Characterization of mouse heart adenylyl cyclase

Journal of Pharmacology and Experimental Therapeutics

Volumn 329, Issue 3, 2009, Pages 1156-1165

  Göttle, Martin ^a   Geduhn, Jens ^a   König, Burkhard ^a   Gille, Andreas ^b,d   Höcherl, Klaus ^a   Seifert, Roland ^c  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY OF KANSAS   (United States)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2'(3') O (N METHYLANTHRANILOYL)NUCLEOSIDE 5' (GAMMA THIO)TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; ADENYLATE CYCLASE INHIBITOR; ADRENALIN; DITERPENE; DOPAMINE; FORSKOLIN; GLUCAGON; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HISTAMINE; ISOENZYME; ISOPRENALINE; MAGNESIUM ION; MANGANESE; NEUROPEPTIDE Y; NORADRENALIN; RECOMBINANT ADENYLATE CYCLASE 5; RECOMBINANT ENZYME; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITOR INTERACTION; ENZYME KINETICS; FEMALE; HEART MUSCLE FIBER MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME ECHOGRAPHY;

ADENYLATE CYCLASE; ANIMALS; CATALYSIS; CATIONS, DIVALENT; CELL LINE; CELL MEMBRANE; ENZYME INHIBITORS; FEMALE; FORSKOLIN; GENE EXPRESSION; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATE; ISOENZYMES; ISOPROTERENOL; KINETICS; METOPROLOL; MICE; MICE, INBRED STRAINS; MYOCARDIUM; PROTEIN ISOFORMS; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT PROTEINS; SPODOPTERA;

EID: 66749133607     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.150953     Document Type: Article

References (40)

