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Volumn 32, Issue 11, 2004, Pages 1304-1310

Valproyl-dephosphoCoA: A novel metabolite of valproate formed in vitro in rat liver mitochondria

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; UNCLASSIFIED DRUG; VALPROIC ACID; VALPROYL DEPHOSPHOCOENZYME A;

EID: 6944246254     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd...     Document Type: Article
Times cited : (25)

References (29)
  • 1
    • 0008463096 scopus 로고    scopus 로고
    • Chemistry and biotransformation
    • (Löscher W ed), Birkhäuser Verlag, Basel, Switzerland
    • Abbott FS and Anari MR (1999) Chemistry and biotransformation, in Valproate (Milestones in Drug Therapy) (Löscher W ed) pp 47-75, Birkhäuser Verlag, Basel, Switzerland.
    • (1999) Valproate (Milestones in Drug Therapy) , pp. 47-75
    • Abbott, F.S.1    Anari, M.R.2
  • 3
    • 0037352050 scopus 로고    scopus 로고
    • 2-Oxo acid dehydrogenase complexes in redox regulation
    • Bunik VI (2003) 2-Oxo acid dehydrogenase complexes in redox regulation. Eur J Biochem 270:1036-1042.
    • (2003) Eur J Biochem , vol.270 , pp. 1036-1042
    • Bunik, V.I.1
  • 5
    • 0028045747 scopus 로고
    • Valproic acid: A reappraisal of its pharmacological properties and clinical efficacy in epilepsy
    • Davis R, Peters DH, and McTavish D (1994) Valproic acid: a reappraisal of its pharmacological properties and clinical efficacy in epilepsy. Drugs 47:332-372.
    • (1994) Drugs , vol.47 , pp. 332-372
    • Davis, R.1    Peters, D.H.2    McTavish, D.3
  • 6
    • 0033912868 scopus 로고    scopus 로고
    • Identification and characterization of N-acetylcysteine conjugates of valproic acid in humans and animals
    • Gopaul SV, Farrell K, and Abbott FS (2000) Identification and characterization of N-acetylcysteine conjugates of valproic acid in humans and animals. Drug Metab Dispos 28:823-832.
    • (2000) Drug Metab Dispos , vol.28 , pp. 823-832
    • Gopaul, S.V.1    Farrell, K.2    Abbott, F.S.3
  • 7
    • 0038347142 scopus 로고    scopus 로고
    • Amino acid conjugates: Metabolites of 2-propylpentanoic acid (valproic acid) in epileptic patients
    • Gopaul SV, Tang W, Farrell K, and Abbott FS (2003) Amino acid conjugates: metabolites of 2-propylpentanoic acid (valproic acid) in epileptic patients. Drug Metab Dispos 31:114-121.
    • (2003) Drug Metab Dispos , vol.31 , pp. 114-121
    • Gopaul, S.V.1    Tang, W.2    Farrell, K.3    Abbott, F.S.4
  • 8
    • 0031829096 scopus 로고    scopus 로고
    • Altered antioxidant enzyme activities in children with a serious adverse experience related to valproic acid therapy
    • Graf WD, Oleinik OE, Glauser TA, Maertens P, Eder DN, and Pippenger CE (1998) Altered antioxidant enzyme activities in children with a serious adverse experience related to valproic acid therapy. Neuropediatrics 29:195-201.
    • (1998) Neuropediatrics , vol.29 , pp. 195-201
    • Graf, W.D.1    Oleinik, O.E.2    Glauser, T.A.3    Maertens, P.4    Eder, D.N.5    Pippenger, C.E.6
  • 10
    • 0025257450 scopus 로고
    • The enzymatic basis for the metabolism and inhibitory effects of valproic acid: Dehydrogenation of valproyl-CoA by 2-methyl-branched-chain acyl-CoA dehydrogenase
    • Ito M, Ikeda Y, Arnez JG, Finochiaro G, and Tanaka K (1990) The enzymatic basis for the metabolism and inhibitory effects of valproic acid: dehydrogenation of valproyl-CoA by 2-methyl-branched-chain acyl-CoA dehydrogenase. Biochim Biophys Acta 1034:213-218.
    • (1990) Biochim Biophys Acta , vol.1034 , pp. 213-218
    • Ito, M.1    Ikeda, Y.2    Arnez, J.G.3    Finochiaro, G.4    Tanaka, K.5
  • 11
    • 0028289068 scopus 로고
    • Metabolic activation of unsaturated derivatives of valproic acid. Identification of novel glutathione adducts formed through coenzyme A-dependent and -independent processes
    • Kassahun K, Hu P, Grillo MP, Davis MR, Jin L, and Baillie TA (1994) Metabolic activation of unsaturated derivatives of valproic acid. Identification of novel glutathione adducts formed through coenzyme A-dependent and -independent processes. Chem-Biol Interact 90:253-275.
    • (1994) Chem-Biol Interact , vol.90 , pp. 253-275
    • Kassahun, K.1    Hu, P.2    Grillo, M.P.3    Davis, M.R.4    Jin, L.5    Baillie, T.A.6
  • 12
    • 0033022361 scopus 로고    scopus 로고
    • Fatal liver failure associated with valproate therapy in a patient with Friedreich's disease: Review of valproate hepatotoxicity in adults
    • König SA, Schenk M, Sick C, Holm E, Heubner C, Weiss A, König I, and Helmann R (1999) Fatal liver failure associated with valproate therapy in a patient with Friedreich's disease: review of valproate hepatotoxicity in adults. Epilepsia 40:1036-1040.
