Structural basis for inhibition of mammalian adenylyl cyclase by calcium

Biochemistry

Volumn 48, Issue 15, 2009, Pages 3387-3397

  Mou, Tung Chung ^a   Masada, Nanako ^b   Cooper, Dermot M F ^b   Sprang, Stephen R ^a  

^a UNIVERSITY OF MONTANA   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLYL CYCLASE; BIPHASIC; BOUND STATE; C1 DOMAINS; CALCIUM IONS; CARDIAC CONTRACTIONS; CARDIAC TISSUES; CYCLASES; LATTER COMPLEXES; METAL ION; METAL SITES; MICROMOLAR CONCENTRATIONS; OPEN CONFORMATIONS; RESOLUTION STRUCTURES; STRUCTURAL BASIS;

CALCIUM ALLOYS; COORDINATION REACTIONS; CRYSTAL STRUCTURE; CRYSTALS; FETAL MONITORING; MAMMALS; MANGANESE; MANGANESE COMPOUNDS; METAL IONS; PUMPING PLANTS;

CALCIUM;

ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; APOENZYME; CALCIUM; CALCIUM CHANNEL; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MAGNESIUM; MANGANESE; METAL ION; PYROPHOSPHATE;

ARTICLE; BINDING AFFINITY; CALCIUM BINDING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME STRUCTURE; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ADENYLATE CYCLASE; ANIMALS; BINDING, COMPETITIVE; CALCIUM; CATALYSIS; CATIONS, DIVALENT; CATTLE; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DIPHOSPHATES; DOGS; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME STABILITY; MAGNESIUM; PROTEIN BINDING; PROTEIN CONFORMATION; RATS; THIONUCLEOTIDES;

MAMMALIA;

EID: 65249111582     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi802122k     Document Type: Article

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