Studies on the extra-mitochondrial CoA-ester formation of valproic and Δ4-valproic acids

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1771, Issue 4, 2007, Pages 533-543

  Aires, Cátia C P ^a   Ruiter, Jos P N ^c   Luís, Paula B M ^a   ten Brink, Herman J ^b   IJlst, Lodewijk ^c   de Almeida, Isabel Tavares ^a   Duran, Marinus ^c   Wanders, Ronald J A ^c   Silva, Margarida F B ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

4 Valproic acid; Acyl CoA synthetase; Drug induced steatosis; Fatty acid activation; Steatosis mechanism; Valproic acid

Indexed keywords

2 PROPYL 4 PENTENOIC ACID; ACYL COENZYME A; DRUG METABOLITE; LONG CHAIN FATTY ACID COENZYME A LIGASE; MEDIUM CHAIN FATTY ACID; VALPROIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; CELL FRACTIONATION; CENTRIFUGATION; CONTROLLED STUDY; DRUG ACTIVATION; DRUG METABOLISM; ENZYME ACTIVATION; ENZYME KINETICS; LIVER CYTOSOL; LIVER HOMOGENATE; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL TOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ACYL COENZYME A; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRATE (SI)-SYNTHASE; COENZYME A; CYTOSOL; ESTERS; HEPATOCYTES; HYDROGEN-ION CONCENTRATION; KINETICS; MALE; MITOCHONDRIA, LIVER; RATS; RATS, WISTAR; REFERENCE STANDARDS; TIME FACTORS; VALPROIC ACID;

RATTUS;

EID: 34047225451     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2007.01.010     Document Type: Article

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