    • (1999) Epilepsia , vol.40 , pp. 1036-1040
    • König, S.A.1    Schenk, M.2    Sick, C.3    Holm, E.4    Heubner, C.5    Weiss, A.6    König, I.7    Helmann, R.8
  • 14
    • 0015820032 scopus 로고
    • Regulation of glutamate metabolism and interactions with the citric acid cycle in rat heart mitochondria
    • LaNoue KF, Walajtys EI, and Williamson JR (1973) Regulation of glutamate metabolism and interactions with the citric acid cycle in rat heart mitochondria. J Biol Chem 248:7171-7183.
    • (1973) J Biol Chem , vol.248 , pp. 7171-7183
    • LaNoue, K.F.1    Walajtys, E.I.2    Williamson, J.R.3
  • 16
    • 0019784208 scopus 로고
    • Valproic acid and several metabolites: Quantitative determination in serum, urine, breast milk and tissues by gas chromatography-mass spectrometry using selected ion monitoring
    • Nau H, Wittfoht W, Schaffer H, Jakobs C, Rating D, and Helge H (1981) Valproic acid and several metabolites: quantitative determination in serum, urine, breast milk and tissues by gas chromatography-mass spectrometry using selected ion monitoring. J Chromatogr 226:69-78.
    • (1981) J Chromatogr , vol.226 , pp. 69-78
    • Nau, H.1    Wittfoht, W.2    Schaffer, H.3    Jakobs, C.4    Rating, D.5    Helge, H.6
  • 17
    • 0032497365 scopus 로고    scopus 로고
    • Thermodynamics of ligand binding and catalysis in human liver medium-chain acyl-CoA dehydrogenase: Comparative studies involving normal and 3′-dephosphorylated C8-CoAs and wild type and Asn191→Ala (N191A) mutant enzymes
    • Peterson KL, Peterson KM, and Srivastava DK (1998) Thermodynamics of ligand binding and catalysis in human liver medium-chain acyl-CoA dehydrogenase: comparative studies involving normal and 3′-dephosphorylated C8-CoAs and wild type and Asn191→Ala (N191A) mutant enzymes. Biochemistry 37:12659-12671.
    • (1998) Biochemistry , vol.37 , pp. 12659-12671
    • Peterson, K.L.1    Peterson, K.M.2    Srivastava, D.K.3
  • 18
    • 0030873898 scopus 로고    scopus 로고
    • Functional role of a distal (3′-phosphate) group of CoA in the recombinant human liver medium-chain acyl-CoA dehydrogenase-catalysed reaction
    • Peterson KL and Srivastava DK (1997) Functional role of a distal (3′-phosphate) group of CoA in the recombinant human liver medium-chain acyl-CoA dehydrogenase-catalysed reaction. Biochem J 325:751-760.
    • (1997) Biochem J , vol.325 , pp. 751-760
    • Peterson, K.L.1    Srivastava, D.K.2
  • 20
    • 0025061083 scopus 로고
    • Comparison of the binding affinities of acyl-CoA-binding protein and fatty-acid-binding protein for long-chain acyl-CoA esters
    • Rasmussen JT, Börchers T, and Knudsen J (1990) Comparison of the binding affinities of acyl-CoA-binding protein and fatty-acid-binding protein for long-chain acyl-CoA esters. Biochem J 265:849-855.
    • (1990) Biochem J , vol.265 , pp. 849-855
    • Rasmussen, J.T.1    Börchers, T.2    Knudsen, J.3
  • 24
  • 26
    • 0026719614 scopus 로고
    • Valproate hepatotoxicity syndrome: Hypotheses of pathogenesis
    • Stephens JR and Levy RH (1992) Valproate hepatotoxicity syndrome: hypotheses of pathogenesis. Pharm Weekbl Sci 14 (3A):118-121.
    • (1992) Pharm Weekbl Sci , vol.14 , Issue.3 A , pp. 118-121
    • Stephens, J.R.1    Levy, R.H.2
  • 27
    • 0029974584 scopus 로고    scopus 로고
    • Bioactivation of atoxic metabolite of valproic acid, (E)-2-propyl-2,4- pentadienoic acid, via glucuronidation. LC/MS/MS characterization of the GSH-glucuronide diconjugates
    • Tang W and Abbott FS (1996) Bioactivation of atoxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, via glucuronidation. LC/MS/MS characterization of the GSH-glucuronide diconjugates. Chem Res Toxicol 9:517-526.
    • (1996) Chem Res Toxicol , vol.9 , pp. 517-526
    • Tang, W.1    Abbott, F.S.2
  • 28
    • 0023162502 scopus 로고
    • Determination of VPA and its metabolites by GC-MS with SIM
    • Tatsuhara T, Muro H, Matsuda Y, and Imai Y (1987) Determination of VPA and its metabolites by GC-MS with SIM. J Chromatogr 399:183-195.
    • (1987) J Chromatogr , vol.399 , pp. 183-195
    • Tatsuhara, T.1    Muro, H.2    Matsuda, Y.3    Imai, Y.4
  • 29
    • 6944231975 scopus 로고    scopus 로고
    • Metabolic strategies
    • Wm. C. Brown Publishers. Dubuque, 1A
    • Zubay G (1998) Metabolic strategies, in Biochemistry, pp 267-281, Wm. C. Brown Publishers. Dubuque, 1A.
    • (1998) Biochemistry , pp. 267-281
    • Zubay, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.