Effects of polyphenolic fraction of silymarin on lipoprotein profile in rats fed cholesterol-rich diets

Pharmacological Research

Volumn 47, Issue 1, 2003, Pages 17-26

  Škottová, Nina ^a   Večeřa, Rostislav ^a   Urbánek, Karel ^a   Váňa, Petr ^a   Walterová, Daniela ^a   Cvak, Ladislav ^b  

^a PALACKÝ UNIVERSITY   (Czech Republic)

^b TEVA PHARMACEUTICALS   (Israel)

Author keywords

Antioxidant status; Lipoprotein profile; Liver lipids; Polymerised polyphenolics; Silymarin

Indexed keywords

CHOLESTEROL; FAT; GLUTATHIONE; HIGH DENSITY LIPOPROTEIN; LIPID; LIPOPROTEIN; OIL; POLYPHENOL DERIVATIVE; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID; SILYMARIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CHOLESTEROL INTAKE; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE TIME EFFECT RELATION; DRUG EFFECT; FATTY LIVER; LIPOPROTEIN BLOOD LEVEL; LOW FAT DIET; NONHUMAN; PRIORITY JOURNAL; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0037285439     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-6618(02)00252-9     Document Type: Article

References (51)

1. Morazzoni P., Bombardelli E. Silybum marianum (Carduus marianus). Fitoterapia. 66:1995;3-42.
2. Flora K., Hahn M., Rosen H., Benner K. Milk thistle (Silybum marianum) for the therapy of liver diseases. Am. J. Gastroenterol. 93:1998;139-143.
3. Luper S. A review of plants used in the treatment of liver disease: part I. Altern. Med. Rev. 3:1998;410-421.
4. Saller R., Meier R., Brignoli R. The use of silymarin in the treatment of liver diseases. Drugs. 61:2001;2035-2063.
5. Wellington K., Jarvis B. Silymarin: a review of its clinical properties in the management of hepatic disorders. BioDrugs. 15:2001;465-489.
6. Valenzuela A., Garrido A. Biochemical bases of the pharmacological action of the flavonoid silymarin and its structural isomer silibinin. Biol. Res. 27:1994;105-112.
7. Basaga H., Poli G., Tekkaya C., Aras I. Free radical scavenging and antioxidative properties of "silibin" complexes on microsomal lipid peroxidation. Cell Biochem. Funct. 15:1997;27-33.
8. Campos R., Garrido A., Guerra R., Valenzuela A. Silybin dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver. Planta Med. 55:1989;417-419.
9. Valenzuela A., Aspillaga M., Vial S., Guerra R. Selectivity of silymarin on the increase of the glutathione content in different tissues of the rat. Planta Med. 55:1989;420-422.
10. Krečman V., Škottová N., Walterová D., Ulrichová J., Šimánek V. Silymarin inhibits the development of diet-induced hypercholesterolemia in rats. Planta Med. 64:1998;138-142.
11. Šimánek V., Škottová N., Bartek J., Psotová J., Kosina P., Balejová L.et al. Extract from Silybum marianum as nutraceutical: a double blind placebo-controlled study in healthy young men. Czech J. Food Sci. 19:2001;106-110.
12. Škottová N., Krečman V., Váňa P., Chmela Z., Ulrichová J., Šimánek V. Effect of silymarin and silibinin-phosphatidylcholine complex on plasma and lipoprotein cholesterol, and oxidation of LDL in rats fed on high cholesterol diet supplemented with currant oil. Acta Univ. Palacki. Olomuc. Fac. Med. 144:2000;55-58.
13. Škottová N., Krečman V. Dietary silymarin improves removal of low density lipoproteins by the perfused rat liver. Acta Univ. Palacki. Olomuc. Fac. Med. 141:1998;39-40.
