Impact of divalent metal ions on regulation of adenylyl cyclase isoforms by forskolin analogs

Biochemical Pharmacology

Volumn 82, Issue 11, 2011, Pages 1673-1681

  Erdorf, Miriam ^a   Mou, Tung Chung ^b   Seifert, Roland ^c  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY OF MONTANA   (United States)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Adenylyl cyclase; Diterpenes; Divalent cations; Forskolin; Molecular modelling

Indexed keywords

7 DEACETYL 7 [O (N METHYLPIPERAZINO) GAMMA BUTYRYL]; ADENYLATE CYCLASE; CYCLIC NUCLEOTIDE; DITERPENE; FORSKOLIN; ISOENZYME; MAGNESIUM ION; MANGANESE; METAL ION; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CORRELATION ANALYSIS; ENZYME ACTIVITY; FLUORESCENCE ANALYSIS; MOLECULAR DOCKING; PRIORITY JOURNAL;

ADENYLATE CYCLASE; AMINO ACID SEQUENCE; ANIMALS; CATIONS, DIVALENT; CATTLE; CELL LINE; DOGS; FLUORESCENT DYES; FORSKOLIN; ISOENZYMES; MAGNESIUM COMPOUNDS; MANGANESE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; RATS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80255125995     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.07.099     Document Type: Article

References (32)

