, Maged S ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Aloe vera; Carbon tetrachloride; Clematis hirsute; Cucumis prophetarum; Hepatoprotection; Propolis; Rats; Silymarin

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ALKALINE PHOSPHATASE; ALOE VERA EXTRACT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBON TETRACHLORIDE; CLEMATIS HIRSUTE EXTRACT; CUCUMIS PROPHETARUM EXTRACT; PLANT EXTRACT; PROPOLIS; SILYMARIN; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CLEMATIS HIRSUTE; CONTROLLED STUDY; CUCUMIS PROPHETARUM; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; EXPERIMENTAL ANIMAL; FEMALE; HISTOPATHOLOGY; LIVER FUNCTION; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; LOW DRUG DOSE; MALE; MEDICINAL PLANT; NONHUMAN; RAT; SOLVENT EXTRACTION;

EID: 60249083687     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2008.213.217     Document Type: Article

References (18)

1. Abdel-Kader, M.S. and S.I. Alqasoumi, 2008. Evaluation of the hepatoprotective effect of the ethanol extracts of Solanum nigrum, Cassia fistula, Balanites aegyptiaca and Carthamus tinctorius against experimentally induced liver injury in rats. Alex. J. Pharma. Sci., 22: 47-50.
2. Al-Yahya, M.A., I.A. Al-Meshal, J.S. Mossa, A.A. Al-Badr and M. Tariq, 1990. Saudi Plants: A Phytochemical and Biological Approach. King Saud University Press, Riyadh, pp: 142-144.
3. Ansorge, S., D. Reinhold and U. Lendeckel, 2003. Propolis and some of its constituents down-regulate DNA synthesis and inflammatory cytokine production but induce TGF-beta1 production of human immune cells. Z. Naturforsch., 58: 580-589.
4. Boon, N., N. Colledge, B. Walker and J. Hunter, 2006. Davidson's Principles and Practice Medicine, Churchill Livingstone Press, UK., ISBN-10: 0-443-10057-8.
5. Brätter, C., M. Tregel, C. Liebenthal and H.D. Volk, 1999. Prophylactic effectiveness of propolis for immunostimulation: A clinical pilot study. Forsch Komplementarmed., 6: 256-260.
6. Chaudhary, S.A., 1998. Flora of the Kingdom of Saudi Arabia. Vol. 1. Ministry of Agriculture and Water National Herbarium, National Agriculture and Water Research Center, Riyadh, pp: 70-79. ISBN: 9960-18-013-1.
7. Dehmlow, C., J. Erhard and H. de Groot, 1996a. Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin. Hepatology, 23: 749-754.
8. Dehmlow, C., N. Murawski and H. de Groot, 1996b. Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin human cells. Life Sci., 52: 1591-1600.
9. Gakova, N., E. Mishurova and K. Kropachova, 1992. Effects of flavobion on nucleic acids in tissues of rats irradiated with gamma rays. Biull. Eksp. Biol. Med., 113: 275-277.
10. Lin, C.C., D.E. Shieh and M.N. Yen, 1997. Hepatoprotective effect of fractions Ban-zhi-lian of experimental liver injuries in rats. J. Ethnopharmacol., 56: 193-200.
11. Morgan, G.R.., 1981. Sugar Bowls (Clematis hirsutissima): A horse restorative of the Nez Perces. J. Ethnopharmacol., 4: 117-120.
12. Mossa, J.S., M.A. Al-Yahya and I.A. Al-Meshal, 1987. Medicinal Plants of Saudi Arabia. 1st Edn. King Saud University Libraries Publications, Riyadh, ISBN: 9960-36-476-3.
13. Prophet, E.P., B. Mills, J.B. Arrington and L.H. Sobin, 1994. Laboratory Methods in Histology. American Registry of Pathology, Washington, DC., ISBN: 1-881041-00-X.
14. Ram, V.J., 2001. Herbal preparations as a source of hepatoprotective agents. Drug News Perspect., 14: 353-363.
15. Saller, R., J. Melzer, J. Reichling, R. Brignoli and R. Meier, 2007. An updated systematic review of the pharmacology of silymarin. Forsch. Komplementarmed, 14: 70-80.
16. Woolson, R.F. and W.R. Clarke, 2002. Statistical Methods for the Analysis of Biomedical Data. John Wiley and Sons. Inc., New York, ID: 55939.
17. Xu, R., W. Zhao, J. Xu, B. Shao and G. Qin, 1996. Studies on bioactive saponins from Chinese medicinal plants. Adv. Exp. Med. Biol., 404: 371-382.
18. Zafar, R. and S.M. Ali, 1998. Anti-hepatotoxic effects of root and root callus extracts of Cichorium intybus L. J. Ethnopharmacol., 63: 227-231.