14. Higashi K., Ishikawa T., Shige H., Tomiyasu K., Yoshida H., Ito T.et al. Olive oil increases the magnitude of postprandial chylomicron remnants compared to milk fat and safflower oil. J. Am. Coll. Nutr. 16:1997;429-434.
15. Grundy SM. Nutrient composition and the metabolic syndrome. In: Jacotot B, Mathé D, Fruchart JC, editors. Atherosclerosis XI. Singapore: Elsevier Science; 1998, p. 519-27.
16. Nestel PJ. Fish oils, lipids and coronary artery disease. In: Jacotot B, Mathé D, Fruchart JC, editors. Atherosclerosis XI. Singapore: Elsevier Science; 1998, p. 195-200.
17. Harper C.R., Jacobson T.A. The fats of life. The role of omega-3 fatty acids in the prevention of coronary heart disease. Arch. Intern. Med. 161:2001;2185-2192.
18. Porter N.A., Caldwell S.E., Mills K.A. Mechanisms of free radical oxidation of unsaturated lipids. Lipids. 30:1995;277-290.
19. Noguchi N, Niki E. Free radicals and active oxygen species. In: Papas AM, editor. Antioxidant status, diet, nutrition, and health. Boca Raton: CRC Press; 1999, p. 3-20.
20. Havel R.J., Eder H.A., Bragdon J.H. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest. 34:1955;1345-1353.
21. Haug A., Hostmark A.T. Lipoprotein lipase, lipoproteins and tissue lipids in rats fed fish oil or coconut oil. J. Nutr. 117:1987;1011-1017.
22. Sedlak J., Lindsay R.H. Estimation of total, protein bound, and non protein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem. 25:1968;192-205.
23. Buege JA, Aust SD. Microsomal lipid peroxidation. In: Fleischer S, Packer L, editors. Methods in enzymology, vol. 52. New York: Academic Press; 1978, p. 302-10.
24. Morazzoni P., Montalbetti A., Malandrino S., Pifferi G. Comparative pharmacokinetics of silipide and silymarin in rats. Eur. J. Drug Metab. Pharmacokinet. 18:1993;289-297.
25. Škottová N., Švagera Z., Večeřa R., Urbánek K., Jegorov A., Šimánek V. Pharmacokinetic study of iodine-labeled silibinins in rat. Pharmacol. Res. 44:2001;247-253.
26. Palkovič M, Škottová N, Mrhová O. Metabolism of lipids and lipoproteins. The vascular wall in rats with spontaneous high and low response to cholesterol diet. In: Palkovič M, editor. Hormones, lipoproteins and atherosclerosis. Adv Physiol Sci, vol. 35. Budapest: Pergamon Press; 1981, p. 329-46.
27. Mahley R.W., Hussain M.M. Chylomicron and chylomicron remnant catabolism. Curr. Opin. Lipidol. 2:1991;170-176.
28. Vahouny G.V., Tombes R., Cassidy M.M., Kritchevsky D., Gallo L.L. Dietary fibers: V. Binding of bile salts, phospholipids and cholesterol from mixed micelles by bile acid sequestrants and dietary fibers. Lipids. 15:1980;1012-1028.
29. Huk I., Schulz F., Abrahamian V., Kaminski M.V. Cholesterol: an antidiarrheal agent in rats with short-bowel syndrome fed elemental diets. Eur. Surg. Res. 18:1986;356-360.
30. Shapiro R.H., Heizer W.D., Goldfinger S.E. Cholestyramine responsive idiopathic diarrhea. Gastroenterology. 58:1970;993.
31. Habba S.F. Chronic diarrhea: identifying a new syndrome. Am. J. Gastroenterol. 95:2000;2140-2141.
32. Ronnemaa T. Effect of high cholesterol, olive oil diet on the lipids and connective tissue in rat liver. A biochemical study. Scand. J. Gastroenterol. 11:1976;849-855.
33. Boigk G., Stroedter L., Herbst H., Waldschmidt J., Riecken E.O., Schuppan D. Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats. Hepatology. 26:1997;643-649.
