Valproate inhibits the mitochondrial pyruvate-driven oxidative phosphorylation in vitro

Journal of Inherited Metabolic Disease

Volumn 20, Issue 3, 1997, Pages 397-400

  Silva, M F B ^a,b   Ruiter, J P N ^b   Ijlst, L ^b   Jakobs, C ^c   Duran, M ^d   Tavares De Almeida, I ^a   Wanders, R J A ^b  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

2 PROPYL 2 PENTENOIC ACID; 2 PROPYL 4 PENTENOIC ACID; ADENOSINE TRIPHOSPHATE; PYRUVIC ACID; VALPROIC ACID;

ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; LIVER CELL; LIVER METABOLISM; LIVER MITOCHONDRION; LIVER TOXICITY; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; RAT;

EID: 0030878541     PISSN: 01418955     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005398516208     Document Type: Conference Paper

References (8)

1. Baillie TA (1992) Metabolism of valproate to hepatotoxic intermediates. Pharmaceutisch Weekblad Scientific 14 (3A): 122-125.
2. Becker CM, Harris RA (1983) Influence of valproic acid on hepatic carbohydrate and lipid metabolism. Arch Biochem Biophys 223: 381-392.
3. Estabrook RW (1967) Mitochondrial respiratory control and the polarographic measurement of ADP:O ratios. Methods Enzymol 10: 41-47.
4. Haas R, Stumpf DA, Parks JK, Eguren L (1981) Inhibitory effects of sodium valproate on oxidative phosphorylation. Neurology 31: 1473-1476.
5. Ponchaut S, Van Hoof F, Veitch K (1992) In vitro effects of valproate and valproate metabolites on mitochondrial oxidations. Biochem Pharmacol 43: 2435-2442.
6. Rumbach L, Warter JM, Rendon A, Marescaux C, Micheletti G, Waksman A (1983) Inhibition of oxidative phosphorylation in hepatic and cerebral mitochondria of sodium valproate-treated rats. J Neurol Sci 61: 417-423.
7. Veitch K, Van Hoof F (1990) In vitro effects of eight-carbon fatty acids on oxidations in rat liver mitochondria. Biochem Pharmacol 40 (9): 2153-2159.
8. Wanders RJA, Ruiter JPN, Wijburg FA (1993) Studies on mitochondrial oxidative phosphorylation in permeabilized human skin fibroblasts: application to mitochondrial encephalomyopathies. Biochim Biophys Acta 1181: 219-222.