Complete β-oxidation of valproate: Cleavage of 3-oxovalproyl-CoA by a mitochondrial 3-oxoacyl-CoA thiolase

Biochemical Journal

Volumn 362, Issue 3, 2002, Pages 755-760

  Silva, Margarida F B ^a   Ruiter, Jos P N ^a   Overmars, Henk ^a   Bootsma, Albert H ^a   Van Gennip, Albert H ^a   Jakobs, Cornelis ^a   Duran, Marinus ^a   Tavares de Almeida, Isabel ^a   Wanders, Ronald J A ^a  

^a UNIVERSITY OF LISBON   (Portugal)

Author keywords

Fatty acid oxidation; Mitochondrial thiolases; Valproate metabolism; Valproic acid

Indexed keywords

HYDROLYSIS; IONIZATION; OXIDATION; ULTRAVIOLET RADIATION;

MITOCHONDRIA; VALPROATE;

BIOCHEMISTRY;

3 HYDROXYVALPROYL COENZYME A; 3 OXOVALPROYL COENZYME A; ACETYL COENZYME A ACYLTRANSFERASE; CARNITINE ACETYLTRANSFERASE; COENZYME A; DRUG METABOLITE; MITOCHONDRIAL ENZYME; PENTANOYL COENZYME A; PENTANOYLCARNITINE; PROPIONYL COENZYME A; PROPIONYLCARNITINE; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME BINDING; FATTY ACID OXIDATION; HYDROLYSIS; MALE; MASS SPECTROMETRY; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; RADIOCHEMISTRY; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY; ULTRAVIOLET RADIATION;

ACETYL-COA C-ACYLTRANSFERASE; ACYL COENZYME A; ANIMALS; CARNITINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEUTERIUM OXIDE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MITOCHONDRIA, LIVER; OXIDATION-REDUCTION; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; VALPROIC ACID;

ANIMALIA;

EID: 0037086594     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3620755     Document Type: Article

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