34. Lottenberg A.M., Oliveira H.C., Nakandakare E.R., Quintao E.C. Effect of dietary fish oil on the rate of very low desity lipoprotein triacylglycerol formation and on the metabolism of chylomicrons. Lipids. 27:1992;326-330.
35. Abdel-Fattah G., Fernandez M.L., McNamara D.J. Regulation of guinea pig very low density lipoprotein secretion rates by dietary fat saturation. J. Lipid. Res. 36:1995;1188-1198.
36. Mason T.M. The role of factors that regulate the synthesis and secretion of very-low-density lipoprotein by hepatocytes. Crit. Rev. Clin. Lab. Sci. 35:1998;461-487.
37. Nestel P.J. Effects of n - 3 fatty acids on lipid metabolism. Ann. Rev. Nutr. 10:1990;149-167.
38. Brown A.M., Castle J., Hebbachi A.M., Gibbons G.F. Administration of n - 3 fatty acids in the diets of rats or directly to hepatocyte cultures results in different effects on hepatocellular ApoB metabolism and secretion. Arterioscler. Thromb. Vasc. Biol. 19:1999;106-114.
39. Kendrick J.S., Wilkinson J., Higgins J.A. Mechanisms of inhibition of hepatic secretion of very low density lipoproteins by dietary fish oils. Biochem. Soc. Trans. 26:1998;183.
40. Nassuato G., Iemmolo R.M., Strazzabosco M., Lirussi F., Deana R., Francesconi M.A.et al. Effect of silibinin on biliary lipid composition: experimental and clinical study. J. Hepatol. 12:1991;290-295.
41. Theriault A., Wang Q., Van Iderstine S.C., Chen B., Franke A.A., Adeli K. Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid. J. Lipid Res. 41:2000;1969-1979.
42. Ide T., Gotoh Y., Sugano M. Dietary regulation of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase and cholesterol synthetic activities in fasted-refeded rats. J. Nutr. 110:1980;158-168.
43. Alejandre M.J., Ramirez H., Segovia J.L., Garcia-Peregrin E. Effect of dietary cholestrol and cholestyramine on developmental pattern of 3-hydroxy-3-methylglutaryl-CoA reductase. Ann. Nutr. Metab. 29:1985;111-118.
44. George R., Davis P.J., Luong L., Poznansky M.J. Cholesterol-mediated regulation of HMG-CoA reductase in microsomes from human skin fibroblasts and rat liver. Biochem. Cell Biol. 68:1990;674-679.
45. Choi Y.S., Tomari Y., Sugano M., Ide T. Effects of short-term cholestyramine feeding on cholesterol metabolism in differently aged rats. Mech. Ageing Dev. 41:1987;149-159.
46. Shepherd J. Mechanism of action of bile acid sequestrants and other lipid-lowering drugs. Cardiology. 76:1989;65-74.
47. Piemonte F., Pastore A., Tozzi G., Tagliacozzi D., Santorelli F.M., Carrozzo R.et al. Glutathione in blood of patients with Friedreich's ataxia. Eur. J. Clin. Invest. 31:2001;1007-1011.
48. Valencia E., Marin A., Hardy G. Glutathione - nutritional and pharmacological viewpoints: part II. Nutrition. 17:2001;485-486.
49. Jenkinson A., Franklin M.F., Wahle K., Duthie G.G. Dietary intake of polyunsaturated fatty acids and indices of oxidative stress in human volunteers. Eur. J. Clin. Nutr. 53:1999;523-528.
50. Cooper A.J., Kristal B.S. Multiple roles of glutathione in the central nervous system. Biol. Chem. 378:1997;793-802.
51. Spolarics Z., Meyenhofer M. Augmented resistance to oxidative stress in fatty rat livers induced by a short-term sucrose-rich diet. Biochim. Biophys. Acta. 1487:2000;190-200.