1. Beazely MA and Watts VJ (2006) Regulatory properties of adenylate cyclases type 5 and 6: a progress report. Eur J Pharmacol 535:1-12.
2. Defer N, Best-Belpomme M, and Hanoune J (2000) Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase. Am J Physiol Renal Physiol 279:F400-F416.
3. 2 adrenoceptor knockout mice. Mol Pharmacol 60:577-583.
4. 2 receptor ligands. Mini Rev Med Chem 4:941-954.
5. Eckstein F (1985) Nucleoside phosphorothioates. Annu Rev Biochem 54:367-402. (Pubitemid 15073651)
6. 1-receptor transgenic mice. Mol Pharmacol 60:712-717.
7. olf α and adenylyl cyclase mRNA expressions in the rat heart during ontogenic development. J Mol Cell Cardiol 31:1137-1142.
8. Fonarow GC (2008) Epidemiology and risk stratification in acute heart failure. Am Heart J 155:200-207.
9. Fryer RM, Reinhart GA, and Esbenshade TA (2006) Histamine in cardiac sympathetic ganglia: a novel neurotransmitter? Mol Interv 6:14-19, 2. (Pubitemid 43327517)
10. Gille A, Guo J, Mou TC, Doughty MB, Lushington GH, and Seifert R (2005) Differential interactions of G-proteins and adenylyl cyclase with nucleoside 5′- triphosphates, nucleoside 5′-[γ-thio]triphosphates and nucleoside 5′-[β,γ-imido]triphosphates. Biochem Pharmacol 71:89-97. (Pubitemid 41713530)
11. Gille A, Lushington GH, Mou TC, Doughty MB, Johnson RA, and Seifert R (2004) Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides. J Biol Chem 279:19955-19969. (Pubitemid 38623438)
12. Gilman AG (1987) G proteins: transducers of receptor-generated signals. Annu Rev Biochem 56:615-649.
13. Glatt CE and Snyder SH (1993) Cloning and expression of an adenylyl cyclase localized to the corpus striatum. Nature 361:536-538. (Pubitemid 23055614)
14. Hanoune J and Defer N (2001) Regulation and role of adenylyl cyclase isoforms. Annu Rev Pharmacol Toxicol 41:145-174. (Pubitemid 32385886)
15. q-protein coupling. J Neurochem 80:678-696.
16. Iwatsubo K, Minamisawa S, Tsunematsu T, Nakagome M, Toya Y, Tomlinson JE, Umemura S, Scarborough RM, Levy DE, and Ishikawa Y (2004) Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration. J Biol Chem 279:40938-40945. (Pubitemid 39287693)
17. s, and its regulation by hormones and guanine nucleotides. Biochem Biophys Res Commun 151:248-256.
18. Laux WH, Pande P, Shoshani I, Gao J, Boudou-Vivet V, Gosselin G, and Johnson RA (2004) Pro-nucleotide inhibitors of adenylyl cyclases in intact cells. J Biol Chem 279:13317-13332. (Pubitemid 38468854)
19. Levy FO, Qvigstad E, Krobert KA, Skomedal T, and Osnes JB (2008) Effects of serotonin in failing cardiac ventricle: signalling mechanisms and potential therapeutic implications. Neuropharmacology 55:1066-1071.
20. Liu X, Thangavel M, Sun SQ, Kaminsky J, Mahautmr P, Stitham J, Hwa J, and Ostrom RS (2008) Adenylyl cyclase type 6 overexpression selectively enhances β-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts. Naunyn Schmiedebergs Arch Pharmacol 377:359-369.
21. Lohse MJ, Engelhardt S, and Eschenhagen T (2003) What is the role of β-adrenergic signaling in heart failure? Circ Res 93:896-906. (Pubitemid 37433227)
22. Manolopoulos VG, Liu J, Unsworth BR, and Lelkes PI (1995) Adenylyl cyclase isoforms are differentially expressed in primary cultures of endothelial cells and whole tissue homogenates from various rat tissues. Biochem Biophys Res Commun 208:323-331.
23. 2 receptor gene and protein levels are differentially expressed in the hearts of rodents and humans. J Pharmacol Exp Ther 309:786-795.
24. Matzdorf C, Kurtz A, and Höcherl K (2007) COX-2 activity determines the level of renin expression but is dispensable for acute upregulation of renin expression in rat kidneys. Am J Physiol Renal Physiol 292:F1782-F1790.
25. McDermott BJ and Bell D (2007) NPY and cardiac diseases. Curr Top Med Chem 7:1692-1703. (Pubitemid 350131006)
26. 2+ current by activation of adenylyl cyclase and inhibition of phosphodiesterase. Nature 345:158-161.
27. Okumura S, Takagi G, Kawabe J, Yang G, Lee MC, Hong C, Liu J, Vatner DE, Sadoshima J, Vatner SF, et al. (2003) Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload. Proc Natl Acad Sci U S A 100:9986-9990. (Pubitemid 37087055)
28. Pinto C, Papa D, Hübner M, Mou TC, Lushington GH, and Seifert R (2008) Activation and inhibition of adenylyl cyclase isoforms by forskolin analogs. J Pharmacol Exp Ther 325:27-36.
29. Risøe PK, Wang Y, Stuestøl JF, Aasen AO, Wang JE, and Dahle MK (2007) Lipopolysaccharide attenuates mRNA levels of several adenylyl cyclase isoforms in vivo. Biochim Biophys Acta 1772:32-39. (Pubitemid 44960724)
30. 1-adrenergic receptor gene: developmental and cardiovascular effects. Proc Natl Acad Sci U S A 93:7375-7380.
31. Rottlaender D, Matthes J, Vatner SF, Seifert R, and Herzig S (2007) Functional adenylyl cyclase inhibition in murine cardiomyocytes by 2′(3′)-O-(N-methylanthraniloyl)- guanosine 5′-[′-thio] triphosphate. J Pharmacol Exp Ther 321:608-615. (Pubitemid 46624491)
32. Salazar NC, Chen J, and Rockman HA (2007) Cardiac GPCRs: GPCR signaling in healthy and failing hearts. Biochim Biophys Acta 1768:1006-1018. (Pubitemid 46463942)
33. Sunahara RK and Taussig R (2002) Isoforms of mammalian adenylyl cyclase: multiplicities of signaling. Mol Interv 2:168-184.
34. Taha HM, Schmidt J, Göttle M, Suryanarayana S, Shen Y, Tang WJ, Gille A, Geduhn J, König B, Dove S, et al. (2009) Molecular analysis of the interaction of adenylyl cyclase toxin, edema factor, with 2′(3′)-O- (N-methyl)anthraniloyl)- substituted purine and pyrimidine nucleotides. Mol Pharmacol 75:693-703.
35. Takahashi T, Tang T, Lai NC, Roth DM, Rebolledo B, Saito M, Lew WY, Clopton P, and Hammond HK (2006) Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction. Circulation 114:388-396. (Pubitemid 44264820)
36. 2-adrenoceptors with isoproterenol, epinephrine, norepinephrine, and dopamine. J Pharmacol Exp Ther 327:760-769.
37. sα splice variants. Biochem Pharmacol 64:9-20.
38. Yan L, Vatner DE, O'Connor JP, Ivessa A, Ge H, Chen W, Hirotani S, Ishikawa Y, Sadoshima J, and Vatner SF (2007) Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell 130:247-258. (Pubitemid 47081133)
39. Yan SZ, Huang ZH, Andrews RK, and Tang WJ (1998) Conversion of forskolininsensitive to forskolin-sensitive (mouse-type IX) adenylyl cyclase. Mol Pharmacol 53:182-187. (Pubitemid 28099726)
40. 2 double knockout mice. Mol Pharmacol 58:887-894.