1. J. Hanoune, and N. Defer Regulation and role of adenylyl cyclase isoforms Annu Rev Pharmacol Toxicol 41 2001 145 174 (Pubitemid 32385886)
2. R.K. Sunahara, and R. Taussig Isoforms of mammalian adenylyl cyclase: multiplicities of signaling Mol Intervent 2 2002 168 184
3. J.J. Tesmer, R.K. Sunahara, R.A. Johnson, G. Gösselin, A.G. Gilman, and S.R. Sprang Two-metal-ion catalysis in adenylyl cyclase Science 285 1999 756 760
4. Sα-GTPγS Science 278 1997 1907 1916 (Pubitemid 28013225)
5. S.Y. Cech, W.C. Broaddus, and M.E. Maguire Adenylate cyclase: the role of magnesium and other divalent cations Mol Cell Biochem 33 1980 67 92
6. A. Gille, G.H. Lushington, T.C. Mou, M.B. Doughty, R.A. Johnson, and R. Seifert Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides J Biol Chem 279 2004 19955 19969 (Pubitemid 38623438)
7. H. Wald, and M.M. Popovtzer Effect of divalent ions on basal and hormone-activated renal adenylate cyclase/cyclic AMP system Miner Electrolyte Metab 10 1984 133 140 (Pubitemid 14199726)
8. K.B. Seamon, and J.W. Daly Forskolin: its biological and chemical properties Adv Cyclic Nucleotide Protein Phosphorylation Res 20 1986 1 150
9. W.C. Putnam, S.M. Swenson, G.A. Reif, D.P. Wallace, G.M. Helmkamp Jr., and J.J. Grantham Identification of a forskolin-like molecule in human renal cysts J Am Soc Nephrol 18 2007 934 943 (Pubitemid 46434510)
10. T. Onda, Y. Hashimoto, M. Nagai, H. Kuramochi, S. Saito, and H. Yamazaki Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms J Biol Chem 276 2001 47785 47793
11. H. Metzger, and E. Lindner The positive inotropic-acting forskolin, a potent adenylate cyclase activator Arzneimittelforschung 31 1981 1248 1250 (Pubitemid 11002870)
12. Y. Toya, C. Schwencke, and Y. Ishikawa Forskolin derivatives with increased selectivity for cardiac adenylyl cyclase J Mol Cell Cardiol 30 1998 97 108 (Pubitemid 28069748)
13. S. Pierre, T. Eschenhagen, G. Geisslinger, and K. Scholich Capturing adenylyl cyclases as potential drug targets Nat Rev Drug Discov 8 2009 321 335
14. C. Pinto, M. Hübner, A. Gille, M. Richter, T.C. Mou, and S.R. Sprang Differential interactions of the catalytic subunits of adenylyl cyclase with forskolin analogs Biochem Pharmacol 78 2009 62 69
15. C. Pinto, D. Papa, M. Hübner, T.C. Mou, G.H. Lushington, and R. Seifert Activation and inhibition of adenylyl cyclase isoforms by forskolin analogs J Pharmacol Exp Ther 325 2008 27 36 (Pubitemid 351439155)
16. W.J. Tang, and J.H. Hurley Catalytic mechanism and regulation of mammalian adenylyl cyclases Mol Pharmacol 54 1998 231 240 (Pubitemid 28368811)
17. A. Laurenza, Y. Khandelwal, N.J. De Souza, R.H. Rupp, H. Metzger, and K.B. Seamon Stimulation of adenylate cyclase by water-soluble analogues of forskolin Mol Pharmacol 32 1987 133 139 (Pubitemid 17112325)
18. N. Takahashi, T. Nemoto, R. Kimura, A. Tachikawa, A. Miwa, and H. Okado Two-photon excitation imaging of pancreatic islets with various fluorescent probes Diabetes 51 2002 S25 S28
19. W.J. Tang, and A.G. Gilman Type-specific regulation of adenylyl cyclase by G protein βγ subunits Science 254 1991 1500 1503 (Pubitemid 21917488)
20. T.C. Mou, A. Gille, D.A. Fancy, R. Seifert, and S.R. Sprang Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2′(3′)-O-(N-methylanthraniloyl)-guanosine 5′-triphosphate J Biol Chem 280 2005 7253 7261 (Pubitemid 40341283)
21. Sα fusion protein Eur J Biochem 255 1998 369 382 (Pubitemid 28340245)
22. M.L. Verdonk, J.C. Cole, M.J. Hartshorn, C.W. Murray, and R.D. Taylor Improved protein-ligand docking using GOLD Proteins 52 2003 609 623 (Pubitemid 37034158)
23. S. Suryanarayana, C. Pinto, T.C. Mou, M. Richter, G.H. Lushington, and R. Seifert The C1 homodimer of adenylyl cyclase binds nucleotides with high affinity but possesses exceedingly low catalytic activity Neurosci Lett 467 2009 1 5
24. G. Zhang, Y. Liu, A.E. Ruoho, and J.H. Hurley Structure of the adenylyl cyclase catalytic core Nature 386 1997 247 253 (Pubitemid 27142504)
25. J.J. Tesmer, and S.R. Sprang The structure, catalytic mechanism and regulation of adenylyl cyclase Curr Opin Struct Biol 8 1998 713 719 (Pubitemid 29004668)
26. T.C. Mou, A. Gille, S. Suryanarayana, M. Richter, R. Seifert, and S.R. Sprang Broad specificity of mammalian adenylyl cyclase for interaction with 2′,3′-substituted purine- and pyrimidine nucleotide inhibitors Mol Pharmacol 70 2006 878 886 (Pubitemid 44268445)
27. M. Göttle, J. Geduhn, B. König, A. Gille, K. Höcherl, and R. Seifert Characterization of mouse heart adenylyl cyclase J Pharmacol Exp Ther 329 2009 1156 1165
28. J.P. Pieroni, A. Harry, J. Chen, O. Jacobowitz, R.P. Magnusson, and R. Iyengar Distinct characteristics of the basal activities of adenylyl cyclases 2 and 6 J Biol Chem 270 1995 21368 21373
29. T.C. Mou, N. Masada, D.M. Cooper, and S.R. Sprang Structural basis for inhibition of mammalian adenylyl cyclase by calcium Biochemistry 48 2009 3387 3397
30. M. Erdorf, and R. Seifert Pharmacological characterization of adenylyl cyclase isoforms in rabbit kidney membranes Naunyn-Schmiedeberg's Arch Pharmacol 383 2011 357 372
31. K.B. Seamon, W. Padgett, J.W. Daly, and Forskolin Unique diterpene activator of adenylate cyclase in membranes and in intact cells Proc Natl Acad Sci U S A 78 1981 3363 3437
32. Y. Shen, N.L. Zhukovskaya, M.I. Zimmer, S. Soelaiman, P. Bergson, and C.R. Wang Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection Proc Natl Acad Sci U S A 101 2004 3242 3247 (Pubitemid